Details for: ZNF26

Gene ID: 7574

Symbol: ZNF26

Ensembl ID: ENSG00000198393

Description: zinc finger protein 26

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.7436
    Cell Significance Index: -18.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.4282
    Cell Significance Index: -17.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.6584
    Cell Significance Index: -20.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.5100
    Cell Significance Index: -17.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.9990
    Cell Significance Index: -20.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.0572
    Cell Significance Index: -17.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.4182
    Cell Significance Index: -19.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0443
    Cell Significance Index: -11.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8644
    Cell Significance Index: -19.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7034
    Cell Significance Index: 28.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4465
    Cell Significance Index: 100.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1228
    Cell Significance Index: 222.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7991
    Cell Significance Index: 721.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7781
    Cell Significance Index: 156.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6531
    Cell Significance Index: 8.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6523
    Cell Significance Index: 70.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5110
    Cell Significance Index: 83.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4965
    Cell Significance Index: 178.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4934
    Cell Significance Index: 88.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4826
    Cell Significance Index: 47.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4587
    Cell Significance Index: 66.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4307
    Cell Significance Index: 16.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3985
    Cell Significance Index: 46.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3950
    Cell Significance Index: 17.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3678
    Cell Significance Index: 23.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3639
    Cell Significance Index: 10.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3260
    Cell Significance Index: 9.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3132
    Cell Significance Index: 20.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2955
    Cell Significance Index: 16.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2813
    Cell Significance Index: 5.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2585
    Cell Significance Index: 19.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2449
    Cell Significance Index: 11.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2440
    Cell Significance Index: 16.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2301
    Cell Significance Index: 6.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2183
    Cell Significance Index: 4.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2173
    Cell Significance Index: 11.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2152
    Cell Significance Index: 26.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1688
    Cell Significance Index: 74.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1636
    Cell Significance Index: 89.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1246
    Cell Significance Index: 17.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1140
    Cell Significance Index: 2.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0928
    Cell Significance Index: 3.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0844
    Cell Significance Index: 2.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0821
    Cell Significance Index: 2.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0686
    Cell Significance Index: 13.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0554
    Cell Significance Index: 85.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0519
    Cell Significance Index: 97.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0484
    Cell Significance Index: 33.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0460
    Cell Significance Index: 84.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0334
    Cell Significance Index: 21.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0237
    Cell Significance Index: 0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0180
    Cell Significance Index: 24.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0130
    Cell Significance Index: 0.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0083
    Cell Significance Index: 3.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0055
    Cell Significance Index: 0.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0047
    Cell Significance Index: 0.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0077
    Cell Significance Index: -0.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0152
    Cell Significance Index: -1.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0170
    Cell Significance Index: -0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0203
    Cell Significance Index: -15.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0249
    Cell Significance Index: -3.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0253
    Cell Significance Index: -0.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0257
    Cell Significance Index: -1.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0274
    Cell Significance Index: -15.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0343
    Cell Significance Index: -0.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0365
    Cell Significance Index: -1.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0380
    Cell Significance Index: -0.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0465
    Cell Significance Index: -1.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0475
    Cell Significance Index: -5.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0671
    Cell Significance Index: -1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0681
    Cell Significance Index: -19.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0713
    Cell Significance Index: -8.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0761
    Cell Significance Index: -13.0000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0774
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0870
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0888
    Cell Significance Index: -9.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0927
    Cell Significance Index: -19.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1056
    Cell Significance Index: -2.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1312
    Cell Significance Index: -3.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1584
    Cell Significance Index: -16.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1911
    Cell Significance Index: -2.8200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1992
    Cell Significance Index: -2.8700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2007
    Cell Significance Index: -3.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2102
    Cell Significance Index: -2.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2274
    Cell Significance Index: -18.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2474
    Cell Significance Index: -15.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2501
    Cell Significance Index: -8.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2932
    Cell Significance Index: -7.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3014
    Cell Significance Index: -4.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3030
    Cell Significance Index: -7.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3154
    Cell Significance Index: -6.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3198
    Cell Significance Index: -10.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3278
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3283
    Cell Significance Index: -2.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3335
    Cell Significance Index: -10.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3511
    Cell Significance Index: -8.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3556
    Cell Significance Index: -5.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF26 is a member of the ZFP family, characterized by its ability to bind to DNA and regulate gene expression through its zinc finger motifs. It belongs to the C2H2 zinc finger subfamily and contains eight zinc finger domains. ZNF26 is specifically expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, mural cells, and immune cells such as monocytes and macrophages. **Pathways and Functions:** ZNF26 is involved in several transcriptional pathways, including: 1. **DNA-binding transcription factor activity**: ZNF26 binds to specific DNA sequences and regulates gene expression by recruiting co-activators or co-repressors. 2. **RNA polymerase II-specific transcription**: ZNF26 interacts with RNA polymerase II to regulate the transcription of genes involved in cellular processes such as cell growth, differentiation, and survival. 3. **Metal ion binding**: ZNF26's zinc finger motifs bind to metal ions, which are essential for its DNA-binding activity. 4. **Protein binding**: ZNF26 interacts with various proteins, including transcriptional co-activators and co-repressors, to regulate gene expression. **Clinical Significance:** Dysregulation of ZNF26 has been implicated in several diseases, including: 1. **Kidney disease**: ZNF26 expression is altered in kidney proximal convoluted tubule epithelial cells in patients with kidney disease, suggesting its role in kidney function and disease. 2. **Immune system disorders**: ZNF26 is expressed in immune cells and plays a role in regulating immune responses, making it a potential target for treating immune-related disorders. 3. **Neurological disorders**: ZNF26 is expressed in neurons and has been implicated in regulating neuronal function and development, making it a potential target for treating neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, ZNF26 is a transcription factor that plays a crucial role in regulating gene expression in various cell types. Its dysregulation has been implicated in several diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the functions and clinical implications of ZNF26. **Recommendations for Future Research:** 1. **Investigate the molecular mechanisms of ZNF26's transcriptional regulation**: Elucidating the specific DNA sequences and transcriptional co-activators/co-repressors that interact with ZNF26 will provide valuable insights into its regulatory mechanisms. 2. **Explore the role of ZNF26 in disease models**: Using ZNF26 knockout or overexpression models will provide insights into its role in disease development and progression. 3. **Develop therapeutic strategies targeting ZNF26**: Identifying specific binding sites for ZNF26 and developing small molecule inhibitors or RNA-based therapies could provide novel therapeutic options for diseases associated with ZNF26 dysregulation. By further investigating the functions and clinical implications of ZNF26, researchers can uncover new therapeutic targets and develop innovative treatments for diseases associated with its dysregulation.

Genular Protein ID: 3139647975

Symbol: ZNF26_HUMAN

Name: Zinc finger protein 26

UniProtKB Accession Codes:

P17031 Q86X57 Q9NWL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 533
  • Mass: 61282
  • Checksum: E7D64DFBE10D0282
  • Sequence:
    • MATSFRTASC WGLLSFKDIS MEFTWDEWQL LDSTQKYLYR DVILENYHNL ISVGYHGTKP 
DLIFKLEQGE DPWIINAKIS RQSCPDGWEE WYQNNQDELE SIERSYACSV LGRLNLSKTH 
DSSRQRLYNT RGKSLTQNSA PSRSYLRKNP DKFHGYEEPY FLKHQRAHSI EKNCVCSECG 
KAFRCKSQLI VHLRIHTGER PYECSKCERA FSAKSNLNAH QRVHTGEKPY SCSECEKVFS 
FRSQLIVHQE IHTGGKPYGC SECGKAYSWK SQLLLHQRSH TGVKPYECSE CGKAFSLKSP 
FVVHQRTHTG VKPHKCSECG KAFRSKSYLL VHIRMHTGEK PYQCSDCGKA FNMKTQLIVH 
QGVHTGNNPY QCGECGKAFG RKEQLTAHLR AHAGEKPYGC SECGKAFSSK SYLVIHRRTH 
TGERPYECSL CERAFCGKSQ LIIHQRTHST EKPYECNECE KAYPRKASLQ IHQKTHSGEK 
PFKCSECGKA FTQKSSLSEH QRVHTGEKPW KCSECGKSFC WNSGLRIHRK THK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.