Details for: ZNF214

Gene ID: 7761

Symbol: ZNF214

Ensembl ID: ENSG00000149050

Description: zinc finger protein 214

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 51.6249
    Cell Significance Index: -8.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.5403
    Cell Significance Index: -8.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.5363
    Cell Significance Index: -8.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5209
    Cell Significance Index: -8.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1054
    Cell Significance Index: 26.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6570
    Cell Significance Index: 41.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4518
    Cell Significance Index: 44.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3681
    Cell Significance Index: 332.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3385
    Cell Significance Index: 20.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3127
    Cell Significance Index: 62.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3022
    Cell Significance Index: 32.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2500
    Cell Significance Index: 40.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2306
    Cell Significance Index: 12.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2179
    Cell Significance Index: 4.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1942
    Cell Significance Index: 134.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1928
    Cell Significance Index: 8.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1494
    Cell Significance Index: 10.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1306
    Cell Significance Index: 24.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1119
    Cell Significance Index: 2.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1108
    Cell Significance Index: 39.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0925
    Cell Significance Index: 13.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0692
    Cell Significance Index: 1.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0673
    Cell Significance Index: 2.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0590
    Cell Significance Index: 1.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0578
    Cell Significance Index: 1.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0433
    Cell Significance Index: 2.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0353
    Cell Significance Index: 7.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0335
    Cell Significance Index: 1.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0320
    Cell Significance Index: 4.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0289
    Cell Significance Index: 15.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0265
    Cell Significance Index: 3.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0254
    Cell Significance Index: 4.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0236
    Cell Significance Index: 3.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0192
    Cell Significance Index: 1.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0162
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0089
    Cell Significance Index: 16.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0089
    Cell Significance Index: 3.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0076
    Cell Significance Index: 4.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0016
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0133
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0151
    Cell Significance Index: -8.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0161
    Cell Significance Index: -0.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0183
    Cell Significance Index: -5.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0188
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0247
    Cell Significance Index: -4.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0268
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0343
    Cell Significance Index: -3.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0378
    Cell Significance Index: -1.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0410
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0439
    Cell Significance Index: -9.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0506
    Cell Significance Index: -1.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0539
    Cell Significance Index: -3.8100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0556
    Cell Significance Index: -0.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0641
    Cell Significance Index: -8.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0727
    Cell Significance Index: -7.5700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0848
    Cell Significance Index: -1.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0852
    Cell Significance Index: -2.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0944
    Cell Significance Index: -5.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1010
    Cell Significance Index: -7.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1031
    Cell Significance Index: -8.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1134
    Cell Significance Index: -3.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1138
    Cell Significance Index: -1.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1150
    Cell Significance Index: -6.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1209
    Cell Significance Index: -3.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1244
    Cell Significance Index: -6.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1286
    Cell Significance Index: -2.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1323
    Cell Significance Index: -3.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1329
    Cell Significance Index: -4.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1371
    Cell Significance Index: -7.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1395
    Cell Significance Index: -3.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1395
    Cell Significance Index: -2.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1453
    Cell Significance Index: -5.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1473
    Cell Significance Index: -6.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1495
    Cell Significance Index: -2.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1559
    Cell Significance Index: -2.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1579
    Cell Significance Index: -5.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1641
    Cell Significance Index: -2.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1751
    Cell Significance Index: -4.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1860
    Cell Significance Index: -4.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1879
    Cell Significance Index: -3.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1965
    Cell Significance Index: -3.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1966
    Cell Significance Index: -3.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2078
    Cell Significance Index: -4.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2110
    Cell Significance Index: -3.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2120
    Cell Significance Index: -5.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2163
    Cell Significance Index: -7.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2167
    Cell Significance Index: -4.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2209
    Cell Significance Index: -5.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2343
    Cell Significance Index: -2.4300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2364
    Cell Significance Index: -3.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2366
    Cell Significance Index: -5.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger DNA binding domain:** ZNF214 possesses a zinc finger DNA binding domain, which enables it to interact with specific DNA sequences and regulate transcriptional activity. 2. **Transcriptional regulation:** ZNF214 is involved in regulating gene expression through its interaction with RNA polymerase II and other transcriptional regulators. 3. **Widespread expression:** ZNF214 is expressed in various human tissues, including immune cells, epithelial tissues, and neural cells. 4. **Cell type specificity:** ZNF214 exhibits cell type-specific expression patterns, suggesting its involvement in tissue-specific functions. **Pathways and Functions:** 1. **DNA binding and transcriptional regulation:** ZNF214 interacts with specific DNA sequences to regulate transcriptional activity, influencing the expression of target genes. 2. **Cell proliferation and differentiation:** ZNF214 plays a role in regulating cell proliferation and differentiation in various tissues, including the immune system and epithelial tissues. 3. **Apoptosis and survival:** ZNF214 may influence apoptosis and survival pathways, contributing to the maintenance of cellular homeostasis. 4. **Immune system development and function:** ZNF214 is expressed in immune cells and may play a role in the development and function of the immune system. **Clinical Significance:** 1. **Cancer research:** ZNF214 has been implicated in cancer development and progression, particularly in hematological malignancies and solid tumors. 2. **Neurological disorders:** ZNF214 expression has been linked to neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Immune system disorders:** ZNF214 may be involved in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Targeted therapies:** ZNF214 may serve as a target for therapeutic interventions in various diseases, including cancer and neurological disorders. In conclusion, ZNF214 is a transcriptional regulator with widespread expression in human tissues, influencing cell proliferation, differentiation, and survival. Further research is needed to fully elucidate the functional significance of ZNF214 and its potential role in various diseases. As a potential therapeutic target, ZNF214 holds promise for the development of novel treatments for cancer, neurological disorders, and immune system disorders.

Genular Protein ID: 2167626383

Symbol: ZN214_HUMAN

Name: Zinc finger protein 214

UniProtKB Accession Codes:

Q9UL59 B2R8Q1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10762538

Title: Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.

PubMed ID: 10762538

DOI: 10.1086/302892

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 606
  • Mass: 70992
  • Checksum: D0CBA2E0F9E3EAB2
  • Sequence:
    • MAVTFEDVTI IFTWEEWKFL DSSQKRLYRE VMWENYTNVM SVENWNESYK SQEEKFRYLE 
YENFSYWQGW WNAGAQMYEN QNYGETVQGT DSKDLTQQDR SQCQEWLILS TQVPGYGNYE 
LTFESKSLRN LKYKNFMPWQ SLETKTTQDY GREIYMSGSH GFQGGRYRLG ISRKNLSMEK 
EQKLIVQHSY IPVEEALPQY VGVICQEDLL RDSMEEKYCG CNKCKGIYYW NSRCVFHKRN 
QPGENLCQCS ICKACFSQRS DLYRHPRNHI GKKLYGCDEV DGNFHQSSGV HFHQRVHIGE 
VPYSCNACGK SFSQISSLHN HQRVHTEEKF YKIECDKDLS RNSLLHIHQR LHIGEKPFKC 
NQCGKSFNRS SVLHVHQRVH TGEKPYKCDE CGKGFSQSSN LRIHQLVHTG EKSYKCEDCG 
KGFTQRSNLQ IHQRVHTGEK PYKCDDCGKD FSHSSDLRIH QRVHTGEKPY TCPECGKGFS 
KSSKLHTHQR VHTGEKPYKC EECGKGFSQR SHLLIHQRVH TGEKPYKCHD CGKGFSHSSN 
LHIHQRVHTG EKPYQCAKCG KGFSHSSALR IHQRVHAGEK PYKCREYYKG FDHNSHLHNN 
HRRGNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.