TFDP1 | ENSG00000198176 | NCBI 7027

Details for: TFDP1

Gene ID: 7027

Symbol: TFDP1

Ensembl ID: ENSG00000198176

Description: transcription factor Dp-1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Activation of bh3-only proteins
(R-HSA-114452)
Activation of noxa and translocation to mitochondria
(R-HSA-111448)
Activation of puma and translocation to mitochondria
(R-HSA-139915)
Apoptosis
(R-HSA-109581)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
E2f mediated regulation of dna replication
(R-HSA-113510)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-HSA-113501)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Programmed cell death
(R-HSA-5357801)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
S phase
(R-HSA-69242)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Anoikis
(GO:0043276)
Chromatin
(GO:0000785)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Epidermis development
(GO:0008544)
Negative regulation of fat cell proliferation
(GO:0070345)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Rb-e2f complex
(GO:0035189)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna biosynthetic process
(GO:2000278)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 95.2124
Cell Significance Index: -24.1500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 73.4924
Cell Significance Index: -30.2800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 60.7497
Cell Significance Index: -24.6800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 60.1115
Cell Significance Index: -28.3800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 54.0062
Cell Significance Index: -27.7800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 26.0279
Cell Significance Index: -24.8500
Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 17.1495
Cell Significance Index: 7.8100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 15.3533
Cell Significance Index: -18.9300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.9740
Cell Significance Index: -24.0400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.1578
Cell Significance Index: -28.2500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.3260
Cell Significance Index: -19.4300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.9660
Cell Significance Index: -8.6800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6289
Cell Significance Index: 177.1800
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.4486
Cell Significance Index: 9.6100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3100
Cell Significance Index: 213.0600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.1161
Cell Significance Index: 31.1900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1026
Cell Significance Index: 29.4400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0296
Cell Significance Index: 206.5400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.0003
Cell Significance Index: 117.9700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8559
Cell Significance Index: 169.8600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8427
Cell Significance Index: 39.2900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7708
Cell Significance Index: 20.9800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7536
Cell Significance Index: 52.1200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7205
Cell Significance Index: 88.5900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5952
Cell Significance Index: 325.0600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5874
Cell Significance Index: 210.7000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5837
Cell Significance Index: 105.2300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5531
Cell Significance Index: 244.5400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5319
Cell Significance Index: 37.6200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4933
Cell Significance Index: 22.3600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4639
Cell Significance Index: 16.1200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4630
Cell Significance Index: 45.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4466
Cell Significance Index: 23.2000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3864
Cell Significance Index: 73.5300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.3588
Cell Significance Index: 224.0800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3460
Cell Significance Index: 15.3000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3218
Cell Significance Index: 41.5800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3191
Cell Significance Index: 23.7800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2966
Cell Significance Index: 13.9400
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.2961
Cell Significance Index: 1.8900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2837
Cell Significance Index: 48.4400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2829
Cell Significance Index: 38.8500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2797
Cell Significance Index: 10.5900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2785
Cell Significance Index: 8.9200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2771
Cell Significance Index: 15.5500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.2167
Cell Significance Index: 4.5400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1793
Cell Significance Index: 11.3000
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.1521
Cell Significance Index: 2.3100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1153
Cell Significance Index: 7.7500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1126
Cell Significance Index: 14.4400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1005
Cell Significance Index: 90.7500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0754
Cell Significance Index: 142.0000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0722
Cell Significance Index: 0.6600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0707
Cell Significance Index: 44.9000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0502
Cell Significance Index: 0.8400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0489
Cell Significance Index: 1.7200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0436
Cell Significance Index: 1.2600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0415
Cell Significance Index: 2.6800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0274
Cell Significance Index: 2.1100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0220
Cell Significance Index: 1.3500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0020
Cell Significance Index: 3.1100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0007
Cell Significance Index: -0.5600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0010
Cell Significance Index: -1.8800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0020
Cell Significance Index: -1.4900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0145
Cell Significance Index: -10.6100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0176
Cell Significance Index: -23.9400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0177
Cell Significance Index: -2.5700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0310
Cell Significance Index: -14.0700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0345
Cell Significance Index: -19.4400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0591
Cell Significance Index: -12.4500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0719
Cell Significance Index: -7.3500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0764
Cell Significance Index: -3.9800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0770
Cell Significance Index: -1.6400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0800
Cell Significance Index: -23.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0897
Cell Significance Index: -10.2800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0926
Cell Significance Index: -2.4400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1345
Cell Significance Index: -15.6800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1385
Cell Significance Index: -15.8100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1424
Cell Significance Index: -2.4400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1510
Cell Significance Index: -2.0600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1732
Cell Significance Index: -2.0700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1807
Cell Significance Index: -3.9200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1867
Cell Significance Index: -4.7700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1929
Cell Significance Index: -5.1700
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2462
Cell Significance Index: -5.3900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2532
Cell Significance Index: -6.3300
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2554
Cell Significance Index: -1.6700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2560
Cell Significance Index: -26.6600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2668
Cell Significance Index: -2.9000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2931
Cell Significance Index: -23.2100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2935
Cell Significance Index: -7.8500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3243
Cell Significance Index: -9.3000
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3343
Cell Significance Index: -9.5400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3367
Cell Significance Index: -17.6800
Cell Name: peg cell (CL4033014)
Fold Change: -0.3367
Cell Significance Index: -7.7800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3879
Cell Significance Index: -23.7800
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.4229
Cell Significance Index: -6.0200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4431
Cell Significance Index: -11.3900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4546
Cell Significance Index: -13.3500
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4703
Cell Significance Index: -11.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Transcriptional Activation:** Dp-1 is a transcriptional activator that regulates the expression of target genes involved in cell cycle progression, apoptosis, and DNA repair. 2. **Cell Cycle Regulation:** Dp-1 is specifically involved in the regulation of the G1/S transition, where it activates the expression of cyclin E and CDK2, promoting cell cycle progression. 3. **Apoptosis Regulation:** Dp-1 is a pro-apoptotic transcription factor that activates the expression of pro-apoptotic proteins, such as Noxa and Puma, promoting cell death. 4. **Chromatin Remodeling:** Dp-1 is involved in chromatin remodeling, facilitating the recruitment of transcriptional machinery to specific genomic regions. 5. **Protein Interactions:** Dp-1 interacts with various proteins, including E2F1, RB1, and HDAC1, to regulate its activity and target gene expression. **Pathways and Functions:** 1. **Cell Cycle Regulation:** Dp-1 regulates the G1/S transition by activating the expression of cyclin E and CDK2, promoting cell cycle progression. 2. **Apoptosis:** Dp-1 activates the expression of pro-apoptotic proteins, such as Noxa and Puma, promoting cell death. 3. **Chromatin Remodeling:** Dp-1 is involved in chromatin remodeling, facilitating the recruitment of transcriptional machinery to specific genomic regions. 4. **Gene Expression:** Dp-1 regulates the expression of target genes involved in cell cycle progression, apoptosis, and DNA repair. 5. **Signaling Pathways:** Dp-1 is involved in various signaling pathways, including the Notch and TGF-β signaling pathways, regulating cell growth, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** Dp-1 is dysregulated in various cancers, contributing to tumorigenesis and resistance to therapy. 2. **Apoptosis Dysregulation:** Dp-1 dysregulation can lead to apoptosis resistance, contributing to cancer progression and therapy resistance. 3. **Neurodegenerative Diseases:** Dp-1 is implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation contributes to neuronal death and disease progression. 4. **Cardiovascular Disease:** Dp-1 is involved in cardiovascular disease, where its dysregulation contributes to cardiac hypertrophy and fibrosis. 5. **Regenerative Medicine:** Dp-1 is a promising target for regenerative medicine, where its dysregulation can be exploited to promote tissue repair and regeneration. In conclusion, the transcription factor Dp-1 is a critical regulator of cell cycle and apoptosis, involved in various cellular processes, including chromatin remodeling, gene expression, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, cardiovascular disease, and regenerative medicine. Further research is needed to fully understand the role of Dp-1 in human disease and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor Dp-1

Genular Protein ID: 356853750

Symbol: TFDP1_HUMAN

Name: Transcription factor Dp-1

UniProtKB Accession Codes:

Q14186 B4DLQ9 Q5JSB4 Q8IZL5

Database IDs:

Citations:

PubMed ID: 8405995

Title: Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

PubMed ID: 8405995

DOI: 10.1101/gad.7.10.1850

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8039504

Title: DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

PubMed ID: 8039504

DOI: 10.1002/j.1460-2075.1994.tb06609.x

PubMed ID: 7739537

Title: In vivo association of E2F and DP family proteins.

PubMed ID: 7739537

DOI: 10.1128/mcb.15.5.2536

PubMed ID: 12004135

Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PubMed ID: 12004135

DOI: 10.1126/science.1069861

PubMed ID: 17531812

Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

PubMed ID: 17531812

DOI: 10.1016/j.molcel.2007.04.015

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 410
Mass: 45070
Checksum: 3FEEFE1E49FD9ED0
Sequence:

MAKDAGLIEA NGELKVFIDQ NLSPGKGVVS LVAVHPSTVN PLGKQLLPKT FGQSNVNIAQ 
QVVIGTPQRP AASNTLVVGS PHTPSTHFAS QNQPSDSSPW SAGKRNRKGE KNGKGLRHFS 
MKVCEKVQRK GTTSYNEVAD ELVAEFSAAD NHILPNESAY DQKNIRRRVY DALNVLMAMN 
IISKEKKEIK WIGLPTNSAQ ECQNLEVERQ RRLERIKQKQ SQLQELILQQ IAFKNLVQRN 
RHAEQQASRP PPPNSVIHLP FIIVNTSKKT VIDCSISNDK FEYLFNFDNT FEIHDDIEVL 
KRMGMACGLE SGSCSAEDLK MARSLVPKAL EPYVTEMAQG TVGGVFITTA GSTSNGTRFS 
ASDLTNGADG MLATSSNGSQ YSGSRVETPV SYVGEDDEED DDFNENDEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TFDP1

Associated with

Cells (max top 100)

Other Information

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. PubMed ID: 8405995

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. PubMed ID: 8039504

In vivo association of E2F and DP family proteins. PubMed ID: 7739537

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. PubMed ID: 12004135

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. PubMed ID: 17531812

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163