Details for: LUZP1

Gene ID: 7798

Symbol: LUZP1

Ensembl ID: ENSG00000169641

Description: leucine zipper protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 354.6878
    Cell Significance Index: -55.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 198.9407
    Cell Significance Index: -50.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.2185
    Cell Significance Index: -57.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.8811
    Cell Significance Index: -46.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.5800
    Cell Significance Index: -53.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.5157
    Cell Significance Index: -46.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.2247
    Cell Significance Index: -55.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9040
    Cell Significance Index: -53.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1661
    Cell Significance Index: -55.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9548
    Cell Significance Index: -39.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5371
    Cell Significance Index: -25.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.2272
    Cell Significance Index: 168.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.0630
    Cell Significance Index: 41.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8913
    Cell Significance Index: 78.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0226
    Cell Significance Index: 405.7400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.5595
    Cell Significance Index: 11.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3991
    Cell Significance Index: 172.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3885
    Cell Significance Index: 106.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3597
    Cell Significance Index: 61.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2525
    Cell Significance Index: 31.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2268
    Cell Significance Index: 848.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2135
    Cell Significance Index: 72.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2045
    Cell Significance Index: 21.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0232
    Cell Significance Index: 184.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0052
    Cell Significance Index: 52.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9850
    Cell Significance Index: 107.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9757
    Cell Significance Index: 349.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9522
    Cell Significance Index: 53.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9113
    Cell Significance Index: 180.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8427
    Cell Significance Index: 137.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7858
    Cell Significance Index: 34.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7811
    Cell Significance Index: 55.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7613
    Cell Significance Index: 336.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7139
    Cell Significance Index: 8.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6800
    Cell Significance Index: 25.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6058
    Cell Significance Index: 39.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5282
    Cell Significance Index: 72.5300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4881
    Cell Significance Index: 7.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4808
    Cell Significance Index: 434.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4756
    Cell Significance Index: 12.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4139
    Cell Significance Index: 226.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3754
    Cell Significance Index: 10.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3493
    Cell Significance Index: 12.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2732
    Cell Significance Index: 7.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2658
    Cell Significance Index: 34.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1772
    Cell Significance Index: 17.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1622
    Cell Significance Index: 0.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1436
    Cell Significance Index: 27.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1390
    Cell Significance Index: 261.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0941
    Cell Significance Index: 4.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0836
    Cell Significance Index: 37.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0760
    Cell Significance Index: 116.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0454
    Cell Significance Index: 61.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0378
    Cell Significance Index: 2.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0339
    Cell Significance Index: 62.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0194
    Cell Significance Index: 1.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0119
    Cell Significance Index: 0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0079
    Cell Significance Index: -5.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0145
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0169
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0307
    Cell Significance Index: -22.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0353
    Cell Significance Index: -22.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0452
    Cell Significance Index: -6.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0494
    Cell Significance Index: -6.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0542
    Cell Significance Index: -3.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0681
    Cell Significance Index: -38.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0685
    Cell Significance Index: -51.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0783
    Cell Significance Index: -13.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1596
    Cell Significance Index: -7.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1611
    Cell Significance Index: -46.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1827
    Cell Significance Index: -18.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1889
    Cell Significance Index: -22.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1957
    Cell Significance Index: -9.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2173
    Cell Significance Index: -45.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2285
    Cell Significance Index: -7.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2893
    Cell Significance Index: -21.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3113
    Cell Significance Index: -6.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3153
    Cell Significance Index: -36.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3269
    Cell Significance Index: -9.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3434
    Cell Significance Index: -5.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3537
    Cell Significance Index: -5.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4032
    Cell Significance Index: -47.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4177
    Cell Significance Index: -43.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4188
    Cell Significance Index: -47.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4191
    Cell Significance Index: -8.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5760
    Cell Significance Index: -45.6200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5782
    Cell Significance Index: -7.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5848
    Cell Significance Index: -5.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5892
    Cell Significance Index: -12.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5987
    Cell Significance Index: -12.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6522
    Cell Significance Index: -9.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6714
    Cell Significance Index: -14.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7294
    Cell Significance Index: -19.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8257
    Cell Significance Index: -52.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8318
    Cell Significance Index: -26.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8400
    Cell Significance Index: -6.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8543
    Cell Significance Index: -14.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8602
    Cell Significance Index: -20.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8684
    Cell Significance Index: -10.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LUZP1 is a member of the leucine zipper protein family, characterized by its ability to form homodimeric or heterodimeric complexes through leucine zipper motifs. This protein exhibits a high degree of tissue specificity, with significant expression in endothelial cells of the vascular tree, lung endothelial cells, basal cells of prostate epithelium, and other cell types. LUZP1's expression pattern suggests a role in maintaining cellular homeostasis and regulating cellular behavior. **Pathways and Functions:** LUZP1 is involved in multiple cellular pathways, including: 1. **Artery Development**: LUZP1 is essential for the proper development of the vascular tree, suggesting a role in angiogenesis and vascular remodeling. 2. **Nucleus and Protein Binding**: LUZP1 interacts with other proteins, influencing nuclear function, transcriptional regulation, and protein-protein interactions. 3. **Extracellular Exosome and Membrane**: LUZP1 is secreted by cells and interacts with the extracellular exosome, influencing cell-cell communication and membrane dynamics. 4. **Centrosome and Cytoplasm**: LUZP1 is involved in the regulation of centrosome function, microtubule organization, and cytoplasmic dynamics. LUZP1's functions can be broadly categorized into: 1. **Cellular Differentiation**: LUZP1 regulates the differentiation of various cell types, including endothelial cells, neural cells, and epithelial cells. 2. **Cellular Adhesion**: LUZP1 interacts with other proteins, influencing cellular adhesion and migration. 3. **Transcriptional Regulation**: LUZP1 modulates gene expression by interacting with transcription factors and co-regulators. **Clinical Significance:** Dysregulation of LUZP1 has been implicated in various diseases, including: 1. **Cardiovascular Diseases**: LUZP1 mutations have been associated with cardiovascular diseases, such as atherosclerosis and cardiac arrhythmias. 2. **Neurological Disorders**: LUZP1 has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. 3. **Cancer**: LUZP1 is involved in cancer progression, with altered expression levels observed in various types of cancer. In conclusion, LUZP1 is a multifunctional protein that plays a crucial role in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying LUZP1's functions and its role in human health and disease.

Genular Protein ID: 726754361

Symbol: LUZP1_HUMAN

Name: Leucine zipper protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12693554

Title: Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.

PubMed ID: 12693554

DOI: 10.1093/dnares/10.1.49

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26638075

Title: A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

PubMed ID: 26638075

DOI: 10.1016/j.cell.2015.10.065

Sequence Information:

  • Length: 1076
  • Mass: 120275
  • Checksum: 682D8C008BE77F1A
  • Sequence:
  • MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS 
    MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL 
    EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA 
    SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL 
    RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT 
    QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG 
    EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ 
    VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA 
    AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG 
    KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP 
    VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD 
    DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS 
    VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK 
    QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS 
    PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR 
    WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF 
    SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH 
    SASMEEEGED CTLSVYRQLH NSLDPSELPG KQGLPESGRV RAEERLRPTR PCAEEN

Genular Protein ID: 1855968882

Symbol: Q05DE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 279
  • Mass: 32864
  • Checksum: 3470FC8A5E9F40C9
  • Sequence:
  • MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS 
    MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL 
    EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA 
    SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL 
    RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.