Details for: ZNF195

Gene ID: 7748

Symbol: ZNF195

Ensembl ID: ENSG00000005801

Description: zinc finger protein 195

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.1732
    Cell Significance Index: -20.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.4997
    Cell Significance Index: -19.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.7659
    Cell Significance Index: -21.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.8392
    Cell Significance Index: -17.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.7380
    Cell Significance Index: -17.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.5027
    Cell Significance Index: -21.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7342
    Cell Significance Index: -18.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5245
    Cell Significance Index: -21.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2386
    Cell Significance Index: -16.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.4592
    Cell Significance Index: 23.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8272
    Cell Significance Index: 134.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7817
    Cell Significance Index: 156.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7510
    Cell Significance Index: 42.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7469
    Cell Significance Index: 38.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6580
    Cell Significance Index: 17.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6047
    Cell Significance Index: 120.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5447
    Cell Significance Index: 15.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5134
    Cell Significance Index: 184.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5045
    Cell Significance Index: 34.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4813
    Cell Significance Index: 30.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4616
    Cell Significance Index: 56.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4198
    Cell Significance Index: 379.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4119
    Cell Significance Index: 74.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3550
    Cell Significance Index: 21.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2991
    Cell Significance Index: 163.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2963
    Cell Significance Index: 8.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2808
    Cell Significance Index: 12.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2630
    Cell Significance Index: 13.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2623
    Cell Significance Index: 49.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2601
    Cell Significance Index: 16.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2596
    Cell Significance Index: 9.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2522
    Cell Significance Index: 11.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2008
    Cell Significance Index: 88.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1955
    Cell Significance Index: 9.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1952
    Cell Significance Index: 26.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1787
    Cell Significance Index: 4.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1778
    Cell Significance Index: 20.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1648
    Cell Significance Index: 5.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1260
    Cell Significance Index: 9.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1198
    Cell Significance Index: 8.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1141
    Cell Significance Index: 5.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0792
    Cell Significance Index: 7.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0777
    Cell Significance Index: 2.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0717
    Cell Significance Index: 1.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0698
    Cell Significance Index: 1.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0636
    Cell Significance Index: 1.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0446
    Cell Significance Index: 3.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0338
    Cell Significance Index: 0.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0314
    Cell Significance Index: 4.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0129
    Cell Significance Index: 1.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -7.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0044
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0136
    Cell Significance Index: -9.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0145
    Cell Significance Index: -6.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0171
    Cell Significance Index: -2.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0176
    Cell Significance Index: -13.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0304
    Cell Significance Index: -17.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0326
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0351
    Cell Significance Index: -21.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0353
    Cell Significance Index: -0.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0372
    Cell Significance Index: -3.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0452
    Cell Significance Index: -3.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0568
    Cell Significance Index: -16.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0701
    Cell Significance Index: -2.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0782
    Cell Significance Index: -9.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0817
    Cell Significance Index: -11.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1082
    Cell Significance Index: -12.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1095
    Cell Significance Index: -23.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1238
    Cell Significance Index: -1.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1260
    Cell Significance Index: -1.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1347
    Cell Significance Index: -3.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1630
    Cell Significance Index: -8.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1794
    Cell Significance Index: -5.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1972
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1988
    Cell Significance Index: -20.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2121
    Cell Significance Index: -3.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2184
    Cell Significance Index: -6.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2186
    Cell Significance Index: -5.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2214
    Cell Significance Index: -4.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2268
    Cell Significance Index: -17.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2423
    Cell Significance Index: -7.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2556
    Cell Significance Index: -6.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2678
    Cell Significance Index: -16.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3257
    Cell Significance Index: -3.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3302
    Cell Significance Index: -10.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3316
    Cell Significance Index: -10.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3466
    Cell Significance Index: -8.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3473
    Cell Significance Index: -4.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3664
    Cell Significance Index: -9.1600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3745
    Cell Significance Index: -4.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3899
    Cell Significance Index: -7.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3962
    Cell Significance Index: -4.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4160
    Cell Significance Index: -8.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4400
    Cell Significance Index: -9.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4499
    Cell Significance Index: -15.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription Factor**: ZNF195 is a transcription factor that regulates gene expression by binding to specific DNA sequences. 2. **Zinc Finger Domain**: The protein contains a zinc finger domain, which is a conserved structural motif that allows the protein to bind to DNA. 3. **Specificity**: ZNF195 binds to specific DNA sequences, including those involved in the regulation of transcription by RNA polymerase II. 4. **Cell Type-Specific Expression**: The gene is significantly expressed in multiple cell types, including neurons, cardiac muscle cells, and pancreatic beta cells. 5. **Regulation of Gene Expression**: ZNF195 regulates gene expression in various cell types, influencing cell growth, differentiation, and survival. **Pathways and Functions** 1. **DNA-Binding Transcription Factor Activity**: ZNF195 binds to specific DNA sequences, regulating transcription by RNA polymerase II. 2. **Gene Expression (Transcription)**: ZNF195 regulates gene expression in various cell types, influencing cell growth, differentiation, and survival. 3. **Generic Transcription Pathway**: ZNF195 is involved in the generic transcription pathway, regulating the expression of genes involved in various cellular processes. 4. **Regulation of DNA-Templated Transcription**: ZNF195 regulates the expression of genes involved in DNA-templated transcription, influencing cell growth and differentiation. 5. **Regulation of Transcription by RNA Polymerase II**: ZNF195 regulates transcription by RNA polymerase II, influencing the expression of genes involved in various cellular processes. **Clinical Significance** 1. **Neurological Disorders**: Alterations in ZNF195 expression have been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease. 2. **Pancreatic Islet Cell Function**: ZNF195 plays a crucial role in regulating pancreatic beta cell function and insulin secretion. 3. **Cardiac Muscle Cell Function**: ZNF195 regulates cardiac muscle cell function and is involved in the development of cardiac hypertrophy. 4. **Cancer**: ZNF195 has been found to be overexpressed in certain types of cancer, including breast and lung cancer. 5. **Neurodevelopmental Disorders**: ZNF195 is involved in the regulation of neurodevelopmental processes, and alterations in its expression have been implicated in disorders such as autism spectrum disorder and schizophrenia. In conclusion, ZNF195 is a transcription factor gene that plays a crucial role in regulating gene expression in various cell types, particularly in the nervous system and pancreatic islet cells. Its dysregulation has been implicated in various diseases, including neurological disorders, cancer, and neurodevelopmental disorders. Further research is needed to fully understand the functions and clinical significance of ZNF195.

Genular Protein ID: 32299700

Symbol: ZN195_HUMAN

Name: Zinc finger protein 195

UniProtKB Accession Codes:

O14628 A8K234 B3KTK2 B4DEL0 C9JLY9 L7MNK2 Q0VAJ6 Q658N8 Q6ZNA9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 9 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 10 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344677

Title: Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5.

PubMed ID: 9344677

DOI: 10.1006/geno.1997.4958

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 629
  • Mass: 72332
  • Checksum: D048217DFC6BFDFB
  • Sequence:
    • MTLLTFRDVA IEFSLEEWKC LDLAQQNLYR DVMLENYRNL FSVGLTVCKP GLITCLEQRK 
EPWNVKRQEA ADGHPEMGFH HATQACLELL GSSDLPASAS QSAGITGVNH RAQPGLNVSV 
DKFTALCSPG VLQTVKWFLE FRCIFSLAMS SHFTQDLLPE QGIQDAFPKR ILRGYGNCGL 
DNLYLRKDWE SLDECKLQKD YNGLNQCSST THSKIFQYNK YVKIFDNFSN LHRRNISNTG 
EKPFKCQECG KSFQMLSFLT EHQKIHTGKK FQKCGECGKT FIQCSHFTEP ENIDTGEKPY 
KCQECNNVIK TCSVLTKNRI YAGGEHYRCE EFGKVFNQCS HLTEHEHGTE EKPCKYEECS 
SVFISCSSLS NQQMILAGEK LSKCETWYKG FNHSPNPSKH QRNEIGGKPF KCEECDSIFK 
WFSDLTKHKR IHTGEKPYKC DECGKAYTQS SHLSEHRRIH TGEKPYQCEE CGKVFRTCSS 
LSNHKRTHSE EKPYTCEECG NIFKQLSDLT KHKKTHTGEK PYKCDECGKN FTQSSNLIVH 
KRIHTGEKPY KCEECGRVFM WFSDITKHKK THTGEKPYKC DECGKNFTQS SNLIVHKRIH 
TGEKPYKCEK CGKAFTQFSH LTVHESIHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.