Details for: VARS1

Gene ID: 7407

Symbol: VARS1

Ensembl ID: ENSG00000204394

Description: valyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.9843
    Cell Significance Index: -13.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.8416
    Cell Significance Index: -14.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.9378
    Cell Significance Index: -16.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.1108
    Cell Significance Index: -20.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.2402
    Cell Significance Index: -16.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3014
    Cell Significance Index: -16.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 9.9308
    Cell Significance Index: 247.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3170
    Cell Significance Index: -17.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9563
    Cell Significance Index: -9.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.3486
    Cell Significance Index: 37.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2252
    Cell Significance Index: -4.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9516
    Cell Significance Index: 134.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2209
    Cell Significance Index: 132.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0681
    Cell Significance Index: 173.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9396
    Cell Significance Index: 12.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7354
    Cell Significance Index: 38.2000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5593
    Cell Significance Index: 7.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5225
    Cell Significance Index: 5.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5014
    Cell Significance Index: 14.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4782
    Cell Significance Index: 10.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4057
    Cell Significance Index: 26.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3816
    Cell Significance Index: 75.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3594
    Cell Significance Index: 16.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3221
    Cell Significance Index: 175.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3165
    Cell Significance Index: 63.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3126
    Cell Significance Index: 4.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3011
    Cell Significance Index: 57.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2902
    Cell Significance Index: 8.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2360
    Cell Significance Index: 42.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2251
    Cell Significance Index: 22.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2209
    Cell Significance Index: 15.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2116
    Cell Significance Index: 93.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2056
    Cell Significance Index: 35.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2003
    Cell Significance Index: 138.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1937
    Cell Significance Index: 4.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1857
    Cell Significance Index: 8.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1599
    Cell Significance Index: 10.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1461
    Cell Significance Index: 20.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1402
    Cell Significance Index: 6.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1401
    Cell Significance Index: 18.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1359
    Cell Significance Index: 48.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1329
    Cell Significance Index: 16.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1324
    Cell Significance Index: 4.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1110
    Cell Significance Index: 5.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0683
    Cell Significance Index: 61.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0585
    Cell Significance Index: 2.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0446
    Cell Significance Index: 0.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0437
    Cell Significance Index: 3.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0435
    Cell Significance Index: 5.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0381
    Cell Significance Index: 4.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0342
    Cell Significance Index: 3.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0123
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0024
    Cell Significance Index: 4.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0013
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0010
    Cell Significance Index: -0.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0014
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0095
    Cell Significance Index: -14.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0265
    Cell Significance Index: -0.9200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0268
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0295
    Cell Significance Index: -16.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0312
    Cell Significance Index: -14.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0319
    Cell Significance Index: -4.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0375
    Cell Significance Index: -23.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0390
    Cell Significance Index: -3.9800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0508
    Cell Significance Index: -0.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0568
    Cell Significance Index: -1.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0623
    Cell Significance Index: -17.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0687
    Cell Significance Index: -0.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0776
    Cell Significance Index: -0.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0822
    Cell Significance Index: -1.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0961
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1024
    Cell Significance Index: -21.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1050
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1085
    Cell Significance Index: -3.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1139
    Cell Significance Index: -6.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1157
    Cell Significance Index: -8.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1313
    Cell Significance Index: -3.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1532
    Cell Significance Index: -15.9600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1641
    Cell Significance Index: -0.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1653
    Cell Significance Index: -4.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1770
    Cell Significance Index: -10.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1804
    Cell Significance Index: -7.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1977
    Cell Significance Index: -10.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2040
    Cell Significance Index: -5.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2080
    Cell Significance Index: -16.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2321
    Cell Significance Index: -1.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2581
    Cell Significance Index: -11.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2914
    Cell Significance Index: -10.2100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2937
    Cell Significance Index: -4.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3001
    Cell Significance Index: -8.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3028
    Cell Significance Index: -3.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3053
    Cell Significance Index: -11.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3185
    Cell Significance Index: -10.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3386
    Cell Significance Index: -11.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Valyl-tRNA synthetase 1 (VARS1) is a cytosolic enzyme that catalyzes the aminoacylation of valine to its corresponding tRNA molecule. This process involves the attachment of the amino acid valine to the 5'-end of the tRNA molecule, forming a covalent bond. VARS1 is a member of the class II aminoacyl-tRNA synthetases, which are responsible for the accurate incorporation of amino acids into proteins. **Pathways and Functions:** VARS1 is involved in several key pathways, including: 1. **Aminoacyl-tRNA editing activity:** VARS1 plays a crucial role in the editing of aminoacyl-tRNA molecules, ensuring that the correct amino acid is incorporated into proteins. 2. **Aminoacyl-tRNA metabolism involved in translational fidelity:** VARS1 is essential for the accurate incorporation of amino acids into proteins, ensuring that the translation process is faithful to the genetic code. 3. **ATP binding:** VARS1 utilizes ATP as an energy source to drive the aminoacylation reaction. 4. **Protein binding:** VARS1 interacts with various proteins, including tRNA molecules, amino acids, and other enzymes, to facilitate the aminoacylation reaction. **Clinical Significance:** Abnormalities in VARS1 have been implicated in various diseases, including: 1. **Cancer:** Mutations in VARS1 have been found in several types of cancer, including colorectal cancer and leukemia. 2. **Immunological disorders:** VARS1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where aberrant protein synthesis can lead to immune system dysfunction. 3. **Neurological disorders:** Abnormalities in VARS1 have been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease, where protein misfolding and aggregation can lead to disease progression. In conclusion, the VARS1 gene plays a critical role in aminoacyl-tRNA metabolism and protein synthesis. Abnormalities in VARS1 have been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which VARS1 contributes to disease and to develop therapeutic strategies to target this gene in the treatment of various diseases.

Genular Protein ID: 1156530065

Symbol: SYVC_HUMAN

Name: Protein G7a

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1898367

Title: Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase.

PubMed ID: 1898367

DOI: 10.1042/bj2780809

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8428657

Title: Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.

PubMed ID: 8428657

DOI: 10.1016/0378-1119(93)90122-j

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26539891

Title: Genes that affect brain structure and function identified by rare variant analyses of mendelian neurologic disease.

PubMed ID: 26539891

DOI: 10.1016/j.neuron.2015.09.048

Sequence Information:

  • Length: 1264
  • Mass: 140476
  • Checksum: 95CCDDBB3AB148AD
  • Sequence:
  • MSTLYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRT PFPPPRLPAL 
    EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG 
    LRSSAQDPQA VLGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPPA 
    RRIWNNVTRW FVTCVRQPEF RAVLGEVVLY SGARPLSHQP GPEAPALPKT AAQLKKEAKK 
    REKLEKFQQK QKIQQQQPPP GEKKPKPEKR EKRDPGVITY DLPTPPGEKK DVSGPMPDSY 
    SPRYVEAAWY PWWEQQGFFK PEYGRPNVSA ANPRGVFMMC IPPPNVTGSL HLGHALTNAI 
    QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWREQ GLSRHQLGRE AFLQEVWKWK 
    EEKGDRIYHQ LKKLGSSLDW DRACFTMDPK LSAAVTEAFV RLHEEGIIYR STRLVNWSCT 
    LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KVQGSDSDEE VVVATTRIET 
    MLGDVAVAVH PKDTRYQHLK GKNVIHPFLS RSLPIVFDEF VDMDFGTGAV KITPAHDQND 
    YEVGQRHGLE AISIMDSRGA LINVPPPFLG LPRFEARKAV LVALKERGLF RGIEDNPMVV 
    PLCNRSKDVV EPLLRPQWYV RCGEMAQAAS AAVTRGDLRI LPEAHQRTWH AWMDNIREWC 
    ISRQLWWGHR IPAYFVTVSD PAVPPGEDPD GRYWVSGRNE AEAREKAAKE FGVSPDKISL 
    QQDEDVLDTW FSSGLFPLSI LGWPNQSEDL SVFYPGTLLE TGHDILFFWV ARMVMLGLKL 
    TGRLPFREVY LHAIVRDAHG RKMSKSLGNV IDPLDVIYGI SLQGLHNQLL NSNLDPSEVE 
    KAKEGQKADF PAGIPECGTD ALRFGLCAYM SQGRDINLDV NRILGYRHFC NKLWNATKFA 
    LRGLGKGFVP SPTSQPGGHE SLVDRWIRSR LTEAVRLSNQ GFQAYDFPAV TTAQYSFWLY 
    ELCDVYLECL KPVLNGVDQV AAECARQTLY TCLDVGLRLL SPFMPFVTEE LFQRLPRRMP 
    QAPPSLCVTP YPEPSECSWK DPEAEAALEL ALSITRAVRS LRADYNLTRI RPDCFLEVAD 
    EATGALASAV SGYVQALASA GVVAVLALGA PAPQGCAVAL ASDRCSIHLQ LQGLVDPARE 
    LGKLQAKRVE AQRQAQRLRE RRAASGYPVK VPLEVQEADE AKLQQTEAEL RKVDEAIALF 
    QKML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.