Details for: UCP3

Gene ID: 7352

Symbol: UCP3

Ensembl ID: ENSG00000175564

Description: uncoupling protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.4372
    Cell Significance Index: -3.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.1537
    Cell Significance Index: -3.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8874
    Cell Significance Index: -3.5600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.3362
    Cell Significance Index: 21.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6902
    Cell Significance Index: 16.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5322
    Cell Significance Index: 13.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3344
    Cell Significance Index: 63.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2645
    Cell Significance Index: 26.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2525
    Cell Significance Index: 5.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1789
    Cell Significance Index: 161.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1270
    Cell Significance Index: 20.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1194
    Cell Significance Index: 12.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1015
    Cell Significance Index: 6.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0991
    Cell Significance Index: 5.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0980
    Cell Significance Index: 2.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0934
    Cell Significance Index: 18.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0824
    Cell Significance Index: 1.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0644
    Cell Significance Index: 2.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0552
    Cell Significance Index: 3.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0394
    Cell Significance Index: 14.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0330
    Cell Significance Index: 22.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0239
    Cell Significance Index: 2.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0226
    Cell Significance Index: 1.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0195
    Cell Significance Index: 3.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0112
    Cell Significance Index: 0.1600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0084
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0076
    Cell Significance Index: 0.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0055
    Cell Significance Index: 0.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0051
    Cell Significance Index: 0.3100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0024
    Cell Significance Index: 0.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0017
    Cell Significance Index: 0.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0017
    Cell Significance Index: 0.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0012
    Cell Significance Index: 0.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0011
    Cell Significance Index: 0.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0025
    Cell Significance Index: -0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0039
    Cell Significance Index: -2.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0055
    Cell Significance Index: -2.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0063
    Cell Significance Index: -1.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0075
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0097
    Cell Significance Index: -1.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0139
    Cell Significance Index: -0.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0147
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0151
    Cell Significance Index: -2.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0179
    Cell Significance Index: -0.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0197
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0210
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0217
    Cell Significance Index: -4.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0233
    Cell Significance Index: -1.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0235
    Cell Significance Index: -1.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0248
    Cell Significance Index: -0.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0257
    Cell Significance Index: -0.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0276
    Cell Significance Index: -3.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0277
    Cell Significance Index: -3.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0290
    Cell Significance Index: -1.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0315
    Cell Significance Index: -2.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0341
    Cell Significance Index: -3.5500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0355
    Cell Significance Index: -0.3800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0358
    Cell Significance Index: -0.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0396
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0424
    Cell Significance Index: -3.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0427
    Cell Significance Index: -3.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0503
    Cell Significance Index: -2.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0540
    Cell Significance Index: -2.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0543
    Cell Significance Index: -2.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0570
    Cell Significance Index: -2.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0617
    Cell Significance Index: -2.1600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0620
    Cell Significance Index: -0.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0621
    Cell Significance Index: -1.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0652
    Cell Significance Index: -1.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0703
    Cell Significance Index: -2.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0705
    Cell Significance Index: -1.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0706
    Cell Significance Index: -2.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0711
    Cell Significance Index: -1.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0754
    Cell Significance Index: -1.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0845
    Cell Significance Index: -3.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0848
    Cell Significance Index: -1.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0878
    Cell Significance Index: -3.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0928
    Cell Significance Index: -0.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0930
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0934
    Cell Significance Index: -1.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0981
    Cell Significance Index: -1.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0990
    Cell Significance Index: -1.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1004
    Cell Significance Index: -1.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1022
    Cell Significance Index: -3.0100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1024
    Cell Significance Index: -1.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** UCP3 is predominantly expressed in skeletal muscle, immune cells (e.g., T lymphocytes), and certain epithelial cells (e.g., colon goblet cells). 2. **Function:** UCP3 acts as an uncoupling protein, dissipating the proton gradient across the mitochondrial inner membrane, thereby uncoupling ATP synthesis from electron transport chain activity. 3. **Thermogenic Potential:** UCP3 is involved in non-shivering thermogenesis, a process that generates heat without muscle contraction, which is essential for maintaining body temperature. 4. **Lipid Metabolism:** UCP3 regulates fatty acid oxidation, which is critical for energy production and storage. **Pathways and Functions:** 1. **Adaptive Thermogenesis:** UCP3 is activated in response to cold stress, exercise, and certain hormones, leading to increased heat production and energy expenditure. 2. **Mitochondrial Uncoupling:** UCP3 dissipates the proton gradient across the mitochondrial inner membrane, uncoupling ATP synthesis from electron transport chain activity. 3. **Lipid Hydroperoxide Transport:** UCP3 regulates the transport of lipid hydroperoxides, which are reactive oxygen species involved in lipid peroxidation. 4. **Protein Binding:** UCP3 interacts with various proteins, including heat shock proteins, to regulate its activity and expression. **Clinical Significance:** 1. **Obesity and Metabolic Disorders:** Altered UCP3 expression has been linked to obesity, insulin resistance, and metabolic syndrome, highlighting its potential as a therapeutic target. 2. **Cancer and Immune Response:** UCP3 has been implicated in the regulation of immune cell function and cancer progression, suggesting its potential as a biomarker or therapeutic target. 3. **Neurodegenerative Diseases:** UCP3 has been associated with neurodegenerative diseases, such as Parkinson's disease, suggesting its potential role in mitochondrial dysfunction and oxidative stress. In conclusion, UCP3 is a multifunctional gene that plays a crucial role in regulating energy metabolism, thermogenesis, and immune response. Further research is necessary to fully elucidate its mechanisms of action and its clinical significance, but its potential as a therapeutic target for metabolic disorders and neurodegenerative diseases is promising.

Genular Protein ID: 2666724639

Symbol: UCP3_HUMAN

Name: Solute carrier family 25 member 9

UniProtKB Accession Codes:

P55916 O60475 Q96HL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9180264

Title: Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.

PubMed ID: 9180264

DOI: 10.1016/s0014-5793(97)00384-0

PubMed ID: 9325252

Title: The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.

PubMed ID: 9325252

DOI: 10.1074/jbc.272.41.25433

PubMed ID: 9196039

Title: UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.

PubMed ID: 9196039

DOI: 10.1006/bbrc.1997.6740

PubMed ID: 9305858

Title: Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin.

PubMed ID: 9305858

DOI: 10.1074/jbc.272.39.24129

PubMed ID: 9498661

Title: Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.

PubMed ID: 9498661

DOI: 10.1007/s001250050897

PubMed ID: 10958796

Title: The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents.

PubMed ID: 10958796

DOI: 10.1074/jbc.m005713200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11171965

Title: Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone).

PubMed ID: 11171965

DOI: 10.1073/pnas.98.4.1416

PubMed ID: 11707458

Title: The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3.

PubMed ID: 11707458

DOI: 10.1074/jbc.m109736200

PubMed ID: 12670931

Title: Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3.

PubMed ID: 12670931

DOI: 10.1074/jbc.m212850200

PubMed ID: 12734183

Title: Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10.

PubMed ID: 12734183

DOI: 10.1074/jbc.m302126200

PubMed ID: 21775425

Title: Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production.

PubMed ID: 21775425

DOI: 10.1074/jbc.m110.216044

PubMed ID: 26915802

Title: UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion.

PubMed ID: 26915802

DOI: 10.1016/j.bbrc.2016.02.075

PubMed ID: 36114012

Title: Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo.

PubMed ID: 36114012

DOI: 10.1002/1873-3468.14494

PubMed ID: 9769326

Title: Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.

PubMed ID: 9769326

DOI: 10.1172/jci4115

Sequence Information:

  • Length: 312
  • Mass: 34216
  • Checksum: D0E04A8DB352B17C
  • Sequence:
    • MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV QTARLVQYRG 
VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD SVKQVYTPKG ADNSSLTTRI 
LAGCTTGAMA VTCAQPTDVV KVRFQASIHL GPSRSDRKYS GTMDAYRTIA REEGVRGLWK 
GTLPNIMRNA IVNCAEVVTY DILKEKLLDY HLLTDNFPCH FVSAFGAGFC ATVVASPVDV 
VKTRYMNSPP GQYFSPLDCM IKMVAQEGPT AFYKGFTPSF LRLGSWNVVM FVTYEQLKRA 
LMKVQMLRES PF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.