Details for: TRGC1

Gene ID: 6966

Symbol: TRGC1

Ensembl ID: ENSG00000211689

Description: T cell receptor gamma constant 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 12.5739
    Cell Significance Index: 441.8300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 6.8051
    Cell Significance Index: 18.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.6206
    Cell Significance Index: 140.5000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 5.0502
    Cell Significance Index: 70.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.6448
    Cell Significance Index: 133.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.3458
    Cell Significance Index: 69.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0674
    Cell Significance Index: 93.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4009
    Cell Significance Index: 266.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2682
    Cell Significance Index: 27.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2675
    Cell Significance Index: 19.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1893
    Cell Significance Index: 117.6500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.0672
    Cell Significance Index: 8.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9432
    Cell Significance Index: 851.6200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8706
    Cell Significance Index: 9.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8124
    Cell Significance Index: 21.7300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.6062
    Cell Significance Index: 6.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5226
    Cell Significance Index: 11.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4623
    Cell Significance Index: 75.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4533
    Cell Significance Index: 49.3100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4420
    Cell Significance Index: 6.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2477
    Cell Significance Index: 17.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2010
    Cell Significance Index: 9.4500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1553
    Cell Significance Index: 1.0300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0627
    Cell Significance Index: 0.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0326
    Cell Significance Index: 1.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0005
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0039
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0094
    Cell Significance Index: -6.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0108
    Cell Significance Index: -6.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0113
    Cell Significance Index: -1.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0156
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0179
    Cell Significance Index: -3.0700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0226
    Cell Significance Index: -0.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0228
    Cell Significance Index: -0.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0234
    Cell Significance Index: -0.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0240
    Cell Significance Index: -3.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0244
    Cell Significance Index: -7.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0245
    Cell Significance Index: -1.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0301
    Cell Significance Index: -5.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0313
    Cell Significance Index: -6.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0353
    Cell Significance Index: -6.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0356
    Cell Significance Index: -4.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0364
    Cell Significance Index: -2.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0457
    Cell Significance Index: -6.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0474
    Cell Significance Index: -6.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0477
    Cell Significance Index: -5.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0608
    Cell Significance Index: -7.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0649
    Cell Significance Index: -2.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0709
    Cell Significance Index: -5.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0827
    Cell Significance Index: -6.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0866
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0973
    Cell Significance Index: -6.5400
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.0983
    Cell Significance Index: -0.5700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1060
    Cell Significance Index: -1.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1113
    Cell Significance Index: -5.7800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1146
    Cell Significance Index: -1.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1250
    Cell Significance Index: -5.8300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1266
    Cell Significance Index: -1.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1348
    Cell Significance Index: -4.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1350
    Cell Significance Index: -5.9700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1390
    Cell Significance Index: -1.0000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1578
    Cell Significance Index: -3.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1579
    Cell Significance Index: -5.9800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1660
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1677
    Cell Significance Index: -3.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1713
    Cell Significance Index: -4.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1745
    Cell Significance Index: -4.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1747
    Cell Significance Index: -6.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1833
    Cell Significance Index: -4.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1846
    Cell Significance Index: -3.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1943
    Cell Significance Index: -6.3600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1949
    Cell Significance Index: -1.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1989
    Cell Significance Index: -6.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2012
    Cell Significance Index: -6.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2055
    Cell Significance Index: -6.5500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2088
    Cell Significance Index: -1.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2094
    Cell Significance Index: -5.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2100
    Cell Significance Index: -6.0200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2113
    Cell Significance Index: -2.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2168
    Cell Significance Index: -2.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2174
    Cell Significance Index: -5.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2246
    Cell Significance Index: -5.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2292
    Cell Significance Index: -6.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2302
    Cell Significance Index: -5.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2318
    Cell Significance Index: -6.2100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2331
    Cell Significance Index: -3.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2342
    Cell Significance Index: -5.4100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2369
    Cell Significance Index: -3.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2374
    Cell Significance Index: -6.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2422
    Cell Significance Index: -6.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2477
    Cell Significance Index: -5.9400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2499
    Cell Significance Index: -3.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2556
    Cell Significance Index: -6.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2619
    Cell Significance Index: -5.1200
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2812
    Cell Significance Index: -3.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TRGC1 gene exhibits several key characteristics that underscore its importance in the immune system. These include: 1. **Expression in specific cell types**: TRGC1 is highly expressed in enterocytes, which are epithelial cells lining the large intestine, and in certain types of innate lymphoid cells, such as NKp46-positive cells. 2. **Association with gamma-delta T cells**: TRGC1 is specifically expressed in gamma-delta T cells, which are crucial for the immune system's ability to recognize and respond to pathogens. 3. **Small molecule binding**: TRGC1 has been shown to bind small molecules, which is essential for the proper functioning of gamma-delta T cells. **Pathways and Functions** TRGC1 is involved in several key pathways and functions that are critical for the immune system's response to pathogens. These include: 1. **Adaptive immune response**: TRGC1 plays a crucial role in the adaptive immune response, which involves the activation of specific immune cells to recognize and respond to pathogens. 2. **Gamma-delta T cell activation**: TRGC1 is essential for the activation of gamma-delta T cells, which are critical for the immune system's ability to recognize and respond to pathogens. 3. **Small molecule binding**: TRGC1 binds small molecules, which is essential for the proper functioning of gamma-delta T cells. 4. **External side of plasma membrane**: TRGC1 is localized to the external side of the plasma membrane, where it can interact with other molecules to regulate immune responses. **Clinical Significance** The TRGC1 gene has significant clinical implications, particularly in the context of immune-related disorders. Some potential clinical applications of TRGC1 include: 1. **Immunotherapy**: TRGC1 may be a target for immunotherapy, which involves the use of antibodies or other molecules to stimulate the immune system's response to cancer or other diseases. 2. **Autoimmune disorders**: TRGC1 may play a role in autoimmune disorders, such as inflammatory bowel disease (IBD), which involves the inappropriate activation of immune cells. 3. **Infectious diseases**: TRGC1 may be involved in the immune system's response to infectious diseases, such as tuberculosis or HIV. In conclusion, TRGC1 is a gene of significant importance in the immune system, particularly in the context of gamma-delta T cell activation and small molecule binding. Its clinical significance is multifaceted, with potential applications in immunotherapy, autoimmune disorders, and infectious diseases. Further research is needed to fully elucidate the function and significance of TRGC1.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.