Details for: TK1

Gene ID: 7083

Symbol: TK1

Ensembl ID: ENSG00000167900

Description: thymidine kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.59
    Marker Score: 2702
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.87
    Marker Score: 1169
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.48
    Marker Score: 1004
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.44
    Marker Score: 1048
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.44
    Marker Score: 4266
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.4
    Marker Score: 3806
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.33
    Marker Score: 996
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3062
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.26
    Marker Score: 1181
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.24
    Marker Score: 2922
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.12
    Marker Score: 587.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71793
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48018
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1861
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.97
    Marker Score: 3809
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14922
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.94
    Marker Score: 294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.92
    Marker Score: 1607
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.91
    Marker Score: 294
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.91
    Marker Score: 970
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.9
    Marker Score: 1194
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.88
    Marker Score: 436
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.86
    Marker Score: 426
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.86
    Marker Score: 274
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.82
    Marker Score: 871
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.81
    Marker Score: 257
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.8
    Marker Score: 810
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.75
    Marker Score: 1283
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.75
    Marker Score: 248
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.74
    Marker Score: 1544
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1494
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.73
    Marker Score: 2982
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.71
    Marker Score: 9380.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.67
    Marker Score: 632
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1811
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2758
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.58
    Marker Score: 419
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.57
    Marker Score: 315
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.56
    Marker Score: 275
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.55
    Marker Score: 192
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.55
    Marker Score: 351
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.55
    Marker Score: 18985
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.55
    Marker Score: 142
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.54
    Marker Score: 341
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.54
    Marker Score: 423
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 255
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.53
    Marker Score: 3402
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.53
    Marker Score: 1966
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.51
    Marker Score: 1214
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.51
    Marker Score: 150
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.51
    Marker Score: 291
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.49
    Marker Score: 226
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.49
    Marker Score: 702
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.47
    Marker Score: 130
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.47
    Marker Score: 569
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.44
    Marker Score: 125
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.44
    Marker Score: 288.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.44
    Marker Score: 179
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 255
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.42
    Marker Score: 522
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.41
    Marker Score: 102
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.4
    Marker Score: 214
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.4
    Marker Score: 148
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.38
    Marker Score: 3245
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 362
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.37
    Marker Score: 136
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.37
    Marker Score: 140
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.37
    Marker Score: 183
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.36
    Marker Score: 151
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.36
    Marker Score: 174
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 154
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.35
    Marker Score: 152
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.35
    Marker Score: 213
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.34
    Marker Score: 2190
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 224
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.33
    Marker Score: 248
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.33
    Marker Score: 169
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.32
    Marker Score: 230
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.32
    Marker Score: 333
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.31
    Marker Score: 280
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.31
    Marker Score: 613
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.31
    Marker Score: 856
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.31
    Marker Score: 138

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Other Information

**Key Characteristics:** TK1 is a cytosolic enzyme, belonging to the kinase family, which phosphorylates thymidine to form thymidine monophosphate (TMP). This reaction is essential for the salvage of deoxyribonucleotides, allowing cells to maintain genomic integrity and regulate cell cycle progression. TK1 is highly expressed in hematopoietic cells, including erythroblasts, B cells, and progenitor cells, where it plays a crucial role in DNA synthesis and repair. **Pathways and Functions:** TK1 is involved in several key pathways, including: 1. **Pyrimidine Salvage Pathway:** TK1 phosphorylates thymidine to form TMP, which is then converted to thymidine diphosphate (ThdP) and subsequently into thymidine triphosphate (TTP). TTP is the primary nucleotide required for DNA synthesis and repair. 2. **DNA Synthesis and Repair:** TK1 regulates DNA synthesis and repair by controlling the availability of deoxyribonucleotides. This is critical for maintaining genomic integrity and preventing mutations. 3. **Cell Cycle Regulation:** TK1 plays a role in regulating cell cycle progression by controlling the availability of deoxyribonucleotides. This is particularly important in rapidly dividing cells, such as hematopoietic cells. 4. **Immune Cell Function:** TK1 is highly expressed in immune cells, including B cells and T cells, where it regulates immune cell function and modulates inflammatory responses. **Clinical Significance:** Recent studies have highlighted the clinical significance of TK1 in various immune-related disorders, including: 1. **Cancer:** Elevated TK1 expression has been observed in various cancers, including leukemia, lymphoma, and solid tumors. This suggests that TK1 may play a role in cancer development and progression. 2. **Autoimmune Diseases:** TK1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates immune cell function and modulates inflammatory responses. 3. **Immunodeficiency Disorders:** TK1 deficiency has been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where it regulates immune cell function and development. In conclusion, TK1 is a crucial enzyme involved in the salvage of deoxyribonucleotides, regulating cell cycle progression, and modulating immune cell function. Its clinical significance in immune-related disorders highlights the importance of further research into the role of TK1 in human disease.

Genular Protein ID: 708657885

Symbol: KITH_HUMAN

Name: N/A

UniProtKB Accession Codes:

P04183 B2RC58 Q969V0 Q9UMG9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6549046

Title: Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.

PubMed ID: 6549046

DOI: 10.1128/mcb.4.11.2316-2320.1984

PubMed ID: 3301530

Title: Sequence, structure and promoter characterization of the human thymidine kinase gene.

PubMed ID: 3301530

DOI: 10.1016/0378-1119(87)90053-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3785218

Title: Genetic analysis of the human thymidine kinase gene promoter.

PubMed ID: 3785218

DOI: 10.1128/mcb.6.8.2903-2909.1986

PubMed ID: 9575153

Title: Serine 13 is the site of mitotic phosphorylation of human thymidine kinase.

PubMed ID: 9575153

DOI: 10.1074/jbc.273.20.12095

PubMed ID: 14697231

Title: Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site.

PubMed ID: 14697231

DOI: 10.1016/j.bbrc.2003.11.147

PubMed ID: 14701726

Title: Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.

PubMed ID: 14701726

DOI: 10.1128/mcb.24.2.514-526.2004

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15611477

Title: Structures of thymidine kinase 1 of human and mycoplasmic origin.

PubMed ID: 15611477

DOI: 10.1073/pnas.0406332102

PubMed ID: 15733844

Title: Structure of a type II thymidine kinase with bound dTTP.

PubMed ID: 15733844

DOI: 10.1016/j.febslet.2005.01.034

PubMed ID: 17407781

Title: Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure.

PubMed ID: 17407781

DOI: 10.1016/j.jmb.2007.02.104

PubMed ID: 22385435

Title: Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1.

PubMed ID: 22385435

DOI: 10.1111/j.1742-4658.2012.08554.x

Sequence Information:

  • Length: 234
  • Mass: 25469
  • Checksum: 76901415C631EF21
  • Sequence:
    • MSCINLPTVL PGSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC LVIKYAKDTR 
YSSSFCTHDR NTMEALPACL LRDVAQEALG VAVIGIDEGQ FFPDIVEFCE AMANAGKTVI 
VAALDGTFQR KPFGAILNLV PLAESVVKLT AVCMECFREA AYTKRLGTEK EVEVIGGADK 
YHSVCRLCYF KKASGQPAGP DNKENCPVPG KPGEAVAARK LFAPQQILQC SPAN

Genular Protein ID: 740955204

Symbol: K7ES52_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ES52

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 2 RuleBase 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 180
  • Mass: 19786
  • Checksum: 079C5F81644E82DA
  • Sequence:
    • MSCINLPTVL PGSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC LVIKYAKDTR 
YSSSFCTHDR NTMEALPACL LRDVAQEALG VAVIGIDEGQ FFPDIVEFCE AMANAGKTVI 
VAALDGTFQR KPFGAILNLV PLAESVVKLT AVCMECFREA AYTKRLGTEK EQILQCSPAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.