Details for: TAF13

Gene ID: 6884

Symbol: TAF13

Ensembl ID: ENSG00000197780

Description: TATA-box binding protein associated factor 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.7015
    Cell Significance Index: -20.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.3347
    Cell Significance Index: -20.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.9126
    Cell Significance Index: -20.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.1182
    Cell Significance Index: -20.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.1458
    Cell Significance Index: -21.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4136
    Cell Significance Index: -19.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4079
    Cell Significance Index: -21.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1984
    Cell Significance Index: -7.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4195
    Cell Significance Index: 239.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1463
    Cell Significance Index: 1035.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0586
    Cell Significance Index: 63.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8900
    Cell Significance Index: 96.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8167
    Cell Significance Index: 23.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7241
    Cell Significance Index: 9.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6720
    Cell Significance Index: 109.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5273
    Cell Significance Index: 14.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5149
    Cell Significance Index: 97.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5116
    Cell Significance Index: 13.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4932
    Cell Significance Index: 34.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3176
    Cell Significance Index: 16.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2987
    Cell Significance Index: 59.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2687
    Cell Significance Index: 48.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2589
    Cell Significance Index: 31.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2567
    Cell Significance Index: 140.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2285
    Cell Significance Index: 4.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2153
    Cell Significance Index: 10.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2087
    Cell Significance Index: 41.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2065
    Cell Significance Index: 9.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1776
    Cell Significance Index: 78.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1774
    Cell Significance Index: 5.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1549
    Cell Significance Index: 11.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1545
    Cell Significance Index: 7.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1234
    Cell Significance Index: 3.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1050
    Cell Significance Index: 14.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1031
    Cell Significance Index: 37.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0840
    Cell Significance Index: 5.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0374
    Cell Significance Index: 2.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0306
    Cell Significance Index: 3.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0198
    Cell Significance Index: 2.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0153
    Cell Significance Index: 1.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0042
    Cell Significance Index: 5.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0057
    Cell Significance Index: -8.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0087
    Cell Significance Index: -16.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0192
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0221
    Cell Significance Index: -16.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0229
    Cell Significance Index: -10.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0274
    Cell Significance Index: -15.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0324
    Cell Significance Index: -3.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0362
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0364
    Cell Significance Index: -22.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0458
    Cell Significance Index: -1.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0461
    Cell Significance Index: -4.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0498
    Cell Significance Index: -3.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0623
    Cell Significance Index: -17.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0834
    Cell Significance Index: -9.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0844
    Cell Significance Index: -2.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0861
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0899
    Cell Significance Index: -13.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0950
    Cell Significance Index: -11.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1105
    Cell Significance Index: -23.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1380
    Cell Significance Index: -8.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1544
    Cell Significance Index: -10.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1551
    Cell Significance Index: -1.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1635
    Cell Significance Index: -9.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1724
    Cell Significance Index: -2.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1775
    Cell Significance Index: -10.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1805
    Cell Significance Index: -5.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1818
    Cell Significance Index: -14.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1944
    Cell Significance Index: -1.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2002
    Cell Significance Index: -20.8500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2202
    Cell Significance Index: -2.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2317
    Cell Significance Index: -3.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2759
    Cell Significance Index: -5.1000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2789
    Cell Significance Index: -3.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3095
    Cell Significance Index: -6.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3115
    Cell Significance Index: -8.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3228
    Cell Significance Index: -16.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3741
    Cell Significance Index: -6.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3771
    Cell Significance Index: -5.6500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3788
    Cell Significance Index: -5.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3794
    Cell Significance Index: -16.7800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3845
    Cell Significance Index: -5.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3950
    Cell Significance Index: -5.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4193
    Cell Significance Index: -14.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4233
    Cell Significance Index: -10.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4304
    Cell Significance Index: -9.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4344
    Cell Significance Index: -15.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4551
    Cell Significance Index: -17.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4559
    Cell Significance Index: -13.3900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4635
    Cell Significance Index: -2.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4763
    Cell Significance Index: -14.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4796
    Cell Significance Index: -12.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4837
    Cell Significance Index: -12.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4947
    Cell Significance Index: -16.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4985
    Cell Significance Index: -10.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4998
    Cell Significance Index: -17.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TAF13 exhibits several key characteristics that make it an essential component of the transcriptional machinery. These include: 1. **TBP association**: TAF13 is a TBP-associated factor, which means it interacts with the TBP protein to form the TFIID complex. 2. **Transcriptional regulation**: TAF13 plays a critical role in regulating transcriptional initiation by RNAPII, particularly in the context of viral infections. 3. **HIV transcriptional regulation**: TAF13 is essential for regulating HIV transcriptional initiation, which is a key factor in understanding the pathogenesis of HIV. 4. **Cell-type specificity**: TAF13 is highly expressed in various cell types, including pancreatic acinar cells, glandular epithelial cells, and fibroblasts from the mammary gland. **Pathways and Functions** TAF13 is involved in various signaling pathways and processes, including: 1. **DNA-templated transcription initiation**: TAF13 is essential for the initiation of transcription by RNAPII, which is a critical step in gene expression. 2. **DNA binding**: TAF13 interacts with DNA to regulate transcriptional initiation. 3. **Gene expression (transcription)**: TAF13 plays a critical role in regulating gene expression by controlling transcriptional initiation. 4. **HIV life cycle**: TAF13 is essential for regulating HIV transcriptional initiation, which is a key factor in understanding the pathogenesis of HIV. 5. **TP53 regulation**: TAF13 interacts with TP53, a tumor suppressor protein, to regulate its activity. **Clinical Significance** TAF13 has significant clinical implications, particularly in the context of: 1. **HIV/AIDS**: TAF13 plays a critical role in regulating HIV transcriptional initiation, which is a key factor in understanding the pathogenesis of HIV. 2. **Cancer**: TAF13 interacts with TP53, a tumor suppressor protein, to regulate its activity, which is essential for preventing cancer. 3. **Immune response**: TAF13 is involved in regulating gene expression in immune cells, which is critical for understanding immune response and disease. 4. **Viral infections**: TAF13 is essential for regulating transcriptional initiation in various viral infections, including HIV. In conclusion, TAF13 is a crucial component of the transcriptional machinery that plays a pivotal role in regulating gene expression, particularly in the context of immune response and disease. Its clinical significance is evident in its involvement in HIV/AIDS, cancer, and viral infections. Further research is necessary to fully elucidate the functions of TAF13 and its role in regulating gene expression.

Genular Protein ID: 887375585

Symbol: TAF13_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q15543 B2R5E5 Q5TYV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 26 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 28 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7729427

Title: Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

PubMed ID: 7729427

DOI: 10.1002/j.1460-2075.1995.tb07138.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28257693

Title: Hypomorphic Pathogenic variants in TAF13 are associated with autosomal-recessive intellectual disability and microcephaly.

PubMed ID: 28257693

DOI: 10.1016/j.ajhg.2017.01.032

PubMed ID: 9695952

Title: Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.

PubMed ID: 9695952

DOI: 10.1016/s0092-8674(00)81423-3

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 124
  • Mass: 14287
  • Checksum: 98B62FF1BC8E7B77
  • Sequence:
    • MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY TESVDILEDL 
VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV KDLLTMNEEL KRARKAFDEA 
NYGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.