Details for: TK1

Gene ID: 7083

Symbol: TK1

Ensembl ID: ENSG00000167900

Description: thymidine kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.5260
    Cell Significance Index: -8.2500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 30.8077
    Cell Significance Index: 14.0300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.1346
    Cell Significance Index: -11.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.7134
    Cell Significance Index: -10.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9370
    Cell Significance Index: -7.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2331
    Cell Significance Index: -11.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4303
    Cell Significance Index: -9.5900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 2.4239
    Cell Significance Index: 1.8500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.9155
    Cell Significance Index: 16.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5789
    Cell Significance Index: 186.2000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.5570
    Cell Significance Index: 6.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3763
    Cell Significance Index: 44.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3415
    Cell Significance Index: 156.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1675
    Cell Significance Index: 189.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1640
    Cell Significance Index: 126.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1427
    Cell Significance Index: 68.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0127
    Cell Significance Index: 35.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9686
    Cell Significance Index: 10.5300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.8609
    Cell Significance Index: 4.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7133
    Cell Significance Index: 70.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5986
    Cell Significance Index: -1.3100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.4996
    Cell Significance Index: 2.4300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.4486
    Cell Significance Index: 5.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4433
    Cell Significance Index: 9.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3935
    Cell Significance Index: 214.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2967
    Cell Significance Index: 15.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2775
    Cell Significance Index: 55.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.2668
    Cell Significance Index: 1.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2408
    Cell Significance Index: 6.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2405
    Cell Significance Index: 6.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2394
    Cell Significance Index: 16.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2128
    Cell Significance Index: 6.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1910
    Cell Significance Index: 84.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1446
    Cell Significance Index: 3.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1376
    Cell Significance Index: 3.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1255
    Cell Significance Index: 2.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1039
    Cell Significance Index: 19.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0740
    Cell Significance Index: 9.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0737
    Cell Significance Index: 4.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0629
    Cell Significance Index: 3.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0515
    Cell Significance Index: 1.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0501
    Cell Significance Index: 1.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0501
    Cell Significance Index: 45.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0263
    Cell Significance Index: 0.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0249
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0182
    Cell Significance Index: 3.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0111
    Cell Significance Index: 8.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0036
    Cell Significance Index: 0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0039
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0048
    Cell Significance Index: -3.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0092
    Cell Significance Index: -12.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0145
    Cell Significance Index: -1.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0166
    Cell Significance Index: -10.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0167
    Cell Significance Index: -2.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0169
    Cell Significance Index: -1.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0170
    Cell Significance Index: -1.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0193
    Cell Significance Index: -3.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0245
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0252
    Cell Significance Index: -11.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0277
    Cell Significance Index: -0.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0283
    Cell Significance Index: -10.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0301
    Cell Significance Index: -3.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0319
    Cell Significance Index: -9.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0586
    Cell Significance Index: -7.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0660
    Cell Significance Index: -7.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0673
    Cell Significance Index: -9.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0730
    Cell Significance Index: -1.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0806
    Cell Significance Index: -3.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0873
    Cell Significance Index: -2.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0887
    Cell Significance Index: -9.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0902
    Cell Significance Index: -6.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0922
    Cell Significance Index: -1.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1252
    Cell Significance Index: -5.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1364
    Cell Significance Index: -10.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1379
    Cell Significance Index: -10.9300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1448
    Cell Significance Index: -1.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1452
    Cell Significance Index: -1.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1474
    Cell Significance Index: -9.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1555
    Cell Significance Index: -4.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1561
    Cell Significance Index: -8.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1626
    Cell Significance Index: -1.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1661
    Cell Significance Index: -11.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1687
    Cell Significance Index: -10.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1715
    Cell Significance Index: -7.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1730
    Cell Significance Index: -2.9100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1761
    Cell Significance Index: -1.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1884
    Cell Significance Index: -2.7000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1885
    Cell Significance Index: -1.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1962
    Cell Significance Index: -9.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1978
    Cell Significance Index: -5.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2005
    Cell Significance Index: -8.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TK1 is a cytosolic enzyme, belonging to the kinase family, which phosphorylates thymidine to form thymidine monophosphate (TMP). This reaction is essential for the salvage of deoxyribonucleotides, allowing cells to maintain genomic integrity and regulate cell cycle progression. TK1 is highly expressed in hematopoietic cells, including erythroblasts, B cells, and progenitor cells, where it plays a crucial role in DNA synthesis and repair. **Pathways and Functions:** TK1 is involved in several key pathways, including: 1. **Pyrimidine Salvage Pathway:** TK1 phosphorylates thymidine to form TMP, which is then converted to thymidine diphosphate (ThdP) and subsequently into thymidine triphosphate (TTP). TTP is the primary nucleotide required for DNA synthesis and repair. 2. **DNA Synthesis and Repair:** TK1 regulates DNA synthesis and repair by controlling the availability of deoxyribonucleotides. This is critical for maintaining genomic integrity and preventing mutations. 3. **Cell Cycle Regulation:** TK1 plays a role in regulating cell cycle progression by controlling the availability of deoxyribonucleotides. This is particularly important in rapidly dividing cells, such as hematopoietic cells. 4. **Immune Cell Function:** TK1 is highly expressed in immune cells, including B cells and T cells, where it regulates immune cell function and modulates inflammatory responses. **Clinical Significance:** Recent studies have highlighted the clinical significance of TK1 in various immune-related disorders, including: 1. **Cancer:** Elevated TK1 expression has been observed in various cancers, including leukemia, lymphoma, and solid tumors. This suggests that TK1 may play a role in cancer development and progression. 2. **Autoimmune Diseases:** TK1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates immune cell function and modulates inflammatory responses. 3. **Immunodeficiency Disorders:** TK1 deficiency has been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where it regulates immune cell function and development. In conclusion, TK1 is a crucial enzyme involved in the salvage of deoxyribonucleotides, regulating cell cycle progression, and modulating immune cell function. Its clinical significance in immune-related disorders highlights the importance of further research into the role of TK1 in human disease.

Genular Protein ID: 708657885

Symbol: KITH_HUMAN

Name: N/A

UniProtKB Accession Codes:

P04183 B2RC58 Q969V0 Q9UMG9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 DrugCentral 1 EC 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6549046

Title: Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.

PubMed ID: 6549046

DOI: 10.1128/mcb.4.11.2316-2320.1984

PubMed ID: 3301530

Title: Sequence, structure and promoter characterization of the human thymidine kinase gene.

PubMed ID: 3301530

DOI: 10.1016/0378-1119(87)90053-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3785218

Title: Genetic analysis of the human thymidine kinase gene promoter.

PubMed ID: 3785218

DOI: 10.1128/mcb.6.8.2903-2909.1986

PubMed ID: 9575153

Title: Serine 13 is the site of mitotic phosphorylation of human thymidine kinase.

PubMed ID: 9575153

DOI: 10.1074/jbc.273.20.12095

PubMed ID: 14697231

Title: Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site.

PubMed ID: 14697231

DOI: 10.1016/j.bbrc.2003.11.147

PubMed ID: 14701726

Title: Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.

PubMed ID: 14701726

DOI: 10.1128/mcb.24.2.514-526.2004

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15611477

Title: Structures of thymidine kinase 1 of human and mycoplasmic origin.

PubMed ID: 15611477

DOI: 10.1073/pnas.0406332102

PubMed ID: 15733844

Title: Structure of a type II thymidine kinase with bound dTTP.

PubMed ID: 15733844

DOI: 10.1016/j.febslet.2005.01.034

PubMed ID: 17407781

Title: Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure.

PubMed ID: 17407781

DOI: 10.1016/j.jmb.2007.02.104

PubMed ID: 22385435

Title: Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1.

PubMed ID: 22385435

DOI: 10.1111/j.1742-4658.2012.08554.x

Sequence Information:

  • Length: 234
  • Mass: 25469
  • Checksum: 76901415C631EF21
  • Sequence:
    • MSCINLPTVL PGSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC LVIKYAKDTR 
YSSSFCTHDR NTMEALPACL LRDVAQEALG VAVIGIDEGQ FFPDIVEFCE AMANAGKTVI 
VAALDGTFQR KPFGAILNLV PLAESVVKLT AVCMECFREA AYTKRLGTEK EVEVIGGADK 
YHSVCRLCYF KKASGQPAGP DNKENCPVPG KPGEAVAARK LFAPQQILQC SPAN

Genular Protein ID: 740955204

Symbol: K7ES52_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ES52

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 2 RuleBase 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 180
  • Mass: 19786
  • Checksum: 079C5F81644E82DA
  • Sequence:
    • MSCINLPTVL PGSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC LVIKYAKDTR 
YSSSFCTHDR NTMEALPACL LRDVAQEALG VAVIGIDEGQ FFPDIVEFCE AMANAGKTVI 
VAALDGTFQR KPFGAILNLV PLAESVVKLT AVCMECFREA AYTKRLGTEK EQILQCSPAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.