Details for: TTC4

Gene ID: 7268

Symbol: TTC4

Ensembl ID: ENSG00000243725

Description: tetratricopeptide repeat domain 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.7330
    Cell Significance Index: -10.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.6476
    Cell Significance Index: -10.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.9165
    Cell Significance Index: -9.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.7723
    Cell Significance Index: -9.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6216
    Cell Significance Index: -10.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0838
    Cell Significance Index: -10.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8680
    Cell Significance Index: 52.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5692
    Cell Significance Index: 114.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5138
    Cell Significance Index: 55.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4515
    Cell Significance Index: 13.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4470
    Cell Significance Index: 44.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4080
    Cell Significance Index: 11.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3736
    Cell Significance Index: 10.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3515
    Cell Significance Index: 43.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3399
    Cell Significance Index: 26.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3392
    Cell Significance Index: 64.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3371
    Cell Significance Index: 304.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3223
    Cell Significance Index: 58.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3078
    Cell Significance Index: 13.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2992
    Cell Significance Index: 16.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2738
    Cell Significance Index: 189.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2675
    Cell Significance Index: 43.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2510
    Cell Significance Index: 17.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2114
    Cell Significance Index: 10.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2085
    Cell Significance Index: 74.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1936
    Cell Significance Index: 4.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1777
    Cell Significance Index: 6.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1751
    Cell Significance Index: 3.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1718
    Cell Significance Index: 7.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1634
    Cell Significance Index: 1.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1577
    Cell Significance Index: 4.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1494
    Cell Significance Index: 9.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1480
    Cell Significance Index: 9.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1276
    Cell Significance Index: 6.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1274
    Cell Significance Index: 2.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1227
    Cell Significance Index: 15.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1047
    Cell Significance Index: 14.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0912
    Cell Significance Index: 10.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0842
    Cell Significance Index: 37.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0583
    Cell Significance Index: 2.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0578
    Cell Significance Index: 1.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0571
    Cell Significance Index: 6.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0403
    Cell Significance Index: 0.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0219
    Cell Significance Index: 11.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0117
    Cell Significance Index: 0.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0051
    Cell Significance Index: -0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0057
    Cell Significance Index: -8.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0079
    Cell Significance Index: -10.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0111
    Cell Significance Index: -8.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0182
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0198
    Cell Significance Index: -12.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0222
    Cell Significance Index: -10.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0249
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0264
    Cell Significance Index: -1.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0329
    Cell Significance Index: -9.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0354
    Cell Significance Index: -0.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0503
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0525
    Cell Significance Index: -8.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0533
    Cell Significance Index: -10.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0557
    Cell Significance Index: -11.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0629
    Cell Significance Index: -8.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0631
    Cell Significance Index: -6.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0641
    Cell Significance Index: -9.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0710
    Cell Significance Index: -8.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0723
    Cell Significance Index: -1.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0739
    Cell Significance Index: -3.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0784
    Cell Significance Index: -2.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0881
    Cell Significance Index: -4.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0889
    Cell Significance Index: -1.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1010
    Cell Significance Index: -6.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1035
    Cell Significance Index: -10.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1147
    Cell Significance Index: -8.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1150
    Cell Significance Index: -7.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1183
    Cell Significance Index: -9.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1504
    Cell Significance Index: -2.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1609
    Cell Significance Index: -10.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1709
    Cell Significance Index: -2.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1745
    Cell Significance Index: -2.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1833
    Cell Significance Index: -4.8200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2013
    Cell Significance Index: -2.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2097
    Cell Significance Index: -4.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2101
    Cell Significance Index: -6.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2135
    Cell Significance Index: -5.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2152
    Cell Significance Index: -6.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2164
    Cell Significance Index: -7.5200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2294
    Cell Significance Index: -2.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2411
    Cell Significance Index: -7.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2584
    Cell Significance Index: -3.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2593
    Cell Significance Index: -9.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2614
    Cell Significance Index: -7.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2646
    Cell Significance Index: -9.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tetratricopeptide Repeat Domain:** The TTC4 protein contains a unique tetratricopeptide repeat domain, which is a characteristic feature of this gene. This domain is responsible for interactions with other proteins and plays a crucial role in regulating cellular processes. 2. **Wide Expression:** The TTC4 gene is expressed in various cell types, including immune cells, epithelial cells, and neural cells. This widespread expression suggests that the TTC4 protein has a multifaceted role in maintaining cellular homeostasis. 3. **Protein Binding:** The TTC4 protein is involved in protein binding, which is essential for regulating cellular processes, including protein folding and cell signaling. **Pathways and Functions:** 1. **Defense Response to Virus:** The TTC4 protein is involved in the defense response to viruses, which is crucial for protecting against viral infections. Studies have shown that the TTC4 protein interacts with other proteins to regulate the innate immune response. 2. **Innate Immune Response:** The TTC4 protein plays a significant role in the innate immune response, which is the first line of defense against pathogens. The protein is involved in regulating the production of cytokines and other immune molecules. 3. **Protein Folding:** The TTC4 protein is involved in protein folding, which is essential for maintaining protein homeostasis. The protein interacts with other proteins to regulate protein folding and prevent protein misfolding. 4. **Hsp70 and Hsp90 Protein Binding:** The TTC4 protein interacts with heat shock proteins (Hsp70 and Hsp90), which are essential for regulating protein folding and cell signaling. **Clinical Significance:** 1. **Immune System Dysfunction:** Dysregulation of the TTC4 gene has been linked to immune system dysfunction, which can lead to various diseases, including autoimmune disorders and cancer. 2. **Neurological Disorders:** The TTC4 protein is also expressed in neural cells, and dysregulation of this gene has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The TTC4 protein has been implicated in cancer development and progression, particularly in epithelial cancers. 4. **Personalized Medicine:** Further studies on the TTC4 gene are necessary to develop personalized medicine approaches for treating diseases associated with this gene. In conclusion, the TTC4 gene plays a crucial role in regulating various cellular processes, including immune response, protein folding, and cell signaling. Further studies on this gene are necessary to understand its role in maintaining cellular homeostasis and immune system function, and to develop personalized medicine approaches for treating diseases associated with this gene.

Genular Protein ID: 193161568

Symbol: TTC4_HUMAN

Name: Tetratricopeptide repeat protein 4

UniProtKB Accession Codes:

O95801 Q53Y95 Q5TA96 Q9H3I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9933562

Title: TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer.

PubMed ID: 9933562

DOI: 10.1006/geno.1998.5633

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18320024

Title: The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.

PubMed ID: 18320024

DOI: 10.1371/journal.pone.0001737

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29251827

Title: Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.

PubMed ID: 29251827

DOI: 10.1002/pmic.201700403

Sequence Information:

  • Length: 387
  • Mass: 44679
  • Checksum: 4FA45889C4C9E427
  • Sequence:
    • MEQPGQDPTS DDVMDSFLEK FQSQPYRGGF HEDQWEKEFE KVPLFMSRAP SEIDPRENPD 
LACLQSIIFD EERSPEEQAK TYKDEGNDYF KEKDYKKAVI SYTEGLKKKC ADPDLNAVLY 
TNRAAAQYYL GNFRSALNDV TAARKLKPCH LKAIIRGALC HLELKHFAEA VNWCDEGLQI 
DAKEKKLLEM RAKADKLKRI EQRDVRKANL KEKKERNQNE ALLQAIKARN IRLSEAACED 
EDSASEGLGE LFLDGLSTEN PHGARLSLDG QGRLSWPVLF LYPEYAQSDF ISAFHEDSRF 
IDHLMVMFGE TPSWDLEQKY CPDNLEVYFE DEDRAELYRV PAKSTLLQVL QHQRYFVKAL 
TPAFLVCVGS SPFCKNFLRG RKVYQIR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.