Details for: TGFBR1

Gene ID: 7046

Symbol: TGFBR1

Ensembl ID: ENSG00000106799

Description: transforming growth factor beta receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 206.8852
    Cell Significance Index: -32.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.8156
    Cell Significance Index: -31.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.1089
    Cell Significance Index: -33.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.9127
    Cell Significance Index: -27.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.1648
    Cell Significance Index: -32.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6953
    Cell Significance Index: -31.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1168
    Cell Significance Index: -24.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2038
    Cell Significance Index: -32.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1720
    Cell Significance Index: -25.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6689
    Cell Significance Index: 22.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4670
    Cell Significance Index: 82.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3838
    Cell Significance Index: 136.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2471
    Cell Significance Index: 202.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7030
    Cell Significance Index: 18.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7014
    Cell Significance Index: 76.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6127
    Cell Significance Index: 121.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5347
    Cell Significance Index: 32.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3395
    Cell Significance Index: 23.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3303
    Cell Significance Index: 25.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2645
    Cell Significance Index: 53.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1978
    Cell Significance Index: 24.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1813
    Cell Significance Index: 24.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1558
    Cell Significance Index: 2.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1430
    Cell Significance Index: 25.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0804
    Cell Significance Index: 1.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0796
    Cell Significance Index: 43.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0655
    Cell Significance Index: 1.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0621
    Cell Significance Index: 11.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0586
    Cell Significance Index: 21.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0566
    Cell Significance Index: 0.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0510
    Cell Significance Index: 6.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0486
    Cell Significance Index: 2.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0479
    Cell Significance Index: 1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0466
    Cell Significance Index: 87.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0449
    Cell Significance Index: 7.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0337
    Cell Significance Index: 14.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0332
    Cell Significance Index: 0.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0326
    Cell Significance Index: 22.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0020
    Cell Significance Index: 1.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0119
    Cell Significance Index: -7.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0129
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0190
    Cell Significance Index: -14.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0213
    Cell Significance Index: -15.6200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0245
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0299
    Cell Significance Index: -4.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0352
    Cell Significance Index: -26.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0431
    Cell Significance Index: -4.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0816
    Cell Significance Index: -6.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0854
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0884
    Cell Significance Index: -18.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0936
    Cell Significance Index: -26.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1034
    Cell Significance Index: -1.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1212
    Cell Significance Index: -14.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1432
    Cell Significance Index: -3.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1514
    Cell Significance Index: -17.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1546
    Cell Significance Index: -19.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1687
    Cell Significance Index: -19.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1755
    Cell Significance Index: -8.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2126
    Cell Significance Index: -4.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2160
    Cell Significance Index: -13.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2277
    Cell Significance Index: -11.8300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2433
    Cell Significance Index: -1.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2484
    Cell Significance Index: -25.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2526
    Cell Significance Index: -5.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2691
    Cell Significance Index: -30.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2715
    Cell Significance Index: -17.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3164
    Cell Significance Index: -22.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3318
    Cell Significance Index: -11.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3439
    Cell Significance Index: -9.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3665
    Cell Significance Index: -29.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3689
    Cell Significance Index: -10.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3705
    Cell Significance Index: -16.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3822
    Cell Significance Index: -19.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3824
    Cell Significance Index: -6.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3873
    Cell Significance Index: -11.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3914
    Cell Significance Index: -10.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4176
    Cell Significance Index: -25.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4425
    Cell Significance Index: -22.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4542
    Cell Significance Index: -30.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4756
    Cell Significance Index: -18.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4946
    Cell Significance Index: -31.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4954
    Cell Significance Index: -26.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5312
    Cell Significance Index: -7.6400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5318
    Cell Significance Index: -5.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5387
    Cell Significance Index: -14.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5445
    Cell Significance Index: -17.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6344
    Cell Significance Index: -9.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7252
    Cell Significance Index: -15.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7975
    Cell Significance Index: -29.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7978
    Cell Significance Index: -26.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8148
    Cell Significance Index: -10.1600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.8325
    Cell Significance Index: -4.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.8629
    Cell Significance Index: -14.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8792
    Cell Significance Index: -30.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** TGFBR1 is a transmembrane receptor tyrosine kinase with a serine/threonine kinase domain, which allows it to phosphorylate and activate downstream signaling molecules. 2. **Signaling Pathways:** TGFBR1 mediates the TGF-beta signaling pathway, which regulates cell growth, differentiation, migration, and apoptosis. It also interacts with other signaling pathways, such as the activin and BMP pathways. 3. **Expression Patterns:** TGFBR1 is widely expressed in various cell types, including immune cells, epithelial cells, and neural cells. 4. **Mutations and Variants:** Mutations in the TGFBR1 gene have been associated with various diseases, including cancer, cardiovascular disease, and autoimmune disorders. **Pathways and Functions:** 1. **TGF-beta Signaling Pathway:** TGFBR1 mediates the TGF-beta signaling pathway, which regulates cell growth, differentiation, migration, and apoptosis. 2. **Activin Signaling Pathway:** TGFBR1 also interacts with the activin signaling pathway, which regulates cell growth and differentiation. 3. **Apoptotic Process:** TGFBR1 can regulate apoptosis by interacting with pro-apoptotic and anti-apoptotic signaling molecules. 4. **Cell Migration and Proliferation:** TGFBR1 regulates cell migration and proliferation by interacting with signaling molecules involved in these processes. 5. **Epithelial-to-Mesenchymal Transition (EMT):** TGFBR1 can regulate EMT by interacting with transcription factors involved in this process. **Clinical Significance:** 1. **Cancer:** Mutations in the TGFBR1 gene have been associated with various cancers, including colorectal, breast, and lung cancer. 2. **Cardiovascular Disease:** TGFBR1 plays a role in regulating cardiovascular development and function, and mutations in the gene have been associated with cardiovascular disease. 3. **Autoimmune Disorders:** TGFBR1 can regulate immune responses, and mutations in the gene have been associated with autoimmune disorders, such as rheumatoid arthritis and lupus. 4. **Neurological Disorders:** TGFBR1 is involved in regulating neural development and function, and mutations in the gene have been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TGFBR1 is a key regulator of cellular processes and disease pathways, and its dysregulation has been implicated in various human diseases. Further research is needed to fully understand the functional significance of TGFBR1 and its role in human disease.

Genular Protein ID: 1475904645

Symbol: TGFR1_HUMAN

Name: TGF-beta receptor type-1

UniProtKB Accession Codes:

P36897 Q6IR47 Q706C0 Q706C1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 3 EMBL 24 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 97 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 10 RefSeq 3 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8242743

Title: Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.

PubMed ID: 8242743

DOI: 10.1016/0092-8674(93)90489-d

PubMed ID: 9417915

Title: Cloning and genomic organization of the human transforming growth factor-beta type I receptor gene.

PubMed ID: 9417915

DOI: 10.1006/geno.1997.5023

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9661882

Title: Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.

PubMed ID: 9661882

PubMed ID: 17845732

Title: Alternative splicing of TGF-betas and their high-affinity receptors T beta RI, T beta RII and T beta RIII (betaglycan) reveal new variants in human prostatic cells.

PubMed ID: 17845732

DOI: 10.1186/1471-2164-8-318

PubMed ID: 7774578

Title: GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

PubMed ID: 7774578

DOI: 10.1002/j.1460-2075.1995.tb07214.x

PubMed ID: 8752209

Title: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.

PubMed ID: 8752209

DOI: 10.1016/s0092-8674(00)80128-2

PubMed ID: 8980228

Title: MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.

PubMed ID: 8980228

DOI: 10.1016/s0092-8674(00)81817-6

PubMed ID: 9233797

Title: Mechanism of TGFbeta receptor inhibition by FKBP12.

PubMed ID: 9233797

DOI: 10.1093/emboj/16.13.3866

PubMed ID: 9311995

Title: TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

PubMed ID: 9311995

DOI: 10.1093/emboj/16.17.5353

PubMed ID: 9346908

Title: TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.

PubMed ID: 9346908

DOI: 10.1074/jbc.272.44.27678

PubMed ID: 9865696

Title: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

PubMed ID: 9865696

DOI: 10.1016/s0092-8674(00)81701-8

PubMed ID: 9472030

Title: Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane.

PubMed ID: 9472030

DOI: 10.1083/jcb.140.4.767

PubMed ID: 11163210

Title: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation.

PubMed ID: 11163210

DOI: 10.1016/s1097-2765(00)00134-9

PubMed ID: 11278251

Title: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.

PubMed ID: 11278251

DOI: 10.1074/jbc.c100008200

PubMed ID: 12941698

Title: TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.

PubMed ID: 12941698

DOI: 10.1093/emboj/cdg428

PubMed ID: 15496141

Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

PubMed ID: 15496141

DOI: 10.1042/bj20040738

PubMed ID: 15761148

Title: Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.

PubMed ID: 15761148

DOI: 10.1126/science.1105718

PubMed ID: 16754747

Title: Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes.

PubMed ID: 16754747

DOI: 10.1096/fj.05-5229fje

PubMed ID: 17099224

Title: Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.

PubMed ID: 17099224

DOI: 10.1093/nar/gkl914

PubMed ID: 18758450

Title: The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.

PubMed ID: 18758450

DOI: 10.1038/ncb1780

PubMed ID: 9759503

Title: TGF-beta signal transduction.

PubMed ID: 9759503

DOI: 10.1146/annurev.biochem.67.1.753

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 22344298

Title: USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma.

PubMed ID: 22344298

DOI: 10.1038/nm.2619

PubMed ID: 25893292

Title: Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.

PubMed ID: 25893292

DOI: 10.1038/onc.2015.100

PubMed ID: 26583432

Title: APPL proteins promote TGFbeta-induced nuclear transport of the TGFbeta type I receptor intracellular domain.

PubMed ID: 26583432

DOI: 10.18632/oncotarget.6346

PubMed ID: 29572483

Title: The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development.

PubMed ID: 29572483

DOI: 10.1038/s41467-018-03609-x

PubMed ID: 8521960

Title: Extracellular domain of type I receptor for transforming growth factor-beta: molecular modelling using protectin (CD59) as a template.

PubMed ID: 8521960

DOI: 10.1016/0014-5793(95)01239-7

PubMed ID: 10025408

Title: Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.

PubMed ID: 10025408

DOI: 10.1016/s0092-8674(00)80555-3

PubMed ID: 11583628

Title: The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.

PubMed ID: 11583628

DOI: 10.1016/s1097-2765(01)00332-x

PubMed ID: 15177479

Title: Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.

PubMed ID: 15177479

DOI: 10.1016/j.bmcl.2004.04.007

PubMed ID: 15317461

Title: Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors.

PubMed ID: 15317461

DOI: 10.1021/jm0400247

PubMed ID: 18243111

Title: Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.

PubMed ID: 18243111

DOI: 10.1016/j.molcel.2007.11.039

PubMed ID: 20207738

Title: Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.

PubMed ID: 20207738

DOI: 10.1074/jbc.m109.079921

PubMed ID: 12947057

Title: TGFBR1*6A and cancer risk: a meta-analysis of seven case-control studies.

PubMed ID: 12947057

DOI: 10.1200/jco.2003.11.524

PubMed ID: 15385056

Title: No major association between TGFBR1*6A and prostate cancer.

PubMed ID: 15385056

DOI: 10.1186/1471-2156-5-28

PubMed ID: 15731757

Title: A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.

PubMed ID: 15731757

DOI: 10.1038/ng1511

PubMed ID: 15505640

Title: TGFBR1(*)6A is not associated with prostate cancer in men of European ancestry.

PubMed ID: 15505640

DOI: 10.1038/sj.pcan.4500765

PubMed ID: 16596670

Title: FBN1, TGFBR1, and the Marfan-craniosynostosis/mental retardation disorders revisited.

PubMed ID: 16596670

DOI: 10.1002/ajmg.a.31202

PubMed ID: 16791849

Title: Identification and in silico analyses of novel TGFBR1 and TGFBR2 mutations in Marfan syndrome-related disorders.

PubMed ID: 16791849

DOI: 10.1002/humu.20353

PubMed ID: 16928994

Title: Aneurysm syndromes caused by mutations in the TGF-beta receptor.

PubMed ID: 16928994

DOI: 10.1056/nejmoa055695

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

PubMed ID: 19883511

Title: Loeys-Dietz syndrome type I and type II: clinical findings and novel mutations in two Italian patients.

PubMed ID: 19883511

DOI: 10.1186/1750-1172-4-24

PubMed ID: 22113417

Title: Clinical features and genetic analysis of Korean patients with Loeys-Dietz syndrome.

PubMed ID: 22113417

DOI: 10.1038/jhg.2011.130

PubMed ID: 21358634

Title: Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1.

PubMed ID: 21358634

DOI: 10.1038/ng.780

Sequence Information:

  • Length: 503
  • Mass: 55960
  • Checksum: 179F11404725DDCB
  • Sequence:
    • MEAAVAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT DGLCFVSVTE 
TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC CNQDHCNKIE LPTTVKSSPG 
LGPVELAAVI AGPVCFVCIS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL 
IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 
SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 
ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 
HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 
ARLTALRIKK TLSQLSQQEG IKM

Genular Protein ID: 1598629789

Symbol: F8W0K6_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W0K6 A0A8V8TMH4

Database IDs:

ARBA 28 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 13 ChiTaRS 1 EC 2 EMBL 1 Ensembl 3 GO 11 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 NCBI Taxonomy 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 6 RuleBase 1 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

Sequence Information:

  • Length: 438
  • Mass: 49264
  • Checksum: 3A2AF8AD3B24A54C
  • Sequence:
    • MCIAEIDLIP RDRPFVCAPS SKTGSVTTTY CCNQDHCNKI ELPTTGPFSV KSSPGLGPVE 
LAAVIAGPVC FVCISLMLMV YICHNRTVIH HRVPNEEDPS LDRPFISEGT TLKDLIYDMT 
TSGSGSGLPL LVQRTIARTI VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE 
AEIYQTVMLR HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL 
ALSTASGLAH LHMEIVGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI 
DIAPNHRVGT KRYMAPEVLD DSINMKHFES FKRADIYAMG LVFWEIARRC SIGGIHEDYQ 
LPYYDLVPSD PSVEEMRKVV CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANGAARLTA 
LRIKKTLSQL SQQEGIKM

Genular Protein ID: 2921775637

Symbol: B4DXN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DXN7

Database IDs:

ARBA 26 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 13 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 16 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 ProteomicsDB 1 RefSeq 3 Rhea 6 SAM 2 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 465
  • Mass: 51871
  • Checksum: 1895068E48AA5A1F
  • Sequence:
    • MEAAVAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT DGLCFVSVTE 
TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC CNQDHCNKIE LPTTVKSSPG 
LGPVELAAVI AGPVCFVCIS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL 
IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 
SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA PNHRVGTKRY MAPEVLDDSI NMKHFESFKR 
ADIYAMGLVF WEIARRCSIG GIHEDYQLPY YDLVPSDPSV EEMRKVVCEQ KLRPNIPNRW 
QSCEALRVMA KIMRECWYAN GAARLTALRI KKTLSQLSQQ EGIKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.