Details for: TNFAIP2

Gene ID: 7127

Symbol: TNFAIP2

Ensembl ID: ENSG00000185215

Description: TNF alpha induced protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.96
    Marker Score: 165603
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.83
    Marker Score: 96267
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.33
    Marker Score: 3438
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.13
    Marker Score: 73764
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.05
    Marker Score: 727
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.99
    Marker Score: 4883
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.98
    Marker Score: 3860
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.79
    Marker Score: 10868
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.75
    Marker Score: 753
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.64
    Marker Score: 42069
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.61
    Marker Score: 18088
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.58
    Marker Score: 1349
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1144
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.55
    Marker Score: 646
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.53
    Marker Score: 1042
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.5
    Marker Score: 741
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.44
    Marker Score: 1441
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.41
    Marker Score: 1642
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2834
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.39
    Marker Score: 3469
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.35
    Marker Score: 5803
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.28
    Marker Score: 327
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.28
    Marker Score: 318
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.27
    Marker Score: 318
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.26
    Marker Score: 842
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1435
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.25
    Marker Score: 1269
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.23
    Marker Score: 2245
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.21
    Marker Score: 2915
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.2
    Marker Score: 502
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.2
    Marker Score: 1278
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.19
    Marker Score: 823
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.16
    Marker Score: 4294
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.14
    Marker Score: 262
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.13
    Marker Score: 526
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.11
    Marker Score: 614
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.11
    Marker Score: 405
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.07
    Marker Score: 5274
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.07
    Marker Score: 611
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.06
    Marker Score: 837
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.06
    Marker Score: 12321
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.05
    Marker Score: 1727
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.05
    Marker Score: 541
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.05
    Marker Score: 259
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.04
    Marker Score: 2713
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.01
    Marker Score: 1127
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71746
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47971
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14566.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.93
    Marker Score: 3192
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.92
    Marker Score: 3839
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.91
    Marker Score: 627
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.89
    Marker Score: 3163
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.89
    Marker Score: 345
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.88
    Marker Score: 177
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5261
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4934.5
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.86
    Marker Score: 193
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.83
    Marker Score: 286
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.82
    Marker Score: 2130
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.81
    Marker Score: 1969.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.79
    Marker Score: 1023
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.78
    Marker Score: 758
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.78
    Marker Score: 4711
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.77
    Marker Score: 375
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1241
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 239
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.74
    Marker Score: 213
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3081.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.73
    Marker Score: 1729
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.73
    Marker Score: 788
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.73
    Marker Score: 826
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 663
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.72
    Marker Score: 298.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1140
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.71
    Marker Score: 204
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.71
    Marker Score: 227
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.7
    Marker Score: 586
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.7
    Marker Score: 864
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.69
    Marker Score: 167
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.69
    Marker Score: 182
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.69
    Marker Score: 435.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.68
    Marker Score: 471
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.67
    Marker Score: 5812
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.67
    Marker Score: 5808
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.66
    Marker Score: 591
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.65
    Marker Score: 1158
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.65
    Marker Score: 589
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.65
    Marker Score: 757
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.64
    Marker Score: 426

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Other Information

**Key Characteristics:** TNFAIP2 is a protein-coding gene that belongs to the TNF superfamily, which is characterized by its ability to interact with TNF receptors and modulate inflammatory responses. The gene is specifically induced by TNF-alpha, a pro-inflammatory cytokine that plays a central role in the immune response. TNFAIP2 is expressed in various cell types, including classical monocytes, fibroblasts, and epithelial cells, making it a potential biomarker for different diseases. **Pathways and Functions:** TNFAIP2 is involved in multiple signaling pathways, including angiogenesis, cell differentiation, and exocytosis. It interacts with various proteins, including TNF receptors, snare proteins, and exocyst components, to regulate cellular processes. Specifically, TNFAIP2 has been shown to: * Regulate angiogenesis by modulating the expression of pro- and anti-angiogenic factors * Influence cell differentiation by interacting with transcription factors and signaling molecules * Modulate exocytosis by interacting with snare proteins and exocyst components * Regulate inflammation by interacting with TNF receptors and other immune-related proteins **Clinical Significance:** TNFAIP2 has been implicated in various diseases, including cancer, inflammatory disorders, and cardiovascular diseases. Its expression is altered in different disease contexts, including: * Cancer: TNFAIP2 is overexpressed in certain types of cancer, including breast and lung cancer, and is associated with tumor progression and metastasis * Inflammatory disorders: TNFAIP2 is involved in the regulation of inflammation in conditions such as rheumatoid arthritis and atherosclerosis * Cardiovascular diseases: TNFAIP2 is associated with cardiovascular disease risk factors, including hypertension and atherosclerosis In conclusion, TNFAIP2 is a multifaceted gene that plays a crucial role in regulating inflammation, cell differentiation, and immune response. Its altered expression has been implicated in various diseases, making it a potential biomarker and therapeutic target for different disease contexts. **Future Directions:** Further research is needed to fully elucidate the mechanisms by which TNFAIP2 regulates cellular processes and to explore its therapeutic potential in different disease contexts. Potential avenues for investigation include: * Elucidating the specific signaling pathways involved in TNFAIP2-mediated regulation of cellular processes * Investigating the role of TNFAIP2 in different disease contexts, including cancer, inflammatory disorders, and cardiovascular diseases * Developing novel therapeutic strategies that target TNFAIP2 or its downstream effectors to modulate inflammation and immune response. Overall, TNFAIP2 is a gene that warrants further investigation, and its dysregulation has significant implications for our understanding of various diseases.

Genular Protein ID: 3533715242

Symbol: TNAP2_HUMAN

Name: Tumor necrosis factor alpha-induced protein 2

UniProtKB Accession Codes:

Q03169 Q86VI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1374453

Title: Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.

PubMed ID: 1374453

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 654
  • Mass: 72661
  • Checksum: 5BB18E96B193CC3D
  • Sequence:
    • MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA 
EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR 
RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA 
TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP 
AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ 
GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL 
AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA 
NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF 
THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL 
KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY 
ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.