Gene TFDP1 - ENSG00000198176 | NCBI Gene ID: 7027

Details for: TFDP1

Gene ID: 7027

Symbol: TFDP1

Ensembl ID: ENSG00000198176

Description: transcription factor Dp-1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Activation of bh3-only proteins
(R-HSA-114452)
Activation of noxa and translocation to mitochondria
(R-HSA-111448)
Activation of puma and translocation to mitochondria
(R-HSA-139915)
Apoptosis
(R-HSA-109581)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
E2f mediated regulation of dna replication
(R-HSA-113510)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-HSA-113501)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Programmed cell death
(R-HSA-5357801)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
S phase
(R-HSA-69242)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Anoikis
(GO:0043276)
Cell cycle
(GO:0007049)
Chromatin
(GO:0000785)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Epidermis development
(GO:0008544)
Negative regulation of fat cell proliferation
(GO:0070345)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Rb-e2f complex
(GO:0035189)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna biosynthetic process
(GO:2000278)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: proerythroblast (CL0000547)
Fold Change: 1.82
Marker Score: 1236
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.44
Marker Score: 5643
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.33
Marker Score: 1387.5
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.3
Marker Score: 12358
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.28
Marker Score: 10954
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.27
Marker Score: 3774
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.26
Marker Score: 11876
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.25
Marker Score: 77073
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.21
Marker Score: 4688
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.21
Marker Score: 908
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.2
Marker Score: 1850
Cell Name: Unknown (CL0000548)
Fold Change: 1.17
Marker Score: 854
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.14
Marker Score: 286
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.11
Marker Score: 9593
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.11
Marker Score: 4273
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.05
Marker Score: 38661
Cell Name: stem cell (CL0000034)
Fold Change: 1.05
Marker Score: 2485
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.03
Marker Score: 10670
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.02
Marker Score: 1150
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.01
Marker Score: 1450
Cell Name: PP cell (CL0000696)
Fold Change: 1
Marker Score: 226
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71661
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47885
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.99
Marker Score: 37744
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Marker Score: 4038
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.99
Marker Score: 931
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.99
Marker Score: 15477
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.99
Marker Score: 1638
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.99
Marker Score: 2688
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.99
Marker Score: 1054
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.98
Marker Score: 33974.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30384
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.96
Marker Score: 2604
Cell Name: basal cell (CL0000646)
Fold Change: 0.95
Marker Score: 1230
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.95
Marker Score: 14208
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2394
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.94
Marker Score: 1383
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 477
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 432
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.91
Marker Score: 344
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.91
Marker Score: 3782
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5199
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.91
Marker Score: 529
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.91
Marker Score: 18026
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.9
Marker Score: 6904
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.9
Marker Score: 1019
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2693
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.9
Marker Score: 5445
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.9
Marker Score: 2107
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.89
Marker Score: 310
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.88
Marker Score: 924
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.88
Marker Score: 434
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.87
Marker Score: 5557
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.87
Marker Score: 2405
Cell Name: peptic cell (CL0000155)
Fold Change: 0.86
Marker Score: 362
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.86
Marker Score: 809
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 306
Cell Name: erythroblast (CL0000765)
Fold Change: 0.84
Marker Score: 526
Cell Name: decidual cell (CL2000002)
Fold Change: 0.84
Marker Score: 3631
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.84
Marker Score: 1917
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.84
Marker Score: 339
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.83
Marker Score: 2095
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.83
Marker Score: 6473
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.83
Marker Score: 6165
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.83
Marker Score: 455
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.82
Marker Score: 240
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.82
Marker Score: 471
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.82
Marker Score: 498
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.81
Marker Score: 878
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.81
Marker Score: 3403.5
Cell Name: plasmablast (CL0000980)
Fold Change: 0.81
Marker Score: 1078
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.8
Marker Score: 1811
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 318
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.79
Marker Score: 6889
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.79
Marker Score: 1280
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.78
Marker Score: 3023
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.78
Marker Score: 712
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.77
Marker Score: 854
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 588
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.77
Marker Score: 684
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.77
Marker Score: 8629
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.76
Marker Score: 958
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.76
Marker Score: 4950
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.76
Marker Score: 478
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.75
Marker Score: 192
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.75
Marker Score: 2582
Cell Name: precursor cell (CL0011115)
Fold Change: 0.75
Marker Score: 182
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.74
Marker Score: 1749
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.74
Marker Score: 251
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.74
Marker Score: 571
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.74
Marker Score: 177
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.74
Marker Score: 234
Cell Name: myelocyte (CL0002193)
Fold Change: 0.73
Marker Score: 315
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.73
Marker Score: 1480
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.73
Marker Score: 731
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.72
Marker Score: 1025
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.72
Marker Score: 300
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.72
Marker Score: 1441
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.72
Marker Score: 351.5

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**Key Characteristics:** 1. **Transcriptional Activation:** Dp-1 is a transcriptional activator that regulates the expression of target genes involved in cell cycle progression, apoptosis, and DNA repair. 2. **Cell Cycle Regulation:** Dp-1 is specifically involved in the regulation of the G1/S transition, where it activates the expression of cyclin E and CDK2, promoting cell cycle progression. 3. **Apoptosis Regulation:** Dp-1 is a pro-apoptotic transcription factor that activates the expression of pro-apoptotic proteins, such as Noxa and Puma, promoting cell death. 4. **Chromatin Remodeling:** Dp-1 is involved in chromatin remodeling, facilitating the recruitment of transcriptional machinery to specific genomic regions. 5. **Protein Interactions:** Dp-1 interacts with various proteins, including E2F1, RB1, and HDAC1, to regulate its activity and target gene expression. **Pathways and Functions:** 1. **Cell Cycle Regulation:** Dp-1 regulates the G1/S transition by activating the expression of cyclin E and CDK2, promoting cell cycle progression. 2. **Apoptosis:** Dp-1 activates the expression of pro-apoptotic proteins, such as Noxa and Puma, promoting cell death. 3. **Chromatin Remodeling:** Dp-1 is involved in chromatin remodeling, facilitating the recruitment of transcriptional machinery to specific genomic regions. 4. **Gene Expression:** Dp-1 regulates the expression of target genes involved in cell cycle progression, apoptosis, and DNA repair. 5. **Signaling Pathways:** Dp-1 is involved in various signaling pathways, including the Notch and TGF-β signaling pathways, regulating cell growth, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** Dp-1 is dysregulated in various cancers, contributing to tumorigenesis and resistance to therapy. 2. **Apoptosis Dysregulation:** Dp-1 dysregulation can lead to apoptosis resistance, contributing to cancer progression and therapy resistance. 3. **Neurodegenerative Diseases:** Dp-1 is implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation contributes to neuronal death and disease progression. 4. **Cardiovascular Disease:** Dp-1 is involved in cardiovascular disease, where its dysregulation contributes to cardiac hypertrophy and fibrosis. 5. **Regenerative Medicine:** Dp-1 is a promising target for regenerative medicine, where its dysregulation can be exploited to promote tissue repair and regeneration. In conclusion, the transcription factor Dp-1 is a critical regulator of cell cycle and apoptosis, involved in various cellular processes, including chromatin remodeling, gene expression, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, cardiovascular disease, and regenerative medicine. Further research is needed to fully understand the role of Dp-1 in human disease and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor Dp-1

Genular Protein ID: 356853750

Symbol: TFDP1_HUMAN

Name: Transcription factor Dp-1

UniProtKB Accession Codes:

Q14186 B4DLQ9 Q5JSB4 Q8IZL5

Database IDs:

Citations:

PubMed ID: 8405995

Title: Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

PubMed ID: 8405995

DOI: 10.1101/gad.7.10.1850

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8039504

Title: DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

PubMed ID: 8039504

DOI: 10.1002/j.1460-2075.1994.tb06609.x

PubMed ID: 7739537

Title: In vivo association of E2F and DP family proteins.

PubMed ID: 7739537

DOI: 10.1128/mcb.15.5.2536

PubMed ID: 12004135

Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PubMed ID: 12004135

DOI: 10.1126/science.1069861

PubMed ID: 17531812

Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

PubMed ID: 17531812

DOI: 10.1016/j.molcel.2007.04.015

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 410
Mass: 45070
Checksum: 3FEEFE1E49FD9ED0
Sequence:

MAKDAGLIEA NGELKVFIDQ NLSPGKGVVS LVAVHPSTVN PLGKQLLPKT FGQSNVNIAQ 
QVVIGTPQRP AASNTLVVGS PHTPSTHFAS QNQPSDSSPW SAGKRNRKGE KNGKGLRHFS 
MKVCEKVQRK GTTSYNEVAD ELVAEFSAAD NHILPNESAY DQKNIRRRVY DALNVLMAMN 
IISKEKKEIK WIGLPTNSAQ ECQNLEVERQ RRLERIKQKQ SQLQELILQQ IAFKNLVQRN 
RHAEQQASRP PPPNSVIHLP FIIVNTSKKT VIDCSISNDK FEYLFNFDNT FEIHDDIEVL 
KRMGMACGLE SGSCSAEDLK MARSLVPKAL EPYVTEMAQG TVGGVFITTA GSTSNGTRFS 
ASDLTNGADG MLATSSNGSQ YSGSRVETPV SYVGEDDEED DDFNENDEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TFDP1

Associated with

Cells (max top 100)

Other Information

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. PubMed ID: 8405995

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. PubMed ID: 8039504

In vivo association of E2F and DP family proteins. PubMed ID: 7739537

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. PubMed ID: 12004135

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. PubMed ID: 17531812

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163