Details for: XPO1

Gene ID: 7514

Symbol: XPO1

Ensembl ID: ENSG00000082898

Description: exportin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 449.7084
    Cell Significance Index: -69.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 279.1321
    Cell Significance Index: -70.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 183.8098
    Cell Significance Index: -75.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 166.3974
    Cell Significance Index: -78.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 156.5265
    Cell Significance Index: -63.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 143.6472
    Cell Significance Index: -73.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.0390
    Cell Significance Index: -64.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.2245
    Cell Significance Index: -76.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.3512
    Cell Significance Index: -73.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.8170
    Cell Significance Index: -67.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.7007
    Cell Significance Index: -77.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.3197
    Cell Significance Index: -31.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.3978
    Cell Significance Index: 512.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.3070
    Cell Significance Index: 185.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7455
    Cell Significance Index: 544.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2901
    Cell Significance Index: 61.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2675
    Cell Significance Index: 63.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1775
    Cell Significance Index: 436.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.0560
    Cell Significance Index: 126.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9337
    Cell Significance Index: 693.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.7546
    Cell Significance Index: 42.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4345
    Cell Significance Index: 110.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9754
    Cell Significance Index: 58.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9087
    Cell Significance Index: 628.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8655
    Cell Significance Index: 472.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8405
    Cell Significance Index: 115.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8307
    Cell Significance Index: 53.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7743
    Cell Significance Index: 139.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6853
    Cell Significance Index: 80.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6695
    Cell Significance Index: 34.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6409
    Cell Significance Index: 78.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5918
    Cell Significance Index: 17.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4943
    Cell Significance Index: 218.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4600
    Cell Significance Index: 866.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4565
    Cell Significance Index: 20.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4021
    Cell Significance Index: 27.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3728
    Cell Significance Index: 60.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3481
    Cell Significance Index: 4.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1347
    Cell Significance Index: 248.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1330
    Cell Significance Index: 204.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1288
    Cell Significance Index: 81.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1277
    Cell Significance Index: 173.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1241
    Cell Significance Index: 4.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1216
    Cell Significance Index: 5.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0937
    Cell Significance Index: 42.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0530
    Cell Significance Index: 5.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0466
    Cell Significance Index: 5.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0432
    Cell Significance Index: 0.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0289
    Cell Significance Index: 1.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0257
    Cell Significance Index: 1.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0033
    Cell Significance Index: 3.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0306
    Cell Significance Index: -22.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0355
    Cell Significance Index: -6.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0374
    Cell Significance Index: -27.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0437
    Cell Significance Index: -8.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0687
    Cell Significance Index: -3.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0692
    Cell Significance Index: -1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0698
    Cell Significance Index: -10.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0752
    Cell Significance Index: -56.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0958
    Cell Significance Index: -54.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1273
    Cell Significance Index: -4.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1605
    Cell Significance Index: -8.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1698
    Cell Significance Index: -2.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1835
    Cell Significance Index: -4.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1867
    Cell Significance Index: -19.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2148
    Cell Significance Index: -22.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2201
    Cell Significance Index: -46.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2311
    Cell Significance Index: -66.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2607
    Cell Significance Index: -18.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2626
    Cell Significance Index: -4.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2649
    Cell Significance Index: -12.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2917
    Cell Significance Index: -7.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3436
    Cell Significance Index: -11.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3976
    Cell Significance Index: -45.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4361
    Cell Significance Index: -11.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4415
    Cell Significance Index: -48.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4585
    Cell Significance Index: -59.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4643
    Cell Significance Index: -53.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4813
    Cell Significance Index: -3.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6104
    Cell Significance Index: -15.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6491
    Cell Significance Index: -13.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6504
    Cell Significance Index: -18.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7298
    Cell Significance Index: -20.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7629
    Cell Significance Index: -56.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7817
    Cell Significance Index: -11.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7978
    Cell Significance Index: -4.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8143
    Cell Significance Index: -22.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8403
    Cell Significance Index: -66.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8972
    Cell Significance Index: -18.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9534
    Cell Significance Index: -20.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9675
    Cell Significance Index: -20.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0481
    Cell Significance Index: -14.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0505
    Cell Significance Index: -22.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0900
    Cell Significance Index: -66.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1179
    Cell Significance Index: -16.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2965
    Cell Significance Index: -32.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3163
    Cell Significance Index: -35.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.3511
    Cell Significance Index: -39.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3571
    Cell Significance Index: -44.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** XPO1 is a member of the Exportin family, characterized by its ability to recognize and bind to specific nuclear export signals (NES) on target proteins and RNAs. It is a dimeric protein, composed of two identical subunits, each with a conserved N-terminal domain (NTD) and a C-terminal domain (CTD). The NTD is responsible for binding to NES, while the CTD interacts with the cytoplasmic machinery to facilitate export. **Pathways and Functions:** XPO1 is involved in various cellular processes, including: 1. **Cell cycle regulation:** XPO1 regulates the export of cyclin-dependent kinases (CDKs), which are essential for cell cycle progression. 2. **Gene expression:** XPO1 modulates the export of mRNAs, influencing gene expression and transcriptional regulation. 3. **Protein transport:** XPO1 facilitates the export of proteins, including those involved in signal transduction, metabolism, and protein degradation. 4. **Nuclear export:** XPO1 is a key component of the nuclear export machinery, responsible for the export of proteins, RNAs, and other molecules from the nucleus to the cytoplasm. **Clinical Significance:** Dysregulation of XPO1 has been implicated in various diseases, including: 1. **Cancer:** XPO1 is overexpressed in many types of cancer, including breast, lung, and prostate cancer, where it promotes tumor progression and metastasis. 2. **Neurodegenerative diseases:** XPO1 is associated with neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it may contribute to protein misfolding and aggregation. 3. **Infectious diseases:** XPO1 is involved in the life cycle of viruses, including HIV, HSV, and RSV, where it facilitates the export of viral RNAs and proteins. 4. **Metabolic disorders:** XPO1 plays a role in regulating glucose metabolism and insulin signaling, making it a potential target for the treatment of metabolic disorders. **Significantly Expressed Cells:** XPO1 is expressed in various cell types, including: 1. **Epithelial cells:** XPO1 is highly expressed in epithelial cells of the lower respiratory tract, where it regulates the export of mRNAs and proteins involved in inflammation and immune responses. 2. **Astrocytes:** XPO1 is expressed in astrocytes of the cerebral cortex, where it modulates the export of mRNAs and proteins involved in neuronal function and survival. 3. **Smooth muscle cells:** XPO1 is expressed in smooth muscle cells of the sphincter of the pupil, where it regulates the export of mRNAs and proteins involved in smooth muscle contraction and relaxation. **Conclusion:** XPO1 is a multifaceted protein that plays a crucial role in various cellular processes, including cell cycle regulation, gene expression, and protein transport. Its dysregulation has been implicated in various diseases, highlighting the importance of XPO1 as a potential therapeutic target. Further research is needed to fully understand the mechanisms of XPO1 and its role in different diseases, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 1482870260

Symbol: XPO1_HUMAN

Name: Exportin-1

UniProtKB Accession Codes:

O14980 A6NL14 A8K1K5 D6W5E2 Q63HP8 Q68CP3 Q99433

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9049309

Title: The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88.

PubMed ID: 9049309

DOI: 10.1093/emboj/16.4.807

PubMed ID: 9368044

Title: Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.

PubMed ID: 9368044

DOI: 10.1074/jbc.272.47.29742

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9323133

Title: CRM1 is an export receptor for leucine-rich nuclear export signals.

PubMed ID: 9323133

DOI: 10.1016/s0092-8674(00)80371-2

PubMed ID: 9311922

Title: Evidence for a role of CRM1 in signal-mediated nuclear protein export.

PubMed ID: 9311922

DOI: 10.1126/science.278.5335.141

PubMed ID: 9837918

Title: The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.

PubMed ID: 9837918

DOI: 10.1074/jbc.273.50.33414

PubMed ID: 10209022

Title: CRM1-mediated recycling of snurportin 1 to the cytoplasm.

PubMed ID: 10209022

DOI: 10.1083/jcb.145.2.255

PubMed ID: 10400785

Title: Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression.

PubMed ID: 10400785

DOI: 10.1128/jvi.73.8.6872-6881.1999

PubMed ID: 10430904

Title: Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region.

PubMed ID: 10430904

DOI: 10.1073/pnas.96.16.9112

PubMed ID: 10358091

Title: A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1.

PubMed ID: 10358091

DOI: 10.1074/jbc.274.24.17309

PubMed ID: 11571268

Title: RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.

PubMed ID: 11571268

DOI: 10.1093/embo-reports/kve200

PubMed ID: 11119609

Title: Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway.

PubMed ID: 11119609

DOI: 10.1128/jvi.75.1.408-419.2001

PubMed ID: 11425870

Title: Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.

PubMed ID: 11425870

DOI: 10.1083/jcb.153.7.1391

PubMed ID: 11932251

Title: Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.

PubMed ID: 11932251

DOI: 10.1074/jbc.c100620200

PubMed ID: 12134013

Title: The carboxy-terminal region of the human immunodeficiency virus type 1 protein Rev has multiple roles in mediating CRM1-related Rev functions.

PubMed ID: 12134013

DOI: 10.1128/jvi.76.16.8079-8089.2002

PubMed ID: 12724356

Title: Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway.

PubMed ID: 12724356

DOI: 10.1242/jcs.00464

PubMed ID: 12808100

Title: Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

PubMed ID: 12808100

DOI: 10.1128/mcb.23.13.4598-4610.2003

PubMed ID: 14612415

Title: A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.

PubMed ID: 14612415

DOI: 10.1128/mcb.23.23.8751-8761.2003

PubMed ID: 15507209

Title: Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.

PubMed ID: 15507209

DOI: 10.1016/j.cell.2004.09.029

PubMed ID: 15574332

Title: PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli.

PubMed ID: 15574332

DOI: 10.1016/j.molcel.2004.11.013

PubMed ID: 15632073

Title: Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo.

PubMed ID: 15632073

DOI: 10.1128/mcb.25.2.728-739.2005

PubMed ID: 16103875

Title: Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells.

PubMed ID: 16103875

DOI: 10.1038/sj.onc.1208962

PubMed ID: 16302269

Title: Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.

PubMed ID: 16302269

DOI: 10.1002/mc.20156

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18316374

Title: CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.

PubMed ID: 18316374

DOI: 10.1074/jbc.m708365200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20826784

Title: Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

PubMed ID: 20826784

DOI: 10.1074/jbc.m110.152777

PubMed ID: 20147401

Title: Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.

PubMed ID: 20147401

DOI: 10.1128/jvi.02554-09

PubMed ID: 20921223

Title: Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.

PubMed ID: 20921223

DOI: 10.1074/jbc.m110.107912

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22022502

Title: An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.

PubMed ID: 22022502

DOI: 10.1371/journal.pone.0026044

PubMed ID: 21637748

Title: SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.

PubMed ID: 21637748

DOI: 10.1371/journal.pone.0019436

PubMed ID: 22500989

Title: Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).

PubMed ID: 22500989

DOI: 10.1016/j.febslet.2012.02.053

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 22275354

Title: Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity.

PubMed ID: 22275354

DOI: 10.1074/jbc.m111.294272

PubMed ID: 22730302

Title: NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.

PubMed ID: 22730302

DOI: 10.1093/nar/gks598

PubMed ID: 23164465

Title: HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing.

PubMed ID: 23164465

DOI: 10.1111/febs.12066

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28325843

Title: A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

PubMed ID: 28325843

DOI: 10.1261/rna.060137.116

PubMed ID: 15574331

Title: Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.

PubMed ID: 15574331

DOI: 10.1016/j.molcel.2004.11.018

Sequence Information:

  • Length: 1071
  • Mass: 123386
  • Checksum: FDB00C065DA2FB1D
  • Sequence:
    • MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL THLKEHPDAW 
TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE GIKKYVVGLI IKTSSDPTCV 
EKEKVYIGKL NMILVQILKQ EWPKHWPTFI SDIVGASRTS ESLCQNNMVI LKLLSEEVFD 
FSSGQITQVK SKHLKDSMCN EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY 
IFETKLISTL IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFVTLFTLT MMQLKQMLPL 
NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHDQLIEKR LNLRETLMEA LHYMLLVSEV 
EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF DVPPRRQLYL PMLFKVRLLM 
VSRMAKPEEV LVVENDQGEV VREFMKDTDS INLYKNMRET LVYLTHLDYV DTERIMTEKL 
HNQVNGTEWS WKNLNTLCWA IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII 
ASNIMYIVGQ YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV 
QVQVGEVMPF IDEILNNINT IICDLQPQQV HTFYEAVGYM IGAQTDQTVQ EHLIEKYMLL 
PNQVWDSIIQ QATKNVDILK DPETVKQLGS ILKTNVRACK AVGHPFVIQL GRIYLDMLNV 
YKCLSENISA AIQANGEMVT KQPLIRSMRT VKRETLKLIS GWVSRSNDPQ MVAENFVPPL 
LDAVLIDYQR NVPAAREPEV LSTMAIIVNK LGGHITAEIP QIFDAVFECT LNMINKDFEE 
YPEHRTNFFL LLQAVNSHCF PAFLAIPPTQ FKLVLDSIIW AFKHTMRNVA DTGLQILFTL 
LQNVAQEEAA AQSFYQTYFC DILQHIFSVV TDTSHTAGLT MHASILAYMF NLVEEGKIST 
SLNPGNPVNN QIFLQEYVAN LLKSAFPHLQ DAQVKLFVTG LFSLNQDIPA FKEHLRDFLV 
QIKEFAGEDT SDLFLEEREI ALRQADEEKH KRQMSVPGIF NPHEIPEEMC D

Genular Protein ID: 4132925369

Symbol: A0A7I2V6B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V6B9

Database IDs:

ARBA 4 AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 8 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 940
  • Mass: 108315
  • Checksum: 093ABA4CABE62AD2
  • Sequence:
    • MILVQILKQE WPKHWPTFIS DIVGASRTSE SLCQNNMVIL KLLSEEVFDF SSGQITQVKS 
KHLKDSMCNE FSQIFQLCQF VMENSQNAPL VHATLETLLR FLNWIPLGYI FETKLISTLI 
YKFLNVPMFR NVSLKCLTEI AGVSVSQYEE QFVTLFTLTM MQLKQMLPLN TNIRLAYSNG 
KDDEQNFIQN LSLFLCTFLK EHDQLIEKRL NLRETLMEAL HYMLLVSEVE ETEIFKICLE 
YWNHLAAELY RESPFSTSAS PLLSGSQHFD VPPRRQLYLP MLFKVRLLMV SRMAKPEEVL 
VVENDQGEVV REFMKDTDSI NLYKNMRETL VYLTHLDYVD TERIMTEKLH NQVNGTEWSW 
KNLNTLCWAI GSISGAMHEE DEKRFLVTVI KDLLGLCEQK RGKDNKAIIA SNIMYIVGQY 
PRFLRAHWKF LKTVVNKLFE FMHETHDGVQ DMACDTFIKI AQKCRRHFVQ VQVGEVMPFI 
DEILNNINTI ICDLQPQQVH TFYEAVGYMI GAQTDQTVQE HLIEKYMLLP NQVWDSIIQQ 
ATKNVDILKD PETVKQLGSI LKTNVRACKA VGHPFVIQLG RIYLDMLNVY KCLSENISAA 
IQANGEMVTK QPLIRSMRTV KRETLKLISG WVSRSNDPQM VAENFVPPLL DAVLIDYQRN 
VPAAREPEVL STMAIIVNKL GGHITAEIPQ IFDAVFECTL NMINKDFEEY PEHRTNFFLL 
LQAVNSHCFP AFLAIPPTQF KLVLDSIIWA FKHTMRNVAD TGLQILFTLL QNVAQEEAAA 
QSFYQTYFCD ILQHIFSVVT DTSHTAGLTM HASILAYMFN LVEEGKISTS LNPGNPVNNQ 
IFLQEYVANL LKSAFPHLQD AQVKLFVTGL FSLNQDIPAF KEHLRDFLVQ IKEFAGEDTS 
DLFLEEREIA LRQADEEKHK RQMSVPGIFN PHEIPEEMCD

Genular Protein ID: 3939948113

Symbol: A0A7I2V2Y6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V2Y6

Database IDs:

ARBA 5 Bgee 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 7 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1026
  • Mass: 118165
  • Checksum: 056BADC813B9BEC7
  • Sequence:
    • MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL THLKEHPDAW 
TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE GIKKYVVGLI IKTSSDPTCV 
EKEKVYIGKL NMILVQILKQ EWPKHWPTFI SDIVGASRTS ESLCQNNMVI LKLLSEEVFD 
FSSGQITQVK SKHLKDSMCN EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY 
IFETKLISTL IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFVTLFTLT MMQLKQMLPL 
NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHDQLIEKR LNLRETLMEA LHYMLLVSEV 
EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF DVPPRRQLYL PMLFKVRLLM 
VSRMAKPEEV LVVENDQGEV VREFMKDTDS INLYKNMRET LVYLTHLDYV DTERIMTEKL 
HNQVNGTEWS WKNLNTLCWA IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII 
ASNIMYIVGQ YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV 
QVQVGEVMPF IDEILNNINT IICDLQPQQN VDILKDPETV KQLGSILKTN VRACKAVGHP 
FVIQLGRIYL DMLNVYKCLS ENISAAIQAN GEMVTKQPLI RSMRTVKRET LKLISGWVSR 
SNDPQMVAEN FVPPLLDAVL IDYQRNVPAA REPEVLSTMA IIVNKLGGHI TAEIPQIFDA 
VFECTLNMIN KDFEEYPEHR TNFFLLLQAV NSHCFPAFLA IPPTQFKLVL DSIIWAFKHT 
MRNVADTGLQ ILFTLLQNVA QEEAAAQSFY QTYFCDILQH IFSVVTDTSH TAGLTMHASI 
LAYMFNLVEE GKISTSLNPG NPVNNQIFLQ EYVANLLKSA FPHLQDAQVK LFVTGLFSLN 
QDIPAFKEHL RDFLVQIKEF AGEDTSDLFL EEREIALRQA DEEKHKRQMS VPGIFNPHEI 
PEEMCD

Genular Protein ID: 3885880309

Symbol: B3KWD0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KWD0

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 718
  • Mass: 82419
  • Checksum: EC4DF6C52E249A8E
  • Sequence:
    • MLLVSEVEET EIFKICLEYW NHLAAELYRE SPFSTSASPL LSGSQHFDVP PRRQLYLPML 
FKVRLLMVSR MAKPEEVLVV ENDQGEVVRE FMKDTDSINL YKNMRETLVY LTHLDYVDTE 
RIMTEKLHNQ VNGTEWSWKN LNTLCWAIGS ISGAMHEEDE KRFLVTVIKD LLGLCEQKRG 
KDNKAIIASN IMYIVGQYPR FLRAHWKFLK TVVNKLFEFM HETHDGVQDM ACDTFIKIAQ 
KCRRHFVQVQ VGEVMPFIDE ILNNINTIIC DLQPQQVHTF YEAVGYMIGA QTDQTVQEHL 
IEKYMLLPNQ VWDSIIQQAT KNVDILKDPE TVKQLGSILK TNVRACKAVG HPFVIQLGRI 
YLDMLNVYKC LSENISAAIQ ANGEMVTKQP LIRSMRTVKR ETLKLISGWV SRSNDPQMVA 
ENFVPPLLDA VLIDYQRNVP AAREPEVLST MAIIVNKLGG HITAEIPQIF DAVFECTLNM 
INKDFEEYPE HRTNFFLLLQ AVNSHCFPAF LAIPPTQFKL VLDSIIWAFK HTMRNVADTG 
LQILFTLLQN VAQEEAAAQS FYQTYFCDIL QHIFSVVTDT SHTAGLTMHA SILAYMFNLV 
EEGKISTSLN PGNPVNNQIF LQEYVANLLK SAFPHLQDAQ VKLFVTGLFS LNQDIPAFKE 
HLRDFLVQIK EFAGEDTSDL FLEEREIALR QADEEKHKRQ MSVPGIFNPH EIPEEMCD

Genular Protein ID: 3946340536

Symbol: A0A7I2V461_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V461

Database IDs:

ARBA 5 AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 7 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1056
  • Mass: 121628
  • Checksum: 9CC379EA9A369615
  • Sequence:
    • MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL THLKEHPDAW 
TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE GIKKYVVGLI IKTSSDPTCV 
EILKQEWPKH WPTFISDIVG ASRTSESLCQ NNMVILKLLS EEVFDFSSGQ ITQVKSKHLK 
DSMCNEFSQI FQLCQFVMEN SQNAPLVHAT LETLLRFLNW IPLGYIFETK LISTLIYKFL 
NVPMFRNVSL KCLTEIAGVS VSQYEEQFVT LFTLTMMQLK QMLPLNTNIR LAYSNGKDDE 
QNFIQNLSLF LCTFLKEHDQ LIEKRLNLRE TLMEALHYML LVSEVEETEI FKICLEYWNH 
LAAELYRESP FSTSASPLLS GSQHFDVPPR RQLYLPMLFK VRLLMVSRMA KPEEVLVVEN 
DQGEVVREFM KDTDSINLYK NMRETLVYLT HLDYVDTERI MTEKLHNQVN GTEWSWKNLN 
TLCWAIGSIS GAMHEEDEKR FLVTVIKDLL GLCEQKRGKD NKAIIASNIM YIVGQYPRFL 
RAHWKFLKTV VNKLFEFMHE THDGVQDMAC DTFIKIAQKC RRHFVQVQVG EVMPFIDEIL 
NNINTIICDL QPQQVHTFYE AVGYMIGAQT DQTVQEHLIE KYMLLPNQVW DSIIQQATKN 
VDILKDPETV KQLGSILKTN VRACKAVGHP FVIQLGRIYL DMLNVYKCLS ENISAAIQAN 
GEMVTKQPLI RSMRTVKRET LKLISGWVSR SNDPQMVAEN FVPPLLDAVL IDYQRNVPAA 
REPEVLSTMA IIVNKLGGHI TAEIPQIFDA VFECTLNMIN KDFEEYPEHR TNFFLLLQAV 
NSHCFPAFLA IPPTQFKLVL DSIIWAFKHT MRNVADTGLQ ILFTLLQNVA QEEAAAQSFY 
QTYFCDILQH IFSVVTDTSH TAGLTMHASI LAYMFNLVEE GKISTSLNPG NPVNNQIFLQ 
EYVANLLKSA FPHLQDAQVK LFVTGLFSLN QDIPAFKEHL RDFLVQIKEF AGEDTSDLFL 
EEREIALRQA DEEKHKRQMS VPGIFNPHEI PEEMCD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.