Details for: ZNF213

Gene ID: 7760

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF213

Ensembl ID: ENSG00000085644

Description: zinc finger protein 213

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • melanocyte CL0000148
    CSI 4.09
    rCSI 3.03%
    PRS 96.09
  • cerebellar granule cell CL0001031
    CSI 3.31
    rCSI 4.87%
    PRS 94.87
  • interneuron CL0000099
    CSI 3.28
    rCSI 6.58%
    PRS 95.26
  • hepatic stellate cell CL0000632
    CSI 3.19
    rCSI 11.94%
    PRS 96.31
  • blood vessel endothelial cell CL0000071
    CSI 2.99
    rCSI 6.2%
    PRS 96.83
  • retinal bipolar neuron CL0000748
    CSI 2.94
    rCSI 5.51%
    PRS 93.51
  • adipocyte CL0000136
    CSI 2.88
    rCSI 3.69%
    PRS 93.79
  • Bergmann glial cell CL0000644
    CSI 2.69
    rCSI 3.68%
    PRS 93.84
  • chondrocyte CL0000138
    CSI 2.52
    rCSI 4%
    PRS 95.56
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.77
    rCSI 3.13%
    PRS 92.38
  • mesothelial cell CL0000077
    CSI 1.64
    rCSI 6.43%
    PRS 90.4
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.19
    rCSI 7.44%
    PRS 93.96
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.29
    rCSI 7.08%
    PRS 89.98

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF213](/details-gene/7760) is a protein-coding gene located on chromosome 16p13.3 that encodes Zinc Finger Protein 213, a putative transcription factor. Functional annotations strongly suggest its involvement in regulating gene expression by binding to DNA and modulating RNA polymerase II activity. Expression data from the **Overall** context indicates that [ZNF213](/details-gene/7760) is a significant marker in a diverse set of specialized cell types, with particularly high expression in [melanocyte](/details-cell/CL0000148)s, [cerebellar granule cell](/details-cell/CL0001031)s, and [interneuron](/details-cell/CL0000099)s. Its initial identification and characterization were reported in a study mapping genes from this chromosomal region [Link](https://doi.org/10.1016/s0167-4781(98)00273-5). ## Cellular Roles and Expression Landscape The expression profile of [ZNF213](/details-gene/7760) points to a role in defining and maintaining the function of specific, terminally differentiated cell lineages rather than a general housekeeping function. **Overall**, it exhibits its highest cell-type significance in [melanocyte](/details-cell/CL0000148)s (CSI: 4.09), suggesting a potential role in pigmentation or melanocyte biology. Beyond melanocytes, [ZNF213](/details-gene/7760) is highly significant across several neuronal and glial populations of the central nervous system. This includes high significance scores in [cerebellar granule cell](/details-cell/CL0001031)s (CSI: 3.31), [interneuron](/details-cell/CL0000099)s (CSI: 3.28), [retinal bipolar neuron](/details-cell/CL0000748)s (CSI: 2.94), and [Bergmann glial cell](/details-cell/CL0000644)s (CSI: 2.69). This pattern suggests that [ZNF213](/details-gene/7760) may regulate transcriptional programs essential for the development, maturation, or function of these specific neural circuits. Additionally, [ZNF213](/details-gene/7760) shows notable significance in various mesenchymal and endothelial-derived cells, including [hepatic stellate cell](/details-cell/CL0000632)s (CSI: 3.19), [blood vessel endothelial cell](/details-cell/CL0000071)s (CSI: 2.99), [adipocyte](/details-cell/CL0000136)s (CSI: 2.88), and [chondrocyte](/details-cell/CL0000138)s (CSI: 2.52). This broad but selective expression pattern across ectodermal, neuroectodermal, and mesodermal lineages underscores its potential role as a key regulator in diverse biological contexts. ## Pathways and Molecular Function Functional annotations are highly consistent with the role of [ZNF213](/details-gene/7760) as a nuclear transcription factor. Gene Ontology (GO) terms classify its molecular function as [Dna-binding transcription factor activity, rna polymerase ii-specific](/details-go/GO:0000981) and [Rna polymerase ii cis-regulatory region sequence-specific dna binding](/details-go/GO:0000978). Its annotated biological process is the [Regulation of transcription by rna polymerase ii](/details-go/GO:0006357), and it is localized to the [Nucleus](/details-go/GO:0005634). These functions are further supported by its association with Reactome pathways such as [Gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160) and [Rna polymerase ii transcription](https://reactome.org/content/detail/R-HSA-73857). This molecular profile strongly suggests that the high significance of [ZNF213](/details-gene/7760) in cells like [melanocyte](/details-cell/CL0000148)s and [cerebellar granule cell](/details-cell/CL0001031)s is due to its role in orchestrating the specific gene expression programs that define the identity and function of these cells. ## Research Directions The specific expression pattern of [ZNF213](/details-gene/7760) in distinct cell types opens several avenues for future research, particularly in understanding cell fate determination and function in both health and disease. ### Proposed Hypotheses 1. **[ZNF213](/details-gene/7760) is a critical regulator of melanogenesis.** Given its top-ranking significance in [melanocyte](/details-cell/CL0000148)s, [ZNF213](/details-gene/7760) may directly regulate the expression of key enzymes and transcription factors (e.g., TYR, TYRP1, MITF) involved in melanin synthesis or control melanocyte survival and proliferation pathways. 2. **[ZNF213](/details-gene/7760) orchestrates a common transcriptional program for neuronal maturation or function in specific CNS subpopulations.** Its high significance in diverse neuronal types like [cerebellar granule cell](/details-cell/CL0001031)s and cortical [interneuron](/details-cell/CL0000099)s suggests it may control a set of genes essential for processes such as synapse formation, ion channel expression, or neurotransmitter regulation common to these cells. ### Key Experimental Approach To test the hypothesis that [ZNF213](/details-gene/7760) is a key regulator of melanogenesis, a CRISPR-Cas9-mediated knockout of the gene could be performed in a human melanocyte cell line (e.g., MNT-1). The functional consequences would be assessed by measuring changes in melanin content via colorimetric assays and evaluating cell morphology. Furthermore, RNA-sequencing could be used to identify downstream target genes, while ChIP-sequencing could determine its direct DNA binding sites, revealing the specific gene regulatory networks it controls in the context of pigmentation. ### Therapeutic Potential The therapeutic potential of [ZNF213](/details-gene/7760) is currently speculative but could be relevant in diseases involving its top-expressing cell types. For instance, if dysregulation of [ZNF213](/details-gene/7760) is linked to melanoma, its role as a transcription factor could make it a target for therapeutic intervention. However, directly targeting nuclear transcription factors with small molecules is historically challenging. An alternative approach would be to target the downstream pathways it regulates. Similarly, if its dysfunction is implicated in neurodevelopmental or neurodegenerative disorders affecting the cerebellum, it could serve as a biomarker or a point of intervention for modulating neuronal function. Its high specificity suggests that targeting it may have limited off-target effects on other major cell lineages.

Genular Protein ID: 3181153438

Symbol: ZN213_HUMAN

Name: Zinc finger protein 213

UniProtKB Accession Codes:

O14771 A8K1B9 B4DMG6 Q96IS1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10023065

Title: Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3.

PubMed ID: 10023065

DOI: 10.1016/s0167-4781(98)00273-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 459
  • Mass: 51263
  • Checksum: 062F64A205533541
  • Sequence:
    • MAAPLEAQDQ APGEGEGLLI VKVEDSSWEQ ESAQHEDGRD SEACRQRFRQ FCYGDVHGPH 
EAFSQLWELC CRWLRPELRT KEQILELLVL EQFLTVLPGE IQGWVREQHP GSGEEAVALV 
EDLQKQPVKA WRQDVPSEEA EPEAAGRGSQ ATGPPPTVGA RRRPSVPQEQ HSHSAQPPAL 
LKEGRPGETT DTCFVSGVHG PVALGDIPFY FSREEWGTLD PAQRDLFWDI KRENSRNTTL 
GFGLKGQSEK SLLQEMVPVV PGQTGSDVTV SWSPEEAEAW ESENRPRAAL GPVVGARRGR 
PPTRRRQFRD LAAEKPHSCG QCGKRFRWGS DLARHQRTHT GEKPHKCPEC DKSFRSSSDL 
VRHQGVHTGE KPFSCSECGK SFSRSAYLAD HQRIHTGEKP FGCSDCGKSF SLRSYLLDHR 
RVHTGERPFG CGECDKSFKQ RAHLIAHQSL HAKMAQPVG