Details for: UPK3A

Gene ID: 7380

Symbol: UPK3A

Ensembl ID: ENSG00000100373

Description: uroplakin 3A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 15.7993
    Cell Significance Index: -2.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.8169
    Cell Significance Index: -2.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.5660
    Cell Significance Index: 88.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 9.4381
    Cell Significance Index: 490.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 5.1712
    Cell Significance Index: -2.6600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.9392
    Cell Significance Index: 57.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 4.7716
    Cell Significance Index: 49.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.9952
    Cell Significance Index: -2.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.0736
    Cell Significance Index: 11.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8790
    Cell Significance Index: 167.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7595
    Cell Significance Index: 11.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6286
    Cell Significance Index: 62.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6132
    Cell Significance Index: 13.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5528
    Cell Significance Index: 41.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5481
    Cell Significance Index: 98.8000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.5268
    Cell Significance Index: 3.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4877
    Cell Significance Index: 440.3600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4849
    Cell Significance Index: 7.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4704
    Cell Significance Index: 57.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3689
    Cell Significance Index: 40.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3360
    Cell Significance Index: 54.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3190
    Cell Significance Index: 19.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2232
    Cell Significance Index: 5.9700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2117
    Cell Significance Index: 1.3100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1999
    Cell Significance Index: 4.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1896
    Cell Significance Index: 13.1100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1820
    Cell Significance Index: 1.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1727
    Cell Significance Index: 34.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.1520
    Cell Significance Index: 1.6200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1478
    Cell Significance Index: 0.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0751
    Cell Significance Index: 1.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0643
    Cell Significance Index: 1.7500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0439
    Cell Significance Index: 0.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0360
    Cell Significance Index: 1.6300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0228
    Cell Significance Index: 0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0182
    Cell Significance Index: 0.9500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0166
    Cell Significance Index: 0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0142
    Cell Significance Index: 0.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0139
    Cell Significance Index: 0.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0100
    Cell Significance Index: 0.1500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0061
    Cell Significance Index: 0.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0054
    Cell Significance Index: 0.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0048
    Cell Significance Index: 0.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0008
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0008
    Cell Significance Index: -0.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0009
    Cell Significance Index: -0.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0023
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0031
    Cell Significance Index: -1.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.1900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0040
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0060
    Cell Significance Index: -0.2800
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0108
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0111
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0111
    Cell Significance Index: -1.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0130
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0146
    Cell Significance Index: -1.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0149
    Cell Significance Index: -1.5200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0151
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0151
    Cell Significance Index: -2.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0176
    Cell Significance Index: -0.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0177
    Cell Significance Index: -1.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0184
    Cell Significance Index: -2.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0205
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0220
    Cell Significance Index: -2.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0222
    Cell Significance Index: -1.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0234
    Cell Significance Index: -2.4400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0237
    Cell Significance Index: -0.3000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0256
    Cell Significance Index: -0.3100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0261
    Cell Significance Index: -0.3300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0281
    Cell Significance Index: -0.3600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0293
    Cell Significance Index: -0.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0319
    Cell Significance Index: -0.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0326
    Cell Significance Index: -2.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0355
    Cell Significance Index: -2.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0379
    Cell Significance Index: -2.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0393
    Cell Significance Index: -0.9600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0420
    Cell Significance Index: -0.3400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0424
    Cell Significance Index: -0.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0434
    Cell Significance Index: -1.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0454
    Cell Significance Index: -2.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0466
    Cell Significance Index: -2.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0489
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0529
    Cell Significance Index: -1.0400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0544
    Cell Significance Index: -1.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0549
    Cell Significance Index: -1.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0550
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UPK3A is a member of the uroplakin family of proteins, which are characterized by their ability to bind to the apical plasma membrane of epithelial cells. The protein is predominantly expressed in urothelial cells of the urinary bladder and is involved in maintaining the integrity of the bladder lining. UPK3A has been shown to interact with various cellular proteins, including keratins and spectrins, to regulate cell-cell adhesion and cytoskeletal dynamics. Moreover, UPK3A has been implicated in the regulation of ion homeostasis, including potassium and sodium ion transport, and the maintenance of cellular water balance. **Pathways and Functions:** The molecular pathways and functions of UPK3A are multifaceted and involve various cellular processes. These include: 1. **Apical Plasma Membrane Urothelial Plaque Formation**: UPK3A plays a critical role in the formation and maintenance of urothelial plaques, which are essential for maintaining the integrity of the bladder lining. 2. **Cell Morphogenesis**: UPK3A is involved in regulating cell shape and morphology, particularly in the context of epithelial cell differentiation and development. 3. **Endoplasmic Reticulum Membrane Association**: UPK3A interacts with the endoplasmic reticulum membrane, regulating protein synthesis and secretion. 4. **Extracellular Exosome Function**: UPK3A is released into the extracellular environment as an exosome, where it may participate in intercellular communication and tissue repair. 5. **Ion Homeostasis**: UPK3A regulates ion transport across the plasma membrane, maintaining potassium and sodium ion balance and cellular water homeostasis. **Clinical Significance:** The dysregulation of UPK3A has been implicated in various diseases, including: 1. **Bladder Cancer**: Alterations in UPK3A expression have been observed in bladder cancer, where it may contribute to tumorigenesis and metastasis. 2. **Kidney Disease**: UPK3A has been implicated in the pathogenesis of kidney disease, including diabetic nephropathy and chronic kidney disease. 3. **Prostate Cancer**: UPK3A expression has been altered in prostate cancer, where it may contribute to tumor progression and metastasis. In conclusion, UPK3A is a multifunctional protein that plays a critical role in maintaining the integrity and function of various epithelial tissues. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying UPK3A function and its clinical significance.

Genular Protein ID: 286710624

Symbol: UPK3A_HUMAN

Name: Uroplakin-3a

UniProtKB Accession Codes:

O75631 B0QY25 O60261 Q32N05 Q5TII6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9818021

Title: Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma.

PubMed ID: 9818021

DOI: 10.1111/j.1349-7006.1998.tb00643.x

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9846985

Title: Uroplakin gene expression by normal and neoplastic human urothelium.

PubMed ID: 9846985

DOI: 10.1016/s0002-9440(10)65709-4

PubMed ID: 15888565

Title: De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure.

PubMed ID: 15888565

DOI: 10.1681/asn.2004090776

PubMed ID: 16731295

Title: Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans.

PubMed ID: 16731295

DOI: 10.1053/j.ajkd.2006.02.177

Sequence Information:

  • Length: 287
  • Mass: 30670
  • Checksum: 2A14B21746FDBD25
  • Sequence:
    • MPPLWALLAL GCLRFGSAVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD SKEALTGTHE 
VYLYVLVDSA ISRNASVQDS TNTPLGSTFL QTEGGRTGPY KAVAFDLIPC SDLPSLDAIG 
DVSKASQILN AYLVRVGANG TCLWDPNFQG LCNAPLSAAT EYRFKYVLVN MSTGLVEDQT 
LWSDPIRTNQ LTPYSTIDTW PGRRSGGMIV ITSILGSLPF FLLVGFAGAI ALSLVDMGSS 
DGETTHDSQI TQEAVPKSLG ASESSYTSVN RGPPLDRAEV YSSKLQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.