Details for: ZNF177

Gene ID: 7730

Symbol: ZNF177

Ensembl ID: ENSG00000188629

Description: zinc finger protein 177

Associated with

  • Blood microparticle
    (GO:0072562)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162080
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.14
    Marker Score: 3692
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.28
    Marker Score: 1432
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.26
    Marker Score: 2239
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.21
    Marker Score: 769
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.09
    Marker Score: 453
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.94
    Marker Score: 720
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.92
    Marker Score: 880
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.88
    Marker Score: 811
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.87
    Marker Score: 1577
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.84
    Marker Score: 841
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1186
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 467
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.69
    Marker Score: 6535
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.69
    Marker Score: 1059
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.69
    Marker Score: 5886
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.67
    Marker Score: 715
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.67
    Marker Score: 429
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.64
    Marker Score: 13733
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 507
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.61
    Marker Score: 37500
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6
    Marker Score: 2331
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.56
    Marker Score: 5290
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8786
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.56
    Marker Score: 21120
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.52
    Marker Score: 7737
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.5
    Marker Score: 3861
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.46
    Marker Score: 255
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.46
    Marker Score: 866
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.45
    Marker Score: 1820
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.44
    Marker Score: 1810
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 112
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 242
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.36
    Marker Score: 7190
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 349
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.34
    Marker Score: 260
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 159
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.27
    Marker Score: 143
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 110
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.26
    Marker Score: 227
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.26
    Marker Score: 625
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.24
    Marker Score: 497
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.24
    Marker Score: 89
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.23
    Marker Score: 266
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.23
    Marker Score: 8502
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.23
    Marker Score: 222
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.22
    Marker Score: 274
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.22
    Marker Score: 1299
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.19
    Marker Score: 95
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.19
    Marker Score: 78.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.19
    Marker Score: 86
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.19
    Marker Score: 98
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 333.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 138
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.14
    Marker Score: 147.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.13
    Marker Score: 1119
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.12
    Marker Score: 153
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.12
    Marker Score: 351
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.11
    Marker Score: 85
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.11
    Marker Score: 85
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 120.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **Transcriptional regulation**: ZNF177 acts as a transcription factor, regulating the expression of target genes through interaction with RNA polymerase II. 2. **DNA-binding specificity**: ZNF177 exhibits sequence-specific DNA binding, allowing it to recognize and bind to specific DNA sequences, thereby controlling gene expression. 3. **Metal ion binding**: ZNF177 contains a metal ion-binding domain, which is essential for its DNA-binding activity and transcriptional regulation. 4. **Cell type specificity**: ZNF177 is expressed in various cell types, including immune cells, epithelial cells, and stem cells, highlighting its diverse roles in different tissues and organs. **Pathways and Functions:** 1. **Immune response**: ZNF177 is involved in regulating the expression of genes involved in immune response, including those related to T cell activation, plasma cell differentiation, and granulocyte development. 2. **Transcriptional regulation**: ZNF177 regulates the expression of target genes through interaction with RNA polymerase II, influencing gene expression in various cell types. 3. **Cell differentiation**: ZNF177 plays a role in regulating cell differentiation processes, including those involved in the development of immune cells and epithelial cells. 4. **Developmental processes**: ZNF177 is involved in regulating developmental processes, including those related to embryonic development and tissue homeostasis. **Clinical Significance:** 1. **Immunological disorders**: Aberrant expression or function of ZNF177 may contribute to the development of immunological disorders, such as autoimmune diseases or immunodeficiency syndromes. 2. **Cancer**: ZNF177's role in regulating gene expression and cell differentiation may be exploited in cancer therapy, particularly in the development of targeted therapies. 3. **Gastrointestinal diseases**: ZNF177's involvement in regulating gene expression in epithelial cells may contribute to the development of gastrointestinal diseases, such as inflammatory bowel disease. 4. **Stem cell biology**: ZNF177's role in regulating stem cell development and differentiation may have implications for the study and treatment of stem cell-related disorders. In conclusion, ZNF177 is a multifunctional gene that plays a crucial role in regulating gene expression and immune response. Its involvement in various biological pathways and its clinical significance highlight the importance of further research into the functions and dysregulation of ZNF177 in different diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.