Details for: ZNF8

Gene ID: 7554

Symbol: ZNF8

Ensembl ID: ENSG00000278129

Description: zinc finger protein 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.1976
    Cell Significance Index: -10.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.7258
    Cell Significance Index: -8.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.8087
    Cell Significance Index: -8.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7294
    Cell Significance Index: 72.1600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.7227
    Cell Significance Index: 7.1300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5992
    Cell Significance Index: 8.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5869
    Cell Significance Index: 529.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4759
    Cell Significance Index: 51.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4072
    Cell Significance Index: 25.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3808
    Cell Significance Index: 61.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3657
    Cell Significance Index: 20.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3475
    Cell Significance Index: 69.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2682
    Cell Significance Index: 31.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2601
    Cell Significance Index: 93.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2471
    Cell Significance Index: 12.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2469
    Cell Significance Index: 17.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2005
    Cell Significance Index: 15.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1957
    Cell Significance Index: 12.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1840
    Cell Significance Index: 4.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1636
    Cell Significance Index: 8.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1521
    Cell Significance Index: 28.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1329
    Cell Significance Index: 3.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1189
    Cell Significance Index: 5.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1135
    Cell Significance Index: 20.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1006
    Cell Significance Index: 3.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0868
    Cell Significance Index: 9.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0797
    Cell Significance Index: 9.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0740
    Cell Significance Index: 3.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0734
    Cell Significance Index: 1.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0648
    Cell Significance Index: 35.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0573
    Cell Significance Index: 25.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0566
    Cell Significance Index: 7.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0545
    Cell Significance Index: 1.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0421
    Cell Significance Index: 1.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0302
    Cell Significance Index: 1.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0162
    Cell Significance Index: 0.4400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0140
    Cell Significance Index: 0.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0124
    Cell Significance Index: 0.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0090
    Cell Significance Index: 6.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0082
    Cell Significance Index: 0.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0048
    Cell Significance Index: 0.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0015
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0077
    Cell Significance Index: -5.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0164
    Cell Significance Index: -10.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0242
    Cell Significance Index: -4.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0337
    Cell Significance Index: -0.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0342
    Cell Significance Index: -9.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0350
    Cell Significance Index: -1.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0352
    Cell Significance Index: -0.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0402
    Cell Significance Index: -2.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0439
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0448
    Cell Significance Index: -9.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0555
    Cell Significance Index: -7.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0639
    Cell Significance Index: -1.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0669
    Cell Significance Index: -7.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0746
    Cell Significance Index: -5.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0751
    Cell Significance Index: -10.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0770
    Cell Significance Index: -1.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0932
    Cell Significance Index: -4.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0994
    Cell Significance Index: -5.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1071
    Cell Significance Index: -3.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1088
    Cell Significance Index: -6.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1130
    Cell Significance Index: -8.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1178
    Cell Significance Index: -2.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1257
    Cell Significance Index: -1.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1379
    Cell Significance Index: -1.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1591
    Cell Significance Index: -5.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1630
    Cell Significance Index: -5.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1802
    Cell Significance Index: -3.3300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1933
    Cell Significance Index: -2.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1935
    Cell Significance Index: -6.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1957
    Cell Significance Index: -3.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2009
    Cell Significance Index: -5.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2026
    Cell Significance Index: -3.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2046
    Cell Significance Index: -4.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2067
    Cell Significance Index: -5.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2070
    Cell Significance Index: -8.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2099
    Cell Significance Index: -4.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2187
    Cell Significance Index: -4.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2193
    Cell Significance Index: -5.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2414
    Cell Significance Index: -3.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2492
    Cell Significance Index: -2.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2522
    Cell Significance Index: -6.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2532
    Cell Significance Index: -9.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2628
    Cell Significance Index: -7.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2659
    Cell Significance Index: -3.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2705
    Cell Significance Index: -3.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2729
    Cell Significance Index: -3.1000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2765
    Cell Significance Index: -5.7700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2779
    Cell Significance Index: -2.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2815
    Cell Significance Index: -3.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2828
    Cell Significance Index: -2.1800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2859
    Cell Significance Index: -3.8600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2961
    Cell Significance Index: -5.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3085
    Cell Significance Index: -4.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3149
    Cell Significance Index: -3.9800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3165
    Cell Significance Index: -4.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF8 is a 3.5-kilobase (kb) long gene that encodes a 374-amino acid protein. The protein features a zinc finger domain, which is responsible for its DNA-binding activity. ZNF8 is highly expressed in various tissues, including kidney proximal convoluted tubule epithelial cells, goblet cells, cardiac endothelial cells, and intestinal epithelial cells. The protein is also detected in cardiac muscle myoblasts and absorptive cells. **Pathways and Functions:** ZNF8 is involved in regulating gene expression through its interaction with RNAPII cis-regulatory elements. This interaction modulates the transcriptional activity of target genes, influencing various cellular processes. Specifically, ZNF8 is implicated in the negative regulation of transcription by RNAPII, which is essential for maintaining cellular homeostasis. ZNF8 is also involved in the BMP signaling pathway, which is critical for development and differentiation. **Clinical Significance:** Dysregulation of ZNF8 has been implicated in various human diseases, including kidney diseases, cardiovascular diseases, and immune disorders. For example, alterations in ZNF8 expression have been observed in patients with kidney proximal convoluted tubule epithelial cell injury and cardiac muscle myoblasts in cardiac hypertrophy. Additionally, ZNF8 has been shown to play a role in modulating the immune response, with implications for the development of autoimmune diseases. In conclusion, ZNF8 is a transcriptional regulator that plays a critical role in maintaining cellular homeostasis and regulating gene expression. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the molecular mechanisms underlying ZNF8 function. **Implications for Future Research:** Further studies are needed to elucidate the molecular mechanisms underlying ZNF8 function and its role in human diseases. Specifically, research should focus on: 1. Characterizing the specific target genes regulated by ZNF8. 2. Investigating the role of ZNF8 in modulating the BMP signaling pathway. 3. Examining the relationship between ZNF8 expression and disease progression in human tissues. 4. Developing therapeutic strategies targeting ZNF8 for the treatment of related diseases. By advancing our understanding of ZNF8 function and its role in human diseases, researchers can identify potential therapeutic targets and develop innovative treatments for a range of clinical conditions.

Genular Protein ID: 608011213

Symbol: ZNF8_HUMAN

Name: Zinc finger protein 8

UniProtKB Accession Codes:

P17098 Q6PI99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2106481

Title: cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes.

PubMed ID: 2106481

DOI: 10.1016/0888-7543(90)90574-e

PubMed ID: 12370310

Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

PubMed ID: 12370310

DOI: 10.1128/mcb.22.21.7633-7644.2002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 575
  • Mass: 64970
  • Checksum: E8F5B9C2FBED92C6
  • Sequence:
    • MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY RDVMLETFGH 
LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP RSESQASRKE EGLPEEEPSH 
VTGREGFPTD APYPTTLGKD RECQSQSLAL KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE 
NCVLSSSPNP FPEISRGEYL YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ 
AIPITELTKS QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL 
VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF NQNSSLGRHK 
RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN HCGKGFRHSS SLAQHQRKHA 
GEKPFECRQR LIFEQTPALT KHEWTEALGC DPPLSQDERT HRSDRPFKCN QCGKCFIQSS 
HLIRHQITHT REEQPHGRSR RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL 
FDIQKIMQEK NPVHVIGVEE PSVGASMLFD IREST

Genular Protein ID: 2108630856

Symbol: B3KS94_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KS94

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 575
  • Mass: 64898
  • Checksum: 18D7B9C0DBCE0407
  • Sequence:
    • MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY RDVMLETFGH 
LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP RSESQASRKE EGLPEEEPSH 
VTGREGFPTD APYPTTLGKD RECQSQSLAL KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE 
NCVLSSSPNP FPEISRGEYL YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ 
AIPITELTKS QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL 
VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF NQNSSLGRHK 
RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN HCGKGFRHSS SLAQHQRKHA 
GEKPFGCRQR LIFEQTPALT KHEWTEALGC DPPLSQDERT HRSDRPFKCN QCGKCFIQSS 
HLIRHQITHT REEQPHGRSR RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL 
FDIQKIMQEK NPVHVIGVEE PSVGASMLFD IREST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.