Details for: UGT8

Gene ID: 7368

Symbol: UGT8

Ensembl ID: ENSG00000174607

Description: UDP glycosyltransferase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2597
    Cell Significance Index: -14.0900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.5201
    Cell Significance Index: 35.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.8493
    Cell Significance Index: 197.0400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.0994
    Cell Significance Index: 15.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8711
    Cell Significance Index: 84.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8433
    Cell Significance Index: 53.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6181
    Cell Significance Index: 39.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5761
    Cell Significance Index: 94.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5750
    Cell Significance Index: 171.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5063
    Cell Significance Index: 22.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3552
    Cell Significance Index: 29.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9682
    Cell Significance Index: 7.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7590
    Cell Significance Index: 15.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7339
    Cell Significance Index: 15.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4787
    Cell Significance Index: 91.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4172
    Cell Significance Index: 14.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2850
    Cell Significance Index: 2.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2834
    Cell Significance Index: 154.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2231
    Cell Significance Index: 7.1500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2027
    Cell Significance Index: 3.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1916
    Cell Significance Index: 22.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1722
    Cell Significance Index: 8.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1467
    Cell Significance Index: 3.3900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.1007
    Cell Significance Index: 1.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0853
    Cell Significance Index: 8.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0742
    Cell Significance Index: 54.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0720
    Cell Significance Index: 49.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0645
    Cell Significance Index: 11.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0596
    Cell Significance Index: 21.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0447
    Cell Significance Index: 7.2800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0268
    Cell Significance Index: 0.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0095
    Cell Significance Index: -12.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0146
    Cell Significance Index: -11.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0164
    Cell Significance Index: -3.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0204
    Cell Significance Index: -11.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0223
    Cell Significance Index: -14.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0280
    Cell Significance Index: -5.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0280
    Cell Significance Index: -5.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0305
    Cell Significance Index: -13.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0332
    Cell Significance Index: -9.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0339
    Cell Significance Index: -15.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0508
    Cell Significance Index: -6.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0520
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0538
    Cell Significance Index: -6.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0602
    Cell Significance Index: -7.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0652
    Cell Significance Index: -13.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0663
    Cell Significance Index: -8.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0740
    Cell Significance Index: -2.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0805
    Cell Significance Index: -11.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0848
    Cell Significance Index: -2.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0998
    Cell Significance Index: -14.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1160
    Cell Significance Index: -7.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1272
    Cell Significance Index: -13.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1313
    Cell Significance Index: -8.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1396
    Cell Significance Index: -17.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1438
    Cell Significance Index: -2.4700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.1463
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1480
    Cell Significance Index: -11.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1677
    Cell Significance Index: -4.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1817
    Cell Significance Index: -7.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1841
    Cell Significance Index: -13.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1930
    Cell Significance Index: -14.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2028
    Cell Significance Index: -11.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2062
    Cell Significance Index: -12.6400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2097
    Cell Significance Index: -1.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2249
    Cell Significance Index: -15.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2469
    Cell Significance Index: -3.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2473
    Cell Significance Index: -12.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2525
    Cell Significance Index: -6.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2632
    Cell Significance Index: -11.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2668
    Cell Significance Index: -14.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2832
    Cell Significance Index: -4.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2859
    Cell Significance Index: -7.1300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2944
    Cell Significance Index: -2.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3061
    Cell Significance Index: -11.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3080
    Cell Significance Index: -16.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3277
    Cell Significance Index: -11.4800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3318
    Cell Significance Index: -2.8200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3368
    Cell Significance Index: -4.2000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3381
    Cell Significance Index: -3.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3427
    Cell Significance Index: -12.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3465
    Cell Significance Index: -10.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3629
    Cell Significance Index: -11.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3801
    Cell Significance Index: -19.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3830
    Cell Significance Index: -10.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3838
    Cell Significance Index: -12.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3867
    Cell Significance Index: -12.2300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.4026
    Cell Significance Index: -4.5000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.4031
    Cell Significance Index: -2.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4038
    Cell Significance Index: -8.5700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4058
    Cell Significance Index: -5.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4324
    Cell Significance Index: -9.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4537
    Cell Significance Index: -10.8800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4540
    Cell Significance Index: -5.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UGT8 is a type II membrane-bound glycosyltransferase, which means it requires a specific cofactor, UDP-galactose, to catalyze the transfer of galactose to sphingosine-1-phosphate (S1P). The enzyme exhibits a broad substrate specificity, allowing it to modify various sphingolipids, including ceramides, glycosphingolipids, and S1P. UGT8 is also capable of transferring galactose to other substrates, such as glucosylceramide and galactosylceramide. **Pathways and Functions** UGT8 is involved in various cellular processes, including: 1. **Glycosphingolipid biosynthesis**: UGT8 catalyzes the transfer of galactose to sphingosine-1-phosphate, resulting in the production of galactosylceramide and other glycosphingolipids. 2. **Glycosphingolipid metabolism**: UGT8 participates in the degradation of glycosphingolipids, particularly galactosylceramide, which is involved in cellular signaling and membrane trafficking. 3. **Sphingolipid signaling**: UGT8 modulates the activity of sphingolipids, including S1P, which plays a crucial role in cell proliferation, differentiation, and survival. 4. **Cytoskeleton organization**: UGT8 has been implicated in the regulation of cytoskeleton organization, particularly in neurons, where it influences axon growth and guidance. 5. **Neurodevelopment**: UGT8 is essential for the development of the central nervous system, including neuron projection morphogenesis and paranodal junction assembly. **Clinical Significance** UGT8 has been implicated in various diseases, including: 1. **Neurological disorders**: UGT8 has been linked to neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS), where its dysregulation disrupts glycosphingolipid metabolism and signaling. 2. **Cardiovascular disease**: UGT8 has been implicated in the development of cardiovascular disease, particularly in the context of sphingolipid metabolism and atherosclerosis. 3. **Cancer**: UGT8 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it promotes cell proliferation and survival. 4. **Immune system disorders**: UGT8 has been implicated in immune system disorders, such as multiple sclerosis and autoimmune diseases, where its dysregulation affects glycosphingolipid metabolism and signaling. In conclusion, UGT8 is a multifunctional enzyme involved in various cellular processes, including glycosphingolipid biosynthesis, metabolism, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in human health and disease. Further research is needed to elucidate the mechanisms underlying UGT8's functions and to explore its potential as a therapeutic target for treating various diseases.

Genular Protein ID: 1283849812

Symbol: CGT_HUMAN

Name: Ceramide UDP-galactosyltransferase

UniProtKB Accession Codes:

Q16880 B3KXU7 O00196

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661025

Title: The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26.

PubMed ID: 8661025

DOI: 10.1006/geno.1996.0242

PubMed ID: 9125199

Title: Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA.

PubMed ID: 9125199

DOI: 10.1006/bbrc.1997.6240

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 541
  • Mass: 61438
  • Checksum: 02FA965FEC8EB788
  • Sequence:
    • MKSYTPYFIL LWSAVGIAKA AKIIIVPPIM FESHMYIFKT LASALHERGH HTVFLLSEGR 
DIAPSNHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA IELFDILDHY TKNCDLMVGN 
HALIQGLKKE KFDLLLVDPN DMCGFVIAHL LGVKYAVFST GLWYPAEVGA PAPLAYVPEF 
NSLLTDRMNL LQRMKNTGVY LISRLGVSFL VLPKYERIMQ KYNLLPEKSM YDLVHGSSLW 
MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPEDLQRWV NGANEHGFVL VSFGAGVKYL 
SEDIANKLAG ALGRLPQKVI WRFSGPKPKN LGNNTKLIEW LPQNDLLGHS KIKAFLSHGG 
LNSIFETIYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WKTVTEKELY EALVKVINNP 
SYRQRAQKLS EIHKDQPGHP VNRTIYWIDY IIRHNGAHHL RAAVHQISFC QYFLLDIAFV 
LLLGAALLYF LLSWVTKFIY RKIKSLWSRN KHSTVNGHYH NGILNGKYKR NGHIKHEKKV 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.