Details for: ZNF3

Gene ID: 7551

Symbol: ZNF3

Ensembl ID: ENSG00000166526

Description: zinc finger protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.2790
    Cell Significance Index: -17.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.6146
    Cell Significance Index: -17.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.1500
    Cell Significance Index: -17.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.4451
    Cell Significance Index: -20.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.3610
    Cell Significance Index: -17.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.9130
    Cell Significance Index: -19.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2755
    Cell Significance Index: -19.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1520
    Cell Significance Index: -20.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4116
    Cell Significance Index: -13.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5502
    Cell Significance Index: -7.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9854
    Cell Significance Index: 114.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8406
    Cell Significance Index: 91.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7689
    Cell Significance Index: 10.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6841
    Cell Significance Index: 111.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6581
    Cell Significance Index: 22.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5727
    Cell Significance Index: 113.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5347
    Cell Significance Index: 15.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5141
    Cell Significance Index: 28.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5115
    Cell Significance Index: 461.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5114
    Cell Significance Index: 50.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5047
    Cell Significance Index: 275.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4911
    Cell Significance Index: 22.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4647
    Cell Significance Index: 63.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4505
    Cell Significance Index: 9.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4465
    Cell Significance Index: 30.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3582
    Cell Significance Index: 10.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3089
    Cell Significance Index: 55.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3044
    Cell Significance Index: 61.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2563
    Cell Significance Index: 48.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2544
    Cell Significance Index: 6.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2274
    Cell Significance Index: 6.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2193
    Cell Significance Index: 26.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2018
    Cell Significance Index: 15.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1814
    Cell Significance Index: 11.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1696
    Cell Significance Index: 10.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1574
    Cell Significance Index: 4.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1571
    Cell Significance Index: 56.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1542
    Cell Significance Index: 8.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1452
    Cell Significance Index: 18.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1416
    Cell Significance Index: 97.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1352
    Cell Significance Index: 59.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1298
    Cell Significance Index: 6.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1123
    Cell Significance Index: 8.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1055
    Cell Significance Index: 13.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1049
    Cell Significance Index: 2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0709
    Cell Significance Index: 3.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0623
    Cell Significance Index: 2.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0606
    Cell Significance Index: 3.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0460
    Cell Significance Index: 0.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0155
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0124
    Cell Significance Index: 23.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0026
    Cell Significance Index: 3.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0017
    Cell Significance Index: 0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0073
    Cell Significance Index: -4.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0078
    Cell Significance Index: -0.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0089
    Cell Significance Index: -0.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0138
    Cell Significance Index: -0.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0139
    Cell Significance Index: -10.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0139
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -14.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0203
    Cell Significance Index: -9.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0325
    Cell Significance Index: -18.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0350
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0407
    Cell Significance Index: -5.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0427
    Cell Significance Index: -4.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0500
    Cell Significance Index: -14.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0534
    Cell Significance Index: -1.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0672
    Cell Significance Index: -1.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0693
    Cell Significance Index: -8.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0935
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0960
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1022
    Cell Significance Index: -21.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1198
    Cell Significance Index: -3.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1308
    Cell Significance Index: -3.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1314
    Cell Significance Index: -3.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1330
    Cell Significance Index: -3.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1780
    Cell Significance Index: -3.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1827
    Cell Significance Index: -19.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1886
    Cell Significance Index: -12.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2143
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2188
    Cell Significance Index: -17.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2574
    Cell Significance Index: -15.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2589
    Cell Significance Index: -11.4500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2655
    Cell Significance Index: -2.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2685
    Cell Significance Index: -4.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2743
    Cell Significance Index: -3.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3146
    Cell Significance Index: -6.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3211
    Cell Significance Index: -12.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3220
    Cell Significance Index: -9.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3407
    Cell Significance Index: -3.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3475
    Cell Significance Index: -4.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3488
    Cell Significance Index: -8.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4469
    Cell Significance Index: -14.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4471
    Cell Significance Index: -13.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4610
    Cell Significance Index: -16.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4612
    Cell Significance Index: -16.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF3 is a member of the zinc finger protein family, characterized by its unique zinc-binding motif, which confers specificity to DNA sequences. This protein is predominantly expressed in cells of the immune system, including leukocytes, and is also found in non-immune cells, such as pulmonary interstitial fibroblasts and intestinal epithelial cells. ZNF3 is a transcription factor that recognizes specific DNA sequences and regulates gene expression by interacting with RNA polymerase II. **Pathways and Functions:** ZNF3 is involved in multiple signaling pathways that regulate cellular differentiation, proliferation, and survival. Some of the key pathways and functions of ZNF3 include: 1. **Cell differentiation:** ZNF3 regulates the expression of genes involved in cellular differentiation, including those involved in the development of immune cells, such as T cells and B cells. 2. **Gene expression:** ZNF3 acts as a transcription factor that recognizes specific DNA sequences and regulates gene expression by interacting with RNA polymerase II. 3. **Immune response:** ZNF3 is involved in the regulation of immune responses, including the activation of leukocytes and the production of cytokines. 4. **Leukocyte activation:** ZNF3 regulates the activation of leukocytes, including T cells and B cells, by modulating the expression of genes involved in immune responses. 5. **Regulation of transcription:** ZNF3 regulates the expression of genes involved in transcriptional regulation, including those involved in the regulation of RNA polymerase II. **Clinical Significance:** ZNF3 has been implicated in various diseases, including: 1. **Autoimmune disorders:** ZNF3 has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus, where dysregulation of immune responses leads to tissue damage. 2. **Cancer:** ZNF3 has been implicated in the development and progression of certain cancers, including leukemia and lymphoma, where dysregulation of gene expression contributes to tumorigenesis. 3. **Neurological disorders:** ZNF3 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of gene expression contributes to disease pathogenesis. In conclusion, ZNF3 is a transcription factor that plays a critical role in regulating cellular differentiation, gene expression, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of ZNF3 in human health and disease. Further research is needed to fully elucidate the mechanisms of ZNF3 and its role in disease pathogenesis.

Genular Protein ID: 1863998209

Symbol: ZNF3_HUMAN

Name: Zinc finger protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1945843

Title: Members of the zinc finger protein gene family sharing a conserved N-terminal module.

PubMed ID: 1945843

DOI: 10.1093/nar/19.20.5661

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 3380682

Title: Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation.

PubMed ID: 3380682

DOI: 10.1093/nar/16.10.4227

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 446
  • Mass: 50916
  • Checksum: EEF50906695779A6
  • Sequence:
  • METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL VTFEDVAVYF 
    IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ EISEDTRSHG VLLGRFQKDI 
    SQGLKFKEAY EREVSLKRPL GNSPGERLNR KMPDFGQVTV EEKLTPRGER SEKYNDFGNS 
    FTVNSNLISH QRLPVGDRPH KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS 
    SHLIQHQRIH TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT 
    HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS QSSHLYQHQR 
    IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE CGKAFRYSSA LVRHQRIHTG 
    EKPLNGIGMS KSSLRVTTEL NIREST

Genular Protein ID: 497750684

Symbol: B3KRP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 429
  • Mass: 49412
  • Checksum: 2EB261F5D0DB4EBC
  • Sequence:
  • MCIFHPILSD FFGAAIHIPH PEIACQHVLF QELVTFEDVA VYFIRKEWKR LEPAQRDLYR 
    DVMLENYGNV FSLDRETRTE NDQEISEDTR SHGVLLGRFQ KDISQGLKFK EAYEREVSLK 
    RPLGNSPGER LNRKMPDFGQ VTVEEKLTPR GERSEKYNDF GNSFTVNSNL ISHQRLPVGD 
    RPHKCDECSK SFNRTSDLIQ HQRIHTGEKP YECNECGKAF SQSSHLIQHQ RIHTEEKPYE 
    CSDCGKTFSC SSALILHRRI HTGEKPYECN ECGKTFSWSS TLTHHQRIHT GEKPYACNEC 
    GKAFSRSSTL IHHQRIHTGE KPYECNECGK AFSQSSHLYQ HQRIHTGEKP NECMECGGKF 
    TYSSGLIQHQ RIHTGENPYE CSECGKAFRY SSALVRHQRI HTGEKPLNGI GMSKSSLRVT 
    TELNIREST

Genular Protein ID: 2019631681

Symbol: Q86U76_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 410
  • Mass: 47101
  • Checksum: 340DF419C48A7104
  • Sequence:
  • MLAAALLKAK SQELVTFEDV AVYFIRKEWK RLEPAQRDLY RDVMLENYGN VFSLDRETRT 
    ENDQEISEDT RSHGVLLGRF QKDISQGLKF KEAYEREVSL KRPLGNSPGE RLNRKMPDFG 
    QVTVEEKLTP RGERSEKYND FGNSFTVNSN LISHQRLPVG DRPHKCDECS KSFNRTSDLI 
    QHQRIHTGEK PYECNECGKA FSQSSHLIQH QRIHTGEKPY ECSDCGKTFS CSSALILHRR 
    IHTGEKPYEC NECGKTFSWS STLTHHQRIH TGEKPYACNE CGKAFSRSST LIHHQRIHTG 
    EKPYECNECG KAFSQSSHLY QHQRIHTGEK PYECMECGGK FTYSSGLIQH QRIHTGENPY 
    ECSECGKAFR YSSALVRHQR IHTGEKPLNG IGMSKSSLRV TTELNIREST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.