Details for: ZNF184

Gene ID: 7738

Symbol: ZNF184

Ensembl ID: ENSG00000096654

Description: zinc finger protein 184

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.5542
    Cell Significance Index: -9.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.2320
    Cell Significance Index: -9.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.2304
    Cell Significance Index: -8.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2566
    Cell Significance Index: -10.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6844
    Cell Significance Index: -9.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6153
    Cell Significance Index: -10.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.3752
    Cell Significance Index: 39.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2660
    Cell Significance Index: -6.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7332
    Cell Significance Index: 662.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6891
    Cell Significance Index: 41.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6553
    Cell Significance Index: 71.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5489
    Cell Significance Index: 89.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5190
    Cell Significance Index: 51.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5079
    Cell Significance Index: 101.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3719
    Cell Significance Index: 19.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2965
    Cell Significance Index: 8.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2848
    Cell Significance Index: 14.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2829
    Cell Significance Index: 32.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2674
    Cell Significance Index: 12.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2552
    Cell Significance Index: 48.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2456
    Cell Significance Index: 16.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2426
    Cell Significance Index: 6.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1871
    Cell Significance Index: 11.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1699
    Cell Significance Index: 3.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1028
    Cell Significance Index: 71.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0876
    Cell Significance Index: 31.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0856
    Cell Significance Index: 2.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0810
    Cell Significance Index: 14.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0679
    Cell Significance Index: 30.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0610
    Cell Significance Index: 33.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0526
    Cell Significance Index: 3.4000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0492
    Cell Significance Index: 0.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0472
    Cell Significance Index: 2.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0459
    Cell Significance Index: 6.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0456
    Cell Significance Index: 5.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0442
    Cell Significance Index: 8.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0430
    Cell Significance Index: 0.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0403
    Cell Significance Index: 0.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0397
    Cell Significance Index: 1.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0283
    Cell Significance Index: 1.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0275
    Cell Significance Index: 1.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0269
    Cell Significance Index: 0.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0245
    Cell Significance Index: 0.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0044
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0092
    Cell Significance Index: -6.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0099
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0122
    Cell Significance Index: -5.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0131
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0167
    Cell Significance Index: -1.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0209
    Cell Significance Index: -13.0800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0234
    Cell Significance Index: -0.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0246
    Cell Significance Index: -1.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0269
    Cell Significance Index: -7.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0290
    Cell Significance Index: -3.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0378
    Cell Significance Index: -1.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0401
    Cell Significance Index: -5.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0460
    Cell Significance Index: -7.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0474
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0526
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0557
    Cell Significance Index: -11.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0598
    Cell Significance Index: -1.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0669
    Cell Significance Index: -2.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0685
    Cell Significance Index: -1.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0687
    Cell Significance Index: -5.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0728
    Cell Significance Index: -9.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0734
    Cell Significance Index: -2.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0869
    Cell Significance Index: -2.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0909
    Cell Significance Index: -1.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0939
    Cell Significance Index: -9.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1018
    Cell Significance Index: -2.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1036
    Cell Significance Index: -7.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1111
    Cell Significance Index: -8.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1187
    Cell Significance Index: -2.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1203
    Cell Significance Index: -7.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1544
    Cell Significance Index: -3.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1623
    Cell Significance Index: -8.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1721
    Cell Significance Index: -5.4800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1840
    Cell Significance Index: -3.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1924
    Cell Significance Index: -6.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1964
    Cell Significance Index: -6.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2088
    Cell Significance Index: -6.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2161
    Cell Significance Index: -5.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2193
    Cell Significance Index: -6.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2337
    Cell Significance Index: -6.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2352
    Cell Significance Index: -4.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2458
    Cell Significance Index: -5.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2531
    Cell Significance Index: -3.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2610
    Cell Significance Index: -9.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2645
    Cell Significance Index: -6.1100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2724
    Cell Significance Index: -2.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF184 is a member of the zinc finger protein family, characterized by its ability to bind to specific DNA sequences through a zinc finger motif. This motif allows ZNF184 to interact with RNA polymerase II and regulate transcriptional activity. The protein is highly expressed in cells involved in tissue development, immune responses, and neural function, suggesting its involvement in regulating cellular differentiation, proliferation, and survival. **Pathways and Functions:** ZNF184 is involved in several key pathways, including: 1. **DNA-binding transcription factor activity**: ZNF184 binds to specific DNA sequences, regulating the expression of target genes involved in cellular development and function. 2. **Gene expression (transcription)**: ZNF184 acts as a transcriptional regulator, controlling the expression of genes involved in cellular differentiation, proliferation, and survival. 3. **Generic transcription pathway**: ZNF184 participates in the general transcription pathway, regulating the expression of genes involved in cellular development and function. 4. **Regulation of transcription by RNA polymerase II**: ZNF184 interacts with RNA polymerase II, regulating the expression of genes involved in transcriptional control. 5. **Zinc ion binding**: ZNF184's zinc finger motif allows it to bind to specific DNA sequences, regulating transcriptional activity. **Clinical Significance:** ZNF184's involvement in various cellular processes makes it a potential therapeutic target for diseases characterized by abnormal cellular development and function. For example: 1. **Cardiovascular diseases**: Abnormal expression of ZNF184 in cardiac endothelial cells may contribute to cardiovascular diseases, such as atherosclerosis and hypertension. 2. **Neurological disorders**: ZNF184's role in regulating neural development and function makes it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune system disorders**: ZNF184's involvement in immune responses makes it a potential target for immune system disorders, such as autoimmune diseases and cancer. In conclusion, ZNF184 is a transcription factor that plays a crucial role in regulating gene expression and cellular development. Its involvement in various cellular processes makes it a potential therapeutic target for diseases characterized by abnormal cellular development and function. Further research is needed to fully understand the role of ZNF184 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 913691021

Symbol: ZN184_HUMAN

Name: Zinc finger protein 184

UniProtKB Accession Codes:

Q99676 B2R715 O60792 Q8TBA9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9073517

Title: Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3.

PubMed ID: 9073517

DOI: 10.1006/geno.1996.4583

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 751
  • Mass: 86174
  • Checksum: 249DFB302C6BC97D
  • Sequence:
    • MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR DLFRDVTLEN 
YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD WETRLENSVS APEPDISEEE 
LSPEVIVEKH KRDDSWSSNL LESWEYEGSL ERQQANQQTL PKEIKVTEKT IPSWEKGPVN 
NEFGKSVNVS SNLVTQEPSP EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH 
QRTHTGEKPY KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH 
TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM EHQKIHTGEK 
PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN GPSTFIRHHM IHTGEKPYEC 
NECGKAFSQH SNLTQHQKTH TGEKPYDCAE CGKSFSYWSS LAQHLKIHTG EKPYKCNECG 
KAFSYCSSLT QHRRIHTREK PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI 
RSSSLAKHER IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH 
LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT FSQSSHLTQH 
QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC NECRKTFSQS TYLIQHQRIH 
SGEKPFGCND CGKSFRYRSA LNKHQRLHPG I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.