Details for: TCF12

Gene ID: 6938

Symbol: TCF12

Ensembl ID: ENSG00000140262

Description: transcription factor 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.49
    Marker Score: 34059
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 6.17
    Marker Score: 4648
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 5.02
    Marker Score: 20918
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 4.81
    Marker Score: 1739
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.73
    Marker Score: 11315
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 4.53
    Marker Score: 4742.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.53
    Marker Score: 3912
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.52
    Marker Score: 80168
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.29
    Marker Score: 3808
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.26
    Marker Score: 22863
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.22
    Marker Score: 31847
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.02
    Marker Score: 2793
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.02
    Marker Score: 2235
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.89
    Marker Score: 8949
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.85
    Marker Score: 4658
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.85
    Marker Score: 2084
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.84
    Marker Score: 5163
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.8
    Marker Score: 9520
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.72
    Marker Score: 2445
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.7
    Marker Score: 12118
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.67
    Marker Score: 8056
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.67
    Marker Score: 4571
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.65
    Marker Score: 7019
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.56
    Marker Score: 1770
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.48
    Marker Score: 2682
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.44
    Marker Score: 3894
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.32
    Marker Score: 2727
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.27
    Marker Score: 73022
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.25
    Marker Score: 3740
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.22
    Marker Score: 4530
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.2
    Marker Score: 13388.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.16
    Marker Score: 106859
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.13
    Marker Score: 14495
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.08
    Marker Score: 888.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.04
    Marker Score: 1765
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.97
    Marker Score: 771
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.97
    Marker Score: 1563
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.97
    Marker Score: 1728
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.9
    Marker Score: 847
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.89
    Marker Score: 61730
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.88
    Marker Score: 1613
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.82
    Marker Score: 2688
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.81
    Marker Score: 1680
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.71
    Marker Score: 9071
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.69
    Marker Score: 20592
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.62
    Marker Score: 1533
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.62
    Marker Score: 3239
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.61
    Marker Score: 7432
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.6
    Marker Score: 38810
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.58
    Marker Score: 816
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.56
    Marker Score: 1433
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.56
    Marker Score: 3717
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.53
    Marker Score: 50306
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.5
    Marker Score: 95009
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.49
    Marker Score: 2160
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.49
    Marker Score: 1288.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.49
    Marker Score: 10314
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.47
    Marker Score: 1624
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.46
    Marker Score: 1869.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.45
    Marker Score: 2638
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.44
    Marker Score: 39166
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.39
    Marker Score: 868
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.38
    Marker Score: 87746
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.36
    Marker Score: 2846
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.29
    Marker Score: 583
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.29
    Marker Score: 2525
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.26
    Marker Score: 1514
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.24
    Marker Score: 8654
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.22
    Marker Score: 3728
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.17
    Marker Score: 7722.5
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.15
    Marker Score: 785
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.12
    Marker Score: 2275
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.12
    Marker Score: 3862
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.03
    Marker Score: 752
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.03
    Marker Score: 766
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.02
    Marker Score: 1426
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.01
    Marker Score: 7139
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.97
    Marker Score: 1240
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.97
    Marker Score: 22143
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.94
    Marker Score: 641
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.92
    Marker Score: 717
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.9
    Marker Score: 7906
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.89
    Marker Score: 791
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.87
    Marker Score: 900
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.86
    Marker Score: 1986
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.85
    Marker Score: 628
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.82
    Marker Score: 2577
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.81
    Marker Score: 111213
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.8
    Marker Score: 571
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.79
    Marker Score: 7271.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.77
    Marker Score: 18272
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.76
    Marker Score: 16678
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.75
    Marker Score: 16489
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.69
    Marker Score: 649
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.67
    Marker Score: 1571
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.66
    Marker Score: 802
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.64
    Marker Score: 1742
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.61
    Marker Score: 782
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.58
    Marker Score: 13586
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.57
    Marker Score: 10089

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** TCF12 exhibits several key characteristics that make it an important transcription factor. These include: 1. **bHLH domain**: TCF12 contains a bHLH domain, which is a characteristic feature of bHLH transcription factors. This domain is responsible for DNA binding and transcriptional activation. 2. **RNA polymerase II specificity**: TCF12 is specific for RNA polymerase II, which is the primary enzyme responsible for transcribing protein-coding genes. 3. **Gene expression regulation**: TCF12 regulates gene expression by binding to specific DNA sequences, known as E-boxes, which are common regulatory elements in many genes. 4. **Cell-type specificity**: TCF12 is expressed in multiple cell types, including neurons, epithelial cells, immune cells, and muscle cells, indicating its diverse roles in different cellular contexts. 5. **Signaling pathways**: TCF12 is involved in signaling pathways, including those mediated by NTRK1 (trka), Runx1, and Smad, which are important for cell growth, differentiation, and survival. **Pathways and Functions** TCF12 is involved in several signaling pathways and cellular processes, including: 1. **Myogenesis**: TCF12 regulates the expression of genes involved in muscle cell differentiation and development. 2. **Neuron differentiation**: TCF12 is required for the proper differentiation and function of neurons. 3. **Immune response**: TCF12 is expressed in immune cells, such as microglia and thymocytes, and regulates the expression of genes involved in immune response. 4. **Gene expression regulation**: TCF12 regulates the expression of genes involved in various cellular processes, including development, differentiation, and cell growth. 5. **Cell differentiation**: TCF12 is involved in the regulation of cell differentiation, including the differentiation of epithelial cells, immune cells, and muscle cells. **Clinical Significance** TCF12 has several clinical implications, including: 1. **Neurological disorders**: TCF12 mutations have been associated with neurological disorders, such as epilepsy and neurodevelopmental disorders. 2. **Immune system disorders**: TCF12 is involved in the regulation of immune responses, and dysregulation of TCF12 has been implicated in autoimmune diseases, such as multiple sclerosis. 3. **Cancer**: TCF12 is involved in the regulation of gene expression in cancer cells, and its dysregulation has been implicated in various types of cancer. 4. **Developmental disorders**: TCF12 is required for the proper development of various tissues and organs, and dysregulation of TCF12 has been implicated in developmental disorders, such as congenital abnormalities. In conclusion, TCF12 is a highly conserved transcription factor that plays a crucial role in various cellular processes, including gene expression, cell differentiation, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action.

Genular Protein ID: 1856989346

Symbol: HTF4_HUMAN

Name: Transcription factor 12

UniProtKB Accession Codes:

Q99081 B4E1W1 Q7Z3D9 Q86TC1 Q86VM2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 11 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1446075

Title: The nucleotide sequence of the human transcription factor HTF4a cDNA.

PubMed ID: 1446075

DOI: 10.3109/10425179209020819

PubMed ID: 1312219

Title: HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

PubMed ID: 1312219

DOI: 10.1128/mcb.12.3.1031-1042.1992

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1886779

Title: HTF4: a new human helix-loop-helix protein.

PubMed ID: 1886779

DOI: 10.1093/nar/19.16.4555

PubMed ID: 12826747

Title: Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4.

PubMed ID: 12826747

DOI: 10.1159/000071042

PubMed ID: 16616331

Title: The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.

PubMed ID: 16616331

DOI: 10.1016/j.ccr.2006.03.012

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23812588

Title: A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.

PubMed ID: 23812588

DOI: 10.1038/nature12287

PubMed ID: 25466284

Title: Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type.

PubMed ID: 25466284

DOI: 10.1016/j.ajhg.2014.10.012

PubMed ID: 32620954

Title: TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.

PubMed ID: 32620954

DOI: 10.1093/hmg/ddaa120

PubMed ID: 19204326

Title: Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

PubMed ID: 19204326

DOI: 10.1182/blood-2008-06-161307

PubMed ID: 23354436

Title: Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis.

PubMed ID: 23354436

DOI: 10.1038/ng.2531

PubMed ID: 25271085

Title: Expanding the mutation spectrum in 182 Spanish probands with craniosynostosis: identification and characterization of novel TCF12 variants.

PubMed ID: 25271085

DOI: 10.1038/ejhg.2014.205

Sequence Information:

  • Length: 682
  • Mass: 72965
  • Checksum: 9736113D9361D3F5
  • Sequence:
    • MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG IDERGGTTSW 
GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGAHEGLSPT PFMNSNLMGK TSERGSFSLY 
SRDTGLPGCQ SSLLRQDLGL GSPAQLSSSG KPGTAYYSFS ATSSRRRPLH DSAALDPLQA 
KKVRKVPPGL PSSVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG THNSSDLWSS 
SNGMSQPGFG GILGTSTSHM SQSSSYGNLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD HTSSSFPSNP 
STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLQSRM EDRLDRLDDA IHVLRNHAVG 
PSTSLPAGHS DIHSLLGPSH NAPIGSLNSN YGGSSLVASS RSASMVGTHR EDSVSLNGNH 
SVLSSTVTTS STDLNHKTQE NYRGGLQSQS GTVVTTEIKT ENKEKDENLH EPPSSDDMKS 
DDESSQKDIK VSSRGRTSST NEDEDLNPEQ KIEREKERRM ANNARERLRV RDINEAFKEL 
GRMCQLHLKS EKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE EEKVSAVSAE 
PPTTLPGTHP GLSETTNPMG HM

Genular Protein ID: 1304783631

Symbol: F5GY10_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GY10

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 536
  • Mass: 58023
  • Checksum: F3822C94BCA627F4
  • Sequence:
    • MYCAYPVPGM GSNSLMYYYN GKTVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG 
THNSSDLWSS SNGMSQPGFG GILGTSTSHM SQSSSYGNLH SHDRLSYPPH SVSPTDINTS 
LPPMSSFHRG STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD 
HTSSSFPSNP STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLKNRV EQQLHEHLQD 
AMSFLKDVCE QSRMEDRLDR LDDAIHVLRN HAVGPSTSLP AGHSDIHSLL GPSHNAPIGS 
LNSNYGGSSL VASSRSASMV GTHREDSVSL NGNHSVLSST VTTSSTDLNH KTQENYRGGL 
QSQSGTVVTT EIKTENKEKD ENLHEPPSSD DMKSDDESSQ KDIKVSSRGR TSSTNEDEDL 
NPEQKIEREK ERRMANNARE RLRVRDINEA FKELGRMCQL HLKSEKPQTK LLILHQAVAV 
ILSLEQQVRE RNLNPKAACL KRREEEKVSA VSAEPPTTLP GTHPGLSETT NPMGHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.