Gene TRGC1 - ENSG00000211689 | NCBI Gene ID: 6966

Details for: TRGC1

Gene ID: 6966

Symbol: TRGC1

Ensembl ID: ENSG00000211689

Description: T cell receptor gamma constant 1

Associated with

Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Gamma-delta t cell activation
(GO:0046629)
Gamma-delta t cell receptor complex
(GO:0042106)
Plasma membrane
(GO:0005886)
Small molecule binding
(GO:0036094)
T cell receptor signaling pathway
(GO:0050852)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1991
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.93
Marker Score: 7896
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.76
Marker Score: 5546
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1167
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.45
Marker Score: 4010
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.39
Marker Score: 4054
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 852
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 484
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.16
Marker Score: 698
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7691
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.16
Marker Score: 356
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.15
Marker Score: 2179
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4810
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.14
Marker Score: 371
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251802
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 506
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.96
Marker Score: 612
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5343
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.87
Marker Score: 504
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.85
Marker Score: 281
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.85
Marker Score: 1200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.83
Marker Score: 381
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 594
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.73
Marker Score: 313
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.72
Marker Score: 159
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.69
Marker Score: 582
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.63
Marker Score: 142
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.61
Marker Score: 9542
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.53
Marker Score: 134
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.52
Marker Score: 374
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.47
Marker Score: 124
Cell Name: promonocyte (CL0000559)
Fold Change: 0.47
Marker Score: 300
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.46
Marker Score: 191.5
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.44
Marker Score: 229
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.44
Marker Score: 421
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.41
Marker Score: 688
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.4
Marker Score: 331
Cell Name: Unknown (CL0000548)
Fold Change: 0.38
Marker Score: 278
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.36
Marker Score: 152
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.36
Marker Score: 130
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.36
Marker Score: 468
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.35
Marker Score: 211
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.34
Marker Score: 78
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.34
Marker Score: 229
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.34
Marker Score: 286
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.34
Marker Score: 84
Cell Name: memory T cell (CL0000813)
Fold Change: 0.33
Marker Score: 143
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.33
Marker Score: 292
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 0.31
Marker Score: 86
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.31
Marker Score: 872
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.31
Marker Score: 7851
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.31
Marker Score: 95
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.3
Marker Score: 103
Cell Name: myelocyte (CL0002193)
Fold Change: 0.3
Marker Score: 128
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.29
Marker Score: 139
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.29
Marker Score: 422
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.29
Marker Score: 147
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.28
Marker Score: 253
Cell Name: thymocyte (CL0000893)
Fold Change: 0.28
Marker Score: 292
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.28
Marker Score: 216
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.27
Marker Score: 126
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.26
Marker Score: 133.5
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.26
Marker Score: 198
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.25
Marker Score: 239
Cell Name: mature T cell (CL0002419)
Fold Change: 0.25
Marker Score: 2440
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.24
Marker Score: 185
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.23
Marker Score: 121
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.23
Marker Score: 74
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.23
Marker Score: 134
Cell Name: neutrophil (CL0000775)
Fold Change: 0.23
Marker Score: 140
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.23
Marker Score: 79
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.22
Marker Score: 447
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2
Marker Score: 115
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.2
Marker Score: 130
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.19
Marker Score: 126
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.19
Marker Score: 102
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.19
Marker Score: 462
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.19
Marker Score: 308
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.19
Marker Score: 303
Cell Name: mast cell (CL0000097)
Fold Change: 0.18
Marker Score: 106
Cell Name: platelet (CL0000233)
Fold Change: 0.18
Marker Score: 81
Cell Name: type II NK T cell (CL0000922)
Fold Change: 0.18
Marker Score: 54

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Other Information

Description

**Key Characteristics** The TRGC1 gene exhibits several key characteristics that underscore its importance in the immune system. These include: 1. **Expression in specific cell types**: TRGC1 is highly expressed in enterocytes, which are epithelial cells lining the large intestine, and in certain types of innate lymphoid cells, such as NKp46-positive cells. 2. **Association with gamma-delta T cells**: TRGC1 is specifically expressed in gamma-delta T cells, which are crucial for the immune system's ability to recognize and respond to pathogens. 3. **Small molecule binding**: TRGC1 has been shown to bind small molecules, which is essential for the proper functioning of gamma-delta T cells. **Pathways and Functions** TRGC1 is involved in several key pathways and functions that are critical for the immune system's response to pathogens. These include: 1. **Adaptive immune response**: TRGC1 plays a crucial role in the adaptive immune response, which involves the activation of specific immune cells to recognize and respond to pathogens. 2. **Gamma-delta T cell activation**: TRGC1 is essential for the activation of gamma-delta T cells, which are critical for the immune system's ability to recognize and respond to pathogens. 3. **Small molecule binding**: TRGC1 binds small molecules, which is essential for the proper functioning of gamma-delta T cells. 4. **External side of plasma membrane**: TRGC1 is localized to the external side of the plasma membrane, where it can interact with other molecules to regulate immune responses. **Clinical Significance** The TRGC1 gene has significant clinical implications, particularly in the context of immune-related disorders. Some potential clinical applications of TRGC1 include: 1. **Immunotherapy**: TRGC1 may be a target for immunotherapy, which involves the use of antibodies or other molecules to stimulate the immune system's response to cancer or other diseases. 2. **Autoimmune disorders**: TRGC1 may play a role in autoimmune disorders, such as inflammatory bowel disease (IBD), which involves the inappropriate activation of immune cells. 3. **Infectious diseases**: TRGC1 may be involved in the immune system's response to infectious diseases, such as tuberculosis or HIV. In conclusion, TRGC1 is a gene of significant importance in the immune system, particularly in the context of gamma-delta T cell activation and small molecule binding. Its clinical significance is multifaceted, with potential applications in immunotherapy, autoimmune disorders, and infectious diseases. Further research is needed to fully elucidate the function and significance of TRGC1.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.