Details for: ZNF12

Gene ID: 7559

Symbol: ZNF12

Ensembl ID: ENSG00000164631

Description: zinc finger protein 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.6226
    Cell Significance Index: -19.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.0911
    Cell Significance Index: -19.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.2999
    Cell Significance Index: -20.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.7839
    Cell Significance Index: -16.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.9315
    Cell Significance Index: -17.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.4645
    Cell Significance Index: -20.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5032
    Cell Significance Index: -20.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2331
    Cell Significance Index: -20.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0248
    Cell Significance Index: -6.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.1499
    Cell Significance Index: 148.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8795
    Cell Significance Index: 185.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0650
    Cell Significance Index: 14.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0152
    Cell Significance Index: 916.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7201
    Cell Significance Index: 19.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5123
    Cell Significance Index: 32.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4568
    Cell Significance Index: 82.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4497
    Cell Significance Index: 55.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4327
    Cell Significance Index: 22.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4285
    Cell Significance Index: 85.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4205
    Cell Significance Index: 12.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4183
    Cell Significance Index: 18.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4127
    Cell Significance Index: 82.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3998
    Cell Significance Index: 54.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2734
    Cell Significance Index: 7.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2712
    Cell Significance Index: 7.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2537
    Cell Significance Index: 16.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2520
    Cell Significance Index: 111.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2388
    Cell Significance Index: 130.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2334
    Cell Significance Index: 16.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2288
    Cell Significance Index: 5.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2039
    Cell Significance Index: 73.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2028
    Cell Significance Index: 10.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1962
    Cell Significance Index: 10.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1472
    Cell Significance Index: 3.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1364
    Cell Significance Index: 6.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1360
    Cell Significance Index: 17.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1303
    Cell Significance Index: 10.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1192
    Cell Significance Index: 22.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0927
    Cell Significance Index: 5.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0735
    Cell Significance Index: 50.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0715
    Cell Significance Index: 2.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0626
    Cell Significance Index: 2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0506
    Cell Significance Index: 2.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0416
    Cell Significance Index: 5.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0200
    Cell Significance Index: 37.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0190
    Cell Significance Index: 1.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0117
    Cell Significance Index: 0.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0083
    Cell Significance Index: 3.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0082
    Cell Significance Index: 5.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0082
    Cell Significance Index: 12.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0031
    Cell Significance Index: 5.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0075
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0170
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0184
    Cell Significance Index: -3.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0188
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0198
    Cell Significance Index: -14.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0313
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0354
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0369
    Cell Significance Index: -23.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0399
    Cell Significance Index: -2.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0450
    Cell Significance Index: -4.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0530
    Cell Significance Index: -15.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0560
    Cell Significance Index: -6.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0657
    Cell Significance Index: -7.6600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0693
    Cell Significance Index: -0.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0724
    Cell Significance Index: -10.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0944
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1054
    Cell Significance Index: -22.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1228
    Cell Significance Index: -3.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1242
    Cell Significance Index: -2.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1696
    Cell Significance Index: -17.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1946
    Cell Significance Index: -15.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2011
    Cell Significance Index: -6.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2090
    Cell Significance Index: -1.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2114
    Cell Significance Index: -9.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2127
    Cell Significance Index: -13.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2521
    Cell Significance Index: -4.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2697
    Cell Significance Index: -6.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2754
    Cell Significance Index: -10.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2797
    Cell Significance Index: -6.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3306
    Cell Significance Index: -9.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3310
    Cell Significance Index: -6.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3484
    Cell Significance Index: -17.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3590
    Cell Significance Index: -8.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3750
    Cell Significance Index: -10.0300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3833
    Cell Significance Index: -5.3800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3889
    Cell Significance Index: -6.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4091
    Cell Significance Index: -6.0400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4152
    Cell Significance Index: -3.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4211
    Cell Significance Index: -13.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4218
    Cell Significance Index: -13.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4310
    Cell Significance Index: -15.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4447
    Cell Significance Index: -11.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4533
    Cell Significance Index: -16.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4547
    Cell Significance Index: -5.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF12 contains a characteristic zinc finger domain, which is essential for its DNA-binding activity. This domain allows ZNF12 to recognize and bind to specific DNA sequences, thereby regulating gene expression. 2. **Transcriptional Regulation:** ZNF12 acts as a transcriptional regulator, modulating the expression of target genes involved in various cellular processes, including cell growth, differentiation, and survival. 3. **Cell-Specific Expression:** The expression of ZNF12 is highly cell-specific, suggesting its role in regulating cellular homeostasis and maintaining tissue integrity. 4. **Protein-Protein Interactions:** ZNF12 interacts with other proteins, including transcription factors and chromatin-modifying enzymes, to regulate gene expression and chromatin structure. **Pathways and Functions:** 1. **Centrosome Formation:** ZNF12 is involved in the regulation of centrosome formation, which is essential for cell division and cytoskeletal organization. 2. **Gene Expression Regulation:** ZNF12 modulates the expression of genes involved in cell growth, differentiation, and survival, thereby regulating cellular homeostasis. 3. **DNA-Binding and Transcription:** ZNF12 recognizes and binds to specific DNA sequences, thereby regulating transcription of target genes. 4. **Chromatin Remodeling:** ZNF12 interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. **Clinical Significance:** 1. **Cancer Research:** Aberrant expression of ZNF12 has been implicated in various cancers, including colorectal cancer and glioblastoma. Understanding the role of ZNF12 in cancer development and progression can lead to the identification of novel therapeutic targets. 2. **Neurological Disorders:** ZNF12 expression is altered in neurological disorders, such as autism spectrum disorder and schizophrenia. Further investigation into the role of ZNF12 in these disorders can provide insights into the underlying mechanisms and potential therapeutic strategies. 3. **Intestinal Health:** ZNF12 expression is essential for maintaining intestinal homeostasis. Dysregulation of ZNF12 can contribute to intestinal disorders, such as inflammatory bowel disease (IBD). 4. **Regenerative Medicine:** ZNF12 plays a role in regulating cell fate decisions and tissue homeostasis. Understanding its role in tissue regeneration can lead to the development of novel therapeutic strategies for tissue repair and regeneration. In conclusion, ZNF12 is a multifaceted transcription factor that plays a crucial role in regulating gene expression, cellular homeostasis, and tissue integrity. Further investigation into the role of ZNF12 in various diseases and disorders can provide valuable insights into the underlying mechanisms and potential therapeutic strategies.

Genular Protein ID: 2860091392

Symbol: ZNF12_HUMAN

Name: Zinc finger protein 12

UniProtKB Accession Codes:

P17014 A8MYC4 A8WFQ8 B2RNQ7 B4DF45 Q6N016 Q8NHZ0 Q9H9P0 Q9ULZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16806083

Title: ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity.

PubMed ID: 16806083

DOI: 10.1016/j.bbrc.2006.06.031

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 697
  • Mass: 81202
  • Checksum: 3D12F61C265D6BE3
  • Sequence:
    • MNKSLGPVSF KDVAVDFTQE EWQQLDPEQK ITYRDVMLEN YSNLVSVGYH IIKPDVISKL 
EQGEEPWIVE GEFLLQSYPD EVWQTDDLIE RIQEEENKPS RQTVFIETLI EERGNVPGKT 
FDVETNPVPS RKIAYKNSLC DSCEKCLTSV SEYISSDGSY ARMKADECSG CGKSLLHIKL 
EKTHPGDQAY EFNQNGEPYT LNEESLYQKI RILEKPFEYI ECQKAFQKDT VFVNHMEEKP 
YKWNGSEIAF LQMSDLTVHQ TSHMEMKPYE CSECGKSFCK KSKFIIHQRT HTGEKPYECN 
QCGKSFCQKG TLTVHQRTHT GEKPYECNEC GKNFYQKLHL IQHQRTHSGE KPYECSYCGK 
SFCQKTHLTQ HQRTHSGERP YVCHDCGKTF SQKSALNDHQ KIHTGVKLYK CSECGKCFCR 
KSTLTTHLRT HTGEKPYECN ECGKFFSRLS YLTVHYRTHS GEKPYECNEC GKTFYLNSAL 
MRHQRVHTGE KPYECNECGK LFSQLSYLTI HHRTHSGVKP YECSECGKTF YQNSALCRHR 
RIHKGEKPYE CYICGKFFSQ MSYLTIHHRI HSGEKPYECS ECGKTFCQNS ALNRHQRTHT 
GEKAYECYEC GKCFSQMSYL TIHHRIHSGE KPFECNECGK AFSRMSYLTV HYRTHSGEKP 
YECTECGKKF YHKSAFNSHQ RIHRRGNMNV IDVGRLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.