Details for: TK2

Gene ID: 7084

Symbol: TK2

Ensembl ID: ENSG00000166548

Description: thymidine kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.9230
    Cell Significance Index: -20.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.8652
    Cell Significance Index: -19.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.9746
    Cell Significance Index: -17.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6857
    Cell Significance Index: -17.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8051
    Cell Significance Index: -20.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5368
    Cell Significance Index: -20.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7139
    Cell Significance Index: -17.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2762
    Cell Significance Index: -20.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6560
    Cell Significance Index: -10.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1026
    Cell Significance Index: 18.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9394
    Cell Significance Index: 102.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8575
    Cell Significance Index: 139.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8219
    Cell Significance Index: 49.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7881
    Cell Significance Index: 711.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7278
    Cell Significance Index: 9.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6427
    Cell Significance Index: 128.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4990
    Cell Significance Index: 34.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4503
    Cell Significance Index: 12.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4329
    Cell Significance Index: 50.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4239
    Cell Significance Index: 58.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4150
    Cell Significance Index: 8.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4092
    Cell Significance Index: 73.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3861
    Cell Significance Index: 76.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3775
    Cell Significance Index: 135.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3048
    Cell Significance Index: 14.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3026
    Cell Significance Index: 16.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2972
    Cell Significance Index: 15.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2761
    Cell Significance Index: 4.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2706
    Cell Significance Index: 33.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2607
    Cell Significance Index: 180.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2552
    Cell Significance Index: 19.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2208
    Cell Significance Index: 5.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2044
    Cell Significance Index: 10.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2013
    Cell Significance Index: 12.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2003
    Cell Significance Index: 19.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1891
    Cell Significance Index: 11.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1845
    Cell Significance Index: 81.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1827
    Cell Significance Index: 12.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1687
    Cell Significance Index: 4.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1662
    Cell Significance Index: 10.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1564
    Cell Significance Index: 7.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1474
    Cell Significance Index: 7.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1399
    Cell Significance Index: 3.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1290
    Cell Significance Index: 16.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1263
    Cell Significance Index: 68.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0971
    Cell Significance Index: 16.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0741
    Cell Significance Index: 14.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0708
    Cell Significance Index: 3.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0570
    Cell Significance Index: 2.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0468
    Cell Significance Index: 88.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0438
    Cell Significance Index: 1.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0351
    Cell Significance Index: 54.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0334
    Cell Significance Index: 45.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0266
    Cell Significance Index: 48.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0126
    Cell Significance Index: 8.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0069
    Cell Significance Index: -4.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0125
    Cell Significance Index: -7.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0183
    Cell Significance Index: -13.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0185
    Cell Significance Index: -1.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0302
    Cell Significance Index: -4.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0392
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0509
    Cell Significance Index: -10.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0563
    Cell Significance Index: -1.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0620
    Cell Significance Index: -17.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0834
    Cell Significance Index: -3.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0850
    Cell Significance Index: -10.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0932
    Cell Significance Index: -10.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1177
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1298
    Cell Significance Index: -8.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1461
    Cell Significance Index: -17.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1500
    Cell Significance Index: -11.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1721
    Cell Significance Index: -4.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1773
    Cell Significance Index: -18.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1808
    Cell Significance Index: -4.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2010
    Cell Significance Index: -3.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2053
    Cell Significance Index: -16.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2135
    Cell Significance Index: -5.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2182
    Cell Significance Index: -3.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2632
    Cell Significance Index: -6.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2692
    Cell Significance Index: -6.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2735
    Cell Significance Index: -7.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2768
    Cell Significance Index: -9.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2841
    Cell Significance Index: -8.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2856
    Cell Significance Index: -17.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3149
    Cell Significance Index: -10.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3245
    Cell Significance Index: -4.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3284
    Cell Significance Index: -7.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3469
    Cell Significance Index: -7.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3593
    Cell Significance Index: -9.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3875
    Cell Significance Index: -5.8400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3907
    Cell Significance Index: -5.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4091
    Cell Significance Index: -6.0400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4280
    Cell Significance Index: -5.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4476
    Cell Significance Index: -13.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4513
    Cell Significance Index: -12.0500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4577
    Cell Significance Index: -3.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic activity:** TK2 exhibits deoxycytidine kinase activity, which phosphorylates deoxycytidine to form deoxycytidine monophosphate (dCMP). This reaction is essential for the salvage of dCMP, a critical nucleotide for DNA synthesis and repair. 2. **Tissue distribution:** TK2 is widely expressed in various tissues, including the kidney, skeletal muscle, cardiac muscle, and immune cells, such as mononuclear cells, innate lymphoid cells, and dendritic cells. 3. **Cellular localization:** TK2 is localized to the cytoplasm and mitochondria, where it plays a role in regulating mitochondrial metabolism and nucleotide salvage. **Pathways and Functions:** 1. **Deoxycytidine salvage pathway:** TK2 is involved in the salvage of dCMP, which is essential for maintaining the balance of nucleotide pools within cells. 2. **DNA synthesis and repair:** TK2 phosphorylates dCMP to form dCTP, which is required for DNA synthesis and repair. 3. **Mitochondrial metabolism:** TK2 regulates mitochondrial metabolism by phosphorylating deoxynucleotides, which is essential for the production of ATP. 4. **Immune regulation:** TK2 is expressed in immune cells, where it plays a role in regulating immune responses, including the activation of innate lymphoid cells and the production of cytokines. **Clinical Significance:** 1. **Immune-related disorders:** Abnormalities in TK2 expression or activity have been linked to various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** TK2 has been implicated in the development and progression of certain cancers, including leukemia and lymphoma, where it plays a role in the salvage of nucleotides and the regulation of cell cycle progression. 3. **Neurological disorders:** TK2 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it plays a role in regulating mitochondrial metabolism and nucleotide salvage. In conclusion, TK2 is a critical enzyme involved in the regulation of cellular metabolism, particularly in the salvage of deoxyribonucleotides. Its expression in immune cells highlights its role in immune regulation, and its involvement in various diseases underscores its clinical significance. Further research is needed to fully elucidate the functions of TK2 and its role in disease pathology.

Genular Protein ID: 905205786

Symbol: KITM_HUMAN

Name: Mt-TK

UniProtKB Accession Codes:

O00142 B4DGJ7 B4DZK7 B7ZAB1 E5KNQ5 E9PH08 O15238

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 49 Ensembl 12 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 6 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9079672

Title: Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2.

PubMed ID: 9079672

DOI: 10.1074/jbc.272.13.8454

PubMed ID: 9989599

Title: Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates.

PubMed ID: 9989599

DOI: 10.1016/s0014-5793(98)01711-6

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11687801

Title: Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.

PubMed ID: 11687801

DOI: 10.1038/ng751

PubMed ID: 12391347

Title: Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA.

PubMed ID: 12391347

DOI: 10.1212/01.wnl.0000028689.93049.9a

PubMed ID: 15639197

Title: Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.

PubMed ID: 15639197

DOI: 10.1016/j.ymgme.2004.09.005

PubMed ID: 15907288

Title: Novel mutations in the thymidine kinase 2 gene (TK2) associated with fatal mitochondrial myopathy and mitochondrial DNA depletion.

PubMed ID: 15907288

DOI: 10.1016/j.nmd.2005.03.010

PubMed ID: 21937588

Title: Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.

PubMed ID: 21937588

DOI: 10.1093/hmg/ddr438

PubMed ID: 25446393

Title: Clinical application of whole exome sequencing reveals a novel compound heterozygous TK2-mutation in two brothers with rapidly progressive combined muscle-brain atrophy, axonal neuropathy, and status epilepticus.

PubMed ID: 25446393

DOI: 10.1016/j.mito.2014.10.007

Sequence Information:

  • Length: 265
  • Mass: 31005
  • Checksum: 1E9CB62D0321A992
  • Sequence:
    • MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA 
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR 
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV 
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH 
MERMLELFEQ NRDRILTPEN RKHCP

Genular Protein ID: 2373835560

Symbol: B4DIW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIW4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 240
  • Mass: 28390
  • Checksum: BEE8E880C7C7911C
  • Sequence:
    • MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVVLTEPVSK 
WRNVRGHNLL GLMYHDASRW GLTLQTYVQL TMLDRHTRPQ VSSVRLMERS IHSARYIFVE 
NLYRSGKMPE VDYVVLSEWF DWILRNMDVS VDLIVYLRTN PETCYQRLKK RCREEEKVIP 
LEYLEAIHHL HEEWLIKGSL FPMAAPVLVI EADHHMERML ELFEQNRDRI LTPENRKHCP

Genular Protein ID: 2412546065

Symbol: J3QRP0_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QRP0

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 146
  • Mass: 16935
  • Checksum: 3A65ED766656EF3C
  • Sequence:
    • MGAFCQRPSS DKEQEKEKKS VICVEGNIAS GKTTCLEFFS NATDVEVLTE PVSKWRNVRG 
HNPLGLMYHD ASRWGLTLQT YVQLTMLDRH TRPQVSSVRL MERSIHSARY IFVENLYRRN 
TWKQFTISMR SGSSKAAFSP WQPLFW

Genular Protein ID: 2755553474

Symbol: A4IF54_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4IF54

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 229
  • Mass: 27052
  • Checksum: B317D47E85D25F1A
  • Sequence:
    • QRPSSDKEQE KEKKSVICVE GNIASGKTTC LEFFSNATDV EVLTEPVSKW RNVRGHNPLG 
LMYHDASRWG LTLQTYVQLT MLDRHTRPQV SSVRLMERSI HSARYIFVEN LYRSGKMPEV 
DYVVLSEWFD WILRNMDVSV DLIVYLRTNP ETCYQRLKKR CREEEKVIPL EYLEAIHHLH 
EEWLIKGSLF PMAAPVLVIE ADHHMERMLE LFEQNRDRIL TPENRKHCP

Genular Protein ID: 3391390958

Symbol: A5PLM0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5PLM0

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 216
  • Mass: 25526
  • Checksum: 513CA9DF067EB1C9
  • Sequence:
    • MTSICVEGNI ASGKTTCLEF FSNATDVEVL TEPVSKWRNV RGHNPLGLMY HDASRWGLTL 
QTYVQLTMLD RHTRPQVSSV RLMERSIHSA RYIFVENLYR SGKMPEVDYV VLSEWFDWIL 
RNMDVSVDLI VYLRTNHETC YQRLKKRCRE EEKVIPLEYL EAIHHLHEEW LIKGSLFPMA 
APVLVIEADH HMERMLELFE QNRDRILTPE NRKHCP

Genular Protein ID: 1396808026

Symbol: B4E0Z4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0Z4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 289
  • Mass: 33314
  • Checksum: 307C890A52CE7158
  • Sequence:
    • MRPGLFKGQA PGSRRRPTAG LAVVRADSHK KEPRASGSAR PAMLLWPLRG WAARALRCFG 
PGSRGSPASG PGPRRVQRRA WPPDKEQEKE KKSVICVEGN IASGKTTCLE FFSNATDVEG 
LMYHDASRWG LTLQTYVQLT MLDRHTRPQV SSVRLMERSI HSARYIFVEN LYRSGKMPEV 
DYVVLSEWFD WILRNMDVSV DLIVYLRTNP ETCYQRLKKR CREEEKVIPL EYLEAIHHLH 
EEWLIKGSLF PMAAPVLVVE ADHHMERMLE LFEQNRDRIL TPENRKHCP

Genular Protein ID: 2384207607

Symbol: Q8IZR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IZR3

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 4 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 307
  • Mass: 35440
  • Checksum: 954CB880E7D933A2
  • Sequence:
    • MRPGLFKGQA PGSRRRPTAG LAVVRADSHR KEPRASGSAR PAMLLWPLRG WAARALRCFG 
PGSRGSPASG PGPRRVQRRA WPPDKEQEKE KKSVICVEGN IASGKTTCLE FFSNATDVEV 
LTEPVSKWRN VRGHNPLGLM YHDASRWGLT LQTYVQLTML DRHTRPQVSS VRLMERSIHS 
ARYIFVENLY RSGKMPEVDY VVLSEWFDWI LRNMDVSVDL IVYLRTNPET CYQRLKKRCR 
EEEKVIPLEY LEAIHHLHEE WLIKGSLFPM AAPVLVIEAD HHMERMLQLF EQNRDRILTP 
ENRKHCP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.