UBE2D1 | ENSG00000072401 | NCBI 7321

Details for: UBE2D1

Gene ID: 7321

Symbol: UBE2D1

Ensembl ID: ENSG00000072401

Description: ubiquitin conjugating enzyme E2 D1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downregulation of smad2/3:smad4 transcriptional activity
(R-HSA-2173795)
Downstream tcr signaling
(R-HSA-202424)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Neddylation
(R-HSA-8951664)
Negative regulators of ddx58/ifih1 signaling
(R-HSA-936440)
Ovarian tumor domain proteases
(R-HSA-5689896)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Peroxisomal protein import
(R-HSA-9033241)
Phosphorylation of the apc/c
(R-HSA-176412)
Post-translational protein modification
(R-HSA-597592)
Protein localization
(R-HSA-9609507)
Protein ubiquitination
(R-HSA-8852135)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by bmp
(R-HSA-201451)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of active ubiquitin: roles of e1 and e2 enzymes
(R-HSA-8866652)
Synthesis of dna
(R-HSA-69239)
Tcr signaling
(R-HSA-202403)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation by ventx
(R-HSA-8853884)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Atp binding
(GO:0005524)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Positive regulation of protein ubiquitination
(GO:0031398)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin conjugating enzyme activity
(GO:0061631)
Ubiquitin protein ligase activity
(GO:0061630)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 276.3826
Cell Significance Index: -42.9900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 162.0385
Cell Significance Index: -41.1000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 97.2697
Cell Significance Index: -40.0700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 93.0902
Cell Significance Index: -43.9500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 89.7707
Cell Significance Index: -36.4700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 79.8623
Cell Significance Index: -41.0800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 38.3245
Cell Significance Index: -36.5900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.2648
Cell Significance Index: -43.4800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.2706
Cell Significance Index: -35.5500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.0769
Cell Significance Index: -43.7100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.6506
Cell Significance Index: -26.5700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.9849
Cell Significance Index: -10.9100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.8052
Cell Significance Index: 51.8500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.2218
Cell Significance Index: 57.1100
Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.2074
Cell Significance Index: 53.8600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.5870
Cell Significance Index: 45.4900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.3388
Cell Significance Index: 156.0200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0650
Cell Significance Index: 79.3700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.9477
Cell Significance Index: 24.9200
Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.8540
Cell Significance Index: 13.7800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8398
Cell Significance Index: 83.0800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7384
Cell Significance Index: 34.7100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7382
Cell Significance Index: 148.0900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7195
Cell Significance Index: 55.2200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6428
Cell Significance Index: 88.2700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6036
Cell Significance Index: 74.2200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5923
Cell Significance Index: 212.4700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5794
Cell Significance Index: 104.4500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.5762
Cell Significance Index: 4.8400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5578
Cell Significance Index: 304.6400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5197
Cell Significance Index: 35.9400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4977
Cell Significance Index: 13.2900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4181
Cell Significance Index: 289.1900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4133
Cell Significance Index: 11.2500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3977
Cell Significance Index: 20.6600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3201
Cell Significance Index: 141.5300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3153
Cell Significance Index: 60.0000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3046
Cell Significance Index: 6.6000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.2680
Cell Significance Index: 5.6100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2470
Cell Significance Index: 31.9100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2397
Cell Significance Index: 8.3300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2134
Cell Significance Index: 42.3500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1940
Cell Significance Index: 5.5900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1891
Cell Significance Index: 9.8500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1634
Cell Significance Index: 8.5800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1575
Cell Significance Index: 11.1400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1022
Cell Significance Index: 13.1000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0744
Cell Significance Index: 8.7700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0651
Cell Significance Index: 4.0000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0598
Cell Significance Index: 2.1000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0004
Cell Significance Index: -0.0200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0024
Cell Significance Index: -0.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0111
Cell Significance Index: -20.9700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0214
Cell Significance Index: -1.4400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0218
Cell Significance Index: -40.2000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0252
Cell Significance Index: -38.8400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0326
Cell Significance Index: -44.3000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0339
Cell Significance Index: -15.3700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0354
Cell Significance Index: -22.4600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0355
Cell Significance Index: -32.0600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0389
Cell Significance Index: -28.5500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0391
Cell Significance Index: -29.5600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0405
Cell Significance Index: -30.0100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0417
Cell Significance Index: -4.2600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0580
Cell Significance Index: -0.9700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0586
Cell Significance Index: -2.7300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0670
Cell Significance Index: -37.7600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0791
Cell Significance Index: -49.4100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1025
Cell Significance Index: -17.5000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1164
Cell Significance Index: -2.4800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1282
Cell Significance Index: -36.9000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1314
Cell Significance Index: -1.2100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1395
Cell Significance Index: -8.7900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1918
Cell Significance Index: -27.8800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2165
Cell Significance Index: -3.8300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2197
Cell Significance Index: -46.2800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2261
Cell Significance Index: -4.9500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2340
Cell Significance Index: -26.8100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2403
Cell Significance Index: -10.6300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2876
Cell Significance Index: -4.3100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2913
Cell Significance Index: -18.7900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2960
Cell Significance Index: -11.2100
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3238
Cell Significance Index: -4.7800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3555
Cell Significance Index: -10.4400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3613
Cell Significance Index: -4.9300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3689
Cell Significance Index: -10.3100
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.3835
Cell Significance Index: -2.3600
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.3925
Cell Significance Index: -4.1700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4025
Cell Significance Index: -12.8900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4120
Cell Significance Index: -42.9000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4172
Cell Significance Index: -4.7400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4614
Cell Significance Index: -36.5400
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4746
Cell Significance Index: -5.6600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5069
Cell Significance Index: -13.5600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5381
Cell Significance Index: -13.4500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5870
Cell Significance Index: -17.2900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6022
Cell Significance Index: -10.3200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7010
Cell Significance Index: -42.9800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8369
Cell Significance Index: -21.3800
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.8546
Cell Significance Index: -5.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Ubiquitin-conjugating enzyme E2 D1**: UBE2D1 is a member of the ubiquitin-conjugating enzyme family, which plays a central role in the ubiquitination process. 2. **Mitotic cell cycle regulation**: UBE2D1 is involved in the regulation of the mitotic cell cycle, particularly in the activation of the anaphase-promoting complex (APC) and the degradation of mitotic proteins. 3. **Antigen processing**: UBE2D1 is involved in the ubiquitination and proteasomal degradation of proteins involved in antigen processing, which is essential for immune system function. 4. **Adaptive immune system**: UBE2D1 is expressed in various immune cells, including T cells, B cells, and dendritic cells, and plays a role in the regulation of immune responses. **Pathways and Functions** 1. **Mitotic cell cycle regulation**: UBE2D1 is involved in the regulation of the mitotic cell cycle, particularly in the activation of the APC and the degradation of mitotic proteins. 2. **Antigen processing**: UBE2D1 is involved in the ubiquitination and proteasomal degradation of proteins involved in antigen processing, which is essential for immune system function. 3. **Adaptive immune system**: UBE2D1 is expressed in various immune cells, including T cells, B cells, and dendritic cells, and plays a role in the regulation of immune responses. 4. **Protein turnover**: UBE2D1 is involved in the ubiquitination and proteasomal degradation of proteins, which is essential for protein turnover and cellular homeostasis. 5. **Cellular responses to stimuli**: UBE2D1 is involved in the regulation of cellular responses to various stimuli, including stress, hypoxia, and cytokines. **Clinical Significance** 1. **Cancer**: Aberrant expression or dysfunction of UBE2D1 has been implicated in various cancers, including breast cancer, lung cancer, and leukemia. 2. **Autoimmune disorders**: UBE2D1 has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 3. **Metabolic disorders**: UBE2D1 has been implicated in the regulation of glucose metabolism and insulin sensitivity, and has been associated with metabolic disorders, including type 2 diabetes. 4. **Immunodeficiency**: UBE2D1 has been implicated in the regulation of immune responses, and its dysfunction has been associated with immunodeficiency disorders. In conclusion, UBE2D1 is a critical gene involved in various cellular processes, including the regulation of the mitotic cell cycle, antigen processing, and immune system function. Its aberrant expression or dysfunction has been implicated in various diseases, including cancer, autoimmune disorders, and metabolic disorders. Further research is needed to fully understand the role of UBE2D1 in human disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin-conjugating enzyme E2 D1
A0A087WW00_HUMAN

Genular Protein ID: 3118678838

Symbol: UB2D1_HUMAN

Name: Ubiquitin-conjugating enzyme E2 D1

UniProtKB Accession Codes:

P51668 A6NLF6 A8K786

Database IDs:

Citations:

PubMed ID: 8090726

Title: Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

PubMed ID: 8090726

DOI: 10.1073/pnas.91.19.8797

PubMed ID: 12480712

Title: UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.

PubMed ID: 12480712

DOI: 10.1182/blood-2002-07-2192

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9362508

Title: Functional expression cloning and characterization of SFT, a stimulator of Fe transport.

PubMed ID: 9362508

DOI: 10.1083/jcb.139.4.895

PubMed ID: 11389839

Title: Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.

PubMed ID: 11389839

DOI: 10.1016/s1097-2765(01)00242-8

PubMed ID: 14562029

Title: The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.

PubMed ID: 14562029

DOI: 10.1038/sj.bjc.6601301

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 18042044

Title: Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

PubMed ID: 18042044

DOI: 10.1042/bj20071338

PubMed ID: 18845142

Title: The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.

PubMed ID: 18845142

DOI: 10.1016/j.yexcr.2008.09.011

PubMed ID: 18359941

Title: Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor.

PubMed ID: 18359941

DOI: 10.1074/jbc.m800402200

PubMed ID: 19103148

Title: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

PubMed ID: 19103148

DOI: 10.1016/j.abb.2008.12.001

PubMed ID: 19854139

Title: Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.

PubMed ID: 19854139

DOI: 10.1016/j.molcel.2009.09.037

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

PubMed ID: 21685362

Title: The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

PubMed ID: 21685362

DOI: 10.1101/gad.2056211

Sequence Information:

Length: 147
Mass: 16602
Checksum: 2E96FD0179EE119D
Sequence:

MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF FLTVHFPTDY 
PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 
PDIAQIYKSD KEKYNRHARE WTQKYAM

Genular Protein ID: 820497434

Symbol: A0A087WW00_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WW00

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 109
Mass: 12421
Checksum: 7EC6C2D62B579D92
Sequence:

MTPDSAYQGG VFFLTVHFPT DYPFKPPKIA FTTKIYHPNI NSNGSICLDI LRSQWSPALT 
VSKVLLSICS LLCDPNPDDP LVPDIAQIYK SDKEKYNRHA REWTQKYAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBE2D1

Associated with

Cells (max top 100)

Other Information

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. PubMed ID: 8090726

UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis. PubMed ID: 12480712

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional expression cloning and characterization of SFT, a stimulator of Fe transport. PubMed ID: 9362508

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. PubMed ID: 11389839

The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. PubMed ID: 14562029

E3-independent monoubiquitination of ubiquitin-binding proteins. PubMed ID: 17588522

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. PubMed ID: 18042044

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. PubMed ID: 18845142

Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. PubMed ID: 18359941

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. PubMed ID: 19103148

Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. PubMed ID: 19854139

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. PubMed ID: 20061386

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. PubMed ID: 22496338

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. PubMed ID: 21685362

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Database document:

PubMed ID: 8090726

PubMed ID: 12480712

PubMed ID: 14702039

PubMed ID: 15164054

PubMed ID: 15489334

PubMed ID: 9362508

PubMed ID: 11389839

PubMed ID: 14562029

PubMed ID: 17588522

PubMed ID: 18042044

PubMed ID: 18845142

PubMed ID: 18359941

PubMed ID: 19103148

PubMed ID: 19854139

PubMed ID: 20061386

PubMed ID: 22496338

PubMed ID: 21685362

PubMed ID: 11237011

PubMed ID: 15164054

PubMed ID: 15496913