Details for: UBE2G1

Gene ID: 7326

Symbol: UBE2G1

Ensembl ID: ENSG00000132388

Description: ubiquitin conjugating enzyme E2 G1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 294.7696
    Cell Significance Index: -45.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 182.4215
    Cell Significance Index: -46.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.1735
    Cell Significance Index: -43.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.4554
    Cell Significance Index: -50.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.4040
    Cell Significance Index: -48.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 74.9305
    Cell Significance Index: -50.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.8867
    Cell Significance Index: -43.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.3120
    Cell Significance Index: -48.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.1113
    Cell Significance Index: -43.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.8306
    Cell Significance Index: -42.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.4935
    Cell Significance Index: -49.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3863
    Cell Significance Index: -24.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.6215
    Cell Significance Index: 144.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.1354
    Cell Significance Index: 100.9000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.3287
    Cell Significance Index: 53.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.5150
    Cell Significance Index: 67.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1670
    Cell Significance Index: 166.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0968
    Cell Significance Index: 244.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0403
    Cell Significance Index: 57.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6404
    Cell Significance Index: 329.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5773
    Cell Significance Index: 313.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4759
    Cell Significance Index: 174.0500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2030
    Cell Significance Index: 19.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9778
    Cell Significance Index: 58.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9437
    Cell Significance Index: 338.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8827
    Cell Significance Index: 143.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8752
    Cell Significance Index: 49.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7517
    Cell Significance Index: 519.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5028
    Cell Significance Index: 11.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4861
    Cell Significance Index: 214.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4454
    Cell Significance Index: 30.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4388
    Cell Significance Index: 53.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4236
    Cell Significance Index: 80.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4151
    Cell Significance Index: 74.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3952
    Cell Significance Index: 17.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3640
    Cell Significance Index: 198.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3556
    Cell Significance Index: 13.4700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.3379
    Cell Significance Index: 1.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2889
    Cell Significance Index: 13.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2436
    Cell Significance Index: 11.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2345
    Cell Significance Index: 6.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2072
    Cell Significance Index: 390.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2022
    Cell Significance Index: 14.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1624
    Cell Significance Index: 8.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1556
    Cell Significance Index: 21.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1517
    Cell Significance Index: 10.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1412
    Cell Significance Index: 64.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1387
    Cell Significance Index: 86.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1110
    Cell Significance Index: 18.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1063
    Cell Significance Index: 1.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0973
    Cell Significance Index: 61.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0970
    Cell Significance Index: 131.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0925
    Cell Significance Index: 170.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0898
    Cell Significance Index: 8.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0774
    Cell Significance Index: 4.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0590
    Cell Significance Index: 90.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0418
    Cell Significance Index: 5.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0320
    Cell Significance Index: 0.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0292
    Cell Significance Index: 0.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0270
    Cell Significance Index: 1.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0174
    Cell Significance Index: 1.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0075
    Cell Significance Index: 0.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0005
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0168
    Cell Significance Index: -2.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0262
    Cell Significance Index: -1.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0378
    Cell Significance Index: -2.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0405
    Cell Significance Index: -29.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0414
    Cell Significance Index: -31.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0565
    Cell Significance Index: -31.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1217
    Cell Significance Index: -12.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1409
    Cell Significance Index: -29.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1442
    Cell Significance Index: -9.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1449
    Cell Significance Index: -4.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1524
    Cell Significance Index: -43.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1543
    Cell Significance Index: -22.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1685
    Cell Significance Index: -3.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1998
    Cell Significance Index: -20.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2211
    Cell Significance Index: -25.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2345
    Cell Significance Index: -3.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2350
    Cell Significance Index: -1.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2426
    Cell Significance Index: -4.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2683
    Cell Significance Index: -3.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2803
    Cell Significance Index: -7.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2808
    Cell Significance Index: -4.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2849
    Cell Significance Index: -14.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2875
    Cell Significance Index: -4.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3469
    Cell Significance Index: -11.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4457
    Cell Significance Index: -12.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4912
    Cell Significance Index: -14.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5208
    Cell Significance Index: -41.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5328
    Cell Significance Index: -14.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5482
    Cell Significance Index: -10.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5505
    Cell Significance Index: -11.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5984
    Cell Significance Index: -12.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6629
    Cell Significance Index: -40.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7010
    Cell Significance Index: -14.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7309
    Cell Significance Index: -17.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7797
    Cell Significance Index: -19.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8323
    Cell Significance Index: -12.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBE2G1 is a member of the ubiquitin-conjugating enzyme 2 (UBE2) family, which is responsible for transferring ubiquitin molecules to target proteins. UBE2G1 is specifically involved in the transfer of ubiquitin to lysine residues, particularly lysine 48 (K48) and lysine 63 (K63), which are recognized by different ubiquitin ligases. This specificity allows for precise regulation of protein degradation and modification. **Pathways and Functions:** UBE2G1 is involved in various cellular processes, including: 1. **Adaptive Immune System:** UBE2G1 plays a crucial role in the adaptive immune response by regulating the degradation of proteins involved in antigen processing and presentation. It is specifically expressed in cells of the adaptive immune system, such as B cells and dendritic cells. 2. **Antigen Processing:** UBE2G1 is involved in the ubiquitination of proteins involved in antigen processing, including the major histocompatibility complex (MHC) class I and II molecules. This process is essential for the presentation of antigens to T cells. 3. **Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process:** UBE2G1 is involved in the degradation of proteins through the proteasome pathway, which is essential for maintaining protein homeostasis and regulating cellular processes. 4. **Protein Modification:** UBE2G1 is involved in the modification of proteins through ubiquitination, which can lead to changes in protein function, localization, and stability. **Clinical Significance:** UBE2G1 has been implicated in various diseases, including: 1. **Cancer:** Altered expression of UBE2G1 has been observed in various types of cancer, including breast, lung, and colon cancer. This suggests that UBE2G1 may play a role in cancer development and progression. 2. **Neurodegenerative Diseases:** UBE2G1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where protein aggregation and degradation are key mechanisms. 3. **Immune-Mediated Diseases:** UBE2G1 has been implicated in immune-mediated diseases, such as autoimmune diseases, where dysregulation of the adaptive immune response can lead to disease. In conclusion, UBE2G1 is a critical regulator of protein degradation and immune function, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which UBE2G1 regulates protein degradation and immune function, and to explore its potential as a therapeutic target for various diseases. **References:** * [Insert references to relevant studies and reviews on UBE2G1] **Author's Note:** As an expert immunologist, I have provided a comprehensive overview of the UBE2G1 gene, highlighting its key characteristics, pathways, and functions. I hope that this article will contribute to the understanding of the role of UBE2G1 in the immune system and its potential implications for human disease.

Genular Protein ID: 2371657732

Symbol: UB2G1_HUMAN

Name: Ubiquitin-conjugating enzyme E2 G1

UniProtKB Accession Codes:

P62253 B2R7P2 D3DTK0 Q99462

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8893823

Title: Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans.

PubMed ID: 8893823

DOI: 10.1159/000134403

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19103148

Title: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

PubMed ID: 19103148

DOI: 10.1016/j.abb.2008.12.001

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

Sequence Information:

  • Length: 170
  • Mass: 19509
  • Checksum: 36B61766D995B332
  • Sequence:
    • MTELQSALLL RRQLAELNKN PVEGFSAGLI DDNDLYRWEV LIIGPPDTLY EGGVFKAHLT 
FPKDYPLRPP KMKFITEIWH PNVDKNGDVC ISILHEPGED KYGYEKPEER WLPIHTVETI 
MISVISMLAD PNGDSPANVD AAKEWREDRN GEFKRKVARC VRKSQETAFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.