Details for: TNFAIP2

Gene ID: 7127

Symbol: TNFAIP2

Ensembl ID: ENSG00000185215

Description: TNF alpha induced protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.2843
    Cell Significance Index: -30.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 116.7387
    Cell Significance Index: -29.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.4793
    Cell Significance Index: -29.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.7388
    Cell Significance Index: -29.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.5102
    Cell Significance Index: -30.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3361
    Cell Significance Index: -24.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6482
    Cell Significance Index: -30.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.0300
    Cell Significance Index: 111.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.4220
    Cell Significance Index: 155.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.2656
    Cell Significance Index: 588.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.1299
    Cell Significance Index: 162.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0564
    Cell Significance Index: 28.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.6244
    Cell Significance Index: 51.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9181
    Cell Significance Index: 235.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8837
    Cell Significance Index: 1028.7200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.7115
    Cell Significance Index: 21.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2632
    Cell Significance Index: 59.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.9806
    Cell Significance Index: 49.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7197
    Cell Significance Index: 92.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6515
    Cell Significance Index: 64.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6105
    Cell Significance Index: 551.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4917
    Cell Significance Index: 11.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3925
    Cell Significance Index: 10.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3012
    Cell Significance Index: 4.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2727
    Cell Significance Index: 44.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2559
    Cell Significance Index: 1.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1734
    Cell Significance Index: 33.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1561
    Cell Significance Index: 69.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1527
    Cell Significance Index: 16.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0567
    Cell Significance Index: 7.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0349
    Cell Significance Index: 4.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0193
    Cell Significance Index: 2.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0033
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0072
    Cell Significance Index: -1.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0098
    Cell Significance Index: -1.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0140
    Cell Significance Index: -8.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0178
    Cell Significance Index: -5.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0200
    Cell Significance Index: -36.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0211
    Cell Significance Index: -7.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0235
    Cell Significance Index: -36.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0321
    Cell Significance Index: -24.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0341
    Cell Significance Index: -24.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0351
    Cell Significance Index: -19.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0386
    Cell Significance Index: -24.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0386
    Cell Significance Index: -1.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0507
    Cell Significance Index: -10.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0530
    Cell Significance Index: -24.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0609
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0766
    Cell Significance Index: -16.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0838
    Cell Significance Index: -9.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1381
    Cell Significance Index: -8.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1428
    Cell Significance Index: -3.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1430
    Cell Significance Index: -10.6600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1560
    Cell Significance Index: -2.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1768
    Cell Significance Index: -25.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1875
    Cell Significance Index: -13.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2006
    Cell Significance Index: -22.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2099
    Cell Significance Index: -16.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2490
    Cell Significance Index: -4.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2539
    Cell Significance Index: -29.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2760
    Cell Significance Index: -12.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2880
    Cell Significance Index: -29.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2885
    Cell Significance Index: -17.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3067
    Cell Significance Index: -8.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3231
    Cell Significance Index: -3.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3292
    Cell Significance Index: -21.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3402
    Cell Significance Index: -9.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3606
    Cell Significance Index: -28.5600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3702
    Cell Significance Index: -6.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3973
    Cell Significance Index: -24.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4396
    Cell Significance Index: -29.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4765
    Cell Significance Index: -24.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4829
    Cell Significance Index: -10.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4847
    Cell Significance Index: -30.5500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.5138
    Cell Significance Index: -3.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5347
    Cell Significance Index: -19.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5371
    Cell Significance Index: -13.7200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5396
    Cell Significance Index: -4.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5697
    Cell Significance Index: -31.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6102
    Cell Significance Index: -32.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6184
    Cell Significance Index: -19.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6252
    Cell Significance Index: -8.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.6321
    Cell Significance Index: -4.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6373
    Cell Significance Index: -28.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6399
    Cell Significance Index: -22.2400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.6403
    Cell Significance Index: -6.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6845
    Cell Significance Index: -20.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6851
    Cell Significance Index: -13.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6891
    Cell Significance Index: -24.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7273
    Cell Significance Index: -19.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7502
    Cell Significance Index: -28.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7762
    Cell Significance Index: -12.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8123
    Cell Significance Index: -26.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8213
    Cell Significance Index: -13.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8267
    Cell Significance Index: -26.3300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.8389
    Cell Significance Index: -12.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFAIP2 is a protein-coding gene that belongs to the TNF superfamily, which is characterized by its ability to interact with TNF receptors and modulate inflammatory responses. The gene is specifically induced by TNF-alpha, a pro-inflammatory cytokine that plays a central role in the immune response. TNFAIP2 is expressed in various cell types, including classical monocytes, fibroblasts, and epithelial cells, making it a potential biomarker for different diseases. **Pathways and Functions:** TNFAIP2 is involved in multiple signaling pathways, including angiogenesis, cell differentiation, and exocytosis. It interacts with various proteins, including TNF receptors, snare proteins, and exocyst components, to regulate cellular processes. Specifically, TNFAIP2 has been shown to: * Regulate angiogenesis by modulating the expression of pro- and anti-angiogenic factors * Influence cell differentiation by interacting with transcription factors and signaling molecules * Modulate exocytosis by interacting with snare proteins and exocyst components * Regulate inflammation by interacting with TNF receptors and other immune-related proteins **Clinical Significance:** TNFAIP2 has been implicated in various diseases, including cancer, inflammatory disorders, and cardiovascular diseases. Its expression is altered in different disease contexts, including: * Cancer: TNFAIP2 is overexpressed in certain types of cancer, including breast and lung cancer, and is associated with tumor progression and metastasis * Inflammatory disorders: TNFAIP2 is involved in the regulation of inflammation in conditions such as rheumatoid arthritis and atherosclerosis * Cardiovascular diseases: TNFAIP2 is associated with cardiovascular disease risk factors, including hypertension and atherosclerosis In conclusion, TNFAIP2 is a multifaceted gene that plays a crucial role in regulating inflammation, cell differentiation, and immune response. Its altered expression has been implicated in various diseases, making it a potential biomarker and therapeutic target for different disease contexts. **Future Directions:** Further research is needed to fully elucidate the mechanisms by which TNFAIP2 regulates cellular processes and to explore its therapeutic potential in different disease contexts. Potential avenues for investigation include: * Elucidating the specific signaling pathways involved in TNFAIP2-mediated regulation of cellular processes * Investigating the role of TNFAIP2 in different disease contexts, including cancer, inflammatory disorders, and cardiovascular diseases * Developing novel therapeutic strategies that target TNFAIP2 or its downstream effectors to modulate inflammation and immune response. Overall, TNFAIP2 is a gene that warrants further investigation, and its dysregulation has significant implications for our understanding of various diseases.

Genular Protein ID: 3533715242

Symbol: TNAP2_HUMAN

Name: Tumor necrosis factor alpha-induced protein 2

UniProtKB Accession Codes:

Q03169 Q86VI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1374453

Title: Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.

PubMed ID: 1374453

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 654
  • Mass: 72661
  • Checksum: 5BB18E96B193CC3D
  • Sequence:
    • MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA 
EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR 
RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA 
TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP 
AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ 
GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL 
AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA 
NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF 
THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL 
KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY 
ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.