Details for: TXK

Gene ID: 7294

Symbol: TXK

Ensembl ID: ENSG00000074966

Description: TXK tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.9621
    Cell Significance Index: -11.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.7372
    Cell Significance Index: -10.8400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 19.9076
    Cell Significance Index: 53.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4326
    Cell Significance Index: -11.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0181
    Cell Significance Index: -8.0900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.6210
    Cell Significance Index: 26.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.5200
    Cell Significance Index: -7.7400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.9009
    Cell Significance Index: 20.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7840
    Cell Significance Index: 109.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2602
    Cell Significance Index: 362.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.0692
    Cell Significance Index: 22.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7448
    Cell Significance Index: 21.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.6191
    Cell Significance Index: 90.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5826
    Cell Significance Index: 44.7100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5145
    Cell Significance Index: 7.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5073
    Cell Significance Index: 96.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4427
    Cell Significance Index: 88.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4223
    Cell Significance Index: 6.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3557
    Cell Significance Index: 12.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3477
    Cell Significance Index: 34.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2929
    Cell Significance Index: 264.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2342
    Cell Significance Index: 2.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1788
    Cell Significance Index: 29.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1532
    Cell Significance Index: 3.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1316
    Cell Significance Index: 3.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0986
    Cell Significance Index: 10.7300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0964
    Cell Significance Index: 1.0000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: 0.0773
    Cell Significance Index: 0.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0683
    Cell Significance Index: 13.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0585
    Cell Significance Index: 37.1800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0551
    Cell Significance Index: 0.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0481
    Cell Significance Index: 90.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0241
    Cell Significance Index: 1.6700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.0234
    Cell Significance Index: 0.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0211
    Cell Significance Index: 0.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0157
    Cell Significance Index: 0.3400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0109
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0070
    Cell Significance Index: 10.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0048
    Cell Significance Index: 8.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0023
    Cell Significance Index: 0.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0061
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0083
    Cell Significance Index: -4.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0130
    Cell Significance Index: -1.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0141
    Cell Significance Index: -6.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0153
    Cell Significance Index: -5.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0181
    Cell Significance Index: -13.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0184
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0194
    Cell Significance Index: -12.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0331
    Cell Significance Index: -1.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0364
    Cell Significance Index: -1.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0365
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0450
    Cell Significance Index: -7.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0555
    Cell Significance Index: -11.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0744
    Cell Significance Index: -7.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0770
    Cell Significance Index: -10.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0815
    Cell Significance Index: -2.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0829
    Cell Significance Index: -9.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0868
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0880
    Cell Significance Index: -10.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0901
    Cell Significance Index: -10.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0985
    Cell Significance Index: -12.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1005
    Cell Significance Index: -10.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1097
    Cell Significance Index: -5.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1127
    Cell Significance Index: -7.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1157
    Cell Significance Index: -8.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1223
    Cell Significance Index: -2.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1256
    Cell Significance Index: -1.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1398
    Cell Significance Index: -3.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1539
    Cell Significance Index: -8.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1551
    Cell Significance Index: -7.2300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1559
    Cell Significance Index: -1.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1601
    Cell Significance Index: -2.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1619
    Cell Significance Index: -10.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1626
    Cell Significance Index: -4.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1657
    Cell Significance Index: -4.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1678
    Cell Significance Index: -5.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1679
    Cell Significance Index: -7.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1691
    Cell Significance Index: -12.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1718
    Cell Significance Index: -7.4700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1798
    Cell Significance Index: -2.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1915
    Cell Significance Index: -11.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1925
    Cell Significance Index: -12.1300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1926
    Cell Significance Index: -1.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2175
    Cell Significance Index: -2.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2200
    Cell Significance Index: -11.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2273
    Cell Significance Index: -6.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2333
    Cell Significance Index: -10.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2447
    Cell Significance Index: -4.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2467
    Cell Significance Index: -5.3300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2538
    Cell Significance Index: -2.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2666
    Cell Significance Index: -13.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2710
    Cell Significance Index: -8.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2744
    Cell Significance Index: -6.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2820
    Cell Significance Index: -10.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TXK is a non-membrane spanning protein tyrosine kinase, meaning it lacks a transmembrane domain and is not anchored to the plasma membrane. Instead, it is localized to the cytosol and nucleus, where it can interact with various signaling proteins and regulate cellular processes. TXK is characterized by its ability to autophosphorylate, which is a critical step in its activation and regulation. **Pathways and Functions** TXK is involved in several key signaling pathways, including: 1. **Activation of phospholipase C activity**: TXK activates phospholipase C, an enzyme that breaks down phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). This activation of phospholipase C leads to the production of DAG and IP3, which in turn activate protein kinase C (PKC) and calcium channels, respectively. 2. **Adaptive immune response**: TXK is involved in the regulation of adaptive immune responses, including the production of cytokines and the activation of T cells. 3. **T cell receptor signaling pathway**: TXK is a key regulator of the T cell receptor (TCR) signaling pathway, which is essential for the activation and proliferation of T cells. 4. **Type II interferon-mediated signaling pathway**: TXK is involved in the regulation of type II interferon (IFN-γ) production and signaling, which is critical for the induction of immune responses against viral infections. **Clinical Significance** TXK has been implicated in various diseases, including: 1. **Autoimmune disorders**: TXK has been shown to play a role in the regulation of autoimmune responses, including the production of cytokines and the activation of immune cells. 2. **Cancer**: TXK has been implicated in the regulation of cancer cell proliferation and survival, making it a potential target for cancer therapy. 3. **Neurological disorders**: TXK has been shown to play a role in the regulation of neuronal function and survival, making it a potential target for the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: TXK has been implicated in the regulation of immune responses against viral infections, making it a potential target for the development of antiviral therapies. In conclusion, TXK is a non-membrane spanning protein tyrosine kinase that plays a crucial role in regulating various cellular processes, including immune response, cellular proliferation, and tissue regeneration. Its involvement in multiple signaling pathways and its implications in various diseases make it a fascinating area of research. Further studies are needed to fully elucidate the functions and clinical significance of the TXK gene.

Genular Protein ID: 358798246

Symbol: TXK_HUMAN

Name: Tyrosine-protein kinase TXK

UniProtKB Accession Codes:

P42681 Q14220

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7951233

Title: TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12.

PubMed ID: 7951233

DOI: 10.1093/hmg/3.6.897

PubMed ID: 8632917

Title: Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene.

PubMed ID: 8632917

PubMed ID: 9813138

Title: Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.

PubMed ID: 9813138

DOI: 10.1006/bbrc.1998.9559

PubMed ID: 10523612

Title: Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes.

PubMed ID: 10523612

DOI: 10.1084/jem.190.8.1147

PubMed ID: 11564877

Title: Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.

PubMed ID: 11564877

DOI: 10.1128/mcb.21.20.6939-6950.2001

PubMed ID: 12081135

Title: Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.

PubMed ID: 12081135

DOI: 10.1248/bpb.25.718

PubMed ID: 11859127

Title: Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.

PubMed ID: 11859127

DOI: 10.4049/jimmunol.168.5.2365

PubMed ID: 17177976

Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.

PubMed ID: 17177976

DOI: 10.1111/j.1365-2249.2006.03249.x

PubMed ID: 19290923

Title: Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.

PubMed ID: 19290923

DOI: 10.1111/j.1600-065x.2008.00757.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 527
  • Mass: 61258
  • Checksum: BCCA081F4155CAA6
  • Sequence:
    • MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSN 
TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW 
KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH 
LGSYTISVFM GARRSTEAAI KHYQIKKNDS GQWYVAERHA FQSIPELIWY HQHNAAGLMT 
RLRYPVGLMG SCLPATAGFS YEKWEIDPSE LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA 
INEGSMSEED FIEEAKVMMK LSHSKLVQLY GVCIQRKPLY IVTEFMENGC LLNYLRENKG 
KLRKEMLLSV CQDICEGMEY LERNGYIHRD LAARNCLVSS TCIVKISDFG MTRYVLDDEY 
VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS 
EGFRLYRPHL APMSIYEVMY SCWHEKPEGR PTFAELLRAV TEIAETW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.