Details for: ZNF177

Gene ID: 7730

Symbol: ZNF177

Ensembl ID: ENSG00000188629

Description: zinc finger protein 177

Associated with

  • Blood microparticle
    (GO:0072562)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.9218
    Cell Significance Index: 15.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3815
    Cell Significance Index: 76.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3800
    Cell Significance Index: 12.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3535
    Cell Significance Index: 21.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3065
    Cell Significance Index: 23.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.2718
    Cell Significance Index: 4.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2460
    Cell Significance Index: 88.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2279
    Cell Significance Index: 14.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1879
    Cell Significance Index: 35.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1718
    Cell Significance Index: 7.7900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1350
    Cell Significance Index: 1.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1297
    Cell Significance Index: 4.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1263
    Cell Significance Index: 7.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1218
    Cell Significance Index: 2.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1060
    Cell Significance Index: 4.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0764
    Cell Significance Index: 9.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0628
    Cell Significance Index: 1.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0571
    Cell Significance Index: 1.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0532
    Cell Significance Index: 48.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0518
    Cell Significance Index: 1.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0396
    Cell Significance Index: 2.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0380
    Cell Significance Index: 3.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0344
    Cell Significance Index: 1.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0218
    Cell Significance Index: 3.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0196
    Cell Significance Index: 3.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0187
    Cell Significance Index: 2.0400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0055
    Cell Significance Index: 0.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0135
    Cell Significance Index: -7.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0156
    Cell Significance Index: -8.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0212
    Cell Significance Index: -0.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0251
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0326
    Cell Significance Index: -3.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0373
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0397
    Cell Significance Index: -8.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0455
    Cell Significance Index: -0.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0499
    Cell Significance Index: -6.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0549
    Cell Significance Index: -0.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0600
    Cell Significance Index: -1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0644
    Cell Significance Index: -9.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0698
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0730
    Cell Significance Index: -8.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0735
    Cell Significance Index: -4.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0745
    Cell Significance Index: -2.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0912
    Cell Significance Index: -1.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0929
    Cell Significance Index: -9.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0951
    Cell Significance Index: -3.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0976
    Cell Significance Index: -1.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1068
    Cell Significance Index: -2.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1199
    Cell Significance Index: -9.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1213
    Cell Significance Index: -2.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1284
    Cell Significance Index: -6.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1302
    Cell Significance Index: -4.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1355
    Cell Significance Index: -2.6800
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.1370
    Cell Significance Index: -1.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1395
    Cell Significance Index: -2.9600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1559
    Cell Significance Index: -0.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1563
    Cell Significance Index: -3.9000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1716
    Cell Significance Index: -1.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1770
    Cell Significance Index: -9.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1783
    Cell Significance Index: -9.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1860
    Cell Significance Index: -8.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1964
    Cell Significance Index: -2.9600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2050
    Cell Significance Index: -4.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2060
    Cell Significance Index: -2.5600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2074
    Cell Significance Index: -4.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2258
    Cell Significance Index: -2.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2261
    Cell Significance Index: -8.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2291
    Cell Significance Index: -5.5500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2420
    Cell Significance Index: -3.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2465
    Cell Significance Index: -3.5400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2475
    Cell Significance Index: -2.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2489
    Cell Significance Index: -5.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2509
    Cell Significance Index: -6.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2690
    Cell Significance Index: -7.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2698
    Cell Significance Index: -5.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2737
    Cell Significance Index: -9.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2817
    Cell Significance Index: -11.5400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2860
    Cell Significance Index: -3.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2980
    Cell Significance Index: -4.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2991
    Cell Significance Index: -8.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3087
    Cell Significance Index: -3.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3123
    Cell Significance Index: -9.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3172
    Cell Significance Index: -8.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3249
    Cell Significance Index: -8.6900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3288
    Cell Significance Index: -4.1500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3295
    Cell Significance Index: -8.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3348
    Cell Significance Index: -8.3500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3348
    Cell Significance Index: -3.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3381
    Cell Significance Index: -6.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3418
    Cell Significance Index: -8.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3432
    Cell Significance Index: -3.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3449
    Cell Significance Index: -7.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3525
    Cell Significance Index: -8.9800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3617
    Cell Significance Index: -4.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3695
    Cell Significance Index: -9.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation**: ZNF177 acts as a transcription factor, regulating the expression of target genes through interaction with RNA polymerase II. 2. **DNA-binding specificity**: ZNF177 exhibits sequence-specific DNA binding, allowing it to recognize and bind to specific DNA sequences, thereby controlling gene expression. 3. **Metal ion binding**: ZNF177 contains a metal ion-binding domain, which is essential for its DNA-binding activity and transcriptional regulation. 4. **Cell type specificity**: ZNF177 is expressed in various cell types, including immune cells, epithelial cells, and stem cells, highlighting its diverse roles in different tissues and organs. **Pathways and Functions:** 1. **Immune response**: ZNF177 is involved in regulating the expression of genes involved in immune response, including those related to T cell activation, plasma cell differentiation, and granulocyte development. 2. **Transcriptional regulation**: ZNF177 regulates the expression of target genes through interaction with RNA polymerase II, influencing gene expression in various cell types. 3. **Cell differentiation**: ZNF177 plays a role in regulating cell differentiation processes, including those involved in the development of immune cells and epithelial cells. 4. **Developmental processes**: ZNF177 is involved in regulating developmental processes, including those related to embryonic development and tissue homeostasis. **Clinical Significance:** 1. **Immunological disorders**: Aberrant expression or function of ZNF177 may contribute to the development of immunological disorders, such as autoimmune diseases or immunodeficiency syndromes. 2. **Cancer**: ZNF177's role in regulating gene expression and cell differentiation may be exploited in cancer therapy, particularly in the development of targeted therapies. 3. **Gastrointestinal diseases**: ZNF177's involvement in regulating gene expression in epithelial cells may contribute to the development of gastrointestinal diseases, such as inflammatory bowel disease. 4. **Stem cell biology**: ZNF177's role in regulating stem cell development and differentiation may have implications for the study and treatment of stem cell-related disorders. In conclusion, ZNF177 is a multifunctional gene that plays a crucial role in regulating gene expression and immune response. Its involvement in various biological pathways and its clinical significance highlight the importance of further research into the functions and dysregulation of ZNF177 in different diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.