UBE2V1 | ENSG00000244687 | NCBI 7335

Details for: UBE2V1

Gene ID: 7335

Symbol: UBE2V1

Ensembl ID: ENSG00000244687

Description: ubiquitin conjugating enzyme E2 V1

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Autophagy
(R-HSA-9612973)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Irak1 recruits ikk complex
(R-HSA-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-HSA-975144)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Macroautophagy
(R-HSA-1632852)
Map kinase activation
(R-HSA-450294)
Mitophagy
(R-HSA-5205647)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Pink1-prkn mediated mitophagy
(R-HSA-5205685)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selective autophagy
(R-HSA-9663891)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Tcr signaling
(R-HSA-202403)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated irf7 activation in tlr7/8 or 9 signaling
(R-HSA-975110)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of intracellular signal transduction
(GO:1902533)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of protein k63-linked ubiquitination
(GO:1902523)
Postreplication repair
(GO:0006301)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein k63-linked ubiquitination
(GO:0070534)
Protein polyubiquitination
(GO:0000209)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna repair
(GO:0006282)
Ubc13-mms2 complex
(GO:0031372)
Ubiquitin conjugating enzyme complex
(GO:0031371)
Ubiquitin ligase complex
(GO:0000151)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 205.0850
Cell Significance Index: -31.9000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 137.1611
Cell Significance Index: -34.7900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 85.3749
Cell Significance Index: -35.1700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 65.5054
Cell Significance Index: -33.7000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 27.3895
Cell Significance Index: -33.7700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.3971
Cell Significance Index: -33.2100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 10.8750
Cell Significance Index: 65.7100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.4087
Cell Significance Index: -31.9700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.9609
Cell Significance Index: -35.3600
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 4.3128
Cell Significance Index: 37.0600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.8958
Cell Significance Index: 85.0500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.7186
Cell Significance Index: 25.0400
Cell Name: peg cell (CL4033014)
Fold Change: 2.4447
Cell Significance Index: 56.4800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.0382
Cell Significance Index: 250.6100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.8713
Cell Significance Index: 337.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8622
Cell Significance Index: 53.3800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.8406
Cell Significance Index: 53.0300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.8115
Cell Significance Index: 20.5800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7863
Cell Significance Index: 358.3200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5405
Cell Significance Index: 167.5600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2262
Cell Significance Index: 94.1000
Cell Name: odontoblast (CL0000060)
Fold Change: 1.2246
Cell Significance Index: 156.9900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.0085
Cell Significance Index: 25.2100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8410
Cell Significance Index: 759.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8392
Cell Significance Index: 83.0200
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.7884
Cell Significance Index: 3.6400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7702
Cell Significance Index: 276.2500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6693
Cell Significance Index: 14.5000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6430
Cell Significance Index: 39.5200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6325
Cell Significance Index: 8.6300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6295
Cell Significance Index: 74.2400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5625
Cell Significance Index: 91.4900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5533
Cell Significance Index: 15.0600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4907
Cell Significance Index: 33.9400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4695
Cell Significance Index: 21.2800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4022
Cell Significance Index: 22.5700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3240
Cell Significance Index: 44.5000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2706
Cell Significance Index: 11.9700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2661
Cell Significance Index: 10.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2234
Cell Significance Index: 13.4100
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.2230
Cell Significance Index: 3.8600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2179
Cell Significance Index: 11.0100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2134
Cell Significance Index: 40.6100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1697
Cell Significance Index: 75.0500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1532
Cell Significance Index: 83.6500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1151
Cell Significance Index: 1.7000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0721
Cell Significance Index: 2.5400
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.0671
Cell Significance Index: 0.8600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0418
Cell Significance Index: 1.9500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0313
Cell Significance Index: 0.6500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0206
Cell Significance Index: 1.4600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0119
Cell Significance Index: 0.6200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0072
Cell Significance Index: 2.0900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0079
Cell Significance Index: -14.8500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0097
Cell Significance Index: -0.2600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0139
Cell Significance Index: -25.6900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0167
Cell Significance Index: -25.6900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0209
Cell Significance Index: -0.9800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0242
Cell Significance Index: -32.9500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0319
Cell Significance Index: -23.6300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0329
Cell Significance Index: -24.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0360
Cell Significance Index: -27.2200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0428
Cell Significance Index: -27.1600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0503
Cell Significance Index: -22.8100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0519
Cell Significance Index: -29.2600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0605
Cell Significance Index: -37.7800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0651
Cell Significance Index: -4.1000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0733
Cell Significance Index: -12.5200
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1328
Cell Significance Index: -1.9900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1451
Cell Significance Index: -3.4800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1479
Cell Significance Index: -3.1500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1533
Cell Significance Index: -22.2800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1615
Cell Significance Index: -16.5000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1725
Cell Significance Index: -36.3300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1920
Cell Significance Index: -24.8000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2059
Cell Significance Index: -24.0000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2435
Cell Significance Index: -4.5000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2468
Cell Significance Index: -28.2700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2476
Cell Significance Index: -6.6400
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.2904
Cell Significance Index: -2.9300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3035
Cell Significance Index: -9.7200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3292
Cell Significance Index: -34.2800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3379
Cell Significance Index: -25.1800
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3622
Cell Significance Index: -7.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3661
Cell Significance Index: -23.6200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3811
Cell Significance Index: -30.1800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4655
Cell Significance Index: -24.4400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.5065
Cell Significance Index: -4.1300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5244
Cell Significance Index: -17.1700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5279
Cell Significance Index: -13.8800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5438
Cell Significance Index: -33.3400
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5464
Cell Significance Index: -11.6800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.6136
Cell Significance Index: -7.6100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6173
Cell Significance Index: -19.6600
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.6630
Cell Significance Index: -13.4900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6859
Cell Significance Index: -24.0300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.7161
Cell Significance Index: -8.9300
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.7271
Cell Significance Index: -15.7100
Cell Name: glioblast (CL0000030)
Fold Change: -0.7389
Cell Significance Index: -4.6400
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.7470
Cell Significance Index: -4.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Ubiquitin Conjugating Enzyme**: UBE2V1 is a member of the ubiquitin-conjugating enzyme family, which plays a central role in the UPP. 2. **Specific Expression in Immune Cells**: The gene is highly expressed in cells of the immune system, including myeloid dendritic cells, monocytes, and T cells. 3. **Involvement in Immune Response**: UBE2V1 is involved in the regulation of immune responses, including the activation of T cells and the presentation of antigens to T cells. 4. **Regulation of Protein Degradation**: The gene is involved in the conjugation of ubiquitin to target proteins, facilitating their degradation by the proteasome. **Pathways and Functions** 1. **Activating Tak1 Mediates p38 MAPK Activation**: UBE2V1 is involved in the activation of the TAK1 (transforming growth factor-β-activated kinase 1) pathway, which leads to the activation of p38 MAPK (mitogen-activated protein kinase). 2. **Adaptive Immune System**: UBE2V1 plays a crucial role in the adaptive immune system, including the activation of T cells and the presentation of antigens to T cells. 3. **Aggrephagy**: The gene is involved in the regulation of aggrephagy, a process of selective autophagy that targets protein aggregates. 4. **Antigen Processing: Ubiquitination & Proteasome Degradation**: UBE2V1 is involved in the ubiquitination and degradation of antigens, facilitating their presentation to T cells. 5. **Autophagy**: The gene is involved in the regulation of autophagy, a process of cellular degradation and recycling. 6. **Cytokine Signaling in Immune System**: UBE2V1 is involved in the regulation of cytokine signaling in the immune system, including the activation of T cells and the production of cytokines. 7. **Toll-like Receptor Signaling**: The gene is involved in the regulation of Toll-like receptor (TLR) signaling, including the activation of NF-κB and the production of cytokines. **Clinical Significance** 1. **Viral Infections**: UBE2V1 is involved in the regulation of immune responses to viral infections, including the activation of T cells and the production of cytokines. 2. **Cancer**: The gene is involved in the regulation of protein degradation and cell cycle regulation, which can impact cancer development and progression. 3. **Autoimmune Diseases**: UBE2V1 may play a role in the regulation of immune responses to self-antigens, which can contribute to the development of autoimmune diseases. 4. **Immunodeficiency Disorders**: Alterations in UBE2V1 expression or function may contribute to immunodeficiency disorders, including impaired T cell function and decreased antibody production. In conclusion, UBE2V1 is a crucial component of the ubiquitin-proteasome pathway, playing a pivotal role in various cellular processes, including protein degradation, cell cycle regulation, and immune response. Its involvement in immune function and responses to pathogens makes it an important gene in the context of viral infections, cancer, autoimmune diseases, and immunodeficiency disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

G3V2F7_HUMAN

Genular Protein ID: 597200085

Symbol: G3V2F7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V2F7

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 105
Mass: 12019
Checksum: 4FD7EB5F45D2B729
Sequence:

MTLTRWTGMI IGPPRTIYEN RIYSLKIECG PKYPEAPPFV RFVTKINMNG VNSSNGVVDP 
RAISVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QCYSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.