Details for: TM7SF2

Gene ID: 7108

Symbol: TM7SF2

Ensembl ID: ENSG00000149809

Description: transmembrane 7 superfamily member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.8015
    Cell Significance Index: -20.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.4746
    Cell Significance Index: -18.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.5038
    Cell Significance Index: -18.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.7411
    Cell Significance Index: -21.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.9056
    Cell Significance Index: -18.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6429
    Cell Significance Index: -20.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 9.2283
    Cell Significance Index: 247.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4472
    Cell Significance Index: -19.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2939
    Cell Significance Index: -20.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5939
    Cell Significance Index: -14.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.5906
    Cell Significance Index: 120.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2784
    Cell Significance Index: 30.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.2326
    Cell Significance Index: 25.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6698
    Cell Significance Index: 124.4800
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.8311
    Cell Significance Index: 9.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6769
    Cell Significance Index: 87.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2163
    Cell Significance Index: 664.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1240
    Cell Significance Index: 223.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0686
    Cell Significance Index: 64.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0336
    Cell Significance Index: 168.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8495
    Cell Significance Index: 29.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8273
    Cell Significance Index: 141.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7656
    Cell Significance Index: 34.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6596
    Cell Significance Index: 118.9000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.5783
    Cell Significance Index: 12.0600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.5613
    Cell Significance Index: 2.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5213
    Cell Significance Index: 99.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5170
    Cell Significance Index: 51.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4720
    Cell Significance Index: 6.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4369
    Cell Significance Index: 56.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4289
    Cell Significance Index: 52.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4197
    Cell Significance Index: 29.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3076
    Cell Significance Index: 16.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2614
    Cell Significance Index: 52.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2609
    Cell Significance Index: 3.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2122
    Cell Significance Index: 76.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1910
    Cell Significance Index: 5.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1689
    Cell Significance Index: 116.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1612
    Cell Significance Index: 5.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1364
    Cell Significance Index: 9.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1149
    Cell Significance Index: 13.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0636
    Cell Significance Index: 48.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0547
    Cell Significance Index: 24.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0366
    Cell Significance Index: 1.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0343
    Cell Significance Index: 25.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0184
    Cell Significance Index: 2.5200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0175
    Cell Significance Index: 0.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0013
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0103
    Cell Significance Index: -19.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -13.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0113
    Cell Significance Index: -0.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0138
    Cell Significance Index: -0.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0216
    Cell Significance Index: -0.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0267
    Cell Significance Index: -15.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0427
    Cell Significance Index: -3.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0441
    Cell Significance Index: -20.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0465
    Cell Significance Index: -1.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0557
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0576
    Cell Significance Index: -12.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0595
    Cell Significance Index: -3.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0613
    Cell Significance Index: -17.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0800
    Cell Significance Index: -10.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0802
    Cell Significance Index: -4.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0840
    Cell Significance Index: -1.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0911
    Cell Significance Index: -5.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0934
    Cell Significance Index: -2.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0985
    Cell Significance Index: -14.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0987
    Cell Significance Index: -11.5000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1018
    Cell Significance Index: -1.0500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1169
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1240
    Cell Significance Index: -14.1500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.1254
    Cell Significance Index: -0.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1260
    Cell Significance Index: -2.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1579
    Cell Significance Index: -1.6400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1795
    Cell Significance Index: -2.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1995
    Cell Significance Index: -13.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2024
    Cell Significance Index: -21.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2025
    Cell Significance Index: -16.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2059
    Cell Significance Index: -6.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2811
    Cell Significance Index: -7.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3140
    Cell Significance Index: -13.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3216
    Cell Significance Index: -19.7200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3444
    Cell Significance Index: -2.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3556
    Cell Significance Index: -9.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3732
    Cell Significance Index: -5.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3836
    Cell Significance Index: -11.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3846
    Cell Significance Index: -8.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4007
    Cell Significance Index: -15.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4099
    Cell Significance Index: -6.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4441
    Cell Significance Index: -7.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4506
    Cell Significance Index: -12.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4562
    Cell Significance Index: -10.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4687
    Cell Significance Index: -9.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization**: TM7SF2 is expressed in various cell types, including cortical cells of the adrenal gland, hepatoblasts, granulosa cells, and primary sensory neurons. 2. **Regulation of gene expression**: TM7SF2 is activated by SREBP, a transcription factor that regulates the expression of genes involved in cholesterol biosynthesis. 3. **Enzyme activity**: The gene's product, ERG24_HUMAN, is a Delta14-sterol reductase, an enzyme that catalyzes the reduction of cholesterol to 14-dehydrocholesterol. 4. **Involvement in cholesterol biosynthesis**: TM7SF2 is involved in the regulation of cholesterol biosynthesis, a process that is essential for the production of cholesterol in the body. **Pathways and Functions:** 1. **Cholesterol biosynthesis pathway**: TM7SF2 is involved in the regulation of cholesterol biosynthesis, a process that involves the conversion of acetyl-CoA to cholesterol. 2. **Delta14-sterol reductase activity**: The gene's product, ERG24_HUMAN, catalyzes the reduction of cholesterol to 14-dehydrocholesterol, a crucial step in the biosynthesis of cholesterol. 3. **Endoplasmic reticulum (ER) function**: TM7SF2 is localized to the ER, a organelle involved in protein folding, lipid synthesis, and cholesterol biosynthesis. 4. **Regulation of lipid metabolism**: TM7SF2 is involved in the regulation of lipid metabolism, a process that involves the breakdown and synthesis of lipids in the body. **Clinical Significance:** 1. **Cholesterol disorders**: TM7SF2 dysregulation has been implicated in various cholesterol disorders, including hypercholesterolemia and atherosclerosis. 2. **Cancer**: TM7SF2 has been identified as a potential oncogene in certain types of cancer, including breast cancer and colon cancer. 3. **Neurological disorders**: TM7SF2 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: TM7SF2 has been identified as a potential target for the treatment of infectious diseases, including tuberculosis and malaria. In conclusion, the TM7SF2 gene plays a crucial role in the regulation of cholesterol biosynthesis and lipid metabolism. Further research is needed to fully understand the mechanisms by which TM7SF2 regulates these processes and to explore its potential applications in the treatment of various diseases.

Genular Protein ID: 2993404355

Symbol: ERG24_HUMAN

Name: Delta(14)-sterol reductase TM7SF2

UniProtKB Accession Codes:

O76062 A8K4H0 O95982 Q8IY06 Q96E64 Q96GZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9615229

Title: Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.

PubMed ID: 9615229

DOI: 10.1006/geno.1998.5296

PubMed ID: 9878250

Title: The human lamin B receptor/sterol reductase multigene family.

PubMed ID: 9878250

DOI: 10.1006/geno.1998.5615

PubMed ID: 27336722

Title: The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.

PubMed ID: 27336722

DOI: 10.7554/elife.16011

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16784888

Title: Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

PubMed ID: 16784888

DOI: 10.1016/j.bbalip.2006.05.004

Sequence Information:

  • Length: 418
  • Mass: 46406
  • Checksum: F5618ABE2BF0A911
  • Sequence:
    • MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP 
RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG 
LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN 
PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH 
EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG 
YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA 
WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.