Details for: ZNF143

Gene ID: 7702

Symbol: ZNF143

Ensembl ID: ENSG00000166478

Description: zinc finger protein 143

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Rna polymerase iii abortive and retractive initiation
    (R-HSA-749476)
  • Rna polymerase iii transcription
    (R-HSA-74158)
  • Rna polymerase iii transcription initiation
    (R-HSA-76046)
  • Rna polymerase iii transcription initiation from type 3 promoter
    (R-HSA-76071)
  • Rna polymerase ii transcribes snrna genes
    (R-HSA-6807505)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of snrna transcription by rna polymerase ii
    (GO:1905382)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription by rna polymerase iii
    (GO:0045945)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of transcription by rna polymerase iii
    (GO:0006359)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.5730
    Cell Significance Index: -20.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.1696
    Cell Significance Index: -22.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.0037
    Cell Significance Index: -24.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.4822
    Cell Significance Index: -19.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.0122
    Cell Significance Index: -24.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.4243
    Cell Significance Index: -19.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1434
    Cell Significance Index: -22.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7365
    Cell Significance Index: -20.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8641
    Cell Significance Index: -23.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4714
    Cell Significance Index: 171.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9228
    Cell Significance Index: 12.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6696
    Cell Significance Index: 66.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6598
    Cell Significance Index: 71.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6561
    Cell Significance Index: 17.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5471
    Cell Significance Index: 108.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5375
    Cell Significance Index: 32.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5154
    Cell Significance Index: 28.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4820
    Cell Significance Index: 13.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4689
    Cell Significance Index: 21.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4526
    Cell Significance Index: 90.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3636
    Cell Significance Index: 10.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3430
    Cell Significance Index: 7.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3388
    Cell Significance Index: 8.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3328
    Cell Significance Index: 23.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3297
    Cell Significance Index: 40.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3139
    Cell Significance Index: 24.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2591
    Cell Significance Index: 46.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2568
    Cell Significance Index: 6.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2440
    Cell Significance Index: 12.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2153
    Cell Significance Index: 13.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2127
    Cell Significance Index: 116.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2081
    Cell Significance Index: 187.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1868
    Cell Significance Index: 25.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1864
    Cell Significance Index: 66.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1708
    Cell Significance Index: 118.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1642
    Cell Significance Index: 72.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1576
    Cell Significance Index: 18.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1426
    Cell Significance Index: 7.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1368
    Cell Significance Index: 6.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1142
    Cell Significance Index: 215.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1132
    Cell Significance Index: 5.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1054
    Cell Significance Index: 6.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1027
    Cell Significance Index: 3.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0736
    Cell Significance Index: 9.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0700
    Cell Significance Index: 1.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0506
    Cell Significance Index: 9.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0466
    Cell Significance Index: 3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0465
    Cell Significance Index: 71.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0389
    Cell Significance Index: 52.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0382
    Cell Significance Index: 0.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0355
    Cell Significance Index: 65.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0343
    Cell Significance Index: 15.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0288
    Cell Significance Index: 3.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0252
    Cell Significance Index: 16.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0060
    Cell Significance Index: 0.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0027
    Cell Significance Index: 0.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0067
    Cell Significance Index: -0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0202
    Cell Significance Index: -14.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0205
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0218
    Cell Significance Index: -16.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0226
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0248
    Cell Significance Index: -18.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0389
    Cell Significance Index: -21.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0434
    Cell Significance Index: -27.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0436
    Cell Significance Index: -1.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0478
    Cell Significance Index: -0.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0496
    Cell Significance Index: -0.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0562
    Cell Significance Index: -0.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0608
    Cell Significance Index: -17.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0659
    Cell Significance Index: -6.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0660
    Cell Significance Index: -11.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0782
    Cell Significance Index: -11.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0873
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1249
    Cell Significance Index: -26.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1356
    Cell Significance Index: -15.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1376
    Cell Significance Index: -14.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1500
    Cell Significance Index: -4.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1546
    Cell Significance Index: -10.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1776
    Cell Significance Index: -6.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1916
    Cell Significance Index: -10.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1971
    Cell Significance Index: -1.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1992
    Cell Significance Index: -4.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2194
    Cell Significance Index: -5.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2350
    Cell Significance Index: -1.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2471
    Cell Significance Index: -2.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2519
    Cell Significance Index: -19.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2837
    Cell Significance Index: -12.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2949
    Cell Significance Index: -18.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3069
    Cell Significance Index: -5.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3327
    Cell Significance Index: -12.6000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3444
    Cell Significance Index: -2.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3484
    Cell Significance Index: -6.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3727
    Cell Significance Index: -9.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3735
    Cell Significance Index: -10.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3989
    Cell Significance Index: -20.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3999
    Cell Significance Index: -11.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4107
    Cell Significance Index: -9.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4400
    Cell Significance Index: -11.7700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4592
    Cell Significance Index: -6.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4667
    Cell Significance Index: -6.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding domain:** ZNF143 possesses a zinc finger domain, which is essential for its DNA-binding activity and allows it to interact with specific DNA sequences. 2. **RNA polymerase II interaction:** ZNF143 interacts with RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes in eukaryotic cells. 3. **Transcriptional regulation:** ZNF143 regulates the expression of snRNA genes, smooth muscle cell proliferation, and the transcription of genes involved in cellular differentiation. 4. **Cell type specificity:** ZNF143 is expressed in diverse cell types, including germ cells, epithelial cells, and neural cells, suggesting its involvement in various physiological and pathological processes. **Pathways and Functions:** 1. **Chromatin remodeling:** ZNF143 regulates chromatin remodeling, allowing for the activation or repression of gene expression. 2. **Transcriptional activation:** ZNF143 activates the transcription of genes involved in smooth muscle cell proliferation and cellular differentiation. 3. **RNA polymerase II-specific transcription:** ZNF143 interacts with RNA polymerase II, regulating the transcription of protein-coding genes. 4. **SnRNA gene expression:** ZNF143 regulates the expression of snRNA genes, which are involved in various post-transcriptional processes. **Clinical Significance:** 1. **Cancer research:** ZNF143's role in regulating transcriptional processes makes it a potential target for cancer therapy. 2. **Cardiovascular disease:** ZNF143's involvement in smooth muscle cell proliferation suggests its potential role in cardiovascular disease. 3. **Neurological disorders:** ZNF143's expression in neural cells highlights its potential involvement in neurological disorders, such as Alzheimer's disease. 4. **Germ cell development:** ZNF143's expression in germ cells suggests its potential role in germ cell development and fertility. In conclusion, ZNF143 is a transcriptional regulator that plays a crucial role in regulating gene expression. Its involvement in various physiological and pathological processes makes it a promising target for future research and therapeutic interventions. Further studies are necessary to fully elucidate the role of ZNF143 in human health and disease.

Genular Protein ID: 744851914

Symbol: ZN143_HUMAN

Name: Zinc finger protein 143

UniProtKB Accession Codes:

P52747 A8K518 B4DLY5 E7ER34 O75559 Q8WUK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 9776743

Title: Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter.

PubMed ID: 9776743

DOI: 10.1093/nar/26.21.4846

PubMed ID: 17938208

Title: CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription.

PubMed ID: 17938208

DOI: 10.1128/mcb.00846-07

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 638
  • Mass: 68896
  • Checksum: D149030016A6058A
  • Sequence:
    • MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL QAVTLADGST 
AYIQHNSKDA KLIDGQVIQL EDGSAAYVQH VPIPKSTGDS LRLEDGQAVQ LEDGTTAFIH 
HTSKDSYDQS ALQAVQLEDG TTAYIHHAVQ VPQSDTILAI QADGTVAGLH TGDATIDPDT 
ISALEQYAAK VSIDGSESVA GTGMIGENEQ EKKMQIVLQG HATRVTAKSQ QSGEKAFRCE 
YDGCGKLYTT AHHLKVHERS HTGDRPYQCE HAGCGKAFAT GYGLKSHVRT HTGEKPYRCS 
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP FEGCGRSFTT SNIRKVHVRT HTGERPYYCT 
EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE YSSLYKHHVV HTHSKPYNCN 
HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ EAFFEPPPGQ GEDVLKGSQI TYVTGVEGDD 
VVSTQVATVT QSGLSQQVTL ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPAHDA 
VISSAGTHSV AMVTAEGTEG EQVAIVAQDL AAFHTASSEM GHQQHSHHLV TTETRPLTLV 
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.