Details for: WIPF1

Gene ID: 7456

Symbol: WIPF1

Ensembl ID: ENSG00000115935

Description: WAS/WASL interacting protein family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.3195
    Cell Significance Index: -37.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.7959
    Cell Significance Index: -31.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 102.0536
    Cell Significance Index: -41.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 90.5485
    Cell Significance Index: -42.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 88.7273
    Cell Significance Index: -45.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.5774
    Cell Significance Index: -42.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.2160
    Cell Significance Index: -37.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.5443
    Cell Significance Index: -34.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3292
    Cell Significance Index: -40.9400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 11.0363
    Cell Significance Index: 29.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3066
    Cell Significance Index: -27.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6958
    Cell Significance Index: -38.2600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.7376
    Cell Significance Index: 8.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.8380
    Cell Significance Index: 83.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.5379
    Cell Significance Index: 299.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.0946
    Cell Significance Index: 40.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0414
    Cell Significance Index: 37.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.1591
    Cell Significance Index: 58.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8376
    Cell Significance Index: 54.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5970
    Cell Significance Index: 17.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5521
    Cell Significance Index: 109.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4118
    Cell Significance Index: 44.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3379
    Cell Significance Index: 4.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2620
    Cell Significance Index: 33.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2487
    Cell Significance Index: 89.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2467
    Cell Significance Index: 13.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2334
    Cell Significance Index: 12.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2059
    Cell Significance Index: 39.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1728
    Cell Significance Index: 17.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1632
    Cell Significance Index: 112.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1618
    Cell Significance Index: 146.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0939
    Cell Significance Index: 176.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0914
    Cell Significance Index: 2.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0848
    Cell Significance Index: 2.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0697
    Cell Significance Index: 9.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0592
    Cell Significance Index: 0.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0580
    Cell Significance Index: 4.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0402
    Cell Significance Index: 18.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0402
    Cell Significance Index: 0.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0356
    Cell Significance Index: 22.6200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0251
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0154
    Cell Significance Index: 23.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0279
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0306
    Cell Significance Index: -22.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0307
    Cell Significance Index: -3.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0314
    Cell Significance Index: -3.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0318
    Cell Significance Index: -19.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0355
    Cell Significance Index: -6.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0368
    Cell Significance Index: -20.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0402
    Cell Significance Index: -22.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0439
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0488
    Cell Significance Index: -36.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0530
    Cell Significance Index: -7.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0577
    Cell Significance Index: -42.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0698
    Cell Significance Index: -14.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0947
    Cell Significance Index: -41.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1064
    Cell Significance Index: -18.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1172
    Cell Significance Index: -33.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1183
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1227
    Cell Significance Index: -25.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1297
    Cell Significance Index: -5.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1686
    Cell Significance Index: -11.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1878
    Cell Significance Index: -4.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2045
    Cell Significance Index: -4.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2199
    Cell Significance Index: -27.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3038
    Cell Significance Index: -31.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3107
    Cell Significance Index: -35.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3122
    Cell Significance Index: -10.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3151
    Cell Significance Index: -40.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3332
    Cell Significance Index: -38.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3559
    Cell Significance Index: -5.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4315
    Cell Significance Index: -20.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4546
    Cell Significance Index: -27.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4596
    Cell Significance Index: -13.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5047
    Cell Significance Index: -8.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5304
    Cell Significance Index: -13.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5440
    Cell Significance Index: -36.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5617
    Cell Significance Index: -44.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5641
    Cell Significance Index: -42.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6106
    Cell Significance Index: -31.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6136
    Cell Significance Index: -37.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6374
    Cell Significance Index: -45.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6430
    Cell Significance Index: -29.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6461
    Cell Significance Index: -28.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6549
    Cell Significance Index: -10.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6837
    Cell Significance Index: -43.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7281
    Cell Significance Index: -38.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7543
    Cell Significance Index: -12.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7790
    Cell Significance Index: -29.5000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.8088
    Cell Significance Index: -4.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8744
    Cell Significance Index: -27.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9085
    Cell Significance Index: -29.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9480
    Cell Significance Index: -33.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9773
    Cell Significance Index: -27.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.0611
    Cell Significance Index: -46.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0771
    Cell Significance Index: -39.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0989
    Cell Significance Index: -30.7100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.1407
    Cell Significance Index: -12.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein:** WIPF1 interacts with actin-binding proteins, such as profilin, to regulate actin filament dynamics. 2. **Regulation of actin dynamics:** WIPF1 modulates actin polymerization and depolymerization, influencing cell migration, phagocytosis, and cell signaling. 3. **Immune system involvement:** WIPF1 is significantly expressed in immune cells, including T cells, natural killer cells, and decidual natural killer cells, suggesting its role in immune response and regulation. 4. **Cell-type specific expression:** WIPF1 is expressed in various cell types, including cardiac neurons and blood cells, indicating its potential role in multiple cellular processes. **Pathways and Functions:** 1. **Actin cytoskeleton regulation:** WIPF1 interacts with actin-binding proteins to regulate actin filament dynamics, influencing cell migration, phagocytosis, and cell signaling. 2. **Cytosol organization:** WIPF1 modulates cytosol organization by regulating actin polymerization and depolymerization, influencing cell shape and movement. 3. **Immune response regulation:** WIPF1 is involved in regulating immune response by modulating actin dynamics and cytoskeleton organization in immune cells. 4. **Cell signaling:** WIPF1 interacts with various signaling proteins, including Rho GTPases, to regulate cell signaling pathways. **Clinical Significance:** Dysregulation of WIPF1 has been implicated in various diseases, including: 1. **Infectious diseases:** WIPF1's role in regulating phagocytosis and immune response suggests its potential involvement in infectious diseases, such as Leishmania infection. 2. **Inflammatory disorders:** WIPF1's involvement in regulating immune response and actin dynamics suggests its potential role in inflammatory disorders, such as rheumatoid arthritis. 3. **Cancer:** WIPF1's expression in cancer cells and its role in regulating cell migration and invasion suggest its potential involvement in cancer progression. 4. **Neurological disorders:** WIPF1's expression in cardiac neurons and its role in regulating cytoskeleton organization suggest its potential involvement in neurological disorders, such as Alzheimer's disease. In conclusion, WIPF1 is a multifaceted gene involved in regulating actin dynamics and immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the functions and significance of WIPF1.

Genular Protein ID: 3788913804

Symbol: WIPF1_HUMAN

Name: WAS/WASL-interacting protein family member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9405671

Title: WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.

PubMed ID: 9405671

DOI: 10.1073/pnas.94.26.14671

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10202051

Title: Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein.

PubMed ID: 10202051

PubMed ID: 10878810

Title: A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.

PubMed ID: 10878810

DOI: 10.1038/35017080

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19798448

Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

PubMed ID: 19798448

DOI: 10.1371/journal.pgen.1000675

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19910490

Title: Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation.

PubMed ID: 19910490

DOI: 10.1091/mbc.e09-02-0106

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22231303

Title: A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP.

PubMed ID: 22231303

DOI: 10.1084/jem.20110896

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16275905

Title: Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.

PubMed ID: 16275905

DOI: 10.1073/pnas.0507021102

Sequence Information:

  • Length: 503
  • Mass: 51258
  • Checksum: 09B7A95E6808A46D
  • Sequence:
  • MPVPPPPAPP PPPTFALANT EKPTLNKTEQ AGRNALLSDI SKGKKLKKTV TNDRSAPILD 
    KPKGAGAGGG GGGFGGGGGF GGGGGGGGGG SFGGGGPPGL GGLFQAGMPK LRSTANRDND 
    SGGSRPPLLP PGGRSTSAKP FSPPSGPGRF PVPSPGHRSG PPEPQRNRMP PPRPDVGSKP 
    DSIPPPVPST PRPIQSSPHN RGSPPVPGGP RQPSPGPTPP PFPGNRGTAL GGGSIRQSPL 
    SSSSPFSNRP PLPPTPSRAL DDKPPPPPPP VGNRPSIHRE AVPPPPPQNN KPPVPSTPRP 
    SASSQAPPPP PPPSRPGPPP LPPSSSGNDE TPRLPQRNLS LSSSTPPLPS PGRSGPLPPP 
    PSERPPPPVR DPPGRSGPLP PPPPVSRNGS TSRALPATPQ LPSRSGVDSP RSGPRPPLPP 
    DRPSAGAPPP PPPSTSIRNG FQDSPCEDEW ESRFYFHPIS DLPPPEPYVQ TTKSYPSKLA 
    RNESRSGSNR RERGAPPLPP IPR

Genular Protein ID: 4207210592

Symbol: Q2YDC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 403
  • Mass: 40479
  • Checksum: 97A90B3546A46143
  • Sequence:
  • MPVPPPPAPP PPPTFALANT EKPTLNKTEQ AGRNALLSDI SKGKKLKKTV TNDRSAPILD 
    KPKGAGAGGG GGGFGGGGGF GGGGGGGGGG SFGGGGPPGL GGLFQAGMPK LRSTANRDND 
    SGGSRPPLLP PGGRSTSAKP FSPPSGPGRF PVPSPGHRSG PPEPQRNRMP PPRPDVGSKP 
    DSIPPPVPST PRPIQSSLHN RGSPPVPGGP RQPSPGPTPP PFPGNRGTAL GGGSIRQSPL 
    SSSSPFSNRP PLPPTPSRAL DDKPPPPPPP VGNRPSIHRE AVPPPPPQNN KPPVPSTPRP 
    SASSQAPPPP PPPSRPGPPP LPPSSSGNDE TPRLPQRNLS LSSSTPPLPS PGRSGPLPPP 
    PSERPPPPVR DPPGRSGMTR RGVSCFQNPA CPNVPIILSV KIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.