Details for: ZNF75A

Gene ID: 7627

Symbol: ZNF75A

Ensembl ID: ENSG00000162086

Description: zinc finger protein 75A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 160.3071
    Cell Significance Index: -24.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.4419
    Cell Significance Index: -22.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.1929
    Cell Significance Index: -21.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.1536
    Cell Significance Index: -25.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.6553
    Cell Significance Index: -21.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.1078
    Cell Significance Index: -26.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7533
    Cell Significance Index: -20.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.0488
    Cell Significance Index: -21.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6877
    Cell Significance Index: -26.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2537
    Cell Significance Index: 248.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8913
    Cell Significance Index: 804.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8538
    Cell Significance Index: 171.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7752
    Cell Significance Index: 21.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7677
    Cell Significance Index: 48.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7651
    Cell Significance Index: 9.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6787
    Cell Significance Index: 73.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6277
    Cell Significance Index: 48.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5797
    Cell Significance Index: 94.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5481
    Cell Significance Index: 196.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5353
    Cell Significance Index: 14.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4840
    Cell Significance Index: 27.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4025
    Cell Significance Index: 55.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3943
    Cell Significance Index: 11.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3933
    Cell Significance Index: 20.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3863
    Cell Significance Index: 17.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3830
    Cell Significance Index: 13.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3781
    Cell Significance Index: 68.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3425
    Cell Significance Index: 23.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3131
    Cell Significance Index: 14.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3081
    Cell Significance Index: 8.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3049
    Cell Significance Index: 11.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2925
    Cell Significance Index: 159.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2811
    Cell Significance Index: 6.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2715
    Cell Significance Index: 32.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2097
    Cell Significance Index: 13.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1968
    Cell Significance Index: 4.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1743
    Cell Significance Index: 10.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1453
    Cell Significance Index: 64.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1443
    Cell Significance Index: 3.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1337
    Cell Significance Index: 16.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1204
    Cell Significance Index: 11.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1152
    Cell Significance Index: 14.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1043
    Cell Significance Index: 7.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1024
    Cell Significance Index: 7.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0674
    Cell Significance Index: 0.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0659
    Cell Significance Index: 12.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0407
    Cell Significance Index: 1.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0299
    Cell Significance Index: 18.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0274
    Cell Significance Index: 51.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0198
    Cell Significance Index: 0.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0182
    Cell Significance Index: 0.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0170
    Cell Significance Index: 26.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0143
    Cell Significance Index: 26.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0139
    Cell Significance Index: 6.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0095
    Cell Significance Index: 0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0084
    Cell Significance Index: 11.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0006
    Cell Significance Index: 0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0139
    Cell Significance Index: -2.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0193
    Cell Significance Index: -2.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0197
    Cell Significance Index: -0.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0199
    Cell Significance Index: -15.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0207
    Cell Significance Index: -15.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0352
    Cell Significance Index: -1.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0378
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0390
    Cell Significance Index: -21.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0438
    Cell Significance Index: -27.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0450
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0468
    Cell Significance Index: -7.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0629
    Cell Significance Index: -6.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0648
    Cell Significance Index: -1.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0808
    Cell Significance Index: -23.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1000
    Cell Significance Index: -11.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1219
    Cell Significance Index: -25.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1325
    Cell Significance Index: -15.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1401
    Cell Significance Index: -3.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1471
    Cell Significance Index: -1.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1476
    Cell Significance Index: -3.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1512
    Cell Significance Index: -10.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1532
    Cell Significance Index: -2.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1533
    Cell Significance Index: -4.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1884
    Cell Significance Index: -1.9500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2005
    Cell Significance Index: -1.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2034
    Cell Significance Index: -4.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2258
    Cell Significance Index: -6.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2265
    Cell Significance Index: -11.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2284
    Cell Significance Index: -23.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2667
    Cell Significance Index: -3.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2742
    Cell Significance Index: -21.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3307
    Cell Significance Index: -8.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3374
    Cell Significance Index: -20.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3442
    Cell Significance Index: -10.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4009
    Cell Significance Index: -10.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4113
    Cell Significance Index: -8.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4270
    Cell Significance Index: -13.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4600
    Cell Significance Index: -15.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5295
    Cell Significance Index: -10.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5498
    Cell Significance Index: -16.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5509
    Cell Significance Index: -19.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5517
    Cell Significance Index: -11.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5737
    Cell Significance Index: -16.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF75A is a member of the zinc finger protein family, characterized by its unique zinc finger domain, which enables it to bind to specific DNA sequences. This protein exhibits a high degree of tissue specificity, with significant expression in pulmonary interstitial fibroblasts, IgG-negative class-switched memory B cells, and various neuronal populations. ZNF75A's expression patterns suggest a role in regulating gene expression in distinct cell types, underscoring its potential as a therapeutic target in diseases characterized by dysregulated transcription. **Pathways and Functions:** ZNF75A's primary function is to regulate gene expression through its ability to bind to specific DNA sequences and interact with RNA polymerase II. This interaction enables ZNF75A to modulate transcriptional activity, influencing the expression of target genes. ZNF75A's involvement in metal ion binding suggests a potential role in regulating protein-protein interactions and cellular signaling pathways. Furthermore, its association with various cellular pathways, including the generic transcription pathway and the regulation of transcription by RNA polymerase II, underscores its critical role in maintaining cellular homeostasis. **Clinical Significance:** The clinical significance of ZNF75A lies in its potential as a therapeutic target in diseases characterized by dysregulated transcription, such as cancer and neurodegenerative disorders. ZNF75A's expression in various neuronal populations suggests a role in regulating neuronal function and plasticity, making it an attractive candidate for the treatment of neurological disorders. Additionally, ZNF75A's involvement in the regulation of transcriptional activity in pulmonary interstitial fibroblasts implies a potential role in the pathogenesis of pulmonary fibrosis. Further research is necessary to fully elucidate ZNF75A's clinical significance and explore its potential as a therapeutic target. **Conclusion:** In conclusion, ZNF75A is a complex transcription factor that plays a multifaceted role in regulating gene expression. Its tissue-specific expression, involvement in metal ion binding, and association with various cellular pathways underscore its critical role in maintaining cellular homeostasis. Further research is necessary to fully elucidate ZNF75A's clinical significance and explore its potential as a therapeutic target in diseases characterized by dysregulated transcription.

Genular Protein ID: 1918241044

Symbol: ZN75A_HUMAN

Name: Zinc finger protein 75A

UniProtKB Accession Codes:

Q96N20 Q0VDI8 Q92669

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661144

Title: The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes.

PubMed ID: 8661144

DOI: 10.1006/geno.1996.0362

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 296
  • Mass: 34694
  • Checksum: D8EBD7023CA726AA
  • Sequence:
    • MYFSQEEWEL LDPTQKALYN DVMQENYETV ISLALFVLPK PKVISCLEQG EEPWVQVSPE 
FKDSAGKSPT GLKLKNDTEN HQPVSLSDLE IQASAGVISK KAKVKVPQKT AGKENHFDMH 
RVGKWHQDFP VKKRKKLSTW KQELLKLMDR HKKDCAREKP FKCQECGKTF RVSSDLIKHQ 
RIHTEEKPYK CQQCDKRFRW SSDLNKHLTT HQGIKPYKCS WCGKSFSQNT NLHTHQRTHT 
GEKPFTCHEC GKKFSQNSHL IKHRRTHTGE QPYTCSICRR NFSRRSSLLR HQKLHL

Genular Protein ID: 866556548

Symbol: Q68CU0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68CU0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 Pfam 2 RefSeq 2 SUPFAM 1

Sequence Information:

  • Length: 34
  • Mass: 3825
  • Checksum: 5E19ECD481EFE80F
  • Sequence:
    • MYFSQEEWEL LDPTQKALLS RARGRAMGSS IPGV

Genular Protein ID: 404324805

Symbol: A0A590UJE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A590UJE0

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 InterPro 7 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 3 Proteomes 2 RefSeq 2 SMART 3 SMR 1 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 537
  • Mass: 62108
  • Checksum: CD745D907ED0B16B
  • Sequence:
    • MMMVDLKVAA YLDPQIRALW ETKGPARESS GQSKKSPQMD CLDPKSSCWH FRNFTYDEAG 
GPREAVSKLQ ELCHLWLKPE IHSKEQILEL LVLEQFLTIL PRETQTQMQK HHPQSIEEAV 
ALVEHLQRES GQTWNGVAVH ELGKEAVLLG ETAEASSFGL KPTESQPVGV SQDEEFWNTY 
EGLQEQLSRN THKETEPVYE RAVPTQQILA FPEQTNTKDW TVTPEHVLPE SQSLLTFEEV 
AMYFSQEEWE LLDPTQKALY NDVMQENYET VISLALFVLP KPKVISCLEQ GEEPWVQVSP 
EFKDSAGKSP TGLKLKNDTE NHQPVSLSDL EIQASAGVIS KKAKVKVPQK TAGKENHFDM 
HRVGKWHQDF PVKKRKKLST WKQELLKLMD RHKKDCAREK PFKCQECGKT FRVSSDLIKH 
QRIHTEEKPY KCQQCDKRFR WSSDLNKHLT THQGIKPYKC SWCGKSFSQN TNLHTHQRTH 
TGEKPFTCHE CGKKFSQNSH LIKHRRTHTG EQPYTCSICR RNFSRRSSLL RHQKLHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.