Details for: ZNF24

Gene ID: 7572

Symbol: ZNF24

Ensembl ID: ENSG00000172466

Description: zinc finger protein 24

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Identical protein binding
    (GO:0042802)
  • Metal ion binding
    (GO:0046872)
  • Myelination
    (GO:0042552)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 299.5270
    Cell Significance Index: -46.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 170.8698
    Cell Significance Index: -43.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 123.7779
    Cell Significance Index: -50.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.7609
    Cell Significance Index: -49.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.7989
    Cell Significance Index: -47.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.6365
    Cell Significance Index: -48.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.1557
    Cell Significance Index: -40.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.6506
    Cell Significance Index: -49.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7446
    Cell Significance Index: -29.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6716
    Cell Significance Index: -16.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4820
    Cell Significance Index: 161.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4271
    Cell Significance Index: 38.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3406
    Cell Significance Index: 80.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0628
    Cell Significance Index: 14.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8662
    Cell Significance Index: 173.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8229
    Cell Significance Index: 101.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8073
    Cell Significance Index: 50.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7760
    Cell Significance Index: 36.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7285
    Cell Significance Index: 131.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7100
    Cell Significance Index: 91.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6552
    Cell Significance Index: 130.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6417
    Cell Significance Index: 88.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6285
    Cell Significance Index: 343.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5438
    Cell Significance Index: 240.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5129
    Cell Significance Index: 33.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4872
    Cell Significance Index: 36.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4774
    Cell Significance Index: 16.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4641
    Cell Significance Index: 24.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4545
    Cell Significance Index: 21.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3990
    Cell Significance Index: 39.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3951
    Cell Significance Index: 17.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3776
    Cell Significance Index: 135.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3138
    Cell Significance Index: 17.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3028
    Cell Significance Index: 3.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2640
    Cell Significance Index: 7.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2601
    Cell Significance Index: 33.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2256
    Cell Significance Index: 38.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2218
    Cell Significance Index: 26.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1967
    Cell Significance Index: 13.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1912
    Cell Significance Index: 10.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1617
    Cell Significance Index: 12.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0991
    Cell Significance Index: 2.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0329
    Cell Significance Index: 0.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0237
    Cell Significance Index: 16.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0101
    Cell Significance Index: 0.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0067
    Cell Significance Index: 0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0020
    Cell Significance Index: 1.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0044
    Cell Significance Index: -0.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0087
    Cell Significance Index: -16.2900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0112
    Cell Significance Index: -0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0189
    Cell Significance Index: -13.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0211
    Cell Significance Index: -32.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0228
    Cell Significance Index: -42.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0298
    Cell Significance Index: -22.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0305
    Cell Significance Index: -19.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0444
    Cell Significance Index: -4.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0524
    Cell Significance Index: -23.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0543
    Cell Significance Index: -30.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0696
    Cell Significance Index: -0.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0785
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1023
    Cell Significance Index: -21.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1218
    Cell Significance Index: -35.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1268
    Cell Significance Index: -2.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1352
    Cell Significance Index: -8.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1375
    Cell Significance Index: -15.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1458
    Cell Significance Index: -23.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1809
    Cell Significance Index: -26.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1978
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2239
    Cell Significance Index: -25.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2307
    Cell Significance Index: -26.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2742
    Cell Significance Index: -18.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3112
    Cell Significance Index: -7.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3316
    Cell Significance Index: -8.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3412
    Cell Significance Index: -10.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3514
    Cell Significance Index: -9.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3932
    Cell Significance Index: -8.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4268
    Cell Significance Index: -3.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4607
    Cell Significance Index: -36.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4682
    Cell Significance Index: -48.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4911
    Cell Significance Index: -15.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4949
    Cell Significance Index: -12.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5706
    Cell Significance Index: -8.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5766
    Cell Significance Index: -14.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5865
    Cell Significance Index: -10.8400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6424
    Cell Significance Index: -6.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6477
    Cell Significance Index: -28.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7070
    Cell Significance Index: -15.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7077
    Cell Significance Index: -8.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7945
    Cell Significance Index: -4.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7947
    Cell Significance Index: -48.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8147
    Cell Significance Index: -41.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8179
    Cell Significance Index: -30.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8220
    Cell Significance Index: -24.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8649
    Cell Significance Index: -16.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9109
    Cell Significance Index: -9.4300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9445
    Cell Significance Index: -7.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9549
    Cell Significance Index: -16.8800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9810
    Cell Significance Index: -13.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF24 is a small, 84-amino acid protein that belongs to the class of zinc finger proteins, which are characterized by their ability to bind to DNA through a zinc-coordinated finger motif. The protein's primary function is to regulate transcription by interacting with specific DNA sequences, either by activating or repressing the transcription of target genes. ZNF24 is highly expressed in various cell types, including IgG-negative class-switched memory B cells, skeletal muscle satellite stem cells, and bladder urothelial cells. **Pathways and Functions:** ZNF24's transcriptional regulatory activity is mediated through its interaction with RNA polymerase II (RNAPII), a key enzyme responsible for transcribing DNA into RNA. ZNF24's binding to specific DNA sequences, such as those involved in myelination and the regulation of transcription by RNAPII, enables it to modulate the expression of target genes. The protein's involvement in the regulation of transcription by RNAPII suggests that ZNF24 plays a critical role in the development and function of immune cells, such as B cells and T cells. Furthermore, ZNF24's expression in skeletal muscle satellite stem cells and bladder urothelial cells highlights its involvement in the development and maintenance of non-immune cell types. The protein's interaction with metal ions, such as zinc and copper, also suggests that ZNF24 may play a role in cellular processes that require the regulation of metal ion homeostasis. **Clinical Significance:** Dysregulation of ZNF24's transcriptional activity has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, alterations in ZNF24 expression have been observed in patients with multiple sclerosis, a chronic autoimmune disease characterized by the demyelination of neurons in the central nervous system. Additionally, ZNF24's involvement in the regulation of transcription by RNAPII suggests that it may play a role in the development of cancer, particularly in tumors that exhibit aberrant RNAPII activity. Furthermore, ZNF24's expression in bladder urothelial cells and its involvement in the regulation of transcription by RNAPII suggest that it may play a role in the development of bladder cancer. Further studies are necessary to fully elucidate the clinical significance of ZNF24 and its potential as a therapeutic target for immune-related disorders. In conclusion, ZNF24 is a transcriptional regulator that plays a critical role in the regulation of gene expression in various cell types, including immune cells and non-immune cell types. Its involvement in the regulation of transcription by RNAPII and its expression in various cell types highlight its importance in cellular processes, including immune responses and cancer development. Further studies are necessary to fully elucidate the molecular mechanisms underlying ZNF24's transcriptional activity and its clinical significance in immune-related disorders.

Genular Protein ID: 2894463788

Symbol: ZNF24_HUMAN

Name: Zinc finger protein 24

UniProtKB Accession Codes:

P17028 O14754 Q53YE4 Q6ICR5 Q8IZN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10585455

Title: Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.

PubMed ID: 10585455

DOI: 10.1074/jbc.274.50.35741

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24224020

Title: Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24.

PubMed ID: 24224020

DOI: 10.1371/journal.pone.0079910

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 368
  • Mass: 42155
  • Checksum: B890EDC512493E0E
  • Sequence:
    • MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI FRQRFRQFGY 
QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF VAILPKELQT WVRDHHPENG 
EEAVTVLEDL ESELDDPGQP VSLRRRKREV LVEDMVSQEE AQGLPSSELD AVENQLKWAS 
WELHSLRHCD DDGRTENGAL APKQELPSAL ESHEVPGTLN MGVPQIFKYG ETCFPKGRFE 
RKRNPSRKKQ HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV 
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL FRHQRRHNAE 
KLLNVVKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.