Details for: TCF12
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 724.7410
Cell Significance Index: -112.7300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 442.4322
Cell Significance Index: -112.2200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 243.2842
Cell Significance Index: -114.8600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 220.9192
Cell Significance Index: -89.7500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 203.3884
Cell Significance Index: -104.6200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 171.1717
Cell Significance Index: -114.8600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 94.1615
Cell Significance Index: -89.9000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 92.9393
Cell Significance Index: -114.5900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 41.9723
Cell Significance Index: -91.8600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 39.6904
Cell Significance Index: -106.3300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.2225
Cell Significance Index: -98.9700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 29.1101
Cell Significance Index: -114.8700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 9.3557
Cell Significance Index: 525.0000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 5.0127
Cell Significance Index: 308.1100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 4.5137
Cell Significance Index: 108.2500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 4.4586
Cell Significance Index: 87.0200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 4.0285
Cell Significance Index: 35.7600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.9394
Cell Significance Index: 101.2600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.8045
Cell Significance Index: 1364.6100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.7779
Cell Significance Index: 289.9100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.6272
Cell Significance Index: 719.8300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.1252
Cell Significance Index: 87.3400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.9979
Cell Significance Index: 74.9400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.6280
Cell Significance Index: 176.7100 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.4655
Cell Significance Index: 35.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9393
Cell Significance Index: 389.0200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.5680
Cell Significance Index: 1084.4600 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.1865
Cell Significance Index: 7.3200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.1033
Cell Significance Index: 48.8000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.0690
Cell Significance Index: 2012.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.9615
Cell Significance Index: 1480.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.9112
Cell Significance Index: 413.5600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8818
Cell Significance Index: 33.3900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.8675
Cell Significance Index: 550.9300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.7414
Cell Significance Index: 1367.3200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5811
Cell Significance Index: 63.2100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.5740
Cell Significance Index: 14.0100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5676
Cell Significance Index: 16.3600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5474
Cell Significance Index: 89.0300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5384
Cell Significance Index: 238.0500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.5266
Cell Significance Index: 716.0900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5014
Cell Significance Index: 68.8500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4059
Cell Significance Index: 49.9200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3675
Cell Significance Index: 66.2600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3478
Cell Significance Index: 5.9600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3045
Cell Significance Index: 8.6900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2605
Cell Significance Index: 142.2600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2038
Cell Significance Index: 4.4200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1894
Cell Significance Index: 2.7200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1622
Cell Significance Index: 0.9800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1123
Cell Significance Index: 5.8500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0702
Cell Significance Index: 13.3500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0646
Cell Significance Index: -2.9300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0876
Cell Significance Index: -54.6900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1024
Cell Significance Index: -75.8800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1091
Cell Significance Index: -80.0200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1387
Cell Significance Index: -8.3300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1468
Cell Significance Index: -3.9200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1498
Cell Significance Index: -113.3500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1515
Cell Significance Index: -14.9900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1617
Cell Significance Index: -91.1700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1689
Cell Significance Index: -17.5900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2757
Cell Significance Index: -40.0800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3294
Cell Significance Index: -56.2400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3458
Cell Significance Index: -99.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3617
Cell Significance Index: -42.6500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4333
Cell Significance Index: -27.9600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4337
Cell Significance Index: -50.5400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4375
Cell Significance Index: -92.1600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4496
Cell Significance Index: -45.9300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.4922
Cell Significance Index: -63.1000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4989
Cell Significance Index: -17.5300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5247
Cell Significance Index: -24.6600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6373
Cell Significance Index: -8.6900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.7037
Cell Significance Index: -90.9100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7315
Cell Significance Index: -83.8100 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.7631
Cell Significance Index: -11.6100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.7781
Cell Significance Index: -36.2800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.7991
Cell Significance Index: -13.4600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.8566
Cell Significance Index: -6.9900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.9469
Cell Significance Index: -13.9800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9823
Cell Significance Index: -112.1300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0259
Cell Significance Index: -27.4900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.1781
Cell Significance Index: -87.8000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2028
Cell Significance Index: -95.2600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.2556
Cell Significance Index: -65.2300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.3037
Cell Significance Index: -92.2000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.3479
Cell Significance Index: -27.9600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.3537
Cell Significance Index: -19.9800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.3776
Cell Significance Index: -23.0600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.3786
Cell Significance Index: -86.8900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -1.3947
Cell Significance Index: -9.4500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4769
Cell Significance Index: -90.5500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.6912
Cell Significance Index: -35.4000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.7019
Cell Significance Index: -59.1400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.7108
Cell Significance Index: -36.3100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.7354
Cell Significance Index: -21.5300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.8288
Cell Significance Index: -96.0200 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -1.8495
Cell Significance Index: -19.8300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.8854
Cell Significance Index: -37.2800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1856989346
Symbol: HTF4_HUMAN
Name: Transcription factor 12
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1446075
Title: The nucleotide sequence of the human transcription factor HTF4a cDNA.
PubMed ID: 1446075
PubMed ID: 1312219
Title: HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.
PubMed ID: 1312219
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1886779
PubMed ID: 12826747
Title: Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4.
PubMed ID: 12826747
DOI: 10.1159/000071042
PubMed ID: 16616331
Title: The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.
PubMed ID: 16616331
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17467953
Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.
PubMed ID: 17467953
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 23812588
Title: A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.
PubMed ID: 23812588
DOI: 10.1038/nature12287
PubMed ID: 25466284
Title: Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type.
PubMed ID: 25466284
PubMed ID: 32620954
Title: TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
PubMed ID: 32620954
DOI: 10.1093/hmg/ddaa120
PubMed ID: 19204326
Title: Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
PubMed ID: 19204326
PubMed ID: 23354436
Title: Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis.
PubMed ID: 23354436
DOI: 10.1038/ng.2531
PubMed ID: 25271085
Title: Expanding the mutation spectrum in 182 Spanish probands with craniosynostosis: identification and characterization of novel TCF12 variants.
PubMed ID: 25271085
Sequence Information:
- Length: 682
- Mass: 72965
- Checksum: 9736113D9361D3F5
- Sequence:
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG IDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGAHEGLSPT PFMNSNLMGK TSERGSFSLY SRDTGLPGCQ SSLLRQDLGL GSPAQLSSSG KPGTAYYSFS ATSSRRRPLH DSAALDPLQA KKVRKVPPGL PSSVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG THNSSDLWSS SNGMSQPGFG GILGTSTSHM SQSSSYGNLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD HTSSSFPSNP STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLQSRM EDRLDRLDDA IHVLRNHAVG PSTSLPAGHS DIHSLLGPSH NAPIGSLNSN YGGSSLVASS RSASMVGTHR EDSVSLNGNH SVLSSTVTTS STDLNHKTQE NYRGGLQSQS GTVVTTEIKT ENKEKDENLH EPPSSDDMKS DDESSQKDIK VSSRGRTSST NEDEDLNPEQ KIEREKERRM ANNARERLRV RDINEAFKEL GRMCQLHLKS EKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE EEKVSAVSAE PPTTLPGTHP GLSETTNPMG HM
Genular Protein ID: 1304783631
Symbol: F5GY10_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 536
- Mass: 58023
- Checksum: F3822C94BCA627F4
- Sequence:
MYCAYPVPGM GSNSLMYYYN GKTVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG THNSSDLWSS SNGMSQPGFG GILGTSTSHM SQSSSYGNLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD HTSSSFPSNP STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLKNRV EQQLHEHLQD AMSFLKDVCE QSRMEDRLDR LDDAIHVLRN HAVGPSTSLP AGHSDIHSLL GPSHNAPIGS LNSNYGGSSL VASSRSASMV GTHREDSVSL NGNHSVLSST VTTSSTDLNH KTQENYRGGL QSQSGTVVTT EIKTENKEKD ENLHEPPSSD DMKSDDESSQ KDIKVSSRGR TSSTNEDEDL NPEQKIEREK ERRMANNARE RLRVRDINEA FKELGRMCQL HLKSEKPQTK LLILHQAVAV ILSLEQQVRE RNLNPKAACL KRREEEKVSA VSAEPPTTLP GTHPGLSETT NPMGHM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.