TBL1X | ENSG00000101849 | NCBI 6907

Details for: TBL1X

Gene ID: 6907

Symbol: TBL1X

Ensembl ID: ENSG00000101849

Description: transducin beta like 1 X-linked

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Adipogenesis
(R-HSA-9843745)
Bmal1:clock,npas2 activates circadian gene expression
(R-HSA-1368108)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Circadian clock
(R-HSA-400253)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Cytoprotection by hmox1
(R-HSA-9707564)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Heme signaling
(R-HSA-9707616)
Infectious disease
(R-HSA-5663205)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of mecp2 binding ability to the ncor/smrt complex
(R-HSA-9022537)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Mitochondrial biogenesis
(R-HSA-1592230)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pervasive developmental disorders
(R-HSA-9005895)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Rora activates gene expression
(R-HSA-1368082)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Viral infection pathways
(R-HSA-9824446)
Histone binding
(GO:0042393)
Histone deacetylase complex
(GO:0000118)
Identical protein binding
(GO:0042802)
Mitotic spindle
(GO:0072686)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Proteolysis
(GO:0006508)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sensory perception of sound
(GO:0007605)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription corepressor activity
(GO:0003714)
Transcription repressor complex
(GO:0017053)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 259.2172
Cell Significance Index: -40.3200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 158.8451
Cell Significance Index: -40.2900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 84.9356
Cell Significance Index: -40.1000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 79.1125
Cell Significance Index: -32.1400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 71.5806
Cell Significance Index: -36.8200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 33.7473
Cell Significance Index: -32.2200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 32.8641
Cell Significance Index: -40.5200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.9182
Cell Significance Index: -37.2900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.4503
Cell Significance Index: -25.0600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.7376
Cell Significance Index: -32.9800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.3243
Cell Significance Index: -40.7400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 9.2924
Cell Significance Index: 248.1200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9079
Cell Significance Index: 577.0800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.4796
Cell Significance Index: 139.1400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.9980
Cell Significance Index: 27.2600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.7761
Cell Significance Index: 78.5600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6979
Cell Significance Index: 47.4500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.6160
Cell Significance Index: 61.2000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.5943
Cell Significance Index: 40.9800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.5705
Cell Significance Index: 26.4600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.2470
Cell Significance Index: 145.3200
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 1.1664
Cell Significance Index: 16.3100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.1382
Cell Significance Index: 14.1200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.1017
Cell Significance Index: 27.5400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.9555
Cell Significance Index: 1799.0200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.9547
Cell Significance Index: 433.2900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7945
Cell Significance Index: 60.9700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7333
Cell Significance Index: 662.0900
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.7047
Cell Significance Index: 15.4300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6109
Cell Significance Index: 31.7400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.6071
Cell Significance Index: 63.2100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5690
Cell Significance Index: 361.3500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.5625
Cell Significance Index: 764.7900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5257
Cell Significance Index: 94.7700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5231
Cell Significance Index: 64.3300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4930
Cell Significance Index: 80.1900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4623
Cell Significance Index: 9.8500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.4600
Cell Significance Index: 848.3900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.4544
Cell Significance Index: 699.5500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4444
Cell Significance Index: 48.3400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4341
Cell Significance Index: 87.0700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3867
Cell Significance Index: 53.1000
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3366
Cell Significance Index: 6.5700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2836
Cell Significance Index: 196.1700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2639
Cell Significance Index: 7.0700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2562
Cell Significance Index: 139.9400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2519
Cell Significance Index: 47.9300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2297
Cell Significance Index: 14.4800
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2231
Cell Significance Index: 2.6600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1270
Cell Significance Index: 8.7900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1259
Cell Significance Index: 12.4500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1258
Cell Significance Index: 8.4600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1229
Cell Significance Index: 15.7600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1004
Cell Significance Index: 6.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0883
Cell Significance Index: 31.6600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0692
Cell Significance Index: 1.5000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0549
Cell Significance Index: 24.2800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0328
Cell Significance Index: 5.6000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0146
Cell Significance Index: 10.7200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0016
Cell Significance Index: 0.2300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0080
Cell Significance Index: -0.2300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0082
Cell Significance Index: -5.1400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0092
Cell Significance Index: -6.7900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0181
Cell Significance Index: -0.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0293
Cell Significance Index: -16.5000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0456
Cell Significance Index: -34.5500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0785
Cell Significance Index: -3.6900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0806
Cell Significance Index: -3.6600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0870
Cell Significance Index: -18.3200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0878
Cell Significance Index: -10.3600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1094
Cell Significance Index: -11.1800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1138
Cell Significance Index: -32.7500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1151
Cell Significance Index: -1.0600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1235
Cell Significance Index: -5.7600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1432
Cell Significance Index: -2.0600
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.1724
Cell Significance Index: -1.5300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1816
Cell Significance Index: -2.6800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1958
Cell Significance Index: -25.3000
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2005
Cell Significance Index: -2.5000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2122
Cell Significance Index: -24.3100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2195
Cell Significance Index: -25.0600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3172
Cell Significance Index: -23.6400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3298
Cell Significance Index: -26.1200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3558
Cell Significance Index: -7.3800
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.3684
Cell Significance Index: -6.3700
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.3906
Cell Significance Index: -4.9300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4068
Cell Significance Index: -13.0300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4097
Cell Significance Index: -20.7000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4301
Cell Significance Index: -30.4200
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4611
Cell Significance Index: -11.2500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4853
Cell Significance Index: -13.2100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4978
Cell Significance Index: -30.5200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4993
Cell Significance Index: -32.2100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5657
Cell Significance Index: -29.7000
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.5659
Cell Significance Index: -8.6100
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5781
Cell Significance Index: -13.8700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5829
Cell Significance Index: -30.3600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5836
Cell Significance Index: -8.3800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6011
Cell Significance Index: -11.1100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.6046
Cell Significance Index: -4.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TBL1X is a F-box-like/WD repeat-containing protein, which suggests its involvement in protein-protein interactions and transcriptional regulation. The gene is highly conserved across species, indicating its essential role in cellular functions. TBL1X is a ubiquitin ligase, which means it plays a key role in protein degradation and turnover. The gene is also involved in the regulation of circadian gene expression, suggesting its potential role in rhythmical processes. Furthermore, TBL1X has been implicated in the regulation of cholesterol biosynthesis and lipid metabolism, highlighting its importance in metabolic processes. **Pathways and Functions** TBL1X is involved in several signaling pathways, including: 1. **Circadian clock regulation**: TBL1X interacts with clock genes, such as Bmal1 and npas2, to regulate circadian gene expression. 2. **Notch signaling**: TBL1X is a component of the Notch signaling pathway, which plays a crucial role in cell fate decisions and development. 3. **Cholesterol biosynthesis**: TBL1X regulates cholesterol biosynthesis by interacting with SREBP (sterol regulatory element-binding protein) and PPARα (peroxisome proliferator-activated receptor alpha). 4. **Lipid metabolism**: TBL1X is involved in the regulation of lipid metabolism by interacting with PPARα and NR1H3. 5. **Transcriptional regulation**: TBL1X regulates transcription by interacting with RNA polymerase II and other transcription factors. **Clinical Significance** TBL1X has been implicated in several diseases, including: 1. **Pervasive developmental disorders**: TBL1X mutations have been associated with pervasive developmental disorders, such as autism spectrum disorder. 2. **Disorders of nervous system development**: TBL1X is involved in the development of the nervous system, and mutations in the gene have been associated with disorders of nervous system development. 3. **Disorders of signal transduction**: TBL1X is involved in the regulation of signal transduction pathways, and mutations in the gene have been associated with disorders of signal transduction by growth factor receptors and second messengers. 4. **Cholesterol-related disorders**: TBL1X regulates cholesterol biosynthesis, and mutations in the gene have been associated with cholesterol-related disorders. In conclusion, TBL1X is a multifunctional gene that plays a crucial role in various cellular processes, including transcriptional regulation, circadian rhythm control, and immune response. Its involvement in several diseases highlights its importance in human health and disease. Further research is needed to fully understand the functions of TBL1X and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

F-box-like/WD repeat-containing protein TBL1X

Genular Protein ID: 1174192327

Symbol: TBL1X_HUMAN

Name: F-box-like/WD repeat-containing protein TBL1X

UniProtKB Accession Codes:

O60907 A8K044 A8K4J7 Q86UY2

Database IDs:

Citations:

PubMed ID: 10330347

Title: X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats.

PubMed ID: 10330347

DOI: 10.1086/302408

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10809664

Title: A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.

PubMed ID: 10809664

PubMed ID: 10944117

Title: Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.

PubMed ID: 10944117

DOI: 10.1093/emboj/19.16.4342

PubMed ID: 11389839

Title: Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.

PubMed ID: 11389839

DOI: 10.1016/s1097-2765(01)00242-8

PubMed ID: 11931768

Title: The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

PubMed ID: 11931768

DOI: 10.1016/s1097-2765(02)00468-9

PubMed ID: 12628926

Title: Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.

PubMed ID: 12628926

DOI: 10.1093/emboj/cdg120

PubMed ID: 14980219

Title: A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.

PubMed ID: 14980219

DOI: 10.1016/s0092-8674(04)00133-3

PubMed ID: 24943844

Title: SUMOylation of GPS2 protein regulates its transcription-suppressing function.

PubMed ID: 24943844

DOI: 10.1091/mbc.e13-12-0733

PubMed ID: 27603907

Title: Mutations in TBL1X are associated with central hypothyroidism.

PubMed ID: 27603907

DOI: 10.1210/jc.2016-2531

PubMed ID: 27880911

Title: USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.

PubMed ID: 27880911

DOI: 10.1016/j.celrep.2016.10.076

PubMed ID: 30591955

Title: Central hypothyroidism and novel clinical phenotypes in hemizygous truncation of TBL1X.

PubMed ID: 30591955

DOI: 10.1210/js.2018-00144

PubMed ID: 21240272

Title: Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.

PubMed ID: 21240272

DOI: 10.1038/nsmb.1983

Sequence Information:

Length: 577
Mass: 62496
Checksum: D830A37781E2A15C
Sequence:

MTELAGASSS CCHRPAGRGA MQSVLHHFQR LRGREGGSHF INTSSPRGEA KMSITSDEVN 
FLVYRYLQES GFSHSAFTFG IESHISQSNI NGTLVPPAAL ISILQKGLQY VEAEISINED 
GTVFDGRPIE SLSLIDAVMP DVVQTRQQAF REKLAQQQAS AAAAAAAATA AATAATTTSA 
GVSHQNPSKN REATVNGEEN RAHSVNNHAK PMEIDGEVEI PSSKATVLRG HESEVFICAW 
NPVSDLLASG SGDSTARIWN LNENSNGGST QLVLRHCIRE GGHDVPSNKD VTSLDWNTNG 
TLLATGSYDG FARIWTEDGN LASTLGQHKG PIFALKWNRK GNYILSAGVD KTTIIWDAHT 
GEAKQQFPFH SAPALDVDWQ NNTTFASCST DMCIHVCRLG CDRPVKTFQG HTNEVNAIKW 
DPSGMLLASC SDDMTLKIWS MKQEVCIHDL QAHNKEIYTI KWSPTGPATS NPNSNIMLAS 
ASFDSTVRLW DIERGVCTHT LTKHQEPVYS VAFSPDGKYL ASGSFDKCVH IWNTQSGNLV 
HSYRGTGGIF EVCWNARGDK VGASASDGSV CVLDLRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TBL1X

Associated with

Cells (max top 100)

Other Information

X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. PubMed ID: 10330347

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. PubMed ID: 10809664

Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. PubMed ID: 10944117

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. PubMed ID: 11389839

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. PubMed ID: 11931768

Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. PubMed ID: 12628926

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. PubMed ID: 14980219

SUMOylation of GPS2 protein regulates its transcription-suppressing function. PubMed ID: 24943844

Mutations in TBL1X are associated with central hypothyroidism. PubMed ID: 27603907

USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B. PubMed ID: 27880911

Central hypothyroidism and novel clinical phenotypes in hemizygous truncation of TBL1X. PubMed ID: 30591955

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. PubMed ID: 21240272