Details for: LRP8

Gene ID: 7804

Symbol: LRP8

Ensembl ID: ENSG00000157193

Description: LDL receptor related protein 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 126.2012
    Cell Significance Index: -19.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.6180
    Cell Significance Index: -19.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.0022
    Cell Significance Index: -19.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0151
    Cell Significance Index: -19.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6037
    Cell Significance Index: -14.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.3537
    Cell Significance Index: 196.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0171
    Cell Significance Index: 12.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9532
    Cell Significance Index: 26.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8944
    Cell Significance Index: 179.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8740
    Cell Significance Index: 53.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8653
    Cell Significance Index: 6.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8531
    Cell Significance Index: 18.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7651
    Cell Significance Index: 18.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7584
    Cell Significance Index: 272.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7559
    Cell Significance Index: 522.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.6778
    Cell Significance Index: 8.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6025
    Cell Significance Index: 33.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4762
    Cell Significance Index: 6.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4759
    Cell Significance Index: 47.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3821
    Cell Significance Index: 345.0300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3446
    Cell Significance Index: 3.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3124
    Cell Significance Index: 9.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2706
    Cell Significance Index: 44.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2551
    Cell Significance Index: 162.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2485
    Cell Significance Index: 27.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2284
    Cell Significance Index: 13.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1615
    Cell Significance Index: 8.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1468
    Cell Significance Index: 5.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1440
    Cell Significance Index: 9.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1152
    Cell Significance Index: 50.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1004
    Cell Significance Index: 2.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0868
    Cell Significance Index: 47.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0818
    Cell Significance Index: 5.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0745
    Cell Significance Index: 14.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0630
    Cell Significance Index: 1.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0584
    Cell Significance Index: 1.2400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0582
    Cell Significance Index: 0.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0472
    Cell Significance Index: 29.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0238
    Cell Significance Index: 1.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0231
    Cell Significance Index: 35.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0212
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0181
    Cell Significance Index: 33.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0033
    Cell Significance Index: 0.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0025
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0130
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0169
    Cell Significance Index: -12.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0180
    Cell Significance Index: -0.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0205
    Cell Significance Index: -3.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0223
    Cell Significance Index: -16.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0228
    Cell Significance Index: -3.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0234
    Cell Significance Index: -0.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0342
    Cell Significance Index: -15.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0511
    Cell Significance Index: -10.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0540
    Cell Significance Index: -1.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0561
    Cell Significance Index: -16.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0579
    Cell Significance Index: -7.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0611
    Cell Significance Index: -2.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0698
    Cell Significance Index: -0.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0701
    Cell Significance Index: -4.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0827
    Cell Significance Index: -6.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0906
    Cell Significance Index: -10.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0920
    Cell Significance Index: -10.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0977
    Cell Significance Index: -12.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1012
    Cell Significance Index: -2.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1058
    Cell Significance Index: -14.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1291
    Cell Significance Index: -2.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1301
    Cell Significance Index: -16.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1347
    Cell Significance Index: -2.0300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1390
    Cell Significance Index: -1.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1533
    Cell Significance Index: -4.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1542
    Cell Significance Index: -17.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1543
    Cell Significance Index: -15.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1546
    Cell Significance Index: -17.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1580
    Cell Significance Index: -5.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1639
    Cell Significance Index: -3.2900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1862
    Cell Significance Index: -2.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1905
    Cell Significance Index: -19.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1928
    Cell Significance Index: -11.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2285
    Cell Significance Index: -10.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2329
    Cell Significance Index: -3.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2372
    Cell Significance Index: -17.6800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2384
    Cell Significance Index: -2.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2525
    Cell Significance Index: -11.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2611
    Cell Significance Index: -6.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2705
    Cell Significance Index: -17.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2957
    Cell Significance Index: -15.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3050
    Cell Significance Index: -11.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3402
    Cell Significance Index: -7.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3491
    Cell Significance Index: -12.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3498
    Cell Significance Index: -7.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3543
    Cell Significance Index: -16.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3837
    Cell Significance Index: -9.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3841
    Cell Significance Index: -10.1000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3861
    Cell Significance Index: -5.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3871
    Cell Significance Index: -4.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ligand Binding**: LRP8 has a high affinity for multiple ligands, including apolipoproteins, amyloid-beta, and retinoids, allowing it to interact with various signaling pathways. 2. **Cellular Localization**: LRP8 is primarily expressed in the nervous system, where it is involved in axon guidance, dendritic development, and synaptic transmission. 3. **Signaling Pathways**: LRP8 is involved in multiple signaling pathways, including the Wnt/β-catenin pathway, the PI3K/AKT pathway, and the MAPK/ERK pathway. 4. **Cellular Functions**: LRP8 regulates various cellular processes, including lipid metabolism, apoptosis, and immune responses. **Pathways and Functions** 1. **Wnt/β-catenin Pathway**: LRP8 is involved in the Wnt/β-catenin pathway, which regulates cell proliferation, differentiation, and survival. 2. **PI3K/AKT Pathway**: LRP8 is also involved in the PI3K/AKT pathway, which regulates cell survival, proliferation, and metabolism. 3. **MAPK/ERK Pathway**: LRP8 regulates the MAPK/ERK pathway, which is involved in cellular responses to growth factors and stress. 4. **Lipid Metabolism**: LRP8 is involved in lipid metabolism, regulating the uptake and clearance of lipids in the brain. 5. **Apoptosis**: LRP8 regulates apoptosis, preventing excessive cell death in the nervous system. 6. **Immune Responses**: LRP8 is involved in immune responses, regulating the activation and function of immune cells. **Clinical Significance** 1. **Neurodegenerative Diseases**: LRP8 is implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's and multiple sclerosis. 2. **Cancer**: LRP8 is overexpressed in certain types of cancer, including breast and lung cancer. 3. **Metabolic Disorders**: LRP8 is involved in lipid metabolism, making it a potential target for therapeutic interventions in metabolic disorders. 4. **Neurodevelopmental Disorders**: LRP8 is expressed in the developing brain, making it a potential target for therapeutic interventions in neurodevelopmental disorders, such as autism and schizophrenia. In conclusion, LRP8 is a multifunctional receptor that plays a critical role in various cellular processes, including lipid metabolism, synaptic plasticity, and immune responses. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of LRP8 and its role in human diseases.

Genular Protein ID: 3431568447

Symbol: LRP8_HUMAN

Name: Low-density lipoprotein receptor-related protein 8

UniProtKB Accession Codes:

Q14114 B1AMT6 B1AMT7 B1AMT8 O14968 Q86V27 Q99876 Q9BR78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChEBI 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626535

Title: Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.

PubMed ID: 8626535

DOI: 10.1074/jbc.271.14.8373

PubMed ID: 9079678

Title: Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene.

PubMed ID: 9079678

DOI: 10.1074/jbc.272.13.8498

PubMed ID: 11152697

Title: Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue.

PubMed ID: 11152697

DOI: 10.1074/jbc.m011795200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10218790

Title: Expression and alternate splicing of apolipoprotein E receptor 2 in brain.

PubMed ID: 10218790

DOI: 10.1016/s0306-4522(98)00489-8

PubMed ID: 12681505

Title: Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells.

PubMed ID: 12681505

DOI: 10.1016/s0014-5793(03)00261-8

PubMed ID: 10508213

Title: Identification and characterization of LRP8 (apoER2) in human blood platelets.

PubMed ID: 10508213

PubMed ID: 12899622

Title: Differential binding of ligands to the apolipoprotein E receptor 2.

PubMed ID: 12899622

DOI: 10.1021/bi034475p

PubMed ID: 12950167

Title: Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.

PubMed ID: 12950167

DOI: 10.1021/bi027093c

PubMed ID: 12807892

Title: Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.

PubMed ID: 12807892

DOI: 10.1074/jbc.m212655200

PubMed ID: 18039658

Title: The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.

PubMed ID: 18039658

DOI: 10.1074/jbc.m708098200

PubMed ID: 20427281

Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

PubMed ID: 20427281

DOI: 10.1074/jbc.m110.123729

PubMed ID: 24381170

Title: Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.

PubMed ID: 24381170

DOI: 10.1074/jbc.m113.529271

PubMed ID: 30873003

Title: Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microscopy.

PubMed ID: 30873003

DOI: 10.3389/fnmol.2019.00053

PubMed ID: 34929721

Title: VLDLR and ApoER2 are receptors for multiple alphaviruses.

PubMed ID: 34929721

DOI: 10.1038/s41586-021-04326-0

PubMed ID: 20223215

Title: Structural basis for specific recognition of reelin by its receptors.

PubMed ID: 20223215

DOI: 10.1016/j.str.2010.01.010

PubMed ID: 12399018

Title: Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease.

PubMed ID: 12399018

DOI: 10.1016/s0304-3940(02)00942-4

PubMed ID: 17847002

Title: An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction.

PubMed ID: 17847002

DOI: 10.1086/521581

Sequence Information:

  • Length: 963
  • Mass: 105634
  • Checksum: B10DCF72F62DE71C
  • Sequence:
    • MGLPEPGPLR LLALLLLLLL LLLLQLQHLA AAAADPLLGG QGPAKDCEKD QFQCRNERCI 
PSVWRCDEDD DCLDHSDEDD CPKKTCADSD FTCDNGHCIH ERWKCDGEEE CPDGSDESEA 
TCTKQVCPAE KLSCGPTSHK CVPASWRCDG EKDCEGGADE AGCATLCAPH EFQCGNRSCL 
AAVFVCDGDD DCGDGSDERG CADPACGPRE FRCGGDGGGA CIPERWVCDR QFDCEDRSDE 
AAELCGRPGP GATSAPAACA TASQFACRSG ECVHLGWRCD GDRDCKDKSD EADCPLGTCR 
GDEFQCGDGT CVLAIKHCNQ EQDCPDGSDE AGCLQGLNEC LHNNGGCSHI CTDLKIGFEC 
TCPAGFQLLD QKTCGDIDEC KDPDACSQIC VNYKGYFKCE CYPGYEMDLL TKNCKAAAGK 
SPSLIFTNRH EVRRIDLVKR NYSRLIPMLK NVVALDVEVA TNRIYWCDLS YRKIYSAYMD 
KASDPKEQEV LIDEQLHSPE GLAVDWVHKH IYWTDSGNKT ISVATVDGGR RRTLFSRNLS 
EPRAIAVDPL RGFMYWSDWG DQAKIEKSGL NGVDRQTLVS DNIEWPNGIT LDLLSQRLYW 
VDSKLHQLSS IDFSGGNRKT LISSTDFLSH PFGIAVFEDK VFWTDLENEA IFSANRLNGL 
EISILAENLN NPHDIVIFHE LKQPRAPDAC ELSVQPNGGC EYLCLPAPQI SSHSPKYTCA 
CPDTMWLGPD MKRCYRAPQS TSTTTLASTM TRTVPATTRA PGTTVHRSTY QNHSTETPSL 
TAAVPSSVSV PRAPSISPST LSPATSNHSQ HYANEDSKMG STVTAAVIGI IVPIVVIALL 
CMSGYLIWRN WKRKNTKSMN FDNPVYRKTT EEEDEDELHI GRTAQIGHVY PAAISSFDRP 
LWAEPCLGET REPEDPAPAL KELFVLPGEP RSQLHQLPKN PLSELPVVKS KRVALSLEDD 
GLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.