Details for: TULP3

Gene ID: 7289

Symbol: TULP3

Ensembl ID: ENSG00000078246

Description: TUB like protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.0710
    Cell Significance Index: -32.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 130.0645
    Cell Significance Index: -32.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.1468
    Cell Significance Index: -33.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.1374
    Cell Significance Index: -25.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.1097
    Cell Significance Index: -33.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.7821
    Cell Significance Index: -25.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9752
    Cell Significance Index: -32.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5174
    Cell Significance Index: -33.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8544
    Cell Significance Index: -17.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3983
    Cell Significance Index: 27.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3542
    Cell Significance Index: 157.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2893
    Cell Significance Index: 255.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8360
    Cell Significance Index: 82.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7817
    Cell Significance Index: 107.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6766
    Cell Significance Index: 37.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6047
    Cell Significance Index: 546.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5336
    Cell Significance Index: 11.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5273
    Cell Significance Index: 364.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5049
    Cell Significance Index: 14.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4393
    Cell Significance Index: 71.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4295
    Cell Significance Index: 2.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3881
    Cell Significance Index: 211.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3789
    Cell Significance Index: 41.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3750
    Cell Significance Index: 75.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3110
    Cell Significance Index: 137.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3000
    Cell Significance Index: 107.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2935
    Cell Significance Index: 17.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2072
    Cell Significance Index: 7.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1840
    Cell Significance Index: 23.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1759
    Cell Significance Index: 31.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1725
    Cell Significance Index: 3.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1653
    Cell Significance Index: 31.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1514
    Cell Significance Index: 3.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1349
    Cell Significance Index: 16.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1301
    Cell Significance Index: 1.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1298
    Cell Significance Index: 244.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1232
    Cell Significance Index: 7.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0984
    Cell Significance Index: 6.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0930
    Cell Significance Index: 59.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0839
    Cell Significance Index: 1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0722
    Cell Significance Index: 111.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0572
    Cell Significance Index: 25.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0546
    Cell Significance Index: 100.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0528
    Cell Significance Index: 1.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0519
    Cell Significance Index: 0.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0480
    Cell Significance Index: 1.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0279
    Cell Significance Index: 37.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0249
    Cell Significance Index: 1.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0166
    Cell Significance Index: 0.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0058
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0128
    Cell Significance Index: -2.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0227
    Cell Significance Index: -14.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0230
    Cell Significance Index: -0.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0260
    Cell Significance Index: -1.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0363
    Cell Significance Index: -27.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0379
    Cell Significance Index: -1.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0381
    Cell Significance Index: -0.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0384
    Cell Significance Index: -1.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0386
    Cell Significance Index: -21.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0441
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0507
    Cell Significance Index: -5.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0519
    Cell Significance Index: -6.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0640
    Cell Significance Index: -1.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0680
    Cell Significance Index: -3.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0919
    Cell Significance Index: -26.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0932
    Cell Significance Index: -19.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1086
    Cell Significance Index: -11.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1252
    Cell Significance Index: -5.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1642
    Cell Significance Index: -4.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1746
    Cell Significance Index: -9.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1788
    Cell Significance Index: -4.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1942
    Cell Significance Index: -22.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2031
    Cell Significance Index: -21.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2162
    Cell Significance Index: -24.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2233
    Cell Significance Index: -13.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2235
    Cell Significance Index: -15.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2473
    Cell Significance Index: -7.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2735
    Cell Significance Index: -17.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2746
    Cell Significance Index: -14.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3305
    Cell Significance Index: -14.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3367
    Cell Significance Index: -26.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3367
    Cell Significance Index: -22.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3519
    Cell Significance Index: -22.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3594
    Cell Significance Index: -18.7200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3812
    Cell Significance Index: -5.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3887
    Cell Significance Index: -6.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4060
    Cell Significance Index: -3.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4091
    Cell Significance Index: -6.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4151
    Cell Significance Index: -15.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4240
    Cell Significance Index: -9.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5703
    Cell Significance Index: -6.2000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5950
    Cell Significance Index: -7.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6039
    Cell Significance Index: -15.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6234
    Cell Significance Index: -14.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6691
    Cell Significance Index: -14.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6735
    Cell Significance Index: -10.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7365
    Cell Significance Index: -25.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7493
    Cell Significance Index: -22.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TULP3 is a non-coding gene, but its protein product is highly conserved across species, suggesting a critical role in cellular function. The gene is primarily expressed in cells with cilia, which are involved in sensing the extracellular environment and regulating cellular responses. TULP3 is also found in cells with microtubules, which are essential for maintaining cell shape and facilitating intracellular transport. The gene's involvement in various developmental processes, including embryonic development and neural tube closure, underscores its importance in tissue formation and patterning. **Pathways and Functions:** TULP3 is involved in several signaling pathways, including: 1. **Ciliary function:** TULP3 is required for the proper formation and function of cilia, which are involved in sensing the extracellular environment and regulating cellular responses. 2. **Hedgehog signaling:** TULP3 negatively regulates the hedgehog signaling pathway, which is crucial for embryonic development and tissue patterning. 3. **G protein-coupled receptor signaling:** TULP3 regulates the activity of g protein-coupled receptors, which are involved in a range of cellular processes, including development and disease. 4. **Intraciliary transport:** TULP3 is involved in regulating the movement of intraciliary transport particles, which are essential for maintaining ciliary function. **Clinical Significance:** Dysregulation of TULP3 has been implicated in various diseases, including: 1. **Cilia-related disorders:** TULP3 mutations have been associated with cilia-related disorders, such as primary ciliary dyskinesia (PCD) and Kartagener syndrome. 2. **Neurodevelopmental disorders:** TULP3 has been implicated in neurodevelopmental disorders, such as epilepsy and autism spectrum disorder. 3. **Cancer:** TULP3 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 4. **Cardiovascular disease:** TULP3 has been implicated in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. In conclusion, TULP3 is a multifaceted gene involved in various developmental and cellular processes. Its dysregulation has been implicated in a range of diseases, highlighting the importance of TULP3 in maintaining cellular homeostasis and tissue development. Further research is needed to fully elucidate the functions of TULP3 and its role in human disease.

Genular Protein ID: 4004304512

Symbol: TULP3_HUMAN

Name: Tubby-like protein 3

UniProtKB Accession Codes:

O75386 B3KNB7 B7Z6A2 D3DUQ4 F8WBZ9 Q8N5B0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 31 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9828123

Title: Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans.

PubMed ID: 9828123

DOI: 10.1006/geno.1998.5567

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375483

Title: G-protein signaling through tubby proteins.

PubMed ID: 11375483

DOI: 10.1126/science.1061233

PubMed ID: 20889716

Title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

PubMed ID: 20889716

DOI: 10.1101/gad.1966210

PubMed ID: 27932497

Title: Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors.

PubMed ID: 27932497

DOI: 10.1091/mbc.e16-11-0813

PubMed ID: 31761534

Title: Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.

PubMed ID: 31761534

DOI: 10.1016/j.cell.2019.11.005

PubMed ID: 35397207

Title: Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations.

PubMed ID: 35397207

DOI: 10.1016/j.ajhg.2022.03.015

Sequence Information:

  • Length: 442
  • Mass: 49642
  • Checksum: 13DBC83305BFAC1D
  • Sequence:
    • MEASRCRLSP SGDSVFHEEM MKMRQAKLDY QRLLLEKRQR KKRLEPFMVQ PNPEARLRRA 
KPRASDEQTP LVNCHTPHSN VILHGIDGPA AVLKPDEVHA PSVSSSVVEE DAENTVDTAS 
KPGLQERLQK HDISESVNFD EETDGISQSA CLERPNSASS QNSTDTGTSG SATAAQPADN 
LLGDIDDLED FVYSPAPQGV TVRCRIIRDK RGMDRGLFPT YYMYLEKEEN QKIFLLAARK 
RKKSKTANYL ISIDPVDLSR EGESYVGKLR SNLMGTKFTV YDRGICPMKG RGLVGAAHTR 
QELAAISYET NVLGFKGPRK MSVIIPGMTL NHKQIPYQPQ NNHDSLLSRW QNRTMENLVE 
LHNKAPVWNS DTQSYVLNFR GRVTQASVKN FQIVHKNDPD YIVMQFGRVA DDVFTLDYNY 
PLCAVQAFGI GLSSFDSKLA CE

Genular Protein ID: 3427503922

Symbol: B7Z1E7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1E7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 266
  • Mass: 30045
  • Checksum: C4D8090EEA9D0E37
  • Sequence:
    • MLKTPWILLP SQDFRSVSKS MDTGTSGSAT AAQPADNLLG DIDDLEDFVY SPAPQGVTVR 
CRIIRDKRGM DRGLFPTYYM YLEKEENQKI FLLAARKRKK SKTANYLISI DPVDLSREGE 
SYVGKLRSNL MGTKFTVYDR GICPMKGRGL VGAAHTRQEL AAISYNHDSL LSRWQNRTME 
NLVELHNKAP VWNSDTQSYV LNFRGRVTQA SVKNFQIVHK NDPDYIVMQF GRVADDVFTL 
DYNYPLCAVQ AFGIGLSSFD SKLACE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.