Details for: ZNF141

Gene ID: 7700

Symbol: ZNF141

Ensembl ID: ENSG00000131127

Description: zinc finger protein 141

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.0897
    Cell Significance Index: -25.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.6281
    Cell Significance Index: -25.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3876
    Cell Significance Index: -26.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5750
    Cell Significance Index: -25.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5757
    Cell Significance Index: -16.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2018
    Cell Significance Index: -22.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7257
    Cell Significance Index: -26.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3157
    Cell Significance Index: 261.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2126
    Cell Significance Index: 15.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1213
    Cell Significance Index: 110.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0495
    Cell Significance Index: 58.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9182
    Cell Significance Index: 70.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8838
    Cell Significance Index: 797.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7999
    Cell Significance Index: 160.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7929
    Cell Significance Index: 86.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7262
    Cell Significance Index: 1367.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7256
    Cell Significance Index: 32.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6861
    Cell Significance Index: 25.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6692
    Cell Significance Index: 13.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6291
    Cell Significance Index: 102.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6189
    Cell Significance Index: 39.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5956
    Cell Significance Index: 916.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5303
    Cell Significance Index: 190.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4681
    Cell Significance Index: 84.3900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4450
    Cell Significance Index: 3.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4353
    Cell Significance Index: 12.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4330
    Cell Significance Index: 26.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4226
    Cell Significance Index: 268.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4013
    Cell Significance Index: 740.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3828
    Cell Significance Index: 26.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2976
    Cell Significance Index: 35.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2863
    Cell Significance Index: 6.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2711
    Cell Significance Index: 12.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2306
    Cell Significance Index: 28.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2226
    Cell Significance Index: 14.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2191
    Cell Significance Index: 6.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2112
    Cell Significance Index: 5.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1899
    Cell Significance Index: 5.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1885
    Cell Significance Index: 256.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1800
    Cell Significance Index: 3.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1697
    Cell Significance Index: 23.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1484
    Cell Significance Index: 3.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1403
    Cell Significance Index: 63.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1395
    Cell Significance Index: 2.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1288
    Cell Significance Index: 6.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0851
    Cell Significance Index: 4.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0758
    Cell Significance Index: 41.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0636
    Cell Significance Index: 28.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0626
    Cell Significance Index: 8.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0373
    Cell Significance Index: 0.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0264
    Cell Significance Index: 0.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0232
    Cell Significance Index: 4.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0139
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0219
    Cell Significance Index: -16.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0262
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0307
    Cell Significance Index: -23.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0343
    Cell Significance Index: -19.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0409
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0420
    Cell Significance Index: -26.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0482
    Cell Significance Index: -5.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0577
    Cell Significance Index: -9.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0581
    Cell Significance Index: -8.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0712
    Cell Significance Index: -1.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0786
    Cell Significance Index: -5.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0909
    Cell Significance Index: -1.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0989
    Cell Significance Index: -10.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1111
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1185
    Cell Significance Index: -24.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1495
    Cell Significance Index: -17.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1579
    Cell Significance Index: -7.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1620
    Cell Significance Index: -2.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1684
    Cell Significance Index: -21.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1693
    Cell Significance Index: -4.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1714
    Cell Significance Index: -12.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2359
    Cell Significance Index: -6.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2574
    Cell Significance Index: -3.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2613
    Cell Significance Index: -16.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2685
    Cell Significance Index: -8.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2686
    Cell Significance Index: -4.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2695
    Cell Significance Index: -5.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2763
    Cell Significance Index: -21.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2777
    Cell Significance Index: -20.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2839
    Cell Significance Index: -5.8900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3089
    Cell Significance Index: -4.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3529
    Cell Significance Index: -9.4400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3605
    Cell Significance Index: -4.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3972
    Cell Significance Index: -10.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4092
    Cell Significance Index: -10.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4204
    Cell Significance Index: -12.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4262
    Cell Significance Index: -5.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4390
    Cell Significance Index: -6.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4774
    Cell Significance Index: -16.5900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5227
    Cell Significance Index: -5.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5282
    Cell Significance Index: -11.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5378
    Cell Significance Index: -9.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5473
    Cell Significance Index: -17.9200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5571
    Cell Significance Index: -7.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5655
    Cell Significance Index: -18.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5656
    Cell Significance Index: -16.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation**: ZNF141 is a member of the zinc finger protein family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. ZNF141 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. 2. **Cellular Specificity**: ZNF141 is significantly expressed in various cell types, including cardiac muscle cells, lens epithelial cells, and smooth muscle cells. This specificity suggests that ZNF141 plays a role in tissue-specific processes. 3. **Morphogenesis**: ZNF141 has been implicated in the regulation of morphogenesis, a process critical for the development and patterning of tissues. Its involvement in limb morphogenesis highlights the importance of ZNF141 in embryonic development. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity**: ZNF141 binds to specific DNA sequences, regulating the expression of target genes. This activity is mediated through its zinc finger domain, which recognizes and interacts with DNA. 2. **RNA Polymerase II-Specific**: ZNF141 interacts with RNA polymerase II, a key enzyme involved in transcriptional regulation. This interaction suggests that ZNF141 plays a role in regulating gene expression through the modulation of RNA polymerase II activity. 3. **Gene Expression (Transcription)**: ZNF141 regulates gene expression by interacting with RNA polymerase II and other transcriptional regulators. Its involvement in the generic transcription pathway highlights its role in the regulation of gene expression. 4. **Regulation of DNA-Templated Transcription**: ZNF141 regulates the transcription of genes by interacting with DNA and RNA polymerase II. This activity is critical for the proper functioning of the transcriptional machinery. **Clinical Significance:** 1. **Cardiovascular Disease**: ZNF141 has been implicated in the regulation of cardiac muscle cell development and function. Alterations in ZNF141 expression have been linked to cardiovascular disease, highlighting its potential as a therapeutic target. 2. **Eye Diseases**: ZNF141 is expressed in lens epithelial cells and has been shown to play a role in the regulation of gene expression. Mutations in ZNF141 have been linked to eye diseases, such as cataracts and glaucoma. 3. **Cancer**: ZNF141 has been implicated in the regulation of gene expression in cancer cells. Its role in the regulation of transcriptional regulators has led to its investigation as a potential therapeutic target in cancer. In conclusion, ZNF141 is a transcription factor protein that plays a crucial role in various cellular processes, including morphogenesis, transcriptional regulation, and cell differentiation. Its involvement in cardiovascular disease, eye diseases, and cancer highlights its potential as a therapeutic target and underscores the importance of further research into its functions and pathways.

Genular Protein ID: 1594604208

Symbol: ZN141_HUMAN

Name: Zinc finger protein 141

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8268908

Title: A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome.

PubMed ID: 8268908

DOI: 10.1093/hmg/2.10.1571

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23160277

Title: Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A.

PubMed ID: 23160277

DOI: 10.1136/jmedgenet-2012-101219

Sequence Information:

  • Length: 474
  • Mass: 55249
  • Checksum: 6133202F1DB207E8
  • Sequence:
  • MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP DLVTCLEQRK 
    EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL RRYEKCGHDN LQLRKGCKSL 
    NECKLQKGGY NEFNECLSTT QSKILQCKAS VKVVSKFSNS NKRKTRHTGE KHFKECGKSF 
    QKFSHLTQHK VIHAGEKPYT CEECGKAFKW SLIFNEHKRI HTGEKPFTCE ECGSIFTTSS 
    HFAKHKIIHT GEKPYKCEEC GKAFNRFTTL TKHKRIHAGE KPITCEECRK IFTSSSNFAK 
    HKRIHTGEKP YKCEECGKAF NRSTTLTKHK RIHTGEKPYT CEECGKAFRQ SSKLNEHKKV 
    HTGERPYKCD ECGKAFGRSR VLNEHKKIHT GEKPYKCEEC GKAFRRSTDR SQHKKIHSAD 
    KPYKCKECDK AFKQFSLLSQ HKKIHTVDKP YKCKDCDKAF KRFSHLNKHK KIHT

Genular Protein ID: 3859548952

Symbol: Q4W5N2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 398
  • Mass: 46393
  • Checksum: 40A467A159BB1FEB
  • Sequence:
  • MCSHFTQDHW PVQGIEDSFH KLILRRYEKC GHDNLQLRKG CKSLNECKLQ KGGYNEFNEC 
    LSTTQSKILQ CKASVKVVSK FSNSNKRKTR HTGEKHFKEC GKSFQKFSHL TQHKVIHAGE 
    KPYTCEECGK AFKWSLIFNE HKRIHTGEKP FTCEECGSIF TTSSHFAKHK IIHTGEKPYK 
    CEECGKAFNR FTTLTKHKRI HAGEKPITCE ECRKIFTSSS NFAKHKRIHT GEKPYKCEEC 
    GKAFNRSTTL TKHKRIHTGE KPYTCEECGK AFRQSSKLNE HKKVHTGERP YKCDECGKAF 
    GRSRVLNEHK KIHTGEKPYK CEECGKAFRR STDRSQHKKI HSADKPYKCK ECDKAFKQFS 
    LLSQHKKIHT VDKPYKCKDC DKAFKRFSHL NKHKKIHT

Genular Protein ID: 3596336608

Symbol: D6RIY0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 201
  • Mass: 23326
  • Checksum: C90FAFDD33CC3968
  • Sequence:
  • MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP DLVTCLEQRK 
    EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL RRYEKCGHDN LQLRKGCKSL 
    NECKLQKGGY NEFNECLSTT QSKILQCKAS VKVVSKFSNS NKRKTRHTGE KHFKECGKSF 
    QKFSHLTQHK NSSISMTTSP F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.