Details for: XPO1

Gene ID: 7514

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: XPO1

Ensembl ID: ENSG00000082898

Description: exportin 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 43.35
    rCSI 72.76%
    PRS 12.82
  • sncg GABAergic cortical interneuron CL4023015
    CSI 33.74
    rCSI 54.26%
    PRS 13.98
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 27.78
    rCSI 32.09%
    PRS 18.85
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 27.71
    rCSI 67.34%
    PRS 12.54
  • radial glial cell CL0000681
    CSI 25.15
    rCSI 34.93%
    PRS 22.01
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 24.08
    rCSI 42.53%
    PRS 12.71
  • L6b glutamatergic cortical neuron CL4023038
    CSI 22.07
    rCSI 68.96%
    PRS 13.66
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 19.26
    rCSI 69.3%
    PRS 12.04
  • retinal ganglion cell CL0000740
    CSI 19.07
    rCSI 42.12%
    PRS 15.44
  • fallopian tube secretory epithelial cell CL4030006
    CSI 17.74
    rCSI 17.08%
    PRS 22.46
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 17.74
    rCSI 55.48%
    PRS 14.71
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 17.67
    rCSI 66.77%
    PRS 13.23
  • retinal pigment epithelial cell CL0002586
    CSI 17.45
    rCSI 34.64%
    PRS 22.69
  • GABAergic amacrine cell CL4030027
    CSI 15.47
    rCSI 53%
    PRS 18.93
  • VIP GABAergic cortical interneuron CL4023016
    CSI 14.09
    rCSI 16.83%
    PRS 12.63
  • glioblast CL0000030
    CSI 13.37
    rCSI 21.33%
    PRS 18.49
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 12.76
    rCSI 15.88%
    PRS 11.99
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 11.98
    rCSI 70.53%
    PRS 13.43
  • H2 horizontal cell CL0004218
    CSI 10.74
    rCSI 53.42%
    PRS 23.49
  • chondrocyte CL0000138
    CSI 10.72
    rCSI 17.04%
    PRS 18.27
  • neural crest cell CL0011012
    CSI 10.63
    rCSI 8.4%
    PRS 14.89
  • central nervous system neuron CL2000029
    CSI 9.76
    rCSI 71.76%
    PRS 13.04
  • sst GABAergic cortical interneuron CL4023017
    CSI 9.64
    rCSI 12.43%
    PRS 13.41
  • stromal cell CL0000499
    CSI 9.27
    rCSI 26.09%
    PRS 28.59
  • extravillous trophoblast CL0008036
    CSI 8.4
    rCSI 10.39%
    PRS 18.98
  • blood vessel smooth muscle cell CL0019018
    CSI 8.18
    rCSI 66.51%
    PRS 21.61
  • Kupffer cell CL0000091
    CSI 7.37
    rCSI 16.84%
    PRS 21.11
  • endothelial cell of placenta CL0009092
    CSI 6.97
    rCSI 34.34%
    PRS 29.27
  • paneth cell CL0000510
    CSI 6.2
    rCSI 9.15%
    PRS 33.7
  • erythroblast CL0000765
    CSI 6.1
    rCSI 16.18%
    PRS 33.8
  • myoepithelial cell CL0000185
    CSI 6.09
    rCSI 15.42%
    PRS 26.69
  • invaginating midget bipolar cell CL4033034
    CSI 5.9
    rCSI 34.85%
    PRS 23.64
  • diffuse bipolar 3a cell CL4033029
    CSI 5.71
    rCSI 38.89%
    PRS 23.04
  • rod bipolar cell CL0000751
    CSI 5.49
    rCSI 9.87%
    PRS 17.87
  • renal alpha-intercalated cell CL0005011
    CSI 5.49
    rCSI 7.33%
    PRS 27.94
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 4.92
    rCSI 3.94%
    PRS 38.43
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.86
    rCSI 10.91%
    PRS 13.42
  • brush cell of tracheobronchial tree CL0002075
    CSI 4.79
    rCSI 14.21%
    PRS 30.3
  • unswitched memory B cell CL0000970
    CSI 4.61
    rCSI 3.88%
    PRS 34.13
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 4.33
    rCSI 22.34%
    PRS 41.7
  • perivascular cell CL4033054
    CSI 4.27
    rCSI 5.84%
    PRS 24.5
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.24
    rCSI 10.96%
    PRS 20.19
  • transit amplifying cell of small intestine CL0009012
    CSI 4.23
    rCSI 18.57%
    PRS 39.5
  • endothelial cell of vascular tree CL0002139
    CSI 4.21
    rCSI 23%
    PRS 33.26
  • parietal epithelial cell CL1000452
    CSI 4.19
    rCSI 11.19%
    PRS 18.05
  • immature B cell CL0000816
    CSI 4.1
    rCSI 3.05%
    PRS 31.9
  • epithelial cell of proximal tubule CL0002306
    CSI 3.93
    rCSI 9.6%
    PRS 21.23
  • ON midget ganglion cell CL4033046
    CSI 3.83
    rCSI 78.1%
    PRS 17.68
  • centrilobular region hepatocyte CL0019029
    CSI 3.81
    rCSI 9.94%
    PRS 32.82
  • OFF midget ganglion cell CL4033047
    CSI 3.68
    rCSI 74.97%
    PRS 18.8
  • renal principal cell CL0005009
    CSI 3.65
    rCSI 9.49%
    PRS 27.66
  • kidney connecting tubule epithelial cell CL1000768
    CSI 3.64
    rCSI 9.23%
    PRS 16.44
  • secretory cell CL0000151
    CSI 3.62
    rCSI 3.78%
    PRS 22.25
  • enteroendocrine cell CL0000164
    CSI 3.62
    rCSI 4.95%
    PRS 24.16
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 3.56
    rCSI 16.34%
    PRS 48.82
  • enteroendocrine cell of small intestine CL0009006
    CSI 3.5
    rCSI 7.71%
    PRS 32.75
  • peripheral nervous system neuron CL2000032
    CSI 3.49
    rCSI 4.76%
    PRS 19.06
  • fraction A pre-pro B cell CL0002045
    CSI 3.48
    rCSI 3.98%
    PRS 43.27
  • precursor B cell CL0000817
    CSI 3.43
    rCSI 3.01%
    PRS 28.9
  • ON parasol ganglion cell CL4033052
    CSI 3.43
    rCSI 48.66%
    PRS 16.8
  • transit amplifying cell of colon CL0009011
    CSI 3.38
    rCSI 3.97%
    PRS 24.96
  • neural progenitor cell CL0011020
    CSI 3.31
    rCSI 14.58%
    PRS 20.17
  • direct pathway medium spiny neuron CL4023026
    CSI 3.28
    rCSI 78.46%
    PRS 11.27
  • neuron CL0000540
    CSI 3.27
    rCSI 8.72%
    PRS 18.89
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.25
    rCSI 78.39%
    PRS 12.22
  • placental villous trophoblast CL2000060
    CSI 3.18
    rCSI 4.91%
    PRS 20.24
  • large pre-B-II cell CL0000957
    CSI 3.12
    rCSI 8.89%
    PRS 36.19
  • goblet cell CL0000160
    CSI 3.07
    rCSI 2.9%
    PRS 22.8
  • hematopoietic precursor cell CL0008001
    CSI 3.07
    rCSI 3.15%
    PRS 34.95
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 2.99
    rCSI 2.1%
    PRS 49.09
  • hematopoietic stem cell CL0000037
    CSI 2.95
    rCSI 1.96%
    PRS 25.91
  • Hofbauer cell CL3000001
    CSI 2.81
    rCSI 5.3%
    PRS 27.46
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 2.78
    rCSI 7.19%
    PRS 53.35
  • mesenchymal stem cell CL0000134
    CSI 2.78
    rCSI 30.42%
    PRS 37.91
  • early lymphoid progenitor CL0000936
    CSI 2.76
    rCSI 2.42%
    PRS 25
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 2.7
    rCSI 10.53%
    PRS 35.52
  • flat midget bipolar cell CL4033033
    CSI 2.55
    rCSI 18.25%
    PRS 23.13
  • diffuse bipolar 3b cell CL4033030
    CSI 2.55
    rCSI 16.93%
    PRS 23.56
  • multi-ciliated epithelial cell CL0005012
    CSI 2.54
    rCSI 2.54%
    PRS 18.53
  • interneuron CL0000099
    CSI 2.52
    rCSI 5.06%
    PRS 15.99
  • ependymal cell CL0000065
    CSI 2.44
    rCSI 4.95%
    PRS 11.27
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.43
    rCSI 7.16%
    PRS 25.65
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.41
    rCSI 2.18%
    PRS 19.62
  • common myeloid progenitor CL0000049
    CSI 2.38
    rCSI 1.93%
    PRS 21.76
  • adipocyte CL0000136
    CSI 2.28
    rCSI 2.93%
    PRS 20.99
  • epithelial cell of lung CL0000082
    CSI 2.26
    rCSI 1.88%
    PRS 20.58
  • renal beta-intercalated cell CL0002201
    CSI 2.26
    rCSI 5.38%
    PRS 24.69
  • subcutaneous adipocyte CL0002521
    CSI 2.25
    rCSI 11.52%
    PRS 22.96
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 2.23
    rCSI 11.19%
    PRS 28.62
  • Mueller cell CL0000636
    CSI 2.21
    rCSI 5.05%
    PRS 18.56
  • cardiac endothelial cell CL0010008
    CSI 2.19
    rCSI 8.83%
    PRS 19.79
  • group 3 innate lymphoid cell CL0001071
    CSI 2.11
    rCSI 1.59%
    PRS 23.11
  • activated type II NK T cell CL0000931
    CSI 2.06
    rCSI 2.32%
    PRS 34.45
  • M cell of gut CL0000682
    CSI 2.04
    rCSI 2.17%
    PRS 36.77
  • type EC enteroendocrine cell CL0000577
    CSI 2.01
    rCSI 7.15%
    PRS 35.05
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 2
    rCSI 6.17%
    PRS 32.16
  • OFF-bipolar cell CL0000750
    CSI 1.98
    rCSI 2.71%
    PRS 33.17
  • alpha-beta T cell CL0000789
    CSI 1.97
    rCSI 2.31%
    PRS 29.9
  • naive B cell CL0000788
    CSI 1.95
    rCSI 1.67%
    PRS 35.08
  • midzonal region hepatocyte CL0019028
    CSI 1.95
    rCSI 4.57%
    PRS 31.04
  • CD14-low, CD16-positive monocyte CL0002396
    CSI -1.4
    rCSI -1.1%
    PRS 20.2%
  • germinal center B cell CL0000844
    CSI -0.4
    rCSI -1.3%
    PRS 47.8%
  • Cajal-Retzius cell CL0000695
    CSI -0.4
    rCSI -2.8%
    PRS 42.1%
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI -0.2
    rCSI -1.2%
    PRS 54.0%
  • intrahepatic cholangiocyte CL0002538
    CSI -0.1
    rCSI -0.3%
    PRS 38.3%
  • pancreatic stellate cell CL0002410
    CSI 0.1
    rCSI 0.4%
    PRS 32.0%
  • pre-conventional dendritic cell CL0002010
    CSI 0.1
    rCSI 1.0%
    PRS 59.8%
  • medium spiny neuron CL1001474
    CSI 0.1
    rCSI 0.7%
    PRS 11.4%
  • basophil CL0000767
    CSI 0.1
    rCSI 0.2%
    PRS 42.8%
  • starburst amacrine cell CL0004232
    CSI 0.1
    rCSI 0.9%
    PRS 23.9%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.1
    rCSI 1.0%
    PRS 39.3%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.1
    rCSI 0.9%
    PRS 16.8%
  • cytotoxic T cell CL0000910
    CSI 0.1
    rCSI 0.8%
    PRS 31.8%
  • bronchial goblet cell CL1000312
    CSI 0.2
    rCSI 0.7%
    PRS 44.5%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.2
    rCSI 0.6%
    PRS 22.5%
  • mucous neck cell CL0000651
    CSI 0.2
    rCSI 0.3%
    PRS 34.1%
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 0.2
    rCSI 2.4%
    PRS 68.3%
  • enteric neuron CL0007011
    CSI 0.2
    rCSI 3.1%
    PRS 49.3%
  • endothelial cell of uterus CL0009095
    CSI 0.2
    rCSI 1.6%
    PRS 54.7%
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.3
    rCSI 1.4%
    PRS 48.4%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 0.3
    rCSI 0.3%
    PRS 30.9%
  • respiratory basal cell CL0002633
    CSI 0.3
    rCSI 0.3%
    PRS 25.6%
  • tracheal goblet cell CL1000329
    CSI 0.3
    rCSI 0.6%
    PRS 41.5%
  • respiratory goblet cell CL0002370
    CSI 0.3
    rCSI 3.0%
    PRS 40.8%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 0.3
    rCSI 0.9%
    PRS 14.3%
  • transit amplifying cell CL0009010
    CSI 0.3
    rCSI 0.4%
    PRS 34.9%
  • helper T cell CL0000912
    CSI 0.3
    rCSI 0.4%
    PRS 30.1%
  • cell of skeletal muscle CL0000188
    CSI 0.3
    rCSI 3.1%
    PRS 74.3%
  • pancreatic epsilon cell CL0005019
    CSI 0.3
    rCSI 1.4%
    PRS 46.3%
  • common dendritic progenitor CL0001029
    CSI 0.3
    rCSI 0.4%
    PRS 28.1%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 0.3
    rCSI 0.7%
    PRS 14.4%
  • mucus secreting cell CL0000319
    CSI 0.3
    rCSI 0.5%
    PRS 27.8%
  • megakaryocyte progenitor cell CL0000553
    CSI 0.3
    rCSI 6.3%
    PRS 58.6%
  • squamous epithelial cell CL0000076
    CSI 0.4
    rCSI 0.8%
    PRS 26.8%
  • duct epithelial cell CL0000068
    CSI 0.4
    rCSI 0.5%
    PRS 23.0%
  • neuroplacodal cell CL0000032
    CSI 0.4
    rCSI 3.3%
    PRS 52.6%
  • contractile cell CL0000183
    CSI 0.4
    rCSI 1.1%
    PRS 20.9%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 0.4
    rCSI 0.8%
    PRS 15.8%
  • glandular epithelial cell CL0000150
    CSI 0.4
    rCSI 1.0%
    PRS 41.7%
  • lung neuroendocrine cell CL1000223
    CSI 0.4
    rCSI 0.6%
    PRS 24.7%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.4
    rCSI 1.1%
    PRS 24.5%
  • elicited macrophage CL0000861
    CSI 0.4
    rCSI 0.4%
    PRS 25.5%
  • innate lymphoid cell CL0001065
    CSI 0.4
    rCSI 0.8%
    PRS 32.2%
  • type L enteroendocrine cell CL0002279
    CSI 0.4
    rCSI 0.7%
    PRS 41.6%
  • class switched memory B cell CL0000972
    CSI 0.4
    rCSI 0.3%
    PRS 36.3%
  • colon epithelial cell CL0011108
    CSI 0.4
    rCSI 0.4%
    PRS 20.3%
  • amacrine cell CL0000561
    CSI 0.4
    rCSI 1.2%
    PRS 16.6%
  • lung secretory cell CL1000272
    CSI 0.4
    rCSI 1.0%
    PRS 20.1%
  • nasal mucosa goblet cell CL0002480
    CSI 0.4
    rCSI 0.5%
    PRS 31.2%
  • podocyte CL0000653
    CSI 0.4
    rCSI 1.9%
    PRS 21.1%
  • corneal epithelial cell CL0000575
    CSI 0.4
    rCSI 1.3%
    PRS 37.9%
  • diffuse bipolar 4 cell CL4033031
    CSI 0.4
    rCSI 5.1%
    PRS 26.0%
  • pancreatic PP cell CL0002275
    CSI 0.5
    rCSI 1.8%
    PRS 36.7%
  • eosinophil CL0000771
    CSI 0.5
    rCSI 3.0%
    PRS 52.6%
  • eye photoreceptor cell CL0000287
    CSI 0.5
    rCSI 5.2%
    PRS 49.6%
  • neuroendocrine cell CL0000165
    CSI 0.5
    rCSI 1.8%
    PRS 41.7%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 0.5
    rCSI 0.8%
    PRS 28.2%
  • erythroid progenitor cell CL0000038
    CSI 0.5
    rCSI 2.7%
    PRS 32.1%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.5
    rCSI 2.5%
    PRS 36.7%
  • progenitor cell CL0011026
    CSI 0.5
    rCSI 1.1%
    PRS 33.0%
  • primitive red blood cell CL0002355
    CSI 0.5
    rCSI 2.7%
    PRS 36.8%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.5
    rCSI 3.2%
    PRS 46.8%
  • lung ciliated cell CL1000271
    CSI 0.5
    rCSI 0.6%
    PRS 16.0%
  • alternatively activated macrophage CL0000890
    CSI 0.6
    rCSI 0.7%
    PRS 33.0%
  • myeloid dendritic cell, human CL0001057
    CSI 0.6
    rCSI 3.2%
    PRS 60.8%
  • epithelial cell of nephron CL1000449
    CSI 0.6
    rCSI 5.4%
    PRS 71.0%
  • forebrain radial glial cell CL0013000
    CSI 0.6
    rCSI 1.8%
    PRS 30.5%
  • glial cell CL0000125
    CSI 0.6
    rCSI 2.2%
    PRS 20.9%
  • alveolar macrophage CL0000583
    CSI 0.6
    rCSI 1.0%
    PRS 25.6%
  • GABAergic neuron CL0000617
    CSI 0.6
    rCSI 2.0%
    PRS 15.5%
  • diffuse bipolar 2 cell CL4033028
    CSI 0.6
    rCSI 4.5%
    PRS 24.0%
  • ON-bipolar cell CL0000749
    CSI 0.6
    rCSI 0.9%
    PRS 25.5%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 0.6
    rCSI 0.7%
    PRS 37.5%
  • retina horizontal cell CL0000745
    CSI 0.6
    rCSI 0.9%
    PRS 20.0%
  • intestinal epithelial cell CL0002563
    CSI 0.6
    rCSI 0.6%
    PRS 22.6%
  • promyelocyte CL0000836
    CSI 0.6
    rCSI 0.9%
    PRS 30.4%
  • hepatocyte CL0000182
    CSI 0.6
    rCSI 1.1%
    PRS 20.1%
  • deuterosomal cell CL4033044
    CSI 0.6
    rCSI 2.1%
    PRS 34.0%
  • diffuse bipolar 1 cell CL4033027
    CSI 0.6
    rCSI 4.8%
    PRS 22.9%
  • choroid plexus epithelial cell CL0000706
    CSI 0.6
    rCSI 1.0%
    PRS 16.6%
  • pancreatic acinar cell CL0002064
    CSI 0.7
    rCSI 0.9%
    PRS 23.8%
  • erythrocyte CL0000232
    CSI 0.7
    rCSI 1.5%
    PRS 28.6%
  • syncytiotrophoblast cell CL0000525
    CSI 0.7
    rCSI 1.9%
    PRS 39.4%
  • H1 horizontal cell CL0004217
    CSI 0.7
    rCSI 2.6%
    PRS 29.2%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 0.7
    rCSI 1.6%
    PRS 34.3%
  • macroglial cell CL0000126
    CSI 0.7
    rCSI 1.8%
    PRS 28.0%
  • mesangial cell CL0000650
    CSI 0.7
    rCSI 2.8%
    PRS 30.9%
  • cardiac neuron CL0010022
    CSI 0.7
    rCSI 2.2%
    PRS 17.6%
  • lung macrophage CL1001603
    CSI 0.7
    rCSI 1.6%
    PRS 25.3%
  • club cell CL0000158
    CSI 0.7
    rCSI 1.0%
    PRS 24.7%
  • pancreatic ductal cell CL0002079
    CSI 0.7
    rCSI 1.4%
    PRS 22.3%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.7
    rCSI 1.7%
    PRS 22.3%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 0.7
    rCSI 1.5%
    PRS 36.3%
  • thymocyte CL0000893
    CSI 0.7
    rCSI 2.6%
    PRS 61.3%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 0.8
    rCSI 6.5%
    PRS 32.6%
  • mature alpha-beta T cell CL0000791
    CSI 0.8
    rCSI 2.8%
    PRS 37.2%
  • conjunctival epithelial cell CL1000432
    CSI 0.8
    rCSI 1.2%
    PRS 21.9%
  • small intestine goblet cell CL1000495
    CSI 0.8
    rCSI 1.7%
    PRS 28.9%
  • intermediate monocyte CL0002393
    CSI 0.8
    rCSI 1.2%
    PRS 22.1%
  • epicardial adipocyte CL1000309
    CSI 0.8
    rCSI 2.6%
    PRS 26.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [XPO1](/details-gene/7514), or Exportin 1 (also known as Chromosome Region Maintenance 1, CRM1), is a pivotal protein that functions as a nuclear export receptor. It recognizes and binds to leucine-rich nuclear export signals (NES) on cargo proteins, mediating their transport from the nucleus to the cytoplasm in a RanGTP-dependent manner ([Link](https://doi.org/10.1016/s0092-8674(00)80371-2), [Link](https://doi.org/10.1126/science.278.5335.141)). This process is fundamental for the proper localization and function of numerous proteins, including tumor suppressors, as well as the export of various RNA species. Expression data indicates that **Overall**, [XPO1](/details-gene/7514) is a highly significant gene in the central nervous system, with particularly high expression in diverse neuronal subtypes, including [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011) and [L2/3-6 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4023040), suggesting a crucial role in maintaining neuronal function and identity. ## Cellular Roles and Expression Landscape The expression profile of [XPO1](/details-gene/7514) underscores its critical importance in the central nervous system. **Overall**, it demonstrates the highest significance in a wide array of neuronal and glial cell types. Top-ranking cells include specialized inhibitory neurons like [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011) and [sncg GABAergic cortical interneurons](/details-cell/CL4023015), as well as excitatory neurons such as [L2/3-6 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4023040). Its high significance extends to progenitor cells like [neuroblasts (sensu Nematoda and Protostomia)](/details-cell/CL0000338) and [radial glial cells](/details-cell/CL0000681), and specialized cells of the retina, including [retinal ganglion cells](/details-cell/CL0000740) and [retinal pigment epithelial cells](/details-cell/CL0002586). This broad and high expression across the nervous system is consistent with a housekeeping function that is essential for the high level of transcriptional and translational activity required by these cells. Conversely, [XPO1](/details-gene/7514) shows low or negligible significance in certain hematopoietic lineages, such as [CD14-low, CD16-positive monocytes](/details-cell/CL0002396) and [germinal center B cells](/details-cell/CL0000844). This pattern suggests that while [XPO1](/details-gene/7514) is a ubiquitous and essential gene, its regulatory importance and expression levels are particularly pronounced in complex, post-mitotic cells like neurons compared to other specialized cell types. ## Pathways and Molecular Function Functionally, [XPO1](/details-gene/7514) is annotated as having **nuclear export signal receptor activity** ([GO:0005049](https://www.ebi.ac.uk/QuickGO/term/GO:0005049)) and is a central component of **nucleocytoplasmic transport** ([GO:0006913](https://www.ebi.ac.uk/QuickGO/term/GO:0006913)). Its primary role involves the export of proteins ([GO:0006611](https://www.ebi.ac.uk/QuickGO/term/GO:0006611)), mRNA ([GO:0006406](https://www.ebi.ac.uk/QuickGO/term/GO:0006406)), and ribosomal subunits ([GO:0000054](https://www.ebi.ac.uk/QuickGO/term/GO:0000054)) from the nucleus. This fundamental process makes [XPO1](/details-gene/7514) a key regulator of major cellular events. Reactome pathway analysis reveals its extensive involvement in the **Cell cycle** ([R-HSA-1640170](https://reactome.org/content/detail/R-HSA-1640170)), particularly during M phase and the mitotic spindle checkpoint ([R-HSA-69618](https://reactome.org/content/detail/R-HSA-69618)), which is supported by early research on its cell cycle-dependent expression ([Link](https://doi.org/10.1074/jbc.272.47.29742)). Furthermore, it plays a role in critical signaling pathways including **Signaling by Wnt** ([R-HSA-195721](https://reactome.org/content/detail/R-HSA-195721)) and **TGF-beta receptor signaling** ([R-HSA-170834](https://reactome.org/content/detail/R-HSA-170834)). Notably, the function of [XPO1](/details-gene/7514) is co-opted during various viral infections. It is essential for the **Export of viral ribonucleoproteins from nucleus** ([R-HSA-168274](https://reactome.org/content/detail/R-HSA-168274)) and is a key host factor in the life cycles of HIV ([R-HSA-162906](https://reactome.org/content/detail/R-HSA-162906)) and influenza ([R-HSA-168255](https://reactome.org/content/detail/R-HSA-168255)), as demonstrated in studies on its interaction with viral proteins ([Link](https://doi.org/10.1128/jvi.75.1.408-419.2001)). ## Research Directions The central role of [XPO1](/details-gene/7514) in cellular homeostasis, combined with its high significance in the CNS, provides fertile ground for further investigation. **Testable Hypotheses:** 1. Given its high expression across diverse neuronal subtypes, [XPO1](/details-gene/7514) may be critical for neuronal plasticity and long-term memory formation by regulating the nuclear export of activity-dependent transcription factors and mRNAs required at the synapse. 2. The hijacking of [XPO1](/details-gene/7514) by viruses suggests that its inhibition could be a broad-spectrum antiviral strategy against neurotropic viruses that rely on nuclear export for replication. **Proposed Experimental Approach:** To test the first hypothesis, a conditional knockout of [XPO1](/details-gene/7514) could be generated in a specific neuronal population (e.g., hippocampal CA1 neurons) in a mouse model. These mice would then be subjected to behavioral paradigms that test learning and memory, such as the Morris water maze. Electrophysiological recordings could assess long-term potentiation (LTP) in hippocampal slices. Furthermore, subcellular fractionation of the targeted neurons followed by mass spectrometry and RNA-seq would identify the specific protein and RNA cargoes whose nucleocytoplasmic transport is disrupted, linking molecular defects to functional deficits. **Therapeutic Potential:** [XPO1](/details-gene/7514) is a well-established therapeutic target in oncology, where its overexpression allows cancer cells to export and inactivate nuclear tumor suppressor proteins. This is associated with diseases cataloged in OMIM ([602559](https://omim.org/entry/602559)). Consequently, **inhibition** of [XPO1](/details-gene/7514) with small molecules (e.g., Selinexor) is an approved therapeutic strategy that forces the nuclear retention and reactivation of tumor suppressors. However, the high expression of [XPO1](/details-gene/7514) in healthy tissues, particularly the CNS, suggests a narrow therapeutic window and a risk of on-target toxicities. Future therapeutic development may focus on creating inhibitors with improved tissue specificity or exploring its potential as a target for treating viral infections.

Genular Protein ID: 1482870260

Symbol: XPO1_HUMAN

Name: Exportin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9049309

Title: The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88.

PubMed ID: 9049309

DOI: 10.1093/emboj/16.4.807

PubMed ID: 9368044

Title: Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.

PubMed ID: 9368044

DOI: 10.1074/jbc.272.47.29742

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9323133

Title: CRM1 is an export receptor for leucine-rich nuclear export signals.

PubMed ID: 9323133

DOI: 10.1016/s0092-8674(00)80371-2

PubMed ID: 9311922

Title: Evidence for a role of CRM1 in signal-mediated nuclear protein export.

PubMed ID: 9311922

DOI: 10.1126/science.278.5335.141

PubMed ID: 9837918

Title: The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.

PubMed ID: 9837918

DOI: 10.1074/jbc.273.50.33414

PubMed ID: 10209022

Title: CRM1-mediated recycling of snurportin 1 to the cytoplasm.

PubMed ID: 10209022

DOI: 10.1083/jcb.145.2.255

PubMed ID: 10400785

Title: Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression.

PubMed ID: 10400785

DOI: 10.1128/jvi.73.8.6872-6881.1999

PubMed ID: 10430904

Title: Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region.

PubMed ID: 10430904

DOI: 10.1073/pnas.96.16.9112

PubMed ID: 10358091

Title: A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1.

PubMed ID: 10358091

DOI: 10.1074/jbc.274.24.17309

PubMed ID: 11571268

Title: RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.

PubMed ID: 11571268

DOI: 10.1093/embo-reports/kve200

PubMed ID: 11119609

Title: Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway.

PubMed ID: 11119609

DOI: 10.1128/jvi.75.1.408-419.2001

PubMed ID: 11425870

Title: Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.

PubMed ID: 11425870

DOI: 10.1083/jcb.153.7.1391

PubMed ID: 11932251

Title: Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.

PubMed ID: 11932251

DOI: 10.1074/jbc.c100620200

PubMed ID: 12134013

Title: The carboxy-terminal region of the human immunodeficiency virus type 1 protein Rev has multiple roles in mediating CRM1-related Rev functions.

PubMed ID: 12134013

DOI: 10.1128/jvi.76.16.8079-8089.2002

PubMed ID: 12724356

Title: Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway.

PubMed ID: 12724356

DOI: 10.1242/jcs.00464

PubMed ID: 12808100

Title: Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

PubMed ID: 12808100

DOI: 10.1128/mcb.23.13.4598-4610.2003

PubMed ID: 14612415

Title: A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.

PubMed ID: 14612415

DOI: 10.1128/mcb.23.23.8751-8761.2003

PubMed ID: 15507209

Title: Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.

PubMed ID: 15507209

DOI: 10.1016/j.cell.2004.09.029

PubMed ID: 15574332

Title: PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli.

PubMed ID: 15574332

DOI: 10.1016/j.molcel.2004.11.013

PubMed ID: 15632073

Title: Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo.

PubMed ID: 15632073

DOI: 10.1128/mcb.25.2.728-739.2005

PubMed ID: 16103875

Title: Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells.

PubMed ID: 16103875

DOI: 10.1038/sj.onc.1208962

PubMed ID: 16302269

Title: Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.

PubMed ID: 16302269

DOI: 10.1002/mc.20156

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18316374

Title: CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.

PubMed ID: 18316374

DOI: 10.1074/jbc.m708365200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20826784

Title: Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

PubMed ID: 20826784

DOI: 10.1074/jbc.m110.152777

PubMed ID: 20147401

Title: Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.

PubMed ID: 20147401

DOI: 10.1128/jvi.02554-09

PubMed ID: 20921223

Title: Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.

PubMed ID: 20921223

DOI: 10.1074/jbc.m110.107912

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22022502

Title: An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.

PubMed ID: 22022502

DOI: 10.1371/journal.pone.0026044

PubMed ID: 21637748

Title: SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.

PubMed ID: 21637748

DOI: 10.1371/journal.pone.0019436

PubMed ID: 22500989

Title: Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).

PubMed ID: 22500989

DOI: 10.1016/j.febslet.2012.02.053

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 22275354

Title: Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity.

PubMed ID: 22275354

DOI: 10.1074/jbc.m111.294272

PubMed ID: 22730302

Title: NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.

PubMed ID: 22730302

DOI: 10.1093/nar/gks598

PubMed ID: 23164465

Title: HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing.

PubMed ID: 23164465

DOI: 10.1111/febs.12066

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28325843

Title: A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

PubMed ID: 28325843

DOI: 10.1261/rna.060137.116

PubMed ID: 15574331

Title: Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.

PubMed ID: 15574331

DOI: 10.1016/j.molcel.2004.11.018

Sequence Information:

  • Length: 1071
  • Mass: 123386
  • Checksum: FDB00C065DA2FB1D
  • Sequence:
  • MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL THLKEHPDAW 
    TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE GIKKYVVGLI IKTSSDPTCV 
    EKEKVYIGKL NMILVQILKQ EWPKHWPTFI SDIVGASRTS ESLCQNNMVI LKLLSEEVFD 
    FSSGQITQVK SKHLKDSMCN EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY 
    IFETKLISTL IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFVTLFTLT MMQLKQMLPL 
    NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHDQLIEKR LNLRETLMEA LHYMLLVSEV 
    EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF DVPPRRQLYL PMLFKVRLLM 
    VSRMAKPEEV LVVENDQGEV VREFMKDTDS INLYKNMRET LVYLTHLDYV DTERIMTEKL 
    HNQVNGTEWS WKNLNTLCWA IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII 
    ASNIMYIVGQ YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV 
    QVQVGEVMPF IDEILNNINT IICDLQPQQV HTFYEAVGYM IGAQTDQTVQ EHLIEKYMLL 
    PNQVWDSIIQ QATKNVDILK DPETVKQLGS ILKTNVRACK AVGHPFVIQL GRIYLDMLNV 
    YKCLSENISA AIQANGEMVT KQPLIRSMRT VKRETLKLIS GWVSRSNDPQ MVAENFVPPL 
    LDAVLIDYQR NVPAAREPEV LSTMAIIVNK LGGHITAEIP QIFDAVFECT LNMINKDFEE 
    YPEHRTNFFL LLQAVNSHCF PAFLAIPPTQ FKLVLDSIIW AFKHTMRNVA DTGLQILFTL 
    LQNVAQEEAA AQSFYQTYFC DILQHIFSVV TDTSHTAGLT MHASILAYMF NLVEEGKIST 
    SLNPGNPVNN QIFLQEYVAN LLKSAFPHLQ DAQVKLFVTG LFSLNQDIPA FKEHLRDFLV 
    QIKEFAGEDT SDLFLEEREI ALRQADEEKH KRQMSVPGIF NPHEIPEEMC D

Genular Protein ID: 4132925369

Symbol: A0A7I2V6B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 940
  • Mass: 108315
  • Checksum: 093ABA4CABE62AD2
  • Sequence:
  • MILVQILKQE WPKHWPTFIS DIVGASRTSE SLCQNNMVIL KLLSEEVFDF SSGQITQVKS 
    KHLKDSMCNE FSQIFQLCQF VMENSQNAPL VHATLETLLR FLNWIPLGYI FETKLISTLI 
    YKFLNVPMFR NVSLKCLTEI AGVSVSQYEE QFVTLFTLTM MQLKQMLPLN TNIRLAYSNG 
    KDDEQNFIQN LSLFLCTFLK EHDQLIEKRL NLRETLMEAL HYMLLVSEVE ETEIFKICLE 
    YWNHLAAELY RESPFSTSAS PLLSGSQHFD VPPRRQLYLP MLFKVRLLMV SRMAKPEEVL 
    VVENDQGEVV REFMKDTDSI NLYKNMRETL VYLTHLDYVD TERIMTEKLH NQVNGTEWSW 
    KNLNTLCWAI GSISGAMHEE DEKRFLVTVI KDLLGLCEQK RGKDNKAIIA SNIMYIVGQY 
    PRFLRAHWKF LKTVVNKLFE FMHETHDGVQ DMACDTFIKI AQKCRRHFVQ VQVGEVMPFI 
    DEILNNINTI ICDLQPQQVH TFYEAVGYMI GAQTDQTVQE HLIEKYMLLP NQVWDSIIQQ 
    ATKNVDILKD PETVKQLGSI LKTNVRACKA VGHPFVIQLG RIYLDMLNVY KCLSENISAA 
    IQANGEMVTK QPLIRSMRTV KRETLKLISG WVSRSNDPQM VAENFVPPLL DAVLIDYQRN 
    VPAAREPEVL STMAIIVNKL GGHITAEIPQ IFDAVFECTL NMINKDFEEY PEHRTNFFLL 
    LQAVNSHCFP AFLAIPPTQF KLVLDSIIWA FKHTMRNVAD TGLQILFTLL QNVAQEEAAA 
    QSFYQTYFCD ILQHIFSVVT DTSHTAGLTM HASILAYMFN LVEEGKISTS LNPGNPVNNQ 
    IFLQEYVANL LKSAFPHLQD AQVKLFVTGL FSLNQDIPAF KEHLRDFLVQ IKEFAGEDTS 
    DLFLEEREIA LRQADEEKHK RQMSVPGIFN PHEIPEEMCD

Genular Protein ID: 3939948113

Symbol: A0A7I2V2Y6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1026
  • Mass: 118165
  • Checksum: 056BADC813B9BEC7
  • Sequence:
  • MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL THLKEHPDAW 
    TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE GIKKYVVGLI IKTSSDPTCV 
    EKEKVYIGKL NMILVQILKQ EWPKHWPTFI SDIVGASRTS ESLCQNNMVI LKLLSEEVFD 
    FSSGQITQVK SKHLKDSMCN EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY 
    IFETKLISTL IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFVTLFTLT MMQLKQMLPL 
    NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHDQLIEKR LNLRETLMEA LHYMLLVSEV 
    EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF DVPPRRQLYL PMLFKVRLLM 
    VSRMAKPEEV LVVENDQGEV VREFMKDTDS INLYKNMRET LVYLTHLDYV DTERIMTEKL 
    HNQVNGTEWS WKNLNTLCWA IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII 
    ASNIMYIVGQ YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV 
    QVQVGEVMPF IDEILNNINT IICDLQPQQN VDILKDPETV KQLGSILKTN VRACKAVGHP 
    FVIQLGRIYL DMLNVYKCLS ENISAAIQAN GEMVTKQPLI RSMRTVKRET LKLISGWVSR 
    SNDPQMVAEN FVPPLLDAVL IDYQRNVPAA REPEVLSTMA IIVNKLGGHI TAEIPQIFDA 
    VFECTLNMIN KDFEEYPEHR TNFFLLLQAV NSHCFPAFLA IPPTQFKLVL DSIIWAFKHT 
    MRNVADTGLQ ILFTLLQNVA QEEAAAQSFY QTYFCDILQH IFSVVTDTSH TAGLTMHASI 
    LAYMFNLVEE GKISTSLNPG NPVNNQIFLQ EYVANLLKSA FPHLQDAQVK LFVTGLFSLN 
    QDIPAFKEHL RDFLVQIKEF AGEDTSDLFL EEREIALRQA DEEKHKRQMS VPGIFNPHEI 
    PEEMCD

Genular Protein ID: 3885880309

Symbol: B3KWD0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 718
  • Mass: 82419
  • Checksum: EC4DF6C52E249A8E
  • Sequence:
  • MLLVSEVEET EIFKICLEYW NHLAAELYRE SPFSTSASPL LSGSQHFDVP PRRQLYLPML 
    FKVRLLMVSR MAKPEEVLVV ENDQGEVVRE FMKDTDSINL YKNMRETLVY LTHLDYVDTE 
    RIMTEKLHNQ VNGTEWSWKN LNTLCWAIGS ISGAMHEEDE KRFLVTVIKD LLGLCEQKRG 
    KDNKAIIASN IMYIVGQYPR FLRAHWKFLK TVVNKLFEFM HETHDGVQDM ACDTFIKIAQ 
    KCRRHFVQVQ VGEVMPFIDE ILNNINTIIC DLQPQQVHTF YEAVGYMIGA QTDQTVQEHL 
    IEKYMLLPNQ VWDSIIQQAT KNVDILKDPE TVKQLGSILK TNVRACKAVG HPFVIQLGRI 
    YLDMLNVYKC LSENISAAIQ ANGEMVTKQP LIRSMRTVKR ETLKLISGWV SRSNDPQMVA 
    ENFVPPLLDA VLIDYQRNVP AAREPEVLST MAIIVNKLGG HITAEIPQIF DAVFECTLNM 
    INKDFEEYPE HRTNFFLLLQ AVNSHCFPAF LAIPPTQFKL VLDSIIWAFK HTMRNVADTG 
    LQILFTLLQN VAQEEAAAQS FYQTYFCDIL QHIFSVVTDT SHTAGLTMHA SILAYMFNLV 
    EEGKISTSLN PGNPVNNQIF LQEYVANLLK SAFPHLQDAQ VKLFVTGLFS LNQDIPAFKE 
    HLRDFLVQIK EFAGEDTSDL FLEEREIALR QADEEKHKRQ MSVPGIFNPH EIPEEMCD

Genular Protein ID: 3946340536

Symbol: A0A7I2V461_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1056
  • Mass: 121628
  • Checksum: 9CC379EA9A369615
  • Sequence:
  • MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL THLKEHPDAW 
    TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE GIKKYVVGLI IKTSSDPTCV 
    EILKQEWPKH WPTFISDIVG ASRTSESLCQ NNMVILKLLS EEVFDFSSGQ ITQVKSKHLK 
    DSMCNEFSQI FQLCQFVMEN SQNAPLVHAT LETLLRFLNW IPLGYIFETK LISTLIYKFL 
    NVPMFRNVSL KCLTEIAGVS VSQYEEQFVT LFTLTMMQLK QMLPLNTNIR LAYSNGKDDE 
    QNFIQNLSLF LCTFLKEHDQ LIEKRLNLRE TLMEALHYML LVSEVEETEI FKICLEYWNH 
    LAAELYRESP FSTSASPLLS GSQHFDVPPR RQLYLPMLFK VRLLMVSRMA KPEEVLVVEN 
    DQGEVVREFM KDTDSINLYK NMRETLVYLT HLDYVDTERI MTEKLHNQVN GTEWSWKNLN 
    TLCWAIGSIS GAMHEEDEKR FLVTVIKDLL GLCEQKRGKD NKAIIASNIM YIVGQYPRFL 
    RAHWKFLKTV VNKLFEFMHE THDGVQDMAC DTFIKIAQKC RRHFVQVQVG EVMPFIDEIL 
    NNINTIICDL QPQQVHTFYE AVGYMIGAQT DQTVQEHLIE KYMLLPNQVW DSIIQQATKN 
    VDILKDPETV KQLGSILKTN VRACKAVGHP FVIQLGRIYL DMLNVYKCLS ENISAAIQAN 
    GEMVTKQPLI RSMRTVKRET LKLISGWVSR SNDPQMVAEN FVPPLLDAVL IDYQRNVPAA 
    REPEVLSTMA IIVNKLGGHI TAEIPQIFDA VFECTLNMIN KDFEEYPEHR TNFFLLLQAV 
    NSHCFPAFLA IPPTQFKLVL DSIIWAFKHT MRNVADTGLQ ILFTLLQNVA QEEAAAQSFY 
    QTYFCDILQH IFSVVTDTSH TAGLTMHASI LAYMFNLVEE GKISTSLNPG NPVNNQIFLQ 
    EYVANLLKSA FPHLQDAQVK LFVTGLFSLN QDIPAFKEHL RDFLVQIKEF AGEDTSDLFL 
    EEREIALRQA DEEKHKRQMS VPGIFNPHEI PEEMCD