Details for: TPD52

Gene ID: 7163

Symbol: TPD52

Ensembl ID: ENSG00000076554

Description: tumor protein D52

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.59
    Marker Score: 1858
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.81
    Marker Score: 968
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.76
    Marker Score: 7865
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.71
    Marker Score: 1417.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.68
    Marker Score: 1558
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.62
    Marker Score: 2230
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.43
    Marker Score: 2331
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.33
    Marker Score: 1149
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.32
    Marker Score: 14780
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.25
    Marker Score: 8682
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.25
    Marker Score: 5130.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.24
    Marker Score: 30147
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.24
    Marker Score: 668
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.24
    Marker Score: 10757
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.19
    Marker Score: 9079
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.1
    Marker Score: 2316
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.04
    Marker Score: 760
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.03
    Marker Score: 3606
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.03
    Marker Score: 2158
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.02
    Marker Score: 847
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.02
    Marker Score: 6000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.94
    Marker Score: 16702
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.94
    Marker Score: 4394
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.92
    Marker Score: 1655
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9
    Marker Score: 2002
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.9
    Marker Score: 4511
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.9
    Marker Score: 765
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.89
    Marker Score: 5932
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.85
    Marker Score: 14450
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.83
    Marker Score: 1072
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.8
    Marker Score: 755
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.77
    Marker Score: 2845
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.77
    Marker Score: 108859
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.76
    Marker Score: 911
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.76
    Marker Score: 16538
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.74
    Marker Score: 1715
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.73
    Marker Score: 1052
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.72
    Marker Score: 2071
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.72
    Marker Score: 4123
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.72
    Marker Score: 2220
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.72
    Marker Score: 685
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.69
    Marker Score: 635
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.68
    Marker Score: 379.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.68
    Marker Score: 464
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.68
    Marker Score: 1501
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.68
    Marker Score: 17315
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.67
    Marker Score: 15893
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.66
    Marker Score: 2446.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.65
    Marker Score: 32890
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.63
    Marker Score: 13976.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.59
    Marker Score: 505
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.59
    Marker Score: 692
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.58
    Marker Score: 6203
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.58
    Marker Score: 1571
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.58
    Marker Score: 454
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.57
    Marker Score: 2873
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.57
    Marker Score: 453
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.57
    Marker Score: 2495
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.55
    Marker Score: 57107
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.55
    Marker Score: 58753.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.55
    Marker Score: 672
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.54
    Marker Score: 1376.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.54
    Marker Score: 2558
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.53
    Marker Score: 1209
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.53
    Marker Score: 3865
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.52
    Marker Score: 529
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.52
    Marker Score: 1425
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.51
    Marker Score: 397
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.5
    Marker Score: 6246
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5
    Marker Score: 3652
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.49
    Marker Score: 527.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.48
    Marker Score: 1792
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.48
    Marker Score: 4219
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.48
    Marker Score: 2577
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.47
    Marker Score: 2271.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.46
    Marker Score: 882
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.46
    Marker Score: 1376
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.45
    Marker Score: 7603
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.43
    Marker Score: 9341
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 335
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3349
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.42
    Marker Score: 5251
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.4
    Marker Score: 3856.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.39
    Marker Score: 380
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.37
    Marker Score: 1040
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.37
    Marker Score: 1661
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.37
    Marker Score: 5585
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.37
    Marker Score: 315
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.37
    Marker Score: 948
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.36
    Marker Score: 637
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.36
    Marker Score: 1469
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.36
    Marker Score: 496
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.36
    Marker Score: 1046
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.35
    Marker Score: 265
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.35
    Marker Score: 940
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.35
    Marker Score: 5220.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.34
    Marker Score: 821
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.33
    Marker Score: 19830
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.31
    Marker Score: 1533
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.31
    Marker Score: 1078

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Other Information

**Key Characteristics:** TPD52 is a protein-coding gene located on chromosome 11q22.3. It is characterized by its ability to bind to calcium ions, facilitate protein-protein interactions, and regulate vesicle-mediated transport. TPD52 is also involved in the regulation of cellular morphology, particularly in the development and differentiation of endocrine cells and immune cells. Its expression is highly specific to various cell types, including endocrine cells, immune cells, and epithelial cells. **Pathways and Functions:** TPD52 is involved in several cellular pathways, including: 1. **Anatomical structure morphogenesis**: TPD52 regulates the development and differentiation of endocrine cells and immune cells, which are essential for maintaining tissue homeostasis. 2. **B cell differentiation**: TPD52 plays a crucial role in the differentiation and maturation of B cells, which are vital for the adaptive immune response. 3. **Calcium ion binding**: TPD52 binds to calcium ions, which is essential for regulating cellular signaling pathways and maintaining cellular homeostasis. 4. **Membrane trafficking**: TPD52 regulates the transport of proteins and lipids between the endoplasmic reticulum and the Golgi apparatus, which is critical for maintaining cellular morphology and function. **Clinical Significance:** TPD52 has been implicated in various diseases, including: 1. **Cancer**: TPD52 is expressed in several types of cancer, including prostate, breast, and lung cancer. Its overexpression has been associated with tumorigenesis and poor patient outcomes. 2. **Immune-related disorders**: TPD52 plays a crucial role in the regulation of immune cell function, particularly in B cell differentiation and maturation. Its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: TPD52 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. Its expression is altered in the brains of patients with these diseases, suggesting a potential role in disease pathology. In conclusion, TPD52 is a multifaceted gene involved in various cellular processes, including morphogenesis, immune function, and cancer development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying TPD52 function and its role in human disease.

Genular Protein ID: 593469874

Symbol: TPD52_HUMAN

Name: Tumor protein D52

UniProtKB Accession Codes:

P55327 B7Z414 C9J502 D0UFD1 D0UFD2 D0UFD3 D0UFD4 D0UFD5 E5RKB4 Q13056 Q53EK8 Q6FGP3 Q6FGS3 Q86YZ2 Q9UCX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7796418

Title: A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence.

PubMed ID: 7796418

PubMed ID: 8632896

Title: Isolation and characterization of a novel gene expressed in multiple cancers.

PubMed ID: 8632896

PubMed ID: 14996714

Title: PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer.

PubMed ID: 14996714

DOI: 10.1158/0008-5472.can-03-3331

PubMed ID: 19732746

Title: Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins.

PubMed ID: 19732746

DOI: 10.1016/j.bbrc.2009.08.165

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9484778

Title: Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system.

PubMed ID: 9484778

DOI: 10.1038/sj.onc.1201604

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 224
  • Mass: 24327
  • Checksum: 4C8183C5914BB976
  • Sequence:
    • MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED 
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK 
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK 
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.