Details for: ZNF138

Gene ID: 7697

Symbol: ZNF138

Ensembl ID: ENSG00000197008

Description: zinc finger protein 138

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 161.2071
    Cell Significance Index: -25.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.3755
    Cell Significance Index: -24.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 52.7252
    Cell Significance Index: -21.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.2092
    Cell Significance Index: -26.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4103
    Cell Significance Index: -22.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9576
    Cell Significance Index: -21.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6953
    Cell Significance Index: -26.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0026
    Cell Significance Index: -8.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4284
    Cell Significance Index: 58.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0243
    Cell Significance Index: 406.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6541
    Cell Significance Index: 101.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4992
    Cell Significance Index: 56.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4385
    Cell Significance Index: 63.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3825
    Cell Significance Index: 224.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3067
    Cell Significance Index: 90.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2263
    Cell Significance Index: 15.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9945
    Cell Significance Index: 356.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8688
    Cell Significance Index: 48.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8120
    Cell Significance Index: 54.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7940
    Cell Significance Index: 47.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7260
    Cell Significance Index: 655.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7171
    Cell Significance Index: 142.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6769
    Cell Significance Index: 73.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6285
    Cell Significance Index: 48.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5509
    Cell Significance Index: 28.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4752
    Cell Significance Index: 29.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4444
    Cell Significance Index: 9.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3995
    Cell Significance Index: 5.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3259
    Cell Significance Index: 9.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3073
    Cell Significance Index: 135.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2891
    Cell Significance Index: 52.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2664
    Cell Significance Index: 6.6600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2400
    Cell Significance Index: 1.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2399
    Cell Significance Index: 16.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2080
    Cell Significance Index: 113.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1927
    Cell Significance Index: 23.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1840
    Cell Significance Index: 8.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1707
    Cell Significance Index: 4.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1503
    Cell Significance Index: 4.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1451
    Cell Significance Index: 19.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1444
    Cell Significance Index: 14.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1352
    Cell Significance Index: 2.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1311
    Cell Significance Index: 15.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0776
    Cell Significance Index: 146.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0749
    Cell Significance Index: 4.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0693
    Cell Significance Index: 31.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0624
    Cell Significance Index: 1.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0612
    Cell Significance Index: 0.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0586
    Cell Significance Index: 90.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0497
    Cell Significance Index: 91.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0409
    Cell Significance Index: 2.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0407
    Cell Significance Index: 25.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0384
    Cell Significance Index: 1.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0319
    Cell Significance Index: 43.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0229
    Cell Significance Index: 4.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0119
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0193
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0255
    Cell Significance Index: -0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0285
    Cell Significance Index: -21.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0388
    Cell Significance Index: -21.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0426
    Cell Significance Index: -26.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0618
    Cell Significance Index: -10.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0642
    Cell Significance Index: -8.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0662
    Cell Significance Index: -19.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0666
    Cell Significance Index: -3.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0743
    Cell Significance Index: -1.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0784
    Cell Significance Index: -1.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0793
    Cell Significance Index: -5.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0796
    Cell Significance Index: -8.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0841
    Cell Significance Index: -9.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0953
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1002
    Cell Significance Index: -11.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1175
    Cell Significance Index: -24.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1533
    Cell Significance Index: -5.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1704
    Cell Significance Index: -3.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1780
    Cell Significance Index: -5.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1879
    Cell Significance Index: -19.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2048
    Cell Significance Index: -4.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2328
    Cell Significance Index: -7.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2478
    Cell Significance Index: -5.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2530
    Cell Significance Index: -20.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2681
    Cell Significance Index: -7.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2814
    Cell Significance Index: -17.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2948
    Cell Significance Index: -6.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3045
    Cell Significance Index: -7.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3120
    Cell Significance Index: -3.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3146
    Cell Significance Index: -4.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3173
    Cell Significance Index: -9.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3307
    Cell Significance Index: -11.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3412
    Cell Significance Index: -5.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3650
    Cell Significance Index: -9.9400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4234
    Cell Significance Index: -6.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4257
    Cell Significance Index: -8.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4425
    Cell Significance Index: -15.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4563
    Cell Significance Index: -13.4400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4675
    Cell Significance Index: -5.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ZNF138 protein is a transcription factor that possesses a zinc finger domain, which is a characteristic feature of many transcription factors. This domain allows the protein to bind to specific DNA sequences, thereby regulating the transcription of target genes. The ZNF138 protein is also known to interact with RNA polymerase II, a key enzyme in the transcriptional process, suggesting its involvement in the regulation of RNA polymerase II-dependent transcription. Additionally, the protein exhibits metal ion-binding properties, which may be important for its function. **Pathways and Functions** The ZNF138 protein is involved in several key pathways, including: 1. **DNA-binding transcription factor activity**: ZNF138 binds to specific DNA sequences, regulating the transcription of target genes. 2. **RNA polymerase II-specific transcription**: ZNF138 interacts with RNA polymerase II, regulating the transcription of RNA polymerase II-dependent genes. 3. **Gene expression (transcription)**: ZNF138 regulates the expression of genes involved in various cellular processes, including development and function of the nervous system. 4. **Generic transcription pathway**: ZNF138 is involved in the regulation of generic transcription, which is the process by which cells express genes in response to environmental cues. 5. **Metal ion binding**: ZNF138 exhibits metal ion-binding properties, which may be important for its function. The functions of ZNF138 are not fully understood, but it is likely involved in the regulation of gene expression in specific cell types, including neural progenitor cells, GABAergic cortical interneurons, and other glutamatergic neurons. Its expression in these cell types suggests its involvement in the development and function of the central nervous system. **Clinical Significance** The clinical significance of ZNF138 is not well established, but its expression in specific cell types suggests its potential involvement in various neurological disorders. For example: 1. **Neurodevelopmental disorders**: ZNF138 may play a role in the development of neurodevelopmental disorders, such as autism and schizophrenia, which are characterized by abnormalities in brain development and function. 2. **Neurodegenerative diseases**: ZNF138 may be involved in the regulation of gene expression in neurons, which could contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cancer**: ZNF138 may play a role in the regulation of gene expression in cancer cells, which could contribute to the development and progression of cancer. Further research is needed to fully understand the clinical significance of ZNF138 and its potential role in various neurological disorders.

Genular Protein ID: 3453608229

Symbol: ZN138_HUMAN

Name: Zinc finger protein 138

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

Sequence Information:

  • Length: 262
  • Mass: 30592
  • Checksum: D2B463F0E584ACE6
  • Sequence:
  • MKRHEMVVAK HSALCSRFAQ DLWLEQNIKD SFQKVTLSRY GKYGHKNLQL RKGCKSVDEC 
    KGHQGGFNGL NQCLKITTSK IFQCNKYVKV MHKFSNSNRH KIRHTENKHF RCKECDKSLC 
    MLSRLTQHKK IHTRENFYKC EECGKTFNWS TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI 
    LTKHKIIRTG EKPYKCAHCG KAFKQSSHLT RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH 
    QIIYTGEEPY KCEECGKAFN LS

Genular Protein ID: 1542426894

Symbol: A0A0A0MRG3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 100
  • Mass: 11518
  • Checksum: A314660FE1FD8D25
  • Sequence:
  • MGPLTFMDVA IEFSLEEWQC LDTAQRNVYR HVMLENYRNL VFLAVAFTFD LSGLNILSFQ 
    SILPFVSALY VMGNRNQCLQ KHLEARNKDL CVLVLPKTFG

Genular Protein ID: 1017774170

Symbol: A0A0A0MT90_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 126
  • Mass: 14581
  • Checksum: 0E5685F05C834A6D
  • Sequence:
  • MGPLTFMDVA IEFSLEEWQC LDTAQRNVYR HVMLENYRNL VFLDLITCLE QGKEPWNMKR 
    HEMVVAKHSA VAFTFDLSGL NILSFQSILP FVSALYVMGN RNQCLQKHLE ARNKDLCVLV 
    LPKTFG

Genular Protein ID: 1476712905

Symbol: C9JHF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 62
  • Mass: 7431
  • Checksum: 4DBE9149FD4C488D
  • Sequence:
  • MGPLTFMDVA IEFSLEEWQC LDTAQRNVYR HVMLENYRNL VFLARPDYLS GTRKRALEYE 
    ET

Genular Protein ID: 3473375138

Symbol: A2RRP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 172
  • Mass: 20231
  • Checksum: F4ED251F0AA6F066
  • Sequence:
  • MHKFSNSNRH KIRHTENKHF RCKECDKSLC MLSRLTQHKK IHTRENFYKC EECGKTFNWS 
    TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI LTKHKIIRTG EKPYKCAHCG KAFKQSSHLT 
    RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH QIIYTGEEPY KCEECGKAFN LS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.