Details for: UPP1

Gene ID: 7378

Symbol: UPP1

Ensembl ID: ENSG00000183696

Description: uridine phosphorylase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.7285
    Cell Significance Index: -33.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 131.7204
    Cell Significance Index: -33.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.1863
    Cell Significance Index: -32.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.2013
    Cell Significance Index: -34.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.1396
    Cell Significance Index: -35.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.7162
    Cell Significance Index: -33.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.0488
    Cell Significance Index: -33.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2353
    Cell Significance Index: -24.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1781
    Cell Significance Index: -28.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5693
    Cell Significance Index: -33.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8342
    Cell Significance Index: -10.5800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.1556
    Cell Significance Index: 73.4400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.1654
    Cell Significance Index: 27.2000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.0646
    Cell Significance Index: 22.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.6245
    Cell Significance Index: 499.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5754
    Cell Significance Index: 47.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8002
    Cell Significance Index: 52.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6240
    Cell Significance Index: 35.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2022
    Cell Significance Index: 195.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1599
    Cell Significance Index: 33.2500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.9640
    Cell Significance Index: 5.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8736
    Cell Significance Index: 8.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7351
    Cell Significance Index: 21.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6822
    Cell Significance Index: 14.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6487
    Cell Significance Index: 7.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6360
    Cell Significance Index: 228.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5861
    Cell Significance Index: 117.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5766
    Cell Significance Index: 62.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5700
    Cell Significance Index: 34.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4869
    Cell Significance Index: 22.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3953
    Cell Significance Index: 356.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3610
    Cell Significance Index: 27.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3588
    Cell Significance Index: 9.5800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.2155
    Cell Significance Index: 0.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1819
    Cell Significance Index: 2.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1694
    Cell Significance Index: 20.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1531
    Cell Significance Index: 6.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1465
    Cell Significance Index: 26.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1183
    Cell Significance Index: 11.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1148
    Cell Significance Index: 62.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0863
    Cell Significance Index: 11.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0810
    Cell Significance Index: 4.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0623
    Cell Significance Index: 2.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0582
    Cell Significance Index: 0.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0072
    Cell Significance Index: 0.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0032
    Cell Significance Index: 2.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0032
    Cell Significance Index: -0.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0096
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0160
    Cell Significance Index: -29.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0164
    Cell Significance Index: -25.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0173
    Cell Significance Index: -23.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0177
    Cell Significance Index: -12.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0215
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0380
    Cell Significance Index: -21.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0476
    Cell Significance Index: -30.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0548
    Cell Significance Index: -24.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0550
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0669
    Cell Significance Index: -7.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0755
    Cell Significance Index: -14.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0862
    Cell Significance Index: -24.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0865
    Cell Significance Index: -11.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0878
    Cell Significance Index: -2.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1029
    Cell Significance Index: -7.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1058
    Cell Significance Index: -12.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1119
    Cell Significance Index: -23.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1209
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1274
    Cell Significance Index: -14.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1540
    Cell Significance Index: -5.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1581
    Cell Significance Index: -18.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1648
    Cell Significance Index: -23.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1653
    Cell Significance Index: -3.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2561
    Cell Significance Index: -18.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2666
    Cell Significance Index: -14.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2866
    Cell Significance Index: -3.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3184
    Cell Significance Index: -33.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3223
    Cell Significance Index: -6.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3296
    Cell Significance Index: -16.6600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3304
    Cell Significance Index: -4.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3413
    Cell Significance Index: -20.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3484
    Cell Significance Index: -8.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3565
    Cell Significance Index: -18.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3631
    Cell Significance Index: -22.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3874
    Cell Significance Index: -23.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3955
    Cell Significance Index: -31.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3967
    Cell Significance Index: -16.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4206
    Cell Significance Index: -28.2800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4239
    Cell Significance Index: -5.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5135
    Cell Significance Index: -33.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5652
    Cell Significance Index: -15.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5677
    Cell Significance Index: -3.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5920
    Cell Significance Index: -27.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5922
    Cell Significance Index: -33.2300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6925
    Cell Significance Index: -11.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6936
    Cell Significance Index: -22.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7138
    Cell Significance Index: -14.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UPP1 is a cytosolic enzyme that exhibits uridine phosphorylase activity, catalyzing the conversion of uridine into uracil. This enzyme is also involved in the degradation of deoxyuridine and thymidine, which are crucial components of nucleotide metabolism. UPP1 is highly expressed in various cell types, including fibroblasts, macrophages, and neural progenitor cells, suggesting its importance in different cellular processes. Notably, UPP1 is significantly upregulated in response to glucose starvation, highlighting its role in energy metabolism and cellular adaptation to nutrient deprivation. **Pathways and Functions:** UPP1 is intricately linked to several metabolic pathways, including: 1. **Cellular response to glucose starvation:** UPP1 is activated in response to glucose deprivation, allowing cells to adapt to energy stress by shifting towards alternative energy sources. 2. **Nucleotide catabolism:** UPP1 plays a critical role in the degradation of nucleotides, such as uridine, deoxyuridine, and thymidine, which are essential for nucleotide synthesis and salvage. 3. **Pyrimidine salvage:** UPP1 is involved in the salvage of pyrimidine bases, including uracil, which are recycled from degraded nucleotides. 4. **Immune function:** UPP1 has been implicated in immune cell activation, particularly in the regulation of macrophage function and cytokine production. **Clinical Significance:** The dysregulation of UPP1 has been linked to various diseases, including: 1. **Cancer:** UPP1 overexpression has been observed in various cancer types, including breast, lung, and prostate cancers, suggesting its potential role in tumorigenesis and cancer progression. 2. **Inflammatory diseases:** UPP1 has been implicated in the pathogenesis of inflammatory diseases, such as atherosclerosis and rheumatoid arthritis, where its activity is linked to the regulation of immune cell function and cytokine production. 3. **Neurological disorders:** UPP1 has been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to disease progression and cognitive decline. In conclusion, UPP1 is a multifunctional enzyme that plays a critical role in various metabolic pathways, including nucleotide catabolism, pyrimidine salvage, and immune function. Its dysregulation has been linked to various diseases, highlighting the need for further research into the mechanisms underlying UPP1's functions and its potential therapeutic applications.

Genular Protein ID: 1817487239

Symbol: UPP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16831 D3DVM4 Q15362

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 8 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 Rhea 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7488099

Title: Cloning and expression of human uridine phosphorylase.

PubMed ID: 7488099

DOI: 10.1006/bbrc.1995.2619

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 13737038

Title: Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor.

PubMed ID: 13737038

DOI: 10.1016/0006-3002(61)91024-1

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 19291308

Title: Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.

PubMed ID: 19291308

DOI: 10.1186/1472-6807-9-14

PubMed ID: 20856879

Title: Active site conformational dynamics in human uridine phosphorylase 1.

PubMed ID: 20856879

DOI: 10.1371/journal.pone.0012741

Sequence Information:

  • Length: 310
  • Mass: 33934
  • Checksum: 110CF678561E53F3
  • Sequence:
    • MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG 
SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV GPVLSVSHGM GIPSISIMLH 
ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG TVVITEQAVD TCFKAEFEQI VLGKRVIRKT 
DLNKKLVQEL LLCSAELSEF TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY 
AAGVRNIEME SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS 
YFIKKKLSKA

Genular Protein ID: 770645285

Symbol: Q86Y75_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86Y75

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 3 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 173
  • Mass: 19233
  • Checksum: F0A472E33AB71897
  • Sequence:
    • MQRKLKVTSL EPGTVVITEQ AVDTCFKAEF EQIVLGKRVI RKTDLNKKLV QELLLCSAEL 
SEFTTVVGNT MCTLDFYEGQ GRLDGALCSY TEKDKQAYLE AAYAAGVRNI EMESSVFAAM 
CSACGLQAAV VCVTLLNRLE GDQISSPRNV LSEYQQRPQR LVSYFIKKKL SKA

Genular Protein ID: 2156153648

Symbol: B4DND0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DND0

Database IDs:

ARBA 3 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 171
  • Mass: 18751
  • Checksum: 7550E779BD9A8B41
  • Sequence:
    • MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG 
SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV GPVLSVSHGM GIPSISIMLH 
ELIKLLYYAR CSNVTIIRIG TSGGIGILKH LRRKDTGKSK GGRERRSTKL R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.