Details for: ZNF213

Gene ID: 7760

Symbol: ZNF213

Ensembl ID: ENSG00000085644

Description: zinc finger protein 213

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 77.4694
    Cell Significance Index: -12.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.8481
    Cell Significance Index: -12.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.7137
    Cell Significance Index: -12.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.4919
    Cell Significance Index: -9.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.1058
    Cell Significance Index: -12.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1846
    Cell Significance Index: -11.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2361
    Cell Significance Index: -12.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2156
    Cell Significance Index: -6.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.6578
    Cell Significance Index: 28.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3840
    Cell Significance Index: 274.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9273
    Cell Significance Index: 91.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8091
    Cell Significance Index: 730.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7967
    Cell Significance Index: 20.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7101
    Cell Significance Index: 17.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6690
    Cell Significance Index: 41.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5612
    Cell Significance Index: 61.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5337
    Cell Significance Index: 86.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4927
    Cell Significance Index: 29.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4283
    Cell Significance Index: 8.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3783
    Cell Significance Index: 10.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3508
    Cell Significance Index: 7.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3103
    Cell Significance Index: 21.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2807
    Cell Significance Index: 10.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2800
    Cell Significance Index: 12.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2564
    Cell Significance Index: 11.3400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2303
    Cell Significance Index: 2.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2288
    Cell Significance Index: 11.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2169
    Cell Significance Index: 25.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1956
    Cell Significance Index: 39.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1956
    Cell Significance Index: 10.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1820
    Cell Significance Index: 34.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1661
    Cell Significance Index: 11.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1560
    Cell Significance Index: 240.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1522
    Cell Significance Index: 280.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1493
    Cell Significance Index: 11.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1344
    Cell Significance Index: 7.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1289
    Cell Significance Index: 46.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1220
    Cell Significance Index: 3.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1220
    Cell Significance Index: 3.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1025
    Cell Significance Index: 18.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1024
    Cell Significance Index: 2.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1001
    Cell Significance Index: 188.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0867
    Cell Significance Index: 3.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0851
    Cell Significance Index: 1.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0828
    Cell Significance Index: 5.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0731
    Cell Significance Index: 1.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0731
    Cell Significance Index: 99.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0721
    Cell Significance Index: 1.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0671
    Cell Significance Index: 3.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0654
    Cell Significance Index: 28.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0577
    Cell Significance Index: 7.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0442
    Cell Significance Index: 24.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0337
    Cell Significance Index: 21.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0334
    Cell Significance Index: 4.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0250
    Cell Significance Index: 0.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0187
    Cell Significance Index: 12.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0141
    Cell Significance Index: 6.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0114
    Cell Significance Index: 1.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0051
    Cell Significance Index: -0.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0151
    Cell Significance Index: -11.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0182
    Cell Significance Index: -10.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0203
    Cell Significance Index: -2.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0218
    Cell Significance Index: -6.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0222
    Cell Significance Index: -3.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0277
    Cell Significance Index: -0.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0386
    Cell Significance Index: -0.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0435
    Cell Significance Index: -4.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0476
    Cell Significance Index: -3.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0544
    Cell Significance Index: -6.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0573
    Cell Significance Index: -7.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0612
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0666
    Cell Significance Index: -3.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0669
    Cell Significance Index: -6.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0865
    Cell Significance Index: -2.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0871
    Cell Significance Index: -6.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0912
    Cell Significance Index: -2.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0912
    Cell Significance Index: -4.7900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0958
    Cell Significance Index: -0.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0960
    Cell Significance Index: -1.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0969
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1051
    Cell Significance Index: -3.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1222
    Cell Significance Index: -2.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1306
    Cell Significance Index: -10.3400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1469
    Cell Significance Index: -0.9800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1591
    Cell Significance Index: -2.2800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1708
    Cell Significance Index: -2.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1798
    Cell Significance Index: -2.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1879
    Cell Significance Index: -6.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1892
    Cell Significance Index: -3.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1982
    Cell Significance Index: -4.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2013
    Cell Significance Index: -12.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2024
    Cell Significance Index: -3.0500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2169
    Cell Significance Index: -3.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2329
    Cell Significance Index: -6.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2478
    Cell Significance Index: -3.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2502
    Cell Significance Index: -8.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription factor activity:** ZNF213 is a DNA-binding transcription factor that regulates gene expression by interacting with RNA polymerase II (RNAP II) and other transcriptional regulators. 2. **Tissue-specific expression:** ZNF213 is highly expressed in various cell types, including lens epithelial cells, cardiac muscle myoblasts, and lymphoid lineage-restricted progenitor cells, suggesting a role in tissue-specific gene regulation. 3. **Metal ion binding:** ZNF213 possesses a zinc finger domain, which enables it to bind metal ions, potentially influencing its interaction with DNA and other proteins. 4. **Regulatory role in transcription:** ZNF213 plays a regulatory role in transcription, particularly in the context of RNAP II-specific transcription, which is crucial for gene expression in many cellular contexts. **Pathways and Functions:** 1. **DNA-binding transcription factor activity:** ZNF213 interacts with DNA to regulate gene expression, influencing the transcription of specific genes involved in development, immune responses, and cellular differentiation. 2. **RNA polymerase II-specific transcription:** ZNF213 regulates RNAP II-specific transcription, which is essential for the transcription of many genes involved in cellular processes, including immune responses and development. 3. **Regulation of transcription by RNAP II:** ZNF213 influences the regulation of transcription by RNAP II, modulating the expression of genes involved in immune responses and cellular differentiation. 4. **Metal ion binding:** ZNF213's zinc finger domain enables it to bind metal ions, which may influence its interaction with DNA and other proteins, affecting its regulatory functions. **Clinical Significance:** 1. **Immune system disorders:** Abnormalities in ZNF213 expression have been linked to immune system disorders, such as autoimmune diseases and lymphoid malignancies. 2. **Cancer:** ZNF213's role in regulating gene expression and immune responses makes it a potential target for cancer therapy, particularly in the context of immune checkpoint inhibitors. 3. **Neurological disorders:** ZNF213's expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells suggests a potential role in neurological disorders, such as schizophrenia and autism spectrum disorder. 4. **Lens development and disease:** ZNF213's expression in lens epithelial cells and lens fiber cells highlights its importance in lens development and disease, such as cataracts and glaucoma. In conclusion, ZNF213 is a transcription factor that plays a crucial role in regulating gene expression, particularly in the context of immune responses and development. Its tissue-specific expression and regulatory functions make it an important target for understanding various cellular processes and diseases, including immune system disorders, cancer, neurological disorders, and lens development and disease. Further research is needed to fully elucidate the molecular mechanisms underlying ZNF213's functions and its potential implications in human diseases.

Genular Protein ID: 3181153438

Symbol: ZN213_HUMAN

Name: Zinc finger protein 213

UniProtKB Accession Codes:

O14771 A8K1B9 B4DMG6 Q96IS1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10023065

Title: Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3.

PubMed ID: 10023065

DOI: 10.1016/s0167-4781(98)00273-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 459
  • Mass: 51263
  • Checksum: 062F64A205533541
  • Sequence:
    • MAAPLEAQDQ APGEGEGLLI VKVEDSSWEQ ESAQHEDGRD SEACRQRFRQ FCYGDVHGPH 
EAFSQLWELC CRWLRPELRT KEQILELLVL EQFLTVLPGE IQGWVREQHP GSGEEAVALV 
EDLQKQPVKA WRQDVPSEEA EPEAAGRGSQ ATGPPPTVGA RRRPSVPQEQ HSHSAQPPAL 
LKEGRPGETT DTCFVSGVHG PVALGDIPFY FSREEWGTLD PAQRDLFWDI KRENSRNTTL 
GFGLKGQSEK SLLQEMVPVV PGQTGSDVTV SWSPEEAEAW ESENRPRAAL GPVVGARRGR 
PPTRRRQFRD LAAEKPHSCG QCGKRFRWGS DLARHQRTHT GEKPHKCPEC DKSFRSSSDL 
VRHQGVHTGE KPFSCSECGK SFSRSAYLAD HQRIHTGEKP FGCSDCGKSF SLRSYLLDHR 
RVHTGERPFG CGECDKSFKQ RAHLIAHQSL HAKMAQPVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.