Details for: TRAF3

Gene ID: 7187

Symbol: TRAF3

Ensembl ID: ENSG00000131323

Description: TNF receptor associated factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.7782
    Cell Significance Index: -32.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.8316
    Cell Significance Index: -32.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.6111
    Cell Significance Index: -28.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.3572
    Cell Significance Index: -32.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6624
    Cell Significance Index: -28.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.6352
    Cell Significance Index: -32.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7811
    Cell Significance Index: -31.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.2943
    Cell Significance Index: -34.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4353
    Cell Significance Index: -20.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3653
    Cell Significance Index: -33.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0564
    Cell Significance Index: 57.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9377
    Cell Significance Index: 55.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6898
    Cell Significance Index: 338.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4499
    Cell Significance Index: 287.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0796
    Cell Significance Index: 72.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0769
    Cell Significance Index: 386.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0326
    Cell Significance Index: 714.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9979
    Cell Significance Index: 25.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9667
    Cell Significance Index: 13.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9495
    Cell Significance Index: 93.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7840
    Cell Significance Index: 707.9400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5332
    Cell Significance Index: 4.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5217
    Cell Significance Index: 56.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5159
    Cell Significance Index: 83.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5070
    Cell Significance Index: 28.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4987
    Cell Significance Index: 29.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4572
    Cell Significance Index: 7.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3731
    Cell Significance Index: 4.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2808
    Cell Significance Index: 8.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2344
    Cell Significance Index: 14.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2337
    Cell Significance Index: 28.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2070
    Cell Significance Index: 4.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2050
    Cell Significance Index: 14.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1906
    Cell Significance Index: 36.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1859
    Cell Significance Index: 33.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1763
    Cell Significance Index: 96.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1717
    Cell Significance Index: 20.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1325
    Cell Significance Index: 4.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1228
    Cell Significance Index: 231.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1211
    Cell Significance Index: 5.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1186
    Cell Significance Index: 52.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1079
    Cell Significance Index: 146.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1055
    Cell Significance Index: 8.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0708
    Cell Significance Index: 44.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0705
    Cell Significance Index: 108.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0340
    Cell Significance Index: 1.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0131
    Cell Significance Index: 5.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0078
    Cell Significance Index: 14.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0135
    Cell Significance Index: -8.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0191
    Cell Significance Index: -3.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0369
    Cell Significance Index: -27.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0392
    Cell Significance Index: -29.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0412
    Cell Significance Index: -23.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0432
    Cell Significance Index: -5.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0633
    Cell Significance Index: -2.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0812
    Cell Significance Index: -11.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0910
    Cell Significance Index: -19.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0980
    Cell Significance Index: -28.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1063
    Cell Significance Index: -5.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1126
    Cell Significance Index: -14.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1352
    Cell Significance Index: -15.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1440
    Cell Significance Index: -18.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1505
    Cell Significance Index: -15.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1616
    Cell Significance Index: -6.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1725
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1840
    Cell Significance Index: -21.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2293
    Cell Significance Index: -5.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2309
    Cell Significance Index: -24.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2338
    Cell Significance Index: -26.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2443
    Cell Significance Index: -5.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2698
    Cell Significance Index: -19.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2785
    Cell Significance Index: -20.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2862
    Cell Significance Index: -14.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2930
    Cell Significance Index: -18.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3131
    Cell Significance Index: -14.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3190
    Cell Significance Index: -10.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3716
    Cell Significance Index: -22.7800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3763
    Cell Significance Index: -3.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3768
    Cell Significance Index: -23.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3792
    Cell Significance Index: -30.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4104
    Cell Significance Index: -8.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4111
    Cell Significance Index: -11.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4139
    Cell Significance Index: -13.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4448
    Cell Significance Index: -6.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4469
    Cell Significance Index: -2.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4512
    Cell Significance Index: -13.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4633
    Cell Significance Index: -24.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4734
    Cell Significance Index: -3.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4888
    Cell Significance Index: -10.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5019
    Cell Significance Index: -12.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5348
    Cell Significance Index: -11.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5417
    Cell Significance Index: -10.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5530
    Cell Significance Index: -11.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5647
    Cell Significance Index: -28.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5669
    Cell Significance Index: -11.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5825
    Cell Significance Index: -14.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6079
    Cell Significance Index: -8.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6105
    Cell Significance Index: -9.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAF3 is a cytoplasmic protein that belongs to the TRAF family of adaptor proteins. It is characterized by its ability to interact with a wide range of signaling molecules, including TLRs, IRFs, and NF-κB components. TRAF3 is highly expressed in various cell types, including immune cells, neurons, and epithelial cells. Notably, its expression is often downregulated in certain types of cancer, suggesting a tumor suppressor role. TRAF3 is also involved in the regulation of apoptosis, particularly in the context of viral infections. **Pathways and Functions** TRAF3 is a key player in several immune-related signaling pathways, including: 1. **Activation of IRF3 and IRF7**: TRAF3 mediates the activation of IRFs IRF3 and IRF7, which are critical for the induction of type I interferons and the subsequent antiviral response. 2. **NF-κB signaling pathway**: TRAF3 regulates the activity of NF-κB, a transcription factor that controls the expression of genes involved in inflammation and immune responses. 3. **TLR signaling pathways**: TRAF3 interacts with TLRs to modulate their signaling activity, preventing excessive inflammation and tissue damage. 4. **Apoptotic process**: TRAF3 is involved in the regulation of apoptosis, particularly in the context of viral infections. **Clinical Significance** Dysregulation of TRAF3 has been implicated in various diseases, including: 1. **Viral infections**: TRAF3 deficiency has been associated with increased susceptibility to viral infections, such as HIV and influenza. 2. **Autoimmune disorders**: TRAF3 dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: Downregulation of TRAF3 has been observed in certain types of cancer, suggesting a tumor suppressor role. 4. **SARS-CoV-2 infection**: TRAF3 has been shown to play a critical role in the regulation of innate immune responses to SARS-CoV-2 infection. In conclusion, TRAF3 is a crucial adaptor protein that plays a pivotal role in the regulation of immune responses, particularly in the context of Toll-like receptor signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of TRAF3 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 4173601311

Symbol: TRAF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13114 B7Z8C4 Q12990 Q13076 Q13947 Q6AZX1 Q9UNL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTC 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 2 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 12 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7527023

Title: A novel RING finger protein interacts with the cytoplasmic domain of CD40.

PubMed ID: 7527023

DOI: 10.1016/s0021-9258(18)43772-6

PubMed ID: 7859281

Title: The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.

PubMed ID: 7859281

DOI: 10.1016/0092-8674(95)90489-1

PubMed ID: 7530216

Title: A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.

PubMed ID: 7530216

DOI: 10.1016/0014-5793(94)01406-q

PubMed ID: 7533327

Title: Involvement of CRAF1, a relative of TRAF, in CD40 signaling.

PubMed ID: 7533327

DOI: 10.1126/science.7533327

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10199393

Title: A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation.

PubMed ID: 10199393

DOI: 10.1016/s0161-5890(98)00099-6

PubMed ID: 8663299

Title: TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.

PubMed ID: 8663299

DOI: 10.1074/jbc.271.25.14661

PubMed ID: 8710854

Title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

PubMed ID: 8710854

DOI: 10.1073/pnas.93.16.8241

PubMed ID: 9168896

Title: Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.

PubMed ID: 9168896

DOI: 10.1006/bbrc.1997.6509

PubMed ID: 9162022

Title: Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.

PubMed ID: 9162022

DOI: 10.1074/jbc.272.22.14029

PubMed ID: 9275204

Title: Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.

PubMed ID: 9275204

DOI: 10.1073/pnas.94.18.9792

PubMed ID: 9718306

Title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

PubMed ID: 9718306

DOI: 10.1021/bi981067q

PubMed ID: 9488716

Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.

PubMed ID: 9488716

DOI: 10.1074/jbc.273.10.5808

PubMed ID: 9774460

Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

PubMed ID: 9774460

DOI: 10.1074/jbc.273.43.28355

PubMed ID: 9774977

Title: ASK1 is essential for JNK/SAPK activation by TRAF2.

PubMed ID: 9774977

DOI: 10.1016/s1097-2765(00)80283-x

PubMed ID: 9418902

Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

PubMed ID: 9418902

DOI: 10.1128/mcb.18.1.558

PubMed ID: 10037686

Title: Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.

PubMed ID: 10037686

DOI: 10.1074/jbc.274.10.6056

PubMed ID: 10523862

Title: Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).

PubMed ID: 10523862

DOI: 10.1038/sj.onc.1202975

PubMed ID: 10809768

Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.

PubMed ID: 10809768

DOI: 10.1074/jbc.275.20.15336

PubMed ID: 10764746

Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

PubMed ID: 10764746

DOI: 10.1074/jbc.m000531200

PubMed ID: 10791955

Title: MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.

PubMed ID: 10791955

DOI: 10.1074/jbc.m001095200

PubMed ID: 10903733

Title: TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.

PubMed ID: 10903733

DOI: 10.4049/jimmunol.165.3.1322

PubMed ID: 11035039

Title: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.

PubMed ID: 11035039

DOI: 10.1074/jbc.m008356200

PubMed ID: 15383523

Title: TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.

PubMed ID: 15383523

DOI: 10.1074/jbc.m407284200

PubMed ID: 15084608

Title: Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.

PubMed ID: 15084608

DOI: 10.1074/jbc.m403286200

PubMed ID: 17991829

Title: DUBA: a deubiquitinase that regulates type I interferon production.

PubMed ID: 17991829

DOI: 10.1126/science.1145918

PubMed ID: 18614628

Title: The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation.

PubMed ID: 18614628

DOI: 10.1128/jvi.00290-08

PubMed ID: 19419966

Title: The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.

PubMed ID: 19419966

DOI: 10.1074/jbc.m808233200

PubMed ID: 19893624

Title: The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.

PubMed ID: 19893624

DOI: 10.1371/journal.ppat.1000650

PubMed ID: 19996094

Title: Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.

PubMed ID: 19996094

DOI: 10.1074/jbc.m109.074971

PubMed ID: 20097753

Title: Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.

PubMed ID: 20097753

DOI: 10.1074/jbc.m109.071043

PubMed ID: 20185819

Title: TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor.

PubMed ID: 20185819

DOI: 10.1074/jbc.m109.076091

PubMed ID: 19937093

Title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.

PubMed ID: 19937093

DOI: 10.1007/s11010-009-0315-y

PubMed ID: 20174559

Title: Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.

PubMed ID: 20174559

DOI: 10.1371/journal.ppat.1000778

PubMed ID: 21302310

Title: Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death.

PubMed ID: 21302310

DOI: 10.1002/jcp.22667

PubMed ID: 23871208

Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

PubMed ID: 23871208

DOI: 10.1016/j.immuni.2013.06.013

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24390324

Title: Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation.

PubMed ID: 24390324

DOI: 10.1128/jvi.02647-13

PubMed ID: 25847972

Title: MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.

PubMed ID: 25847972

DOI: 10.4049/jimmunol.1402851

PubMed ID: 27387501

Title: Citrobacter rodentium NleB protein inhibits tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) ubiquitination to reduce host type I interferon production.

PubMed ID: 27387501

DOI: 10.1074/jbc.m116.738278

PubMed ID: 27438768

Title: Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex.

PubMed ID: 27438768

DOI: 10.1016/j.immuni.2016.06.023

PubMed ID: 27980081

Title: DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.

PubMed ID: 27980081

DOI: 10.1042/bcj20160956

PubMed ID: 32562145

Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.

PubMed ID: 32562145

DOI: 10.1007/s13238-020-00734-6

PubMed ID: 33148796

Title: Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses.

PubMed ID: 33148796

DOI: 10.1128/jvi.01856-20

PubMed ID: 34011520

Title: Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.

PubMed ID: 34011520

DOI: 10.4049/jimmunol.2001262

PubMed ID: 33608556

Title: E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.

PubMed ID: 33608556

DOI: 10.1038/s41467-021-21456-1

PubMed ID: 36897010

Title: FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3-TBK1-IRF3 complex.

PubMed ID: 36897010

DOI: 10.1002/jmv.28655

PubMed ID: 10984535

Title: Molecular basis for CD40 signaling mediated by TRAF3.

PubMed ID: 10984535

DOI: 10.1073/pnas.97.19.10395

PubMed ID: 12005438

Title: Downstream regulator TANK binds to the CD40 recognition site on TRAF3.

PubMed ID: 12005438

DOI: 10.1016/s0969-2126(02)00733-5

PubMed ID: 14517219

Title: Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.

PubMed ID: 14517219

DOI: 10.1074/jbc.m309381200

PubMed ID: 15585864

Title: Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation.

PubMed ID: 15585864

DOI: 10.4049/jimmunol.173.12.7394

PubMed ID: 16009714

Title: LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3.

PubMed ID: 16009714

DOI: 10.1074/jbc.m502511200

PubMed ID: 20832341

Title: Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.

PubMed ID: 20832341

DOI: 10.1016/j.immuni.2010.08.014

Sequence Information:

  • Length: 568
  • Mass: 64490
  • Checksum: 9456E440C0A90FBF
  • Sequence:
    • MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL 
CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV FKDNCCKREI LALQIYCRNE 
SRGCAEQLML GHLLVHLKND CHFEELPCVR PDCKEKVLRK DLRDHVEKAC KYREATCSHC 
KSQVPMIALQ KHEDTDCPCV VVSCPHKCSV QTLLRSELSA HLSECVNAPS TCSFKRYGCV 
FQGTNQQIKA HEASSAVQHV NLLKEWSNSL EKKVSLLQNE SVEKNKSIQS LHNQICSFEI 
EIERQKEMLR NNESKILHLQ RVIDSQAEKL KELDKEIRPF RQNWEEADSM KSSVESLQNR 
VTELESVDKS AGQVARNTGL LESQLSRHDQ MLSVHDIRLA DMDLRFQVLE TASYNGVLIW 
KIRDYKRRKQ EAVMGKTLSL YSQPFYTGYF GYKMCARVYL NGDGMGKGTH LSLFFVIMRG 
EYDALLPWPF KQKVTLMLMD QGSSRRHLGD AFKPDPNSSS FKKPTGEMNI ASGCPVFVAQ 
TVLENGTYIK DDTIFIKVIV DTSDLPDP

Genular Protein ID: 3654513938

Symbol: A6NHG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NHG8

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 3 GO 11 Gene3D 1 GeneTree 1 HGNC 1 InterPro 11 NCBI Taxonomy 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 2 SMART 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 543
  • Mass: 61760
  • Checksum: 83D34832BDFEFC7C
  • Sequence:
    • MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL 
CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV FKDNCCKREI LALQIYCRNE 
SRGCAEQLML GHLLVHLKND CHFEELPCVR PDCKEKVLRK DLRDHVEKAC KYREATCSHC 
KSQVPMIALQ KHEDTDCPCV VVSCPHKCSV QTLLRSEGTN QQIKAHEASS AVQHVNLLKE 
WSNSLEKKVS LLQNESVEKN KSIQSLHNQI CSFEIEIERQ KEMLRNNESK ILHLQRVIDS 
QAEKLKELDK EIRPFRQNWE EADSMKSSVE SLQNRVTELE SVDKSAGQVA RNTGLLESQL 
SRHDQMLSVH DIRLADMDLR FQVLETASYN GVLIWKIRDY KRRKQEAVMG KTLSLYSQPF 
YTGYFGYKMC ARVYLNGDGM GKGTHLSLFF VIMRGEYDAL LPWPFKQKVT LMLMDQGSSR 
RHLGDAFKPD PNSSSFKKPT GEMNIASGCP VFVAQTVLEN GTYIKDDTIF IKVIVDTSDL 
PDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.