Details for: VRK2

Gene ID: 7444

Symbol: VRK2

Ensembl ID: ENSG00000028116

Description: VRK serine/threonine kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.2129
    Cell Significance Index: -21.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.0080
    Cell Significance Index: -25.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.3475
    Cell Significance Index: -24.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.0903
    Cell Significance Index: -28.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.1467
    Cell Significance Index: -22.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.8179
    Cell Significance Index: -26.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.4177
    Cell Significance Index: -27.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1853
    Cell Significance Index: -24.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4014
    Cell Significance Index: -25.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9506
    Cell Significance Index: -24.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2059
    Cell Significance Index: -28.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.5835
    Cell Significance Index: 491.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7073
    Cell Significance Index: 338.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4874
    Cell Significance Index: 29.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4329
    Cell Significance Index: 109.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3391
    Cell Significance Index: 132.4700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.3384
    Cell Significance Index: 19.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9150
    Cell Significance Index: 25.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6893
    Cell Significance Index: 112.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6751
    Cell Significance Index: 14.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6702
    Cell Significance Index: 17.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6533
    Cell Significance Index: 17.5100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6523
    Cell Significance Index: 5.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6266
    Cell Significance Index: 35.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6142
    Cell Significance Index: 8.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5842
    Cell Significance Index: 35.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4352
    Cell Significance Index: 10.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4284
    Cell Significance Index: 49.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3626
    Cell Significance Index: 9.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3474
    Cell Significance Index: 17.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3472
    Cell Significance Index: 62.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3297
    Cell Significance Index: 228.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2603
    Cell Significance Index: 32.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2500
    Cell Significance Index: 11.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2365
    Cell Significance Index: 10.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2036
    Cell Significance Index: 4.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1664
    Cell Significance Index: 19.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1571
    Cell Significance Index: 69.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1365
    Cell Significance Index: 210.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1187
    Cell Significance Index: 64.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1161
    Cell Significance Index: 214.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1103
    Cell Significance Index: 7.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1030
    Cell Significance Index: 65.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1001
    Cell Significance Index: 188.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0950
    Cell Significance Index: 4.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0895
    Cell Significance Index: 4.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0834
    Cell Significance Index: 4.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0805
    Cell Significance Index: 36.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0766
    Cell Significance Index: 104.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0753
    Cell Significance Index: 12.8500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0486
    Cell Significance Index: 0.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0405
    Cell Significance Index: 5.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0251
    Cell Significance Index: 0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0204
    Cell Significance Index: 2.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0140
    Cell Significance Index: 2.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0177
    Cell Significance Index: -6.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0229
    Cell Significance Index: -16.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0278
    Cell Significance Index: -20.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0309
    Cell Significance Index: -23.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0414
    Cell Significance Index: -2.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0442
    Cell Significance Index: -24.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0485
    Cell Significance Index: -30.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0500
    Cell Significance Index: -1.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0531
    Cell Significance Index: -5.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0653
    Cell Significance Index: -8.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0731
    Cell Significance Index: -10.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0775
    Cell Significance Index: -2.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0821
    Cell Significance Index: -23.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0849
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0884
    Cell Significance Index: -10.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0902
    Cell Significance Index: -2.8900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0993
    Cell Significance Index: -1.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1109
    Cell Significance Index: -0.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1210
    Cell Significance Index: -2.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1267
    Cell Significance Index: -1.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1298
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1379
    Cell Significance Index: -29.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1468
    Cell Significance Index: -10.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1662
    Cell Significance Index: -12.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1937
    Cell Significance Index: -20.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2390
    Cell Significance Index: -5.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2588
    Cell Significance Index: -15.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2627
    Cell Significance Index: -16.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2771
    Cell Significance Index: -7.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2893
    Cell Significance Index: -22.9100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2975
    Cell Significance Index: -3.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3068
    Cell Significance Index: -5.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3381
    Cell Significance Index: -4.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3669
    Cell Significance Index: -24.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3729
    Cell Significance Index: -22.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4197
    Cell Significance Index: -3.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4362
    Cell Significance Index: -12.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5228
    Cell Significance Index: -23.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5370
    Cell Significance Index: -18.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5392
    Cell Significance Index: -28.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5412
    Cell Significance Index: -7.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5450
    Cell Significance Index: -14.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5775
    Cell Significance Index: -21.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6036
    Cell Significance Index: -7.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VRK2 is a serine/threonine kinase that exhibits specificity for phosphorylating serine and threonine residues on target proteins. Its activity is regulated through autophosphorylation, which modulates its kinase activity. VRK2 is also involved in the regulation of various signaling pathways, including the Rac1 and Rho GTPase cycles, which are crucial for cell migration, proliferation, and survival. Additionally, VRK2 has been implicated in the regulation of the interleukin-1-mediated signaling pathway, which is involved in inflammation and immune responses. **Pathways and Functions:** VRK2 is involved in multiple signaling pathways, including: 1. **Cell Cycle Regulation:** VRK2 plays a crucial role in regulating the cell cycle, particularly during mitosis and meiosis. It phosphorylates and activates proteins involved in the regulation of the cell cycle, including cyclin-dependent kinases and phosphatases. 2. **Oxidative Stress Response:** VRK2 is involved in the regulation of the cellular response to oxidative stress. It phosphorylates and activates proteins involved in the antioxidant response, including antioxidant enzymes and transcription factors. 3. **Signaling by Rho GTPases:** VRK2 is involved in the regulation of the Rho GTPase cycle, which is crucial for cell migration, proliferation, and survival. It phosphorylates and activates proteins involved in the regulation of the Rho GTPase cycle, including Rho kinases and guanine nucleotide exchange factors. 4. **Interleukin-1 Signaling Pathway:** VRK2 is involved in the regulation of the interleukin-1-mediated signaling pathway, which is involved in inflammation and immune responses. It phosphorylates and activates proteins involved in the regulation of the interleukin-1 signaling pathway, including transcription factors and cytokines. **Clinical Significance:** The dysregulation of VRK2 has been implicated in various diseases, including: 1. **Cancer:** VRK2 has been implicated in the regulation of cell proliferation and survival in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** VRK2 has been implicated in the regulation of neuronal function and survival in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease:** VRK2 has been implicated in the regulation of cardiac function and survival in various cardiovascular diseases, including heart failure and atherosclerosis. 4. **Inflammatory Disorders:** VRK2 has been implicated in the regulation of the interleukin-1-mediated signaling pathway, which is involved in inflammation and immune responses. Dysregulation of VRK2 has been implicated in various inflammatory disorders, including rheumatoid arthritis and inflammatory bowel disease. In conclusion, VRK2 is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell cycle regulation, oxidative stress response, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, cardiovascular disease, and inflammatory disorders. Further research is needed to fully understand the role of VRK2 in human disease and to develop therapeutic strategies to target this kinase.

Genular Protein ID: 3810237229

Symbol: VRK2_HUMAN

Name: Serine/threonine-protein kinase VRK2

UniProtKB Accession Codes:

Q86Y07 B4DKL0 D6W5D4 D6W5D6 Q49AK9 Q53EU9 Q53S39 Q53S77 Q53TU1 Q86Y08 Q86Y09 Q86Y10 Q86Y11 Q86Y12 Q8IXI5 Q99987

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 19 EMDB 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 7 RefSeq 21 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344656

Title: Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to Vaccinia virus B1R kinase.

PubMed ID: 9344656

DOI: 10.1006/geno.1997.4938

PubMed ID: 16704422

Title: The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.

PubMed ID: 16704422

DOI: 10.1111/j.1742-4658.2006.05256.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14645249

Title: Characterization of three paralogous members of the Mammalian vaccinia related kinase family.

PubMed ID: 14645249

DOI: 10.1074/jbc.m310813200

PubMed ID: 16963744

Title: Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival.

PubMed ID: 16963744

DOI: 10.1099/vir.0.81953-0

PubMed ID: 16495336

Title: The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus.

PubMed ID: 16495336

DOI: 10.1091/mbc.e05-12-1179

PubMed ID: 17709393

Title: Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1.

PubMed ID: 17709393

DOI: 10.1128/mcb.00025-07

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18617507

Title: Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.

PubMed ID: 18617507

DOI: 10.1074/mcp.m700586-mcp200

PubMed ID: 18286207

Title: Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.

PubMed ID: 18286207

DOI: 10.1371/journal.pone.0001660

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20679487

Title: VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.

PubMed ID: 20679487

DOI: 10.1128/mcb.01581-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31341052

Title: The Vaccinia Virus (VACV) B1 and Cellular VRK2 Kinases Promote VACV Replication Factory Formation through Phosphorylation-Dependent Inhibition of VACV B12.

PubMed ID: 31341052

DOI: 10.1128/jvi.00855-19

PubMed ID: 33177193

Title: The Vaccinia Virus B12 Pseudokinase Represses Viral Replication via Interaction with the Cellular Kinase VRK1 and Activation of the Antiviral Effector BAF.

PubMed ID: 33177193

DOI: 10.1128/jvi.02114-20

PubMed ID: 19141289

Title: Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.

PubMed ID: 19141289

DOI: 10.1016/j.str.2008.10.018

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 508
  • Mass: 58141
  • Checksum: 9F3F6FCC9280568F
  • Sequence:
    • MPPKRNEKYK LPIPFPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN KPEKDARHVV 
KVEYQENGPL FSELKFYQRV AKKDCIKKWI ERKQLDYLGI PLFYGSGLTE FKGRSYRFMV 
MERLGIDLQK ISGQNGTFKK STVLQLGIRM LDVLEYIHEN EYVHGDIKAA NLLLGYKNPD 
QVYLADYGLS YRYCPNGNHK QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM 
LRWLCGKLPW EQNLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY 
DEKPNYQALK KILNPHGIPL GPLDFSTKGQ SINVHTPNSQ KVDSQKAATK QVNKAHNRLI 
EKKVHSERSA ESCATWKVQK EEKLIGLMNN EAAQESTRRR QKYQESQEPL NEVNSFPQKI 
SYTQFPNSFY EPHQDFTSPD IFKKSRSPSW YKYTSTVSTG ITDLESSTGL WPTISQFTLS 
EETNADVYYY RIIIPVLLML VFLALFFL

Genular Protein ID: 3816554370

Symbol: A8K9L2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K9L2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 396
  • Mass: 45020
  • Checksum: 83B5E84674E4CDFB
  • Sequence:
    • MPPKRNEKYK LPIPFPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN KPEKDARHVV 
KVEYQENGPL FSELKFYQRV AKKDCIKKWI ERKQLDYLGI PLFYGSGLTE FKGRSYRFMV 
MERLGIDLQK ISGQNGTFKK STVLQLGIRM LDVLEYIHEN EYVHGDVKAA NLLLGYKNPD 
QVYLADYGLS YRYCPNGNHK QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM 
LRWLCGKLPW EQNLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY 
DEKPNYQALK KILNPHGIPL GPLDFSTKGQ SINVHTPNSQ KVDSQKAATK QVNKAHNRLI 
EKKVHSERSA ESCATWKVQK EEKLIGLMNN EAAQFR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.