Details for: ELOA

Gene ID: 6924

Symbol: ELOA

Ensembl ID: ENSG00000011007

Description: elongin A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.2544
    Cell Significance Index: -23.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.6349
    Cell Significance Index: -23.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8736
    Cell Significance Index: -26.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6716
    Cell Significance Index: -17.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4382
    Cell Significance Index: 142.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3272
    Cell Significance Index: 215.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2579
    Cell Significance Index: 34.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0217
    Cell Significance Index: 13.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6302
    Cell Significance Index: 77.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6132
    Cell Significance Index: 31.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5899
    Cell Significance Index: 26.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5720
    Cell Significance Index: 103.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5504
    Cell Significance Index: 28.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5224
    Cell Significance Index: 36.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5147
    Cell Significance Index: 33.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4435
    Cell Significance Index: 88.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3887
    Cell Significance Index: 18.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3759
    Cell Significance Index: 75.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3676
    Cell Significance Index: 50.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3270
    Cell Significance Index: 4.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3138
    Cell Significance Index: 9.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2776
    Cell Significance Index: 151.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2535
    Cell Significance Index: 90.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2445
    Cell Significance Index: 108.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2414
    Cell Significance Index: 17.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1938
    Cell Significance Index: 33.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1855
    Cell Significance Index: 5.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1707
    Cell Significance Index: 8.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1596
    Cell Significance Index: 20.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1309
    Cell Significance Index: 8.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1287
    Cell Significance Index: 24.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0993
    Cell Significance Index: 68.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0938
    Cell Significance Index: 12.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0773
    Cell Significance Index: 4.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0652
    Cell Significance Index: 4.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0485
    Cell Significance Index: 43.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0306
    Cell Significance Index: 23.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0305
    Cell Significance Index: 0.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0261
    Cell Significance Index: 1.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0134
    Cell Significance Index: 1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0071
    Cell Significance Index: 13.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0057
    Cell Significance Index: 0.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0113
    Cell Significance Index: -15.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0204
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0220
    Cell Significance Index: -16.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0279
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0306
    Cell Significance Index: -0.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0393
    Cell Significance Index: -17.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0418
    Cell Significance Index: -23.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0543
    Cell Significance Index: -6.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0546
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0557
    Cell Significance Index: -34.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0627
    Cell Significance Index: -9.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0836
    Cell Significance Index: -24.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0850
    Cell Significance Index: -1.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1020
    Cell Significance Index: -6.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1150
    Cell Significance Index: -2.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1152
    Cell Significance Index: -13.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1196
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1440
    Cell Significance Index: -30.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1477
    Cell Significance Index: -4.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1621
    Cell Significance Index: -8.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1697
    Cell Significance Index: -2.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1702
    Cell Significance Index: -3.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1788
    Cell Significance Index: -12.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1993
    Cell Significance Index: -5.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2220
    Cell Significance Index: -6.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2551
    Cell Significance Index: -26.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2615
    Cell Significance Index: -1.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2653
    Cell Significance Index: -21.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2658
    Cell Significance Index: -6.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3203
    Cell Significance Index: -6.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3336
    Cell Significance Index: -6.5100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3642
    Cell Significance Index: -2.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3799
    Cell Significance Index: -6.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3820
    Cell Significance Index: -23.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3828
    Cell Significance Index: -16.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4360
    Cell Significance Index: -4.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4420
    Cell Significance Index: -8.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4528
    Cell Significance Index: -4.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4532
    Cell Significance Index: -10.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4547
    Cell Significance Index: -17.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4613
    Cell Significance Index: -6.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4880
    Cell Significance Index: -19.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5062
    Cell Significance Index: -14.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5633
    Cell Significance Index: -14.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5863
    Cell Significance Index: -4.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5890
    Cell Significance Index: -21.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6152
    Cell Significance Index: -13.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6311
    Cell Significance Index: -22.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6418
    Cell Significance Index: -20.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6491
    Cell Significance Index: -21.2500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6528
    Cell Significance Index: -9.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6640
    Cell Significance Index: -7.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6942
    Cell Significance Index: -19.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Elongin A is a 110-kDa protein that is significantly expressed in various cell types, including pancreatic acinar cells, extravillous trophoblasts, cortical thymic epithelial cells, and oogonial cells. It is part of the elongin complex, which is composed of elongin A, elongin B, and CBP. The elongin complex is involved in the regulation of transcription elongation by RNA polymerase II, and it plays a crucial role in the regulation of gene expression in response to DNA damage. Elongin A is also involved in the regulation of transcription elongation by RNA polymerase II in the context of viral infections, such as HIV-1. The HIV-1 Tat protein is a key regulatory protein that interacts with the elongin complex to regulate the activity of RNA polymerase II and promote viral transcription. Elongin A is required for the formation of the HIV-1 elongation complex, which is essential for the efficient transcription of the HIV-1 genome. **Pathways and Functions** The elongin A gene is involved in several key pathways, including: 1. **Transcription elongation by RNA polymerase II**: Elongin A is a key component of the elongin complex, which regulates the activity of RNA polymerase II and promotes transcription elongation. 2. **Viral infection pathways**: Elongin A is involved in the regulation of transcription elongation by RNA polymerase II in the context of viral infections, such as HIV-1. 3. **DNA damage response**: Elongin A is required for the formation of the DNA damage response complex, which regulates the activity of DNA repair genes. 4. **Transcriptional regulation by p53**: Elongin A is involved in the regulation of transcriptional regulation by p53, a key tumor suppressor protein. **Clinical Significance** The elongin A gene has several potential clinical implications: 1. **HIV-1 infection**: Elongin A is required for the efficient transcription of the HIV-1 genome, and its dysregulation may contribute to the development of HIV-1-related diseases. 2. **Cancer**: Elongin A is involved in the regulation of transcription elongation by RNA polymerase II, and its dysregulation may contribute to the development of cancer. 3. **DNA damage response**: Elongin A is required for the formation of the DNA damage response complex, and its dysregulation may contribute to the development of DNA damage-related diseases. 4. **Transcriptional regulation**: Elongin A is involved in the regulation of transcriptional regulation by p53, and its dysregulation may contribute to the development of p53-related diseases. In conclusion, the elongin A gene is a critical component of the elongin complex, which regulates transcription elongation by RNA polymerase II. Its dysregulation may contribute to the development of various diseases, including HIV-1 infection, cancer, and DNA damage-related diseases. Further research is needed to fully understand the role of elongin A in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 1859436444

Symbol: ELOA1_HUMAN

Name: Elongin 110 kDa subunit

UniProtKB Accession Codes:

Q14241 B2R7Q8 Q8IXH1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8654961

Title: A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin.

PubMed ID: 8654961

DOI: 10.1016/0378-1119(95)00750-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19920177

Title: Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.

PubMed ID: 19920177

DOI: 10.1073/pnas.0907052106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35633597

Title: UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.

PubMed ID: 35633597

DOI: 10.1016/j.dnarep.2022.103343

Sequence Information:

  • Length: 772
  • Mass: 87230
  • Checksum: 0D2C93B1D54EB09A
  • Sequence:
    • MAAESALQVV EKLQARLAAN PDPKKLLKYL KKLSTLPITV DILAETGVGK TVNSLRKHEH 
VGSFARDLVA QWKKLVPVER NAEPDEQDFE KSNSRKRPRD ALQKEEEMEG DYQETWKATG 
SRSYSPDHRQ KKHRKLSELE RPHKVSHGHE RRDERKRCHR MSPTYSSDPE SSDYGHVQSP 
PSCTSPHQMY VDHYRSLEED QEPIVSHQKP GKGHSNAFQD RLGASQERHL GEPHGKGVVS 
QNKEHKSSHK DKRPVDAKSD EKASVVSREK SHKALSKEEN RRPPSGDNAR EKPPSSGVKK 
EKDREGSSLK KKCLPPSEAA SDNHLKKPKH RDPEKAKLDK SKQGLDSFDT GKGAGDLLPK 
VKEKGSNNLK TPEGKVKTNL DRKSLGSLPK VEETDMEDEF EQPTMSFESY LSYDQPRKKK 
KKIVKTSATA LGDKGLKKND SKSTGKNLDS VQKLPKVNKT KSEKPAGADL AKLRKVPDVL 
PVLPDLPLPA IQANYRPLPS LELISSFQPK RKAFSSPQEE EEAGFTGRRM NSKMQVYSGS 
KCAYLPKMMT LHQQCIRVLK NNIDSIFEVG GVPYSVLEPV LERCTPDQLY RIEEYNHVLI 
EETDQLWKVH CHRDFKEERP EEYESWREMY LRLQDAREQR LRVLTKNIQF AHANKPKGRQ 
AKMAFVNSVA KPPRDVRRRQ EKFGTGGAAV PEKIKIKPAP YPMGSSHASA SSISFNPSPE 
EPAYDGPSTS SAHLAPVVSS TVSYDPRKPT VKKIAPMMAK TIKAFKNRFS RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.