Details for: ZNF354A

Gene ID: 6940

Symbol: ZNF354A

Ensembl ID: ENSG00000169131

Description: zinc finger protein 354A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.7126
    Cell Significance Index: -12.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.5327
    Cell Significance Index: -12.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.4884
    Cell Significance Index: -13.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.2826
    Cell Significance Index: -11.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.9397
    Cell Significance Index: -13.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.0765
    Cell Significance Index: -11.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9980
    Cell Significance Index: -13.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9345
    Cell Significance Index: -10.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5453
    Cell Significance Index: -13.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2793
    Cell Significance Index: 243.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7706
    Cell Significance Index: 76.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6163
    Cell Significance Index: 556.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5928
    Cell Significance Index: 35.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5544
    Cell Significance Index: 9.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5090
    Cell Significance Index: 55.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4872
    Cell Significance Index: 97.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4805
    Cell Significance Index: 12.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4673
    Cell Significance Index: 12.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4138
    Cell Significance Index: 67.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3484
    Cell Significance Index: 21.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3336
    Cell Significance Index: 7.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3046
    Cell Significance Index: 21.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2652
    Cell Significance Index: 20.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2599
    Cell Significance Index: 17.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2333
    Cell Significance Index: 46.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2032
    Cell Significance Index: 23.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1981
    Cell Significance Index: 71.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1977
    Cell Significance Index: 27.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1852
    Cell Significance Index: 7.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1715
    Cell Significance Index: 7.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1682
    Cell Significance Index: 4.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1615
    Cell Significance Index: 8.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1575
    Cell Significance Index: 9.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1415
    Cell Significance Index: 1.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1344
    Cell Significance Index: 59.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1272
    Cell Significance Index: 7.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1208
    Cell Significance Index: 14.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1201
    Cell Significance Index: 2.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1183
    Cell Significance Index: 7.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1160
    Cell Significance Index: 2.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1077
    Cell Significance Index: 19.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0966
    Cell Significance Index: 4.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0932
    Cell Significance Index: 2.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0828
    Cell Significance Index: 2.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0740
    Cell Significance Index: 9.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0696
    Cell Significance Index: 3.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0549
    Cell Significance Index: 1.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0548
    Cell Significance Index: 29.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0477
    Cell Significance Index: 1.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0458
    Cell Significance Index: 3.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0417
    Cell Significance Index: 2.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0169
    Cell Significance Index: 2.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0156
    Cell Significance Index: 0.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0062
    Cell Significance Index: 0.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0060
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0031
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0107
    Cell Significance Index: -8.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0134
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0192
    Cell Significance Index: -8.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0193
    Cell Significance Index: -1.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0216
    Cell Significance Index: -12.1600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0224
    Cell Significance Index: -0.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0244
    Cell Significance Index: -0.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0269
    Cell Significance Index: -3.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0356
    Cell Significance Index: -5.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0358
    Cell Significance Index: -0.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0386
    Cell Significance Index: -11.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0415
    Cell Significance Index: -4.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0478
    Cell Significance Index: -0.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0480
    Cell Significance Index: -1.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0667
    Cell Significance Index: -4.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0687
    Cell Significance Index: -14.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1076
    Cell Significance Index: -0.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1274
    Cell Significance Index: -1.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1305
    Cell Significance Index: -13.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1314
    Cell Significance Index: -10.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1404
    Cell Significance Index: -2.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1524
    Cell Significance Index: -10.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1533
    Cell Significance Index: -1.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1787
    Cell Significance Index: -5.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1881
    Cell Significance Index: -5.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1914
    Cell Significance Index: -6.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1924
    Cell Significance Index: -5.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1950
    Cell Significance Index: -5.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2007
    Cell Significance Index: -6.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2059
    Cell Significance Index: -3.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2363
    Cell Significance Index: -5.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2587
    Cell Significance Index: -5.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2643
    Cell Significance Index: -9.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2814
    Cell Significance Index: -6.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2893
    Cell Significance Index: -3.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2898
    Cell Significance Index: -8.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3127
    Cell Significance Index: -7.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA Binding and Transcriptional Regulation**: ZNF354A is a member of the zinc finger protein family, characterized by its unique DNA-binding motif. This allows it to specifically interact with RNA polymerase II cis-regulatory regions, thereby influencing gene expression. 2. **Transcriptional Regulation by RNA Polymerase II**: ZNF354A's primary function is to regulate the expression of genes involved in transcriptional control, including those involved in cellular differentiation, development, and immune responses. 3. **Tissue-Specific Expression**: ZNF354A is significantly expressed in germ cells, cardiac endothelial cells, and immune cells, highlighting its importance in various cellular processes. **Pathways and Functions:** 1. **Cytosol and Nucleus**: ZNF354A is localized to the cytosol and nucleus, where it interacts with RNA polymerase II and other transcriptional regulators to control gene expression. 2. **Metal Ion Binding**: The zinc finger motif in ZNF354A allows it to bind metal ions, which are essential for its DNA-binding activity. 3. **Regulation of Transcription by RNA Polymerase II**: ZNF354A influences the expression of genes involved in transcriptional control, including those involved in cellular differentiation, development, and immune responses. 4. **Sensory Perception of Sound**: ZNF354A has also been implicated in the sensory perception of sound, highlighting its broader functional scope. **Clinical Significance:** 1. **Immunological Disorders**: ZNF354A's role in immune cell development and function makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases and immunodeficiency disorders. 2. **Cancer Research**: The transcriptional regulation activities of ZNF354A may influence cancer development and progression, making it a potential therapeutic target. 3. **Neurological Disorders**: ZNF354A's involvement in the sensory perception of sound and its expression in neuronal cells highlights its potential role in neurological disorders, such as auditory processing disorders. In conclusion, ZNF354A is a critical gene that plays a pivotal role in transcriptional regulation, influencing gene expression in various cellular processes. Further research is necessary to fully elucidate the molecular mechanisms underlying ZNF354A's functions and to explore its potential therapeutic applications in immunological and neurological disorders.

Genular Protein ID: 4177196401

Symbol: Z354A_HUMAN

Name: Zinc finger protein 354A

UniProtKB Accession Codes:

O60765 Q9UNJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9465904

Title: Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1.

PubMed ID: 9465904

DOI: 10.1159/000134673

PubMed ID: 9919311

Title: Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear.

PubMed ID: 9919311

DOI: 10.1023/b:scam.0000007114.14371.f4

PubMed ID: 23665872

Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

PubMed ID: 23665872

DOI: 10.1007/s00018-013-1359-4

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 605
  • Mass: 69237
  • Checksum: 464D20BBD9045AF9
  • Sequence:
    • MAAGQREARP QVSLTFEDVA VLFTRDEWRK LAPSQRNLYR DVMLENYRNL VSLGLPFTKP 
KVISLLQQGE DPWEVEKDGS GVSSLGSKSS HKTTKSTQTQ DSSFQGLILK RSNRNVPWDL 
KLEKPYIYEG RLEKKQDKKG SFQIVSATHK KIPTIERSHK NTELSQNFSP KSVLIRQQIL 
PREKTPPKCE IQGNSLKQNS QLLNQPKITA DKRYKCSLCE KTFINTSSLR KHEKNHSGEK 
LFKCKECSKA FSQSSALIQH QITHTGEKPY ICKECGKAFT LSTSLYKHLR THTVEKSYRC 
KECGKSFSRR SGLFIHQKIH AEENPCKYNP GRKASSCSTS LSGCQRIHSR KKSYLCNECG 
NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH ERIHTGEKPY RCNECGKGFT 
SISRLNRHRI IHTGEKFYNC NECGKALSSH STLIIHERIH TGEKPCKCKV CGKAFRQSSA 
LIQHQRMHTG ERPYKCNECG KTFRCNSSLS NHQRIHTGEK PYRCEECGIS FGQSSALIQH 
RRIHTGEKPF KCNTCGKTFR QSSSRIAHQR IHTGEKPYEC NTCGKLFNHR SSLTNHYKIH 
IEEDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.