Details for: TNFRSF4

Gene ID: 7293

Symbol: TNFRSF4

Ensembl ID: ENSG00000186827

Description: TNF receptor superfamily member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 51.9463
    Cell Significance Index: -8.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.2249
    Cell Significance Index: -7.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.8129
    Cell Significance Index: 344.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5452
    Cell Significance Index: -8.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.1678
    Cell Significance Index: 181.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.1186
    Cell Significance Index: 127.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4156
    Cell Significance Index: -9.1500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.3455
    Cell Significance Index: 51.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0831
    Cell Significance Index: -8.2200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.0419
    Cell Significance Index: 35.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.6214
    Cell Significance Index: -4.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.3478
    Cell Significance Index: 20.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2296
    Cell Significance Index: 234.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8024
    Cell Significance Index: 79.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7096
    Cell Significance Index: 20.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7051
    Cell Significance Index: 636.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7046
    Cell Significance Index: 45.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5761
    Cell Significance Index: 12.2700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5665
    Cell Significance Index: 5.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4510
    Cell Significance Index: 73.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4291
    Cell Significance Index: 46.6800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.3150
    Cell Significance Index: 0.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2373
    Cell Significance Index: 14.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2331
    Cell Significance Index: 16.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1711
    Cell Significance Index: 2.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1706
    Cell Significance Index: 0.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1291
    Cell Significance Index: 0.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0338
    Cell Significance Index: 4.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0167
    Cell Significance Index: 0.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0077
    Cell Significance Index: 0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0037
    Cell Significance Index: 0.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0033
    Cell Significance Index: -2.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0047
    Cell Significance Index: -0.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -11.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0076
    Cell Significance Index: -3.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -12.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -12.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0135
    Cell Significance Index: -7.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0154
    Cell Significance Index: -9.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0156
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0157
    Cell Significance Index: -11.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0167
    Cell Significance Index: -9.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0195
    Cell Significance Index: -0.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0199
    Cell Significance Index: -7.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -10.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0251
    Cell Significance Index: -4.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0308
    Cell Significance Index: -8.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0434
    Cell Significance Index: -2.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0440
    Cell Significance Index: -7.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0512
    Cell Significance Index: -5.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0535
    Cell Significance Index: -6.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0536
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0559
    Cell Significance Index: -11.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0596
    Cell Significance Index: -1.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0609
    Cell Significance Index: -6.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0619
    Cell Significance Index: -2.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0650
    Cell Significance Index: -8.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0674
    Cell Significance Index: -9.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0693
    Cell Significance Index: -8.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0695
    Cell Significance Index: -0.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0781
    Cell Significance Index: -8.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0819
    Cell Significance Index: -9.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0837
    Cell Significance Index: -1.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0848
    Cell Significance Index: -1.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0951
    Cell Significance Index: -4.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1019
    Cell Significance Index: -7.8200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1120
    Cell Significance Index: -1.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1178
    Cell Significance Index: -3.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1218
    Cell Significance Index: -8.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1233
    Cell Significance Index: -9.1900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1244
    Cell Significance Index: -1.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1572
    Cell Significance Index: -8.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1580
    Cell Significance Index: -8.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1589
    Cell Significance Index: -4.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1638
    Cell Significance Index: -10.0700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.1664
    Cell Significance Index: -0.6200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1765
    Cell Significance Index: -1.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1779
    Cell Significance Index: -7.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1787
    Cell Significance Index: -8.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1894
    Cell Significance Index: -6.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1937
    Cell Significance Index: -4.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1944
    Cell Significance Index: -6.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2084
    Cell Significance Index: -7.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2109
    Cell Significance Index: -3.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2153
    Cell Significance Index: -7.0500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2155
    Cell Significance Index: -3.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2195
    Cell Significance Index: -6.9900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2266
    Cell Significance Index: -2.1200
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.2453
    Cell Significance Index: -1.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2507
    Cell Significance Index: -6.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2531
    Cell Significance Index: -9.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2570
    Cell Significance Index: -5.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2575
    Cell Significance Index: -2.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2586
    Cell Significance Index: -7.3800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2761
    Cell Significance Index: -4.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2788
    Cell Significance Index: -7.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFRSF4 is a member of the TNF receptor superfamily, characterized by its ability to bind to TNF ligands, such as TNF-α and lymphotoxin-alpha. The receptor is expressed on various cell types, including T cells, natural killer cells, and endothelial cells, and is involved in both canonical and non-canonical signaling pathways. Notably, TNFRSF4 exhibits a unique ligand-binding profile, with a preference for binding to TNF-α over other TNF ligands. **Pathways and Functions:** TNFRSF4 is involved in several key signaling pathways, including: 1. **Tumor Necrosis Factor-mediated Signaling Pathway:** TNFRSF4 interacts with TNF-α, triggering a cascade of intracellular events that regulate inflammation, immune responses, and cell survival. 2. **Tnfr2 Non-canonical NF-κB Pathway:** This pathway involves the activation of NF-κB, a transcription factor that regulates gene expression in response to various stimuli, including TNF-α. 3. **Cytokine Signaling in Immune System:** TNFRSF4 interacts with cytokines, such as IL-1β and IL-6, modulating immune responses and inflammation. 4. **Negative Regulation of DNA-binding Transcription Factor Activity:** TNFRSF4 can inhibit the activity of transcription factors, such as NF-κB and AP-1, thereby regulating gene expression and cellular proliferation. **Clinical Significance:** TNFRSF4 has been implicated in various diseases, including: 1. **Inflammatory Disorders:** TNFRSF4 has been linked to the pathogenesis of inflammatory conditions, such as rheumatoid arthritis and lupus, where it contributes to the regulation of immune responses and tissue damage. 2. **Cancer:** TNFRSF4 has been shown to promote tumor growth and progression in various cancer types, including breast cancer and colon cancer. 3. **Autoimmune Diseases:** TNFRSF4 has been implicated in the regulation of autoimmune responses, with alterations in its expression and signaling contributing to the development of conditions such as multiple sclerosis and type 1 diabetes. 4. **Immunological Disorders:** TNFRSF4 has been shown to play a role in the regulation of T cell responses, with alterations in its expression contributing to conditions such as autoimmune hepatitis and graft-versus-host disease. In conclusion, TNFRSF4 is a complex gene that plays a multifaceted role in the regulation of immune responses and cellular homeostasis. Its involvement in various signaling pathways and its expression on multiple cell types make it a key player in the pathogenesis of various diseases. Further research is necessary to fully elucidate the functions of TNFRSF4 and its role in human disease.

Genular Protein ID: 521283785

Symbol: TNR4_HUMAN

Name: Tumor necrosis factor receptor superfamily member 4

UniProtKB Accession Codes:

P43489 Q13663 Q2M312 Q5T7M0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7510240

Title: The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen.

PubMed ID: 7510240

DOI: 10.1002/eji.1830240329

PubMed ID: 7704935

Title: Identification of OX40 ligand and preliminary characterization of its activities on OX40 receptor.

PubMed ID: 7704935

PubMed ID: 10861060

Title: The HTLV-I protein transcriptionally modulates OX40 antigen expression.

PubMed ID: 10861060

DOI: 10.4049/jimmunol.165.1.263

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9418902

Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

PubMed ID: 9418902

DOI: 10.1128/mcb.18.1.558

PubMed ID: 9488716

Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.

PubMed ID: 9488716

DOI: 10.1074/jbc.273.10.5808

PubMed ID: 23674671

Title: CD134 is a cellular receptor specific for human herpesvirus-6B entry.

PubMed ID: 23674671

DOI: 10.1073/pnas.1305187110

PubMed ID: 16905106

Title: The crystal structure of the costimulatory OX40-OX40L complex.

PubMed ID: 16905106

DOI: 10.1016/j.str.2006.06.015

PubMed ID: 23897980

Title: Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.

PubMed ID: 23897980

DOI: 10.1084/jem.20130592

Sequence Information:

  • Length: 277
  • Mass: 29341
  • Checksum: 49F15525941550BF
  • Sequence:
    • MCVGARRLGR GPCAALLLLG LGLSTVTGLH CVGDTYPSND RCCHECRPGN GMVSRCSRSQ 
NTVCRPCGPG FYNDVVSSKP CKPCTWCNLR SGSERKQLCT ATQDTVCRCR AGTQPLDSYK 
PGVDCAPCPP GHFSPGDNQA CKPWTNCTLA GKHTLQPASN SSDAICEDRD PPATQPQETQ 
GPPARPITVQ PTEAWPRTSQ GPSTRPVEVP GGRAVAAILG LGLVLGLLGP LAILLALYLL 
RRDQRLPPDA HKPPGGGSFR TPIQEEQADA HSTLAKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.