Details for: UGDH

Gene ID: 7358

Symbol: UGDH

Ensembl ID: ENSG00000109814

Description: UDP-glucose 6-dehydrogenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 211.1926
    Cell Significance Index: -32.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.1220
    Cell Significance Index: -31.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.8853
    Cell Significance Index: -37.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.8169
    Cell Significance Index: -32.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.4542
    Cell Significance Index: -27.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.5528
    Cell Significance Index: -32.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.1702
    Cell Significance Index: -27.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.7893
    Cell Significance Index: -33.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6094
    Cell Significance Index: -31.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4160
    Cell Significance Index: -33.2100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.9115
    Cell Significance Index: 42.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5829
    Cell Significance Index: -10.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.8513
    Cell Significance Index: 64.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.0462
    Cell Significance Index: 87.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.0446
    Cell Significance Index: 226.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.3202
    Cell Significance Index: 66.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0295
    Cell Significance Index: 30.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8828
    Cell Significance Index: 40.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8526
    Cell Significance Index: 83.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7662
    Cell Significance Index: 350.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6434
    Cell Significance Index: 34.4000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.5737
    Cell Significance Index: 16.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2896
    Cell Significance Index: 66.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2291
    Cell Significance Index: 16.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0539
    Cell Significance Index: 951.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9704
    Cell Significance Index: 33.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9622
    Cell Significance Index: 66.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9433
    Cell Significance Index: 170.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8968
    Cell Significance Index: 7.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7243
    Cell Significance Index: 99.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7072
    Cell Significance Index: 386.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6732
    Cell Significance Index: 82.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4886
    Cell Significance Index: 13.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4693
    Cell Significance Index: 94.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4394
    Cell Significance Index: 15.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4359
    Cell Significance Index: 55.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3790
    Cell Significance Index: 4.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3785
    Cell Significance Index: 8.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3492
    Cell Significance Index: 34.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3288
    Cell Significance Index: 10.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3142
    Cell Significance Index: 35.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2956
    Cell Significance Index: 5.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2454
    Cell Significance Index: 88.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2453
    Cell Significance Index: 41.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2286
    Cell Significance Index: 6.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2113
    Cell Significance Index: 93.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2065
    Cell Significance Index: 5.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1659
    Cell Significance Index: 31.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1480
    Cell Significance Index: 19.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1348
    Cell Significance Index: 21.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1265
    Cell Significance Index: 1.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0809
    Cell Significance Index: 8.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0596
    Cell Significance Index: 2.8000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0387
    Cell Significance Index: 0.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0221
    Cell Significance Index: 0.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0150
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0069
    Cell Significance Index: 12.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0007
    Cell Significance Index: 0.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0053
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0152
    Cell Significance Index: -27.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0178
    Cell Significance Index: -27.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0225
    Cell Significance Index: -14.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0255
    Cell Significance Index: -34.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0278
    Cell Significance Index: -20.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0313
    Cell Significance Index: -17.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0340
    Cell Significance Index: -15.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0393
    Cell Significance Index: -0.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0612
    Cell Significance Index: -4.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0657
    Cell Significance Index: -4.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0685
    Cell Significance Index: -14.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0724
    Cell Significance Index: -7.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0875
    Cell Significance Index: -25.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0897
    Cell Significance Index: -4.1800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0917
    Cell Significance Index: -1.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1152
    Cell Significance Index: -2.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1209
    Cell Significance Index: -3.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1330
    Cell Significance Index: -19.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1403
    Cell Significance Index: -16.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1447
    Cell Significance Index: -9.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1469
    Cell Significance Index: -16.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1481
    Cell Significance Index: -17.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1542
    Cell Significance Index: -8.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1896
    Cell Significance Index: -10.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3004
    Cell Significance Index: -31.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3128
    Cell Significance Index: -20.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3273
    Cell Significance Index: -22.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3275
    Cell Significance Index: -3.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3275
    Cell Significance Index: -25.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3431
    Cell Significance Index: -4.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3499
    Cell Significance Index: -27.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3561
    Cell Significance Index: -5.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3768
    Cell Significance Index: -23.1000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3879
    Cell Significance Index: -2.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3921
    Cell Significance Index: -9.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4257
    Cell Significance Index: -22.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4476
    Cell Significance Index: -7.6700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4845
    Cell Significance Index: -6.2400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.4872
    Cell Significance Index: -4.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5085
    Cell Significance Index: -22.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UGDH shares significant sequence homology with other UDP-glucose dehydrogenases from various species, suggesting its evolutionary conservation and essential role in maintaining cellular function. The enzyme's substrate specificity is characterized by its ability to convert UDP-glucose into UDP-glucuronate, a reaction that is critical for the synthesis of glycosaminoglycans and chondroitin sulfate. UGDH also exhibits a unique ability to form a hexamer, which may contribute to its stability and activity. **Pathways and Functions** UGDH is involved in multiple biological pathways, including: 1. **Pentose Phosphate Pathway**: UGDH is a key enzyme in the pentose phosphate pathway, generating NADPH through the conversion of glucose-6-phosphate into 6-phosphogluconolactone. 2. **Glucuronidation**: UGDH is involved in the glucuronidation process, converting UDP-glucose into UDP-glucuronate, a reaction that is critical for the synthesis of glycosaminoglycans and chondroitin sulfate. 3. **Carbohydrate Metabolic Process**: UGDH plays a role in regulating carbohydrate metabolism by controlling the conversion of glucose-6-phosphate into 6-phosphogluconolactone. 4. **Chondroitin Sulfate Biosynthetic Process**: UGDH is involved in the biosynthesis of chondroitin sulfate, a glycosaminoglycan that plays a critical role in maintaining tissue structure and function. **Clinical Significance** Dysregulation of UGDH has been implicated in various diseases and disorders, including: 1. **Glycosaminoglycan Deficiencies**: Mutations in the UGDH gene have been associated with glycosaminoglycan deficiencies, including chondroitin sulfate synthase deficiency and dermatan sulfate sulfatase deficiency. 2. **Cancer**: UGDH has been shown to play a role in cancer development and progression, particularly in the context of glucuronidation and the metabolism of carcinogens. 3. **Inflammatory Disorders**: UGDH has been implicated in inflammatory disorders, including atherosclerosis and rheumatoid arthritis, where its dysregulation can contribute to tissue damage and inflammation. In conclusion, UGDH is a critical enzyme that plays a multifaceted role in various biological processes, including carbohydrate metabolism, glucuronidation, and the biosynthesis of glycosaminoglycans and chondroitin sulfate. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of understanding its function and regulation in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 3703514284

Symbol: UGDH_HUMAN

Name: UDP-glucose 6-dehydrogenase

UniProtKB Accession Codes:

O60701 B3KUU2 B4DN25 O60589

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EC 1 EMBL 16 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIR 1 PIRSF 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9737970

Title: Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes.

PubMed ID: 9737970

DOI: 10.1074/jbc.273.39.25117

PubMed ID: 9850599

Title: cDNA cloning and expression analysis of the human UDPglucose dehydrogenase.

PubMed ID: 9850599

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21595445

Title: Role of packing defects in the evolution of allostery and induced fit in human UDP-glucose dehydrogenase.

PubMed ID: 21595445

DOI: 10.1021/bi2005637

PubMed ID: 21961565

Title: Conformational flexibility in the allosteric regulation of human UDP-alpha-D-glucose 6-dehydrogenase.

PubMed ID: 21961565

DOI: 10.1021/bi201381e

PubMed ID: 21502315

Title: Structure and mechanism of human UDP-glucose 6-dehydrogenase.

PubMed ID: 21502315

DOI: 10.1074/jbc.m111.234682

PubMed ID: 21984906

Title: Structural basis of cooperativity in human UDP-glucose dehydrogenase.

PubMed ID: 21984906

DOI: 10.1371/journal.pone.0025226

PubMed ID: 23106432

Title: Cofactor binding triggers a molecular switch to allosterically activate human UDP-alpha-D-glucose 6-dehydrogenase.

PubMed ID: 23106432

DOI: 10.1021/bi301067w

PubMed ID: 22123821

Title: Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.

PubMed ID: 22123821

DOI: 10.1074/jbc.m111.313015

PubMed ID: 25478983

Title: Hysteresis in human UDP-glucose dehydrogenase is due to a restrained hexameric structure that favors feedback inhibition.

PubMed ID: 25478983

DOI: 10.1021/bi500594x

PubMed ID: 27966912

Title: Allostery and Hysteresis Are Coupled in Human UDP-Glucose Dehydrogenase.

PubMed ID: 27966912

DOI: 10.1021/acs.biochem.6b01044

PubMed ID: 30420606

Title: The entropic force generated by intrinsically disordered segments tunes protein function.

PubMed ID: 30420606

DOI: 10.1038/s41586-018-0699-5

PubMed ID: 30457329

Title: Hysteresis and Allostery in Human UDP-Glucose Dehydrogenase Require a Flexible Protein Core.

PubMed ID: 30457329

DOI: 10.1021/acs.biochem.8b00497

PubMed ID: 32001716

Title: Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy.

PubMed ID: 32001716

DOI: 10.1038/s41467-020-14360-7

Sequence Information:

  • Length: 494
  • Mass: 55024
  • Checksum: 9C9DA5E1227D65CC
  • Sequence:
    • MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV 
VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS 
NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI 
GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL 
CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE 
GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF 
KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP 
KFSLQDPPNK KPKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.