Details for: ZNF141

Gene ID: 7700

Symbol: ZNF141

Ensembl ID: ENSG00000131127

Description: zinc finger protein 141

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.66
    Marker Score: 48736.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.62
    Marker Score: 3169
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.33
    Marker Score: 3138
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.21
    Marker Score: 9240
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.05
    Marker Score: 1198
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.87
    Marker Score: 1089
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.72
    Marker Score: 503
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.69
    Marker Score: 3705
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.5
    Marker Score: 475
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.46
    Marker Score: 709
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50292
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.22
    Marker Score: 11588
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2
    Marker Score: 73760
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.2
    Marker Score: 1323
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.19
    Marker Score: 26540
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.19
    Marker Score: 915
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.19
    Marker Score: 497
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.19
    Marker Score: 1365
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1825
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.17
    Marker Score: 10015
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.14
    Marker Score: 1996
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.14
    Marker Score: 22642
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.11
    Marker Score: 10423
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.09
    Marker Score: 41553
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.09
    Marker Score: 345
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.07
    Marker Score: 16005
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22447
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.04
    Marker Score: 4037
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71732
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47956
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.95
    Marker Score: 7250
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.95
    Marker Score: 3918
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14540
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2716
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.89
    Marker Score: 603
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.88
    Marker Score: 241
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.88
    Marker Score: 3114
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4952
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.85
    Marker Score: 290
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.84
    Marker Score: 479
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.84
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1307
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.79
    Marker Score: 1527
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.79
    Marker Score: 415
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.77
    Marker Score: 963
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 809
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.74
    Marker Score: 222
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.73
    Marker Score: 434
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 549
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.72
    Marker Score: 327
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2939
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.69
    Marker Score: 739
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 631
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 221
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.68
    Marker Score: 253
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.68
    Marker Score: 381.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.68
    Marker Score: 381
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.66
    Marker Score: 1173
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.66
    Marker Score: 749
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.66
    Marker Score: 823
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.66
    Marker Score: 245
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.65
    Marker Score: 234
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.65
    Marker Score: 227
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.65
    Marker Score: 320
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.64
    Marker Score: 613
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.64
    Marker Score: 223
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.64
    Marker Score: 4105
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.63
    Marker Score: 422
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.63
    Marker Score: 654
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 196
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 410
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1454
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.62
    Marker Score: 887
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.61
    Marker Score: 249
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.61
    Marker Score: 2481
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.61
    Marker Score: 2626
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.6
    Marker Score: 228
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6
    Marker Score: 315
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.59
    Marker Score: 157
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.59
    Marker Score: 832
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.59
    Marker Score: 1744
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.58
    Marker Score: 210
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.58
    Marker Score: 606
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.58
    Marker Score: 286
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.57
    Marker Score: 247
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.56
    Marker Score: 425
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.56
    Marker Score: 1521
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.56
    Marker Score: 472
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.56
    Marker Score: 272

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Other Information

**Key Characteristics:** 1. **Transcriptional Regulation**: ZNF141 is a member of the zinc finger protein family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. ZNF141 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. 2. **Cellular Specificity**: ZNF141 is significantly expressed in various cell types, including cardiac muscle cells, lens epithelial cells, and smooth muscle cells. This specificity suggests that ZNF141 plays a role in tissue-specific processes. 3. **Morphogenesis**: ZNF141 has been implicated in the regulation of morphogenesis, a process critical for the development and patterning of tissues. Its involvement in limb morphogenesis highlights the importance of ZNF141 in embryonic development. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity**: ZNF141 binds to specific DNA sequences, regulating the expression of target genes. This activity is mediated through its zinc finger domain, which recognizes and interacts with DNA. 2. **RNA Polymerase II-Specific**: ZNF141 interacts with RNA polymerase II, a key enzyme involved in transcriptional regulation. This interaction suggests that ZNF141 plays a role in regulating gene expression through the modulation of RNA polymerase II activity. 3. **Gene Expression (Transcription)**: ZNF141 regulates gene expression by interacting with RNA polymerase II and other transcriptional regulators. Its involvement in the generic transcription pathway highlights its role in the regulation of gene expression. 4. **Regulation of DNA-Templated Transcription**: ZNF141 regulates the transcription of genes by interacting with DNA and RNA polymerase II. This activity is critical for the proper functioning of the transcriptional machinery. **Clinical Significance:** 1. **Cardiovascular Disease**: ZNF141 has been implicated in the regulation of cardiac muscle cell development and function. Alterations in ZNF141 expression have been linked to cardiovascular disease, highlighting its potential as a therapeutic target. 2. **Eye Diseases**: ZNF141 is expressed in lens epithelial cells and has been shown to play a role in the regulation of gene expression. Mutations in ZNF141 have been linked to eye diseases, such as cataracts and glaucoma. 3. **Cancer**: ZNF141 has been implicated in the regulation of gene expression in cancer cells. Its role in the regulation of transcriptional regulators has led to its investigation as a potential therapeutic target in cancer. In conclusion, ZNF141 is a transcription factor protein that plays a crucial role in various cellular processes, including morphogenesis, transcriptional regulation, and cell differentiation. Its involvement in cardiovascular disease, eye diseases, and cancer highlights its potential as a therapeutic target and underscores the importance of further research into its functions and pathways.

Genular Protein ID: 1594604208

Symbol: ZN141_HUMAN

Name: Zinc finger protein 141

UniProtKB Accession Codes:

Q15928 Q6DK07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268908

Title: A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome.

PubMed ID: 8268908

DOI: 10.1093/hmg/2.10.1571

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23160277

Title: Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A.

PubMed ID: 23160277

DOI: 10.1136/jmedgenet-2012-101219

Sequence Information:

  • Length: 474
  • Mass: 55249
  • Checksum: 6133202F1DB207E8
  • Sequence:
    • MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP DLVTCLEQRK 
EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL RRYEKCGHDN LQLRKGCKSL 
NECKLQKGGY NEFNECLSTT QSKILQCKAS VKVVSKFSNS NKRKTRHTGE KHFKECGKSF 
QKFSHLTQHK VIHAGEKPYT CEECGKAFKW SLIFNEHKRI HTGEKPFTCE ECGSIFTTSS 
HFAKHKIIHT GEKPYKCEEC GKAFNRFTTL TKHKRIHAGE KPITCEECRK IFTSSSNFAK 
HKRIHTGEKP YKCEECGKAF NRSTTLTKHK RIHTGEKPYT CEECGKAFRQ SSKLNEHKKV 
HTGERPYKCD ECGKAFGRSR VLNEHKKIHT GEKPYKCEEC GKAFRRSTDR SQHKKIHSAD 
KPYKCKECDK AFKQFSLLSQ HKKIHTVDKP YKCKDCDKAF KRFSHLNKHK KIHT

Genular Protein ID: 3596336608

Symbol: D6RIY0_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RIY0

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 201
  • Mass: 23326
  • Checksum: C90FAFDD33CC3968
  • Sequence:
    • MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP DLVTCLEQRK 
EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL RRYEKCGHDN LQLRKGCKSL 
NECKLQKGGY NEFNECLSTT QSKILQCKAS VKVVSKFSNS NKRKTRHTGE KHFKECGKSF 
QKFSHLTQHK NSSISMTTSP F

Genular Protein ID: 3859548952

Symbol: Q4W5N2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4W5N2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 398
  • Mass: 46393
  • Checksum: 40A467A159BB1FEB
  • Sequence:
    • MCSHFTQDHW PVQGIEDSFH KLILRRYEKC GHDNLQLRKG CKSLNECKLQ KGGYNEFNEC 
LSTTQSKILQ CKASVKVVSK FSNSNKRKTR HTGEKHFKEC GKSFQKFSHL TQHKVIHAGE 
KPYTCEECGK AFKWSLIFNE HKRIHTGEKP FTCEECGSIF TTSSHFAKHK IIHTGEKPYK 
CEECGKAFNR FTTLTKHKRI HAGEKPITCE ECRKIFTSSS NFAKHKRIHT GEKPYKCEEC 
GKAFNRSTTL TKHKRIHTGE KPYTCEECGK AFRQSSKLNE HKKVHTGERP YKCDECGKAF 
GRSRVLNEHK KIHTGEKPYK CEECGKAFRR STDRSQHKKI HSADKPYKCK ECDKAFKQFS 
LLSQHKKIHT VDKPYKCKDC DKAFKRFSHL NKHKKIHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.