Details for: ZNF232

Gene ID: 7775

Symbol: ZNF232

Ensembl ID: ENSG00000167840

Description: zinc finger protein 232

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.1187
    Cell Significance Index: -10.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.9273
    Cell Significance Index: -9.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.4306
    Cell Significance Index: -10.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.5648
    Cell Significance Index: -10.5600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.1248
    Cell Significance Index: 84.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6284
    Cell Significance Index: -9.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3040
    Cell Significance Index: 248.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9277
    Cell Significance Index: 91.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6285
    Cell Significance Index: 567.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5843
    Cell Significance Index: 35.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5718
    Cell Significance Index: 62.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4971
    Cell Significance Index: 80.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2794
    Cell Significance Index: 19.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2478
    Cell Significance Index: 8.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1783
    Cell Significance Index: 123.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1449
    Cell Significance Index: 29.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1371
    Cell Significance Index: 1.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1328
    Cell Significance Index: 8.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1275
    Cell Significance Index: 5.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1255
    Cell Significance Index: 24.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1251
    Cell Significance Index: 7.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1172
    Cell Significance Index: 16.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1027
    Cell Significance Index: 2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1001
    Cell Significance Index: 28.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0923
    Cell Significance Index: 2.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0912
    Cell Significance Index: 2.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0848
    Cell Significance Index: 30.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0600
    Cell Significance Index: 26.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0597
    Cell Significance Index: 1.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0560
    Cell Significance Index: 2.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0526
    Cell Significance Index: 1.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0460
    Cell Significance Index: 25.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0334
    Cell Significance Index: 0.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0323
    Cell Significance Index: 0.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0294
    Cell Significance Index: 0.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0267
    Cell Significance Index: 3.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0136
    Cell Significance Index: 0.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0125
    Cell Significance Index: 1.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0115
    Cell Significance Index: 0.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0114
    Cell Significance Index: 2.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0108
    Cell Significance Index: 1.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0096
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0090
    Cell Significance Index: -12.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0188
    Cell Significance Index: -10.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0200
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0203
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0220
    Cell Significance Index: -1.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0234
    Cell Significance Index: -2.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0282
    Cell Significance Index: -4.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0306
    Cell Significance Index: -0.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0342
    Cell Significance Index: -3.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0353
    Cell Significance Index: -4.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0495
    Cell Significance Index: -3.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0565
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0615
    Cell Significance Index: -12.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0619
    Cell Significance Index: -7.1000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0695
    Cell Significance Index: -0.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0718
    Cell Significance Index: -2.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0780
    Cell Significance Index: -4.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0865
    Cell Significance Index: -0.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0902
    Cell Significance Index: -5.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0955
    Cell Significance Index: -2.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0968
    Cell Significance Index: -10.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0989
    Cell Significance Index: -2.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0992
    Cell Significance Index: -5.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1073
    Cell Significance Index: -8.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1194
    Cell Significance Index: -3.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1253
    Cell Significance Index: -3.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1257
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1284
    Cell Significance Index: -1.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1328
    Cell Significance Index: -8.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1393
    Cell Significance Index: -2.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1496
    Cell Significance Index: -1.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1502
    Cell Significance Index: -1.5600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1513
    Cell Significance Index: -2.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1527
    Cell Significance Index: -2.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1830
    Cell Significance Index: -8.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1884
    Cell Significance Index: -5.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1905
    Cell Significance Index: -2.8700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1912
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1958
    Cell Significance Index: -1.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1966
    Cell Significance Index: -5.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2157
    Cell Significance Index: -2.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2188
    Cell Significance Index: -3.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2229
    Cell Significance Index: -8.4400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2258
    Cell Significance Index: -1.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2298
    Cell Significance Index: -8.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2309
    Cell Significance Index: -6.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2431
    Cell Significance Index: -7.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF232 acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. Its ability to interact with RNA polymerase II and other transcriptional machinery suggests its role in coordinating gene expression programs. 2. **Metal Ion Binding:** The presence of a metal ion binding motif in ZNF232 implies its potential involvement in redox reactions, DNA repair, or other metal-dependent processes. 3. **Cell Type-Specific Expression:** ZNF232 is significantly expressed in specific cell types, such as GABAergic interneurons and intestinal epithelial cells, indicating its role in these tissues. 4. **Intracellular Localization:** The localization of ZNF232 within the cell nucleus and cytosol suggests its involvement in both transcriptional regulation and other cellular processes. **Pathways and Functions:** 1. **Transcriptional Regulation by RNA Polymerase II:** ZNF232 interacts with RNA polymerase II, a key enzyme in the transcriptional machinery, to regulate the expression of target genes. 2. **DNA-Binding Transcription Factor Activity:** ZNF232's ability to bind to specific DNA sequences enables it to modulate gene expression by recruiting or repelling transcriptional machinery. 3. **Metal Ion Binding and Redox Reactions:** The metal ion binding motif in ZNF232 may be involved in redox reactions, DNA repair, or other metal-dependent processes. 4. **Regulation of Transcription by RNA Polymerase II Cis-Regulatory Region Sequence-Specific DNA Binding:** ZNF232's ability to bind to specific DNA sequences within the RNA polymerase II cis-regulatory region enables it to regulate the expression of target genes. **Clinical Significance:** 1. **Neurological Disorders:** Abnormal expression of ZNF232 in GABAergic interneurons may contribute to neurological disorders, such as epilepsy or schizophrenia. 2. **Intestinal Dysregulation:** Altered expression of ZNF232 in intestinal epithelial cells may contribute to gastrointestinal disorders, such as inflammatory bowel disease or cancer. 3. **Cancer Development:** Dysregulation of ZNF232's transcriptional regulatory functions may contribute to cancer development and progression. 4. **Gene Therapy and Targeted Therapies:** Understanding the complex functions of ZNF232 may provide insights into the development of targeted therapies for diseases associated with its dysregulation. In conclusion, ZNF232 is a multifaceted gene with significant implications in various cellular processes. Further research into its functions and clinical significance is necessary to fully appreciate its role in maintaining tissue homeostasis and overall organismal health.

Genular Protein ID: 2504912249

Symbol: ZN232_HUMAN

Name: Zinc finger protein 232

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11311944

Title: ZNF232: structure and expression analysis of a novel human C(2)H(2) zinc finger gene, member of the SCAN/LeR domain subfamily.

PubMed ID: 11311944

DOI: 10.1016/s0167-4781(01)00177-4

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 444
  • Mass: 50697
  • Checksum: A475F9713A5EE642
  • Sequence:
  • MEPPGPVRGP LQDSSWYEPS AELVQTRMAV SLTAAETLAL QGTQGQEKMM MMGPKEEEQS 
    CEYETRLPGN HSTSQEIFRQ RFRHLRYQET PGPREALSQL RVLCCEWLRP EKHTKEQILE 
    FLVLEQFLTI LPEELQSWVR GHHPKSGEEA VTVLEDLEKG LEPEPQVPGP AHGPAQEEPW 
    EKKESLGAAQ EALSIQLQPK ETQPFPKSEQ VYLHFLSVVT EDGPEPKDKG SLPQPPITEV 
    ESQVFSEKLA TDTSTFEATS EGTLELQQRN PKAERLRWSP AQEESFRQMV VIHKEIPTGK 
    KDHECSECGK TFIYNSHLVV HQRVHSGEKP YKCSDCGKTF KQSSNLGQHQ RIHTGEKPFE 
    CNECGKAFRW GAHLVQHQRI HSGEKPYECN ECGKAFSQSS YLSQHRRIHS GEKPFICKEC 
    GKAYGWCSEL IRHRRVHARK EPSH

Genular Protein ID: 693447707

Symbol: A0A8Q3SIT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 396
  • Mass: 45558
  • Checksum: C9E02253126C4FF8
  • Sequence:
  • MMMMGPKEEE QSCEYETRLP GNHSTSQEIF RQRFRHLRYQ ETPGPREALS QLRVLCCEWL 
    RPEKHTKEQI LEFLVLEQFL TILPEELQSW VRGHHPKSGE EAVTVLEDLE KGLEPEPQVP 
    GPAHGPAQEE PWEKKESLGA AQEALSIQLQ PKETQPFPKS EQVYLHFLSV VTEDGPEPKD 
    KGSLPQPPIT EVESQVFSEK LATDTSTFEA TSEGTLELQQ RNPKAERLRW SPAQEESFRQ 
    MVVIHKEIPT GKKDHECSEC GKTFIYNSHL VVHQRVHSGE KPYKCSDCGK TFKQSSNLGQ 
    HQRIHTGEKP FECNECGKAF RWGAHLVQHQ RIHSGEKPYE CNECGKAFSQ SSYLSQHRRI 
    HSGEKPFICK ECGKAYGWCS ELIRHRRVHA RKEPSH

Genular Protein ID: 936193252

Symbol: A0A8Q3SIR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 416
  • Mass: 47634
  • Checksum: 1A349CF8F162E1FB
  • Sequence:
  • MEPPGPVRGP LQDSSWYEPS AELVQTRMAV SLTAAETLAL QGTQGQEKMM MMGPKEEEQS 
    CEYETRLPGN HSTSQEIFRQ RFRHLRYQET PGPREALSQL RVLCCEWLRP EKHTKEQILE 
    FLVLEQFLTI LPEELQSWVP GPAHGPAQEE PWEKKESLGA AQEALSIQLQ PKETQPFPKS 
    EQVYLHFLSV VTEDGPEPKD KGSLPQPPIT EVESQVFSEK LATDTSTFEA TSEGTLELQQ 
    RNPKAERLRW SPAQEESFRQ MVVIHKEIPT GKKDHECSEC GKTFIYNSHL VVHQRVHSGE 
    KPYKCSDCGK TFKQSSNLGQ HQRIHTGEKP FECNECGKAF RWGAHLVQHQ RIHSGEKPYE 
    CNECGKAFSQ SSYLSQHRRI HSGEKPFICK ECGKAYGWCS ELIRHRRVHA RKEPSH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.