Details for: TPD52

Gene ID: 7163

Symbol: TPD52

Ensembl ID: ENSG00000076554

Description: tumor protein D52

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 272.5895
    Cell Significance Index: -42.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 153.4044
    Cell Significance Index: -38.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.2383
    Cell Significance Index: -39.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.0087
    Cell Significance Index: -45.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.0305
    Cell Significance Index: -45.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.0742
    Cell Significance Index: -40.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.6403
    Cell Significance Index: -42.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.3975
    Cell Significance Index: -35.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3455
    Cell Significance Index: -40.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9882
    Cell Significance Index: -43.3600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 8.2836
    Cell Significance Index: 62.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.4010
    Cell Significance Index: 41.6300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.3752
    Cell Significance Index: 33.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.3730
    Cell Significance Index: 46.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2474
    Cell Significance Index: 86.7100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.2415
    Cell Significance Index: 32.7000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.1173
    Cell Significance Index: 27.4600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.0518
    Cell Significance Index: 7.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6993
    Cell Significance Index: 122.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.6614
    Cell Significance Index: 167.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5474
    Cell Significance Index: 118.7700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.4217
    Cell Significance Index: 25.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2367
    Cell Significance Index: 448.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2301
    Cell Significance Index: 166.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0440
    Cell Significance Index: 241.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9714
    Cell Significance Index: 29.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6745
    Cell Significance Index: 48.2500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.5393
    Cell Significance Index: 15.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4995
    Cell Significance Index: 148.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4925
    Cell Significance Index: 296.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3281
    Cell Significance Index: 239.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3258
    Cell Significance Index: 89.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2055
    Cell Significance Index: 33.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1194
    Cell Significance Index: 58.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0358
    Cell Significance Index: 127.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0026
    Cell Significance Index: 47.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0016
    Cell Significance Index: 52.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9727
    Cell Significance Index: 36.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9209
    Cell Significance Index: 831.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8861
    Cell Significance Index: 24.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8825
    Cell Significance Index: 39.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8736
    Cell Significance Index: 313.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7635
    Cell Significance Index: 83.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7623
    Cell Significance Index: 7.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7502
    Cell Significance Index: 96.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7139
    Cell Significance Index: 389.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6847
    Cell Significance Index: 47.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5320
    Cell Significance Index: 367.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4976
    Cell Significance Index: 84.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4506
    Cell Significance Index: 10.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4400
    Cell Significance Index: 194.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3456
    Cell Significance Index: 11.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3382
    Cell Significance Index: 64.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1617
    Cell Significance Index: 12.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1467
    Cell Significance Index: 199.4800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1358
    Cell Significance Index: 0.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1167
    Cell Significance Index: 2.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1124
    Cell Significance Index: 173.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1082
    Cell Significance Index: 1.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0832
    Cell Significance Index: 153.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0674
    Cell Significance Index: 51.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0580
    Cell Significance Index: 109.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0304
    Cell Significance Index: 19.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0223
    Cell Significance Index: 0.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0110
    Cell Significance Index: 8.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0266
    Cell Significance Index: -16.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0418
    Cell Significance Index: -8.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0468
    Cell Significance Index: -26.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0638
    Cell Significance Index: -28.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0716
    Cell Significance Index: -10.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0808
    Cell Significance Index: -8.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0993
    Cell Significance Index: -7.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1095
    Cell Significance Index: -12.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1175
    Cell Significance Index: -3.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1322
    Cell Significance Index: -38.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1343
    Cell Significance Index: -15.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1495
    Cell Significance Index: -20.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1998
    Cell Significance Index: -23.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2442
    Cell Significance Index: -15.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2558
    Cell Significance Index: -13.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3034
    Cell Significance Index: -38.9000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3267
    Cell Significance Index: -2.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3678
    Cell Significance Index: -20.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3693
    Cell Significance Index: -29.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3715
    Cell Significance Index: -23.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3868
    Cell Significance Index: -40.2800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4222
    Cell Significance Index: -4.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4320
    Cell Significance Index: -9.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4353
    Cell Significance Index: -9.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4608
    Cell Significance Index: -10.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4729
    Cell Significance Index: -4.9000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4764
    Cell Significance Index: -5.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5205
    Cell Significance Index: -18.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5475
    Cell Significance Index: -16.0800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5626
    Cell Significance Index: -6.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5880
    Cell Significance Index: -36.0500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.6675
    Cell Significance Index: -6.6800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6822
    Cell Significance Index: -8.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TPD52 is a protein-coding gene located on chromosome 11q22.3. It is characterized by its ability to bind to calcium ions, facilitate protein-protein interactions, and regulate vesicle-mediated transport. TPD52 is also involved in the regulation of cellular morphology, particularly in the development and differentiation of endocrine cells and immune cells. Its expression is highly specific to various cell types, including endocrine cells, immune cells, and epithelial cells. **Pathways and Functions:** TPD52 is involved in several cellular pathways, including: 1. **Anatomical structure morphogenesis**: TPD52 regulates the development and differentiation of endocrine cells and immune cells, which are essential for maintaining tissue homeostasis. 2. **B cell differentiation**: TPD52 plays a crucial role in the differentiation and maturation of B cells, which are vital for the adaptive immune response. 3. **Calcium ion binding**: TPD52 binds to calcium ions, which is essential for regulating cellular signaling pathways and maintaining cellular homeostasis. 4. **Membrane trafficking**: TPD52 regulates the transport of proteins and lipids between the endoplasmic reticulum and the Golgi apparatus, which is critical for maintaining cellular morphology and function. **Clinical Significance:** TPD52 has been implicated in various diseases, including: 1. **Cancer**: TPD52 is expressed in several types of cancer, including prostate, breast, and lung cancer. Its overexpression has been associated with tumorigenesis and poor patient outcomes. 2. **Immune-related disorders**: TPD52 plays a crucial role in the regulation of immune cell function, particularly in B cell differentiation and maturation. Its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: TPD52 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. Its expression is altered in the brains of patients with these diseases, suggesting a potential role in disease pathology. In conclusion, TPD52 is a multifaceted gene involved in various cellular processes, including morphogenesis, immune function, and cancer development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying TPD52 function and its role in human disease.

Genular Protein ID: 593469874

Symbol: TPD52_HUMAN

Name: Tumor protein D52

UniProtKB Accession Codes:

P55327 B7Z414 C9J502 D0UFD1 D0UFD2 D0UFD3 D0UFD4 D0UFD5 E5RKB4 Q13056 Q53EK8 Q6FGP3 Q6FGS3 Q86YZ2 Q9UCX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 Ensembl 7 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7796418

Title: A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence.

PubMed ID: 7796418

PubMed ID: 8632896

Title: Isolation and characterization of a novel gene expressed in multiple cancers.

PubMed ID: 8632896

PubMed ID: 14996714

Title: PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer.

PubMed ID: 14996714

DOI: 10.1158/0008-5472.can-03-3331

PubMed ID: 19732746

Title: Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins.

PubMed ID: 19732746

DOI: 10.1016/j.bbrc.2009.08.165

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9484778

Title: Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system.

PubMed ID: 9484778

DOI: 10.1038/sj.onc.1201604

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 224
  • Mass: 24327
  • Checksum: 4C8183C5914BB976
  • Sequence:
    • MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED 
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK 
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK 
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.