VDR | ENSG00000111424 | NCBI 7421

Details for: VDR

Gene ID: 7421

Symbol: VDR

Ensembl ID: ENSG00000111424

Description: vitamin D receptor

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroids
(R-HSA-8957322)
Nuclear receptor transcription pathway
(R-HSA-383280)
Post-translational protein modification
(R-HSA-597592)
Rna polymerase ii transcription
(R-HSA-73857)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Vitamin d (calciferol) metabolism
(R-HSA-196791)
Apoptotic process involved in mammary gland involution
(GO:0060057)
Bile acid nuclear receptor activity
(GO:0038186)
Calcitriol binding
(GO:1902098)
Calcium ion transport
(GO:0006816)
Cell differentiation
(GO:0030154)
Cell morphogenesis
(GO:0000902)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Decidualization
(GO:0046697)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Intestinal absorption
(GO:0050892)
Intracellular calcium ion homeostasis
(GO:0006874)
Lactation
(GO:0007595)
Lithocholic acid binding
(GO:1902121)
Mammary gland branching involved in pregnancy
(GO:0060745)
Mrna transcription by rna polymerase ii
(GO:0042789)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear receptor-mediated bile acid signaling pathway
(GO:0038185)
Nuclear receptor activity
(GO:0004879)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphate ion transmembrane transport
(GO:0035435)
Positive regulation of apoptotic process involved in mammary gland involution
(GO:0060058)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vitamin d 24-hydroxylase activity
(GO:0010980)
Positive regulation of vitamin d receptor signaling pathway
(GO:0070564)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of calcidiol 1-monooxygenase activity
(GO:0060558)
Response to bile acid
(GO:1903412)
Retinoic acid receptor signaling pathway
(GO:0048384)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Skeletal system development
(GO:0001501)
Vitamin d receptor signaling pathway
(GO:0070561)
Vitamin d response element binding
(GO:0070644)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 52.2678
Cell Significance Index: -8.1300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 32.1317
Cell Significance Index: -8.1500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 20.1596
Cell Significance Index: -8.1900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 12.4884
Cell Significance Index: -8.3800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.5939
Cell Significance Index: -8.1300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.3970
Cell Significance Index: -9.1000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.2231
Cell Significance Index: 86.3700
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 3.0800
Cell Significance Index: 3.9900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.0252
Cell Significance Index: 209.2100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.8299
Cell Significance Index: 81.5400
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 2.1650
Cell Significance Index: 21.8400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 2.1540
Cell Significance Index: 32.4600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.1083
Cell Significance Index: 95.5600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.0755
Cell Significance Index: -8.1900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.0241
Cell Significance Index: -4.4300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5673
Cell Significance Index: 254.9100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4268
Cell Significance Index: 155.1900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.1109
Cell Significance Index: 27.7700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0994
Cell Significance Index: 15.0000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.9967
Cell Significance Index: 20.6800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9910
Cell Significance Index: 21.4700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.9490
Cell Significance Index: 20.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.8405
Cell Significance Index: 23.4900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8252
Cell Significance Index: 58.3600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7427
Cell Significance Index: 38.5800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.7154
Cell Significance Index: 10.7200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6916
Cell Significance Index: 305.8000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6589
Cell Significance Index: 594.9200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5019
Cell Significance Index: 95.5200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4328
Cell Significance Index: 20.3400
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.3859
Cell Significance Index: 0.8700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3581
Cell Significance Index: 41.7300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3074
Cell Significance Index: 10.8000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2732
Cell Significance Index: 8.7500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2441
Cell Significance Index: 27.8600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2425
Cell Significance Index: 6.6000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2217
Cell Significance Index: 39.9700
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.2027
Cell Significance Index: 1.1900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1808
Cell Significance Index: 22.2400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1769
Cell Significance Index: 22.6800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1712
Cell Significance Index: 16.9400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1679
Cell Significance Index: 33.3300
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1624
Cell Significance Index: 20.9800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1088
Cell Significance Index: 2.0100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1053
Cell Significance Index: 0.9700
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.0890
Cell Significance Index: 0.5800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0820
Cell Significance Index: 44.7900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0573
Cell Significance Index: 4.2700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.0439
Cell Significance Index: 0.6300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0265
Cell Significance Index: 4.5300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0054
Cell Significance Index: 0.1600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0051
Cell Significance Index: 3.8900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0034
Cell Significance Index: 0.0400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0012
Cell Significance Index: 0.8500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0010
Cell Significance Index: 0.2100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0009
Cell Significance Index: 0.6100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0014
Cell Significance Index: -1.0500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0015
Cell Significance Index: -2.8800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0019
Cell Significance Index: -1.1900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0024
Cell Significance Index: -4.3700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0040
Cell Significance Index: -6.2100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0049
Cell Significance Index: -0.2300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0050
Cell Significance Index: -2.8200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0055
Cell Significance Index: -7.4400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0069
Cell Significance Index: -0.8100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0099
Cell Significance Index: -6.2700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0105
Cell Significance Index: -1.0700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0110
Cell Significance Index: -3.9600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0123
Cell Significance Index: -2.6000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0173
Cell Significance Index: -7.8400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0179
Cell Significance Index: -5.1400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0343
Cell Significance Index: -4.9800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0374
Cell Significance Index: -4.2900
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0406
Cell Significance Index: -0.3100
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.0407
Cell Significance Index: -0.3500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0429
Cell Significance Index: -1.2300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0583
Cell Significance Index: -8.0000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0594
Cell Significance Index: -0.8500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0732
Cell Significance Index: -4.4900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0735
Cell Significance Index: -5.8200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0758
Cell Significance Index: -7.9000
Cell Name: enterocyte (CL0000584)
Fold Change: -0.0919
Cell Significance Index: -0.5700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0980
Cell Significance Index: -7.5200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0994
Cell Significance Index: -5.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1045
Cell Significance Index: -6.7400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1172
Cell Significance Index: -7.8800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1196
Cell Significance Index: -2.0500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1211
Cell Significance Index: -4.4500
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1263
Cell Significance Index: -1.0300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1323
Cell Significance Index: -8.3400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1373
Cell Significance Index: -8.4400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1496
Cell Significance Index: -7.8000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1552
Cell Significance Index: -8.7100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1566
Cell Significance Index: -4.1900
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1599
Cell Significance Index: -3.1200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1635
Cell Significance Index: -7.2300
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.1657
Cell Significance Index: -1.0200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1665
Cell Significance Index: -8.7400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1671
Cell Significance Index: -7.2700
Cell Name: precursor cell (CL0011115)
Fold Change: -0.1681
Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structure:** VDR is a member of the nuclear receptor superfamily, consisting of four cysteine-rich domains (A, B, C, and D) that facilitate ligand binding and DNA recognition. 2. **Ligand Binding:** VDR is activated by the hydroxylated metabolites of vitamin D, including 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3). 3. **DNA Binding:** VDR binds to specific DNA sequences, known as vitamin D response elements (VDREs), which are located in the promoter regions of target genes. 4. **Transcriptional Regulation:** VDR modulates the expression of target genes by recruiting coactivators and corepressors, which influence chromatin structure and transcriptional activity. **Pathways and Functions:** 1. **Calcium Homeostasis:** VDR regulates the expression of genes involved in calcium homeostasis, including calcium-sensing receptors, parathyroid hormone receptors, and calbindin. 2. **Immune Function:** VDR modulates the expression of genes involved in immune responses, including cytokines, chemokines, and antimicrobial peptides. 3. **Cell Differentiation:** VDR regulates the expression of genes involved in cell differentiation, including those involved in bone formation, adipogenesis, and keratinocyte differentiation. 4. **Apoptosis:** VDR modulates the expression of genes involved in apoptosis, including those involved in the regulation of pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** Dysregulation of VDR has been implicated in various diseases, including: 1. **Autoimmune Disorders:** VDR has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Cancer:** VDR has been shown to have both tumor-suppressive and tumor-promoting effects, depending on the context. 3. **Osteoporosis:** VDR has been implicated in the regulation of bone mineral density and osteoblast function, making it a potential target for the treatment of osteoporosis. 4. **Infectious Diseases:** VDR has been shown to have antimicrobial effects, making it a potential target for the treatment of infectious diseases. In conclusion, the Vitamin D Receptor is a critical regulator of gene expression and immune function, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which VDR regulates gene expression and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Vitamin D3 receptor

Genular Protein ID: 1673468528

Symbol: VDR_HUMAN

Name: Vitamin D3 receptor

UniProtKB Accession Codes:

P11473 B2R5Q1 G3V1V9 Q5PSV3

Database IDs:

Citations:

PubMed ID: 2835767

Title: Cloning and expression of full-length cDNA encoding human vitamin D receptor.

PubMed ID: 2835767

DOI: 10.1073/pnas.85.10.3294

PubMed ID: 1324736

Title: A single receptor identical with that from intestine/T47D cells mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells.

PubMed ID: 1324736

DOI: 10.1016/0167-4781(92)90063-6

PubMed ID: 9212063

Title: Structural organization of the human vitamin D receptor chromosomal gene and its promoter.

PubMed ID: 9212063

DOI: 10.1210/mend.11.8.9951

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1850412

Title: Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing.

PubMed ID: 1850412

DOI: 10.1016/s0021-9258(20)89488-5

PubMed ID: 16252240

Title: Promoter and 3'-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study.

PubMed ID: 16252240

DOI: 10.1086/497438

PubMed ID: 9267036

Title: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

PubMed ID: 9267036

DOI: 10.1016/s0092-8674(00)80516-4

PubMed ID: 9632709

Title: Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription.

PubMed ID: 9632709

DOI: 10.1074/jbc.273.26.16434

PubMed ID: 10866662

Title: A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.

PubMed ID: 10866662

DOI: 10.1128/mcb.20.14.5048-5063.2000

PubMed ID: 12145331

Title: Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor.

PubMed ID: 12145331

DOI: 10.1210/me.2001-0345

PubMed ID: 12016314

Title: Vitamin D receptor as an intestinal bile acid sensor.

PubMed ID: 12016314

DOI: 10.1126/science.1070477

PubMed ID: 16252006

Title: Ligand-induced transrepression by VDR through association of WSTF with acetylated histones.

PubMed ID: 16252006

DOI: 10.1038/sj.emboj.7600853

PubMed ID: 25452584

Title: Retraction: 'Ligand-induced transrepression by VDR through association of WSTF with acetylated histones'.

PubMed ID: 25452584

DOI: 10.15252/embj.201470110

PubMed ID: 16207705

Title: Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor.

PubMed ID: 16207705

DOI: 10.1074/jbc.m509347200

PubMed ID: 22323358

Title: IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.

PubMed ID: 22323358

DOI: 10.1093/hmg/dds025

PubMed ID: 30468856

Title: Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways.

PubMed ID: 30468856

DOI: 10.1016/j.jsbmb.2018.11.008

PubMed ID: 32354638

Title: Lithocholic acid increases intestinal phosphate and calcium absorption in a vitamin D receptor dependent but transcellular pathway independent manner.

PubMed ID: 32354638

DOI: 10.1016/j.kint.2020.01.032

PubMed ID: 37478846

Title: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

PubMed ID: 37478846

DOI: 10.1016/j.molcel.2023.06.028

PubMed ID: 10678179

Title: The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.

PubMed ID: 10678179

DOI: 10.1016/s1097-2765(00)80413-x

PubMed ID: 11344298

Title: Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands.

PubMed ID: 11344298

DOI: 10.1073/pnas.091018698

PubMed ID: 11980721

Title: Structural basis of VDR-DNA interactions on direct repeat response elements.

PubMed ID: 11980721

DOI: 10.1093/emboj/21.9.2242

PubMed ID: 15055995

Title: Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification.

PubMed ID: 15055995

DOI: 10.1021/jm0310582

PubMed ID: 15225774

Title: Structural analysis of RXR-VDR interactions on DR3 DNA.

PubMed ID: 15225774

DOI: 10.1016/j.jsbmb.2004.03.084

PubMed ID: 15728261

Title: Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.

PubMed ID: 15728261

DOI: 10.1124/mol.104.008730

PubMed ID: 16913708

Title: Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues.

PubMed ID: 16913708

DOI: 10.1021/jm0604070

PubMed ID: 2849209

Title: Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets.

PubMed ID: 2849209

DOI: 10.1126/science.2849209

PubMed ID: 8381803

Title: A new point mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor in a kindred with hereditary 1,25-dihydroxyvitamin D-resistant rickets.

PubMed ID: 8381803

DOI: 10.1210/jcem.76.2.8381803

PubMed ID: 1652893

Title: A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection.

PubMed ID: 1652893

PubMed ID: 2177843

Title: A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3.

PubMed ID: 2177843

DOI: 10.1210/mend-4-4-623

PubMed ID: 8106618

Title: Hereditary 1 alpha,25-dihydroxyvitamin D-resistant rickets resulting from a mutation in the vitamin D receptor deoxyribonucleic acid-binding domain.

PubMed ID: 8106618

DOI: 10.1210/jcem.78.2.8106618

PubMed ID: 8392085

Title: Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3.

PubMed ID: 8392085

DOI: 10.1172/jci116539

PubMed ID: 7828346

Title: Two mutations causing vitamin D resistant rickets: modelling on the basis of steroid hormone receptor DNA-binding domain crystal structures.

PubMed ID: 7828346

DOI: 10.1111/j.1365-2265.1994.tb01822.x

PubMed ID: 8675579

Title: A novel mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets.

PubMed ID: 8675579

DOI: 10.1210/jcem.81.7.8675579

PubMed ID: 8961271

Title: Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D(3): point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner.

PubMed ID: 8961271

DOI: 10.1210/mend.10.12.8961271

PubMed ID: 9005998

Title: Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness.

PubMed ID: 9005998

DOI: 10.1172/jci119158

PubMed ID: 15032981

Title: Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis.

PubMed ID: 15032981

DOI: 10.1111/j..2004.00183.x

PubMed ID: 17970811

Title: A novel mutation in the VDR gene in hereditary vitamin D-resistant rickets.

PubMed ID: 17970811

DOI: 10.1111/j.1365-2133.2007.08232.x

PubMed ID: 28698609

Title: Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.

PubMed ID: 28698609

DOI: 10.1038/s41598-017-05081-x

Sequence Information:

Length: 427
Mass: 48289
Checksum: F95F300D042C4CB7
Sequence:

MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC 
PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL 
RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG 
DSSSSCSDHC ITSSDMMDSS SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK 
VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV 
TKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDAA LIEAIQDRLS 
NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ YRCLSFQPEC SMKLTPLVLE 
VFGNEIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: VDR

Associated with

Cells (max top 100)

Other Information

Cloning and expression of full-length cDNA encoding human vitamin D receptor. PubMed ID: 2835767

A single receptor identical with that from intestine/T47D cells mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells. PubMed ID: 1324736

Structural organization of the human vitamin D receptor chromosomal gene and its promoter. PubMed ID: 9212063

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing. PubMed ID: 1850412

Promoter and 3'-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study. PubMed ID: 16252240

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. PubMed ID: 9267036

Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription. PubMed ID: 9632709

A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP. PubMed ID: 10866662

Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor. PubMed ID: 12145331

Vitamin D receptor as an intestinal bile acid sensor. PubMed ID: 12016314

Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. PubMed ID: 16252006

Retraction: 'Ligand-induced transrepression by VDR through association of WSTF with acetylated histones'. PubMed ID: 25452584

Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. PubMed ID: 16207705

IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. PubMed ID: 22323358

Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways. PubMed ID: 30468856

Lithocholic acid increases intestinal phosphate and calcium absorption in a vitamin D receptor dependent but transcellular pathway independent manner. PubMed ID: 32354638

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. PubMed ID: 37478846

The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. PubMed ID: 10678179

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands. PubMed ID: 11344298

Structural basis of VDR-DNA interactions on direct repeat response elements. PubMed ID: 11980721

Structural analysis of RXR-VDR interactions on DR3 DNA. PubMed ID: 15225774

Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction. PubMed ID: 15728261

Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues. PubMed ID: 16913708

Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. PubMed ID: 2849209

A new point mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor in a kindred with hereditary 1,25-dihydroxyvitamin D-resistant rickets. PubMed ID: 8381803

A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection. PubMed ID: 1652893

A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3. PubMed ID: 2177843

Hereditary 1 alpha,25-dihydroxyvitamin D-resistant rickets resulting from a mutation in the vitamin D receptor deoxyribonucleic acid-binding domain. PubMed ID: 8106618

Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3. PubMed ID: 8392085

Two mutations causing vitamin D resistant rickets: modelling on the basis of steroid hormone receptor DNA-binding domain crystal structures. PubMed ID: 7828346

A novel mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets. PubMed ID: 8675579

Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D(3): point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner. PubMed ID: 8961271

Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness. PubMed ID: 9005998

Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis. PubMed ID: 15032981

A novel mutation in the VDR gene in hereditary vitamin D-resistant rickets. PubMed ID: 17970811

Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. PubMed ID: 28698609