Details for: TM7SF2

Gene ID: 7108

Symbol: TM7SF2

Ensembl ID: ENSG00000149809

Description: transmembrane 7 superfamily member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.35
    Marker Score: 77133
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.17
    Marker Score: 10380
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.95
    Marker Score: 19634
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.81
    Marker Score: 4117
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.73
    Marker Score: 581
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.7
    Marker Score: 2351
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.68
    Marker Score: 1886
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.62
    Marker Score: 56279
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.53
    Marker Score: 13168
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.52
    Marker Score: 3845
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5
    Marker Score: 1000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.47
    Marker Score: 5436
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.4
    Marker Score: 1504
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.38
    Marker Score: 2290
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.36
    Marker Score: 2191
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.34
    Marker Score: 8734
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.31
    Marker Score: 3557
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3
    Marker Score: 5119
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.26
    Marker Score: 295
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.23
    Marker Score: 607
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.2
    Marker Score: 9338.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.18
    Marker Score: 549
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.17
    Marker Score: 2443
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.17
    Marker Score: 642
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.14
    Marker Score: 224
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.13
    Marker Score: 534
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.12
    Marker Score: 747
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.12
    Marker Score: 650
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.11
    Marker Score: 9623
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17207
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.09
    Marker Score: 1606
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.08
    Marker Score: 1523
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.08
    Marker Score: 640
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.06
    Marker Score: 2844
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.04
    Marker Score: 1811.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.03
    Marker Score: 413
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.01
    Marker Score: 3593.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.01
    Marker Score: 1209
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71756
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47981
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.99
    Marker Score: 370
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.99
    Marker Score: 478
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.98
    Marker Score: 2078
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.95
    Marker Score: 1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.94
    Marker Score: 1325
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.92
    Marker Score: 1468
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.89
    Marker Score: 244
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.88
    Marker Score: 370
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.88
    Marker Score: 1667.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.87
    Marker Score: 906
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4977
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1403
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.85
    Marker Score: 1554
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.85
    Marker Score: 217
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.83
    Marker Score: 691.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.82
    Marker Score: 734
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.79
    Marker Score: 377
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.78
    Marker Score: 8009
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.76
    Marker Score: 700
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.76
    Marker Score: 425
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2602
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.76
    Marker Score: 766
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.75
    Marker Score: 5605
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.75
    Marker Score: 1787
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.73
    Marker Score: 776
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.73
    Marker Score: 3834
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.73
    Marker Score: 240
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.72
    Marker Score: 1222
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.72
    Marker Score: 298
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 430
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.71
    Marker Score: 1669
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.71
    Marker Score: 499
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.71
    Marker Score: 433
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2935
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.7
    Marker Score: 362
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.7
    Marker Score: 4125
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.69
    Marker Score: 2812
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 626
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.68
    Marker Score: 10238
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.68
    Marker Score: 795.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.67
    Marker Score: 357
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.67
    Marker Score: 964
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.66
    Marker Score: 416
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.66
    Marker Score: 567
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.65
    Marker Score: 721
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.64
    Marker Score: 4121

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Other Information

**Key Characteristics:** 1. **Cellular localization**: TM7SF2 is expressed in various cell types, including cortical cells of the adrenal gland, hepatoblasts, granulosa cells, and primary sensory neurons. 2. **Regulation of gene expression**: TM7SF2 is activated by SREBP, a transcription factor that regulates the expression of genes involved in cholesterol biosynthesis. 3. **Enzyme activity**: The gene's product, ERG24_HUMAN, is a Delta14-sterol reductase, an enzyme that catalyzes the reduction of cholesterol to 14-dehydrocholesterol. 4. **Involvement in cholesterol biosynthesis**: TM7SF2 is involved in the regulation of cholesterol biosynthesis, a process that is essential for the production of cholesterol in the body. **Pathways and Functions:** 1. **Cholesterol biosynthesis pathway**: TM7SF2 is involved in the regulation of cholesterol biosynthesis, a process that involves the conversion of acetyl-CoA to cholesterol. 2. **Delta14-sterol reductase activity**: The gene's product, ERG24_HUMAN, catalyzes the reduction of cholesterol to 14-dehydrocholesterol, a crucial step in the biosynthesis of cholesterol. 3. **Endoplasmic reticulum (ER) function**: TM7SF2 is localized to the ER, a organelle involved in protein folding, lipid synthesis, and cholesterol biosynthesis. 4. **Regulation of lipid metabolism**: TM7SF2 is involved in the regulation of lipid metabolism, a process that involves the breakdown and synthesis of lipids in the body. **Clinical Significance:** 1. **Cholesterol disorders**: TM7SF2 dysregulation has been implicated in various cholesterol disorders, including hypercholesterolemia and atherosclerosis. 2. **Cancer**: TM7SF2 has been identified as a potential oncogene in certain types of cancer, including breast cancer and colon cancer. 3. **Neurological disorders**: TM7SF2 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: TM7SF2 has been identified as a potential target for the treatment of infectious diseases, including tuberculosis and malaria. In conclusion, the TM7SF2 gene plays a crucial role in the regulation of cholesterol biosynthesis and lipid metabolism. Further research is needed to fully understand the mechanisms by which TM7SF2 regulates these processes and to explore its potential applications in the treatment of various diseases.

Genular Protein ID: 2993404355

Symbol: ERG24_HUMAN

Name: Delta(14)-sterol reductase TM7SF2

UniProtKB Accession Codes:

O76062 A8K4H0 O95982 Q8IY06 Q96E64 Q96GZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9615229

Title: Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.

PubMed ID: 9615229

DOI: 10.1006/geno.1998.5296

PubMed ID: 9878250

Title: The human lamin B receptor/sterol reductase multigene family.

PubMed ID: 9878250

DOI: 10.1006/geno.1998.5615

PubMed ID: 27336722

Title: The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.

PubMed ID: 27336722

DOI: 10.7554/elife.16011

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16784888

Title: Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

PubMed ID: 16784888

DOI: 10.1016/j.bbalip.2006.05.004

Sequence Information:

  • Length: 418
  • Mass: 46406
  • Checksum: F5618ABE2BF0A911
  • Sequence:
    • MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP 
RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG 
LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN 
PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH 
EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG 
YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA 
WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.