Details for: UCK2

Gene ID: 7371

Symbol: UCK2

Ensembl ID: ENSG00000143179

Description: uridine-cytidine kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 138.4163
    Cell Significance Index: -21.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 83.9269
    Cell Significance Index: -21.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.7977
    Cell Significance Index: -23.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7922
    Cell Significance Index: -23.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6567
    Cell Significance Index: -23.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2689
    Cell Significance Index: -13.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6364
    Cell Significance Index: 324.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3358
    Cell Significance Index: 37.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2985
    Cell Significance Index: 260.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2435
    Cell Significance Index: 74.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0092
    Cell Significance Index: 109.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9825
    Cell Significance Index: 55.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9063
    Cell Significance Index: 325.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7773
    Cell Significance Index: 126.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.7648
    Cell Significance Index: 18.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7525
    Cell Significance Index: 87.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7151
    Cell Significance Index: 17.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6806
    Cell Significance Index: 19.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6492
    Cell Significance Index: 14.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5709
    Cell Significance Index: 15.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5583
    Cell Significance Index: 26.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5425
    Cell Significance Index: 13.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5147
    Cell Significance Index: 464.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5025
    Cell Significance Index: 34.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4610
    Cell Significance Index: 11.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4437
    Cell Significance Index: 16.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4282
    Cell Significance Index: 18.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4016
    Cell Significance Index: 24.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3964
    Cell Significance Index: 26.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3863
    Cell Significance Index: 17.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3755
    Cell Significance Index: 259.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3729
    Cell Significance Index: 24.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3211
    Cell Significance Index: 16.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2754
    Cell Significance Index: 21.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2627
    Cell Significance Index: 7.5300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2052
    Cell Significance Index: 2.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2026
    Cell Significance Index: 38.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1960
    Cell Significance Index: 9.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1935
    Cell Significance Index: 4.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1836
    Cell Significance Index: 23.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1795
    Cell Significance Index: 17.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1485
    Cell Significance Index: 18.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1379
    Cell Significance Index: 75.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1378
    Cell Significance Index: 24.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1295
    Cell Significance Index: 57.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1144
    Cell Significance Index: 1.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1037
    Cell Significance Index: 2.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0963
    Cell Significance Index: 16.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0655
    Cell Significance Index: 2.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0396
    Cell Significance Index: 2.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0298
    Cell Significance Index: 2.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0189
    Cell Significance Index: 12.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0144
    Cell Significance Index: 22.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0120
    Cell Significance Index: 22.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0111
    Cell Significance Index: 0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0074
    Cell Significance Index: 1.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0051
    Cell Significance Index: 6.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0048
    Cell Significance Index: 0.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0123
    Cell Significance Index: -0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0162
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0230
    Cell Significance Index: -0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0261
    Cell Significance Index: -19.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0281
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0300
    Cell Significance Index: -22.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0336
    Cell Significance Index: -18.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0410
    Cell Significance Index: -25.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0418
    Cell Significance Index: -0.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0509
    Cell Significance Index: -1.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0644
    Cell Significance Index: -7.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0688
    Cell Significance Index: -19.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0948
    Cell Significance Index: -9.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1090
    Cell Significance Index: -12.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1159
    Cell Significance Index: -24.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1329
    Cell Significance Index: -2.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1384
    Cell Significance Index: -1.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1509
    Cell Significance Index: -4.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2143
    Cell Significance Index: -13.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2146
    Cell Significance Index: -22.3500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2299
    Cell Significance Index: -3.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2374
    Cell Significance Index: -4.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2399
    Cell Significance Index: -4.2400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2670
    Cell Significance Index: -2.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2726
    Cell Significance Index: -21.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2789
    Cell Significance Index: -8.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2966
    Cell Significance Index: -4.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3015
    Cell Significance Index: -6.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3026
    Cell Significance Index: -18.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3073
    Cell Significance Index: -10.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3121
    Cell Significance Index: -9.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3145
    Cell Significance Index: -8.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3219
    Cell Significance Index: -16.9000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3392
    Cell Significance Index: -6.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3406
    Cell Significance Index: -11.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4004
    Cell Significance Index: -4.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4026
    Cell Significance Index: -7.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4222
    Cell Significance Index: -12.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4271
    Cell Significance Index: -11.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzyme specificity**: UCK2 is a cytidine kinase, which means it specifically phosphorylates cytidine and uridine nucleotides. 2. **Cytosolic localization**: UCK2 is primarily found in the cytosol of cells, where it can access its substrates and interact with other enzymes. 3. **Expression patterns**: UCK2 is expressed in a range of cell types, including neurons, germ cells, mural cells, and specific subpopulations of cortical interneurons. 4. **Substrate specificity**: UCK2 has a high affinity for cytidine and uridine nucleotides, but its activity is also influenced by the presence of other nucleotides, such as ATP and ADP. **Pathways and Functions** 1. **Nucleotide salvage pathway**: UCK2 is involved in the salvage pathway of nucleotides, where it phosphorylates cytidine and uridine nucleotides to produce their respective nucleoside monophosphates (CMP andUMP). 2. **Energy metabolism**: UCK2 plays a role in energy metabolism by phosphorylating ATP and ADP, which can influence the balance of nucleotide pools and energy production. 3. **Nucleic acid synthesis**: UCK2 is involved in the synthesis of nucleic acids, such as RNA and DNA, by providing the necessary nucleoside monophosphates. 4. **Regulation of nucleotide pools**: UCK2 helps regulate the balance of nucleotide pools within cells by controlling the availability of cytidine and uridine nucleotides. **Clinical Significance** 1. **Neurological disorders**: Mutations or dysregulation of UCK2 have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. 2. **Cancer**: UCK2 has been found to be overexpressed in certain types of cancer, including glioblastoma and breast cancer, suggesting its potential role in tumorigenesis. 3. **Nucleotide metabolism disorders**: UCK2 deficiency or dysfunction can lead to nucleotide metabolism disorders, such as those observed in patients with cytidine deaminase deficiency. 4. **Pharmacological applications**: UCK2 inhibitors have been explored as potential therapeutic agents for the treatment of neurological disorders and cancer. In conclusion, UCK2 is a critical enzyme involved in nucleotide salvage, energy metabolism, and nucleic acid synthesis. Its dysregulation or dysfunction has been implicated in various neurological and cancer disorders, highlighting the importance of understanding its role in cellular homeostasis. Further research is needed to fully elucidate the mechanisms by which UCK2 influences cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 1944007818

Symbol: UCK2_HUMAN

Name: Uridine-cytidine kinase 2

UniProtKB Accession Codes:

Q9BZX2 Q5VV91 Q7KZV3 Q92528 Q96KG5 Q9BU42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8812458

Title: Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method.

PubMed ID: 8812458

DOI: 10.1006/geno.1996.0467

PubMed ID: 11306702

Title: Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.

PubMed ID: 11306702

DOI: 10.1124/mol.59.5.1181

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11494055

Title: Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells.

PubMed ID: 11494055

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 15130468

Title: Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase.

PubMed ID: 15130468

DOI: 10.1016/j.str.2004.02.038

PubMed ID: 15735337

Title: Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative.

PubMed ID: 15735337

DOI: 10.1107/s0907444904032937

Sequence Information:

  • Length: 261
  • Mass: 29299
  • Checksum: 71791346F091EBFD
  • Sequence:
    • MAGDSEQTLQ NHQQPNGGEP FLIGVSGGTA SGKSSVCAKI VQLLGQNEVD YRQKQVVILS 
QDSFYRVLTS EQKAKALKGQ FNFDHPDAFD NELILKTLKE ITEGKTVQIP VYDFVSHSRK 
EETVTVYPAD VVLFEGILAF YSQEVRDLFQ MKLFVDTDAD TRLSRRVLRD ISERGRDLEQ 
ILSQYITFVK PAFEEFCLPT KKYADVIIPR GADNLVAINL IVQHIQDILN GGPSKRQTNG 
CLNGYTPSRK RQASESSSRP H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.