Details for: USP7

Gene ID: 7874

Symbol: USP7

Ensembl ID: ENSG00000187555

Description: ubiquitin specific peptidase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.7894
    Cell Significance Index: -42.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.9594
    Cell Significance Index: -43.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 105.6688
    Cell Significance Index: -43.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 100.5459
    Cell Significance Index: -47.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 88.5037
    Cell Significance Index: -45.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.4328
    Cell Significance Index: -44.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.9102
    Cell Significance Index: -45.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.8245
    Cell Significance Index: -46.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.9134
    Cell Significance Index: -33.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2343
    Cell Significance Index: -20.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.8111
    Cell Significance Index: 263.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1666
    Cell Significance Index: 29.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7905
    Cell Significance Index: 291.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3268
    Cell Significance Index: 266.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2646
    Cell Significance Index: 250.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0543
    Cell Significance Index: 190.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9063
    Cell Significance Index: 41.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8732
    Cell Significance Index: 107.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8724
    Cell Significance Index: 24.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7841
    Cell Significance Index: 40.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7746
    Cell Significance Index: 91.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7540
    Cell Significance Index: 21.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7356
    Cell Significance Index: 263.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6231
    Cell Significance Index: 275.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6119
    Cell Significance Index: 84.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5784
    Cell Significance Index: 12.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5422
    Cell Significance Index: 58.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5298
    Cell Significance Index: 29.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5298
    Cell Significance Index: 366.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4929
    Cell Significance Index: 22.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4830
    Cell Significance Index: 263.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4604
    Cell Significance Index: 4.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4170
    Cell Significance Index: 26.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3884
    Cell Significance Index: 27.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3286
    Cell Significance Index: 20.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3108
    Cell Significance Index: 8.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2758
    Cell Significance Index: 7.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2748
    Cell Significance Index: 12.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2712
    Cell Significance Index: 17.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2600
    Cell Significance Index: 19.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2533
    Cell Significance Index: 17.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1932
    Cell Significance Index: 5.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1746
    Cell Significance Index: 33.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1357
    Cell Significance Index: 3.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0549
    Cell Significance Index: 103.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0409
    Cell Significance Index: 36.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0340
    Cell Significance Index: 0.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0283
    Cell Significance Index: 18.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0181
    Cell Significance Index: 27.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0090
    Cell Significance Index: 0.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0076
    Cell Significance Index: 3.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0052
    Cell Significance Index: 0.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0417
    Cell Significance Index: -31.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0426
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0474
    Cell Significance Index: -35.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0753
    Cell Significance Index: -42.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0763
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0859
    Cell Significance Index: -53.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0859
    Cell Significance Index: -3.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1144
    Cell Significance Index: -4.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1169
    Cell Significance Index: -11.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1265
    Cell Significance Index: -36.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1383
    Cell Significance Index: -16.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1532
    Cell Significance Index: -22.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1973
    Cell Significance Index: -5.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2086
    Cell Significance Index: -15.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2100
    Cell Significance Index: -5.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2316
    Cell Significance Index: -8.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2383
    Cell Significance Index: -50.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2398
    Cell Significance Index: -27.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2987
    Cell Significance Index: -5.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3415
    Cell Significance Index: -8.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3870
    Cell Significance Index: -40.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4405
    Cell Significance Index: -14.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4515
    Cell Significance Index: -35.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4671
    Cell Significance Index: -12.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5124
    Cell Significance Index: -26.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5659
    Cell Significance Index: -10.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5793
    Cell Significance Index: -3.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6480
    Cell Significance Index: -13.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6695
    Cell Significance Index: -17.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6930
    Cell Significance Index: -16.0100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7081
    Cell Significance Index: -15.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7717
    Cell Significance Index: -47.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7801
    Cell Significance Index: -11.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8282
    Cell Significance Index: -28.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8592
    Cell Significance Index: -14.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8651
    Cell Significance Index: -43.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8796
    Cell Significance Index: -19.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8968
    Cell Significance Index: -29.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9187
    Cell Significance Index: -29.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.9206
    Cell Significance Index: -14.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9240
    Cell Significance Index: -11.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9513
    Cell Significance Index: -11.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9573
    Cell Significance Index: -28.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9855
    Cell Significance Index: -16.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** USP7 is a cysteine-type deubiquitinase enzyme, which means it specifically removes ubiquitin from lysine residues on target proteins. It is highly specific and has been shown to regulate the activity of numerous proteins, including those involved in DNA repair, protein degradation, and signaling pathways. USP7 is also known to interact with various proteins, including p53, PML, and TP53, which are involved in cell cycle regulation, apoptosis, and DNA repair. **Pathways and Functions** USP7 is involved in various cellular pathways, including: 1. **DNA Repair**: USP7 plays a crucial role in maintaining genome stability by regulating the activity of proteins involved in DNA repair, such as BRCA1 and BRCA2. 2. **Protein Degradation**: USP7 regulates the stability and localization of proteins by removing ubiquitin from lysine residues on target proteins. 3. **Signaling Pathways**: USP7 interacts with various signaling proteins, including p53, PML, and TP53, to regulate cell cycle progression, apoptosis, and DNA repair. 4. **Transcriptional Regulation**: USP7 regulates the activity of transcription factors, including p53, to control gene expression. 5. **Telomere Capping**: USP7 is involved in the regulation of telomere capping, which is essential for maintaining genome stability. **Clinical Significance** Dysregulation of USP7 has been implicated in various diseases, including: 1. **Cancer**: USP7 is often overexpressed in cancer cells, where it promotes cell survival and resistance to apoptosis. 2. **Neurodegenerative Diseases**: USP7 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Autoimmune Diseases**: USP7 has been shown to play a role in regulating immune responses and has been implicated in autoimmune diseases, such as multiple sclerosis. 4. **Infectious Diseases**: USP7 has been implicated in the regulation of immune responses to infections and has been shown to interact with bacterial and viral proteins. In conclusion, USP7 is a critical enzyme that plays a central role in regulating various cellular processes, including DNA repair, protein degradation, and signaling pathways. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 952233295

Symbol: UBP7_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 7

UniProtKB Accession Codes:

Q93009 A6NMY8 B7Z815 H0Y3G8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 ELM 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 63 PDBsum 63 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9034339

Title: A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein.

PubMed ID: 9034339

DOI: 10.1093/emboj/16.3.566

PubMed ID: 9130697

Title:

PubMed ID: 9130697

DOI: 10.1093/emboj/16.7.1519

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 12093161

Title: USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.

PubMed ID: 12093161

DOI: 10.1006/mcne.2002.1103

PubMed ID: 11923872

Title: Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.

PubMed ID: 11923872

DOI: 10.1038/nature737

PubMed ID: 14506283

Title: Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.

PubMed ID: 14506283

DOI: 10.1074/jbc.m307200200

PubMed ID: 15053880

Title: A dynamic role of HAUSP in the p53-Mdm2 pathway.

PubMed ID: 15053880

DOI: 10.1016/s1097-2765(04)00157-1

PubMed ID: 16160161

Title: Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.

PubMed ID: 16160161

DOI: 10.1128/jvi.79.19.12342-12354.2005

PubMed ID: 16845383

Title: Critical role for Daxx in regulating Mdm2.

PubMed ID: 16845383

DOI: 10.1038/ncb1442

PubMed ID: 16964248

Title: FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.

PubMed ID: 16964248

DOI: 10.1038/ncb1469

PubMed ID: 17651432

Title: Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization.

PubMed ID: 17651432

DOI: 10.1111/j.1742-4658.2007.05952.x

PubMed ID: 18566590

Title: The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.

PubMed ID: 18566590

DOI: 10.1038/emboj.2008.115

PubMed ID: 18716620

Title: The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.

PubMed ID: 18716620

DOI: 10.1038/nature07290

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18590780

Title: Identification of a novel higher molecular weight isoform of USP7/HAUSP that interacts with the Herpes simplex virus type-1 immediate early protein ICP0.

PubMed ID: 18590780

DOI: 10.1016/j.virusres.2008.05.017

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20153724

Title: Daxx is reciprocally regulated by Mdm2 and Hausp.

PubMed ID: 20153724

DOI: 10.1016/j.bbrc.2010.02.051

PubMed ID: 20601937

Title: Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.

PubMed ID: 20601937

DOI: 10.1038/emboj.2010.129

PubMed ID: 20719947

Title: Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.

PubMed ID: 20719947

DOI: 10.1128/jvi.01183-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21170034

Title: TSPYL5 suppresses p53 levels and function by physical interaction with USP7.

PubMed ID: 21170034

DOI: 10.1038/ncb2142

PubMed ID: 21258371

Title: Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.

PubMed ID: 21258371

DOI: 10.1038/ncb2153

PubMed ID: 21745816

Title: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.

PubMed ID: 21745816

DOI: 10.1093/nar/gkr528

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22072767

Title: Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.

PubMed ID: 22072767

DOI: 10.1128/jvi.05442-11

PubMed ID: 22411829

Title: M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.

PubMed ID: 22411829

DOI: 10.1073/pnas.1116349109

PubMed ID: 22689415

Title: Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.

PubMed ID: 22689415

DOI: 10.1002/cbic.201200261

PubMed ID: 22863774

Title: The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.

PubMed ID: 22863774

DOI: 10.1038/emboj.2012.218

PubMed ID: 22466611

Title: UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.

PubMed ID: 22466611

DOI: 10.1038/ng.2230

PubMed ID: 22466612

Title: Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.

PubMed ID: 22466612

DOI: 10.1038/ng.2228

PubMed ID: 23973222

Title: Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

PubMed ID: 23973222

DOI: 10.1016/j.immuni.2013.05.018

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24216761

Title: Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.

PubMed ID: 24216761

DOI: 10.1128/mcb.00968-13

PubMed ID: 25266658

Title: The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin.

PubMed ID: 25266658

DOI: 10.1128/mcb.00731-14

PubMed ID: 25283148

Title: ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.

PubMed ID: 25283148

DOI: 10.1038/ncomms6059

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25865756

Title: The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.

PubMed ID: 25865756

DOI: 10.1038/ncomms7752

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 26678539

Title: Mixed lineage leukemia 5 (MLL5) protein stability is cooperatively regulated by O-GlcNac transferase (OGT) and ubiquitin specific protease 7 (USP7).

PubMed ID: 26678539

DOI: 10.1371/journal.pone.0145023

PubMed ID: 27123980

Title: USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock.

PubMed ID: 27123980

DOI: 10.1371/journal.pone.0154263

PubMed ID: 26786098

Title: Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7.

PubMed ID: 26786098

DOI: 10.1074/jbc.m115.710632

PubMed ID: 28655758

Title: Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.

PubMed ID: 28655758

DOI: 10.1074/jbc.m117.780130

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29343584

Title: Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase.

PubMed ID: 29343584

DOI: 10.1128/jvi.02003-17

PubMed ID: 31666375

Title: USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue.

PubMed ID: 31666375

DOI: 10.1128/jvi.01553-19

PubMed ID: 35216969

Title: Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.

PubMed ID: 35216969

DOI: 10.1016/j.jbc.2022.101750

PubMed ID: 12507430

Title: Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.

PubMed ID: 12507430

DOI: 10.1016/s0092-8674(02)01199-6

PubMed ID: 15808506

Title: Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.

PubMed ID: 15808506

DOI: 10.1016/j.molcel.2005.02.029

PubMed ID: 16402859

Title: Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.

PubMed ID: 16402859

DOI: 10.1371/journal.pbio.0040027

PubMed ID: 16474402

Title: Molecular recognition of p53 and MDM2 by USP7/HAUSP.

PubMed ID: 16474402

DOI: 10.1038/nsmb1067

PubMed ID: 25944111

Title: Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.

PubMed ID: 25944111

DOI: 10.15252/embj.201490497

PubMed ID: 26365382

Title: USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder.

PubMed ID: 26365382

DOI: 10.1016/j.molcel.2015.07.033

PubMed ID: 30679821

Title: Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.

PubMed ID: 30679821

DOI: 10.1038/s41436-019-0433-1

Sequence Information:

  • Length: 1102
  • Mass: 128302
  • Checksum: F1A5A5C421396E45
  • Sequence:
    • MNHQQQQQQQ KAGEQQLSEP EDMEMEAGDT DDPPRITQNP VINGNVALSD GHNTAEEDME 
DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP HQKSVGFFLQ 
CNAESDSTSW SCHAQAVLKI INYRDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE 
KGFIDDDKVT FEVFVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK 
AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC 
RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI QLSIKGKKNI 
FESFVDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK 
INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF 
DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQA VTDHDIPQQL 
VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS 
SLAEFVQSLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE LSDNENPWTI 
FLETVDPELA ASGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS CKIRDLLPVM 
CDRAGFIQDT SLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK DDPENDNSEL 
PTAKEYFRDL YHRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF 
KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCIWLN 
SQFREEEITL YPDKHGCVRD LLEECKKAVE LGEKASGKLR LLEIVSYKII GVHQEDELLE 
CLSPATSRTF RIEEIPLDQV DIDKENEMLV TVAHFHKEVF GTFGIPFLLR IHQGEHFREV 
MKRIQSLLDI QEKEFEKFKF AIVMMGRHQY INEDEYEVNL KDFEPQPGNM SHPRPWLGLD 
HFNKAPKRSR YTYLEKAIKI HN

Genular Protein ID: 1447437176

Symbol: B7Z855_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z855

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 1 InterPro 9 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 4 RefSeq 1 SUPFAM 2

Sequence Information:

  • Length: 1003
  • Mass: 117027
  • Checksum: E255883306356BC3
  • Sequence:
    • MVMPRFYPDR PHQKSVGFFL QCNAESDSTS WSCHAQAVLK IINYRDDEKS FSRRISHLFF 
HKENDWGFSN FMAWSEVTDP EKGFIDDDKV TFEVFVQADA PHGVAWDSKK HTGYVGLKNQ 
GATCYMNSLL QTLFFTNQLR KAVYMMPTEG DDSSKSVPLA LQRVFYELQH SDKPVGTKKL 
TKSFGWETLD SFMQHDVQEL CRVLLDNVEN KMKGTCVEGT IPKLFRGKMV SYIQCKEVDY 
RSDRREDYYD IQLSIKGKKN IFESFVDYVA VEQLDGDNKY DAGEHGLQEA EKGVKFLTLP 
PVLHLQLMRF MYDPQTDQNI KINDRFEFPE QLPLDEFLQK TDPKDPANYI LHAVLVHSGD 
NHGGHYVVYL NPKGDGKWCK FDDDVVSRCT KEEAIEHNYG GHDDDLSVRH CTNAYMLVYI 
RESKLSEVLQ AVTDHDIPQQ LVERLQEEKR IEAQKRKERQ EAHLYMQVQI VAEDQFCGHQ 
GNDMYDEEKV KYTVFKVLKN SSLAEFVQSL SQTMGFPQDQ IRLWPMQARS NGTKRPAMLD 
NEADGNKTMI ELSDNENPWT IFLETVDPEL AASGATLPKF DKDHDVMLFL KMYDPKTRSL 
NYCGHIYTPI SCKIRDLLPV MCDRAGFIQD TSLILYEEVK PNLTERIQDY DVSLDKALDE 
LMDGDIIVFQ KDDPENDNSE LPTAKEYFRD LYHRVDVIFC DKTIPNDPGF VVTLSNRMNY 
FQVAKTVAQR LNTDPMLLQF FKSQGYRDGP GNPLRHNYEG TLRDLLQFFK PRQPKKLYYQ 
QLKMKITDFE NRRSFKCIWL NSQFREEEIT LYPDKHGCVR DLLEECKKAV ELGEKASGKL 
RLLEIVSYKI IGVHQEDELL ECLSPATSRT FRIEEIPLDQ VDIDKENEML VTVAHFHKEV 
FGTFGIPFLL RIHQGEHFRE VMRRIQSLLD IQEKEFEKFK FAIVMMGRHQ YINEDEYEVN 
LKDFEPQPGN MSHPRPWLGL DHFNKAPKRS RYTYLEKAIK IHN

Genular Protein ID: 4279439271

Symbol: B7ZAX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZAX6

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 1 InterPro 9 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 Pfam 4 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 1086
  • Mass: 126170
  • Checksum: 0C87535F74B37F6A
  • Sequence:
    • MAGNHRLGLE AGDTDDPPRI TQNPVINGNV ALSDGHNTAE EDMEDDTSWR SEATFQFTVE 
RFSRLSESVL SPPCFVRNLP WKIMVMPRFY PDRPHQKSVG FFLQCNAESD STSWSCHAQA 
VLKIINYRDD EKSFSRRISH LFFHKENDWG FSNFMAWSEV TDPEKGFIDD DKVTFEVFVQ 
ADAPHGVAWD SKKHTGYVGL KNQGATCYMN SLLQTLFFTN QLRKAVYMMP TEGDDSSKSV 
PLALQRVFYE LQHSDKPVGT KKLTKSFGWE TLDSFMQHDV QELCRVLLDN VENKMKGTCV 
EGTIPKLFRG KMVSYIQCKE VDYRSDRRED YYDIQLSIKG KKNIFESFVD YVAVGQLDGD 
NKYDAGEHGL QEAEKGVKFL TLPPVLHLQL MRFMYDPQTD QNIKINDRFE FPEQLPLDEF 
LQKTDPKDPA NYILHAVLVH SGDNHGGHYV VYLNPKGDGK WCKFDDDVVS RCTKEEAIEH 
NYGGHDDDLS VRHCTNAYML VYIRESKLSE VLQAVTDHDI PQQLVERLQE EKRIEAQKRK 
ERQEAHLYMQ VQIVAEDQFC GHQGNDMYDE EKVKYTVFKV LKNSSLAEFV QSLSQTMGFP 
QDQIRLWPMQ ARSNGTKRPA MLDNEADGNK TMIELSDNEN PWTIFLETVD PELAASGATL 
PKFDKDHDVM LFLKMYDPKT RSLNYCGHIY TPISCKIRDL LPVMCDRAGF IQDTSLILYE 
EVKPNLTERI QDYDVSLDKA LDELMDGDII VFQKDDPEND NSELPTAKEY FRDLYHRVDV 
IFCDKTIPSD PGFVVTLSNR MNYFQVAKTV AQRLNTDPML LQFFKSQGYR DGPGNPLRHN 
YEGTLRDLLQ FFKPRQPKKL YYQQLKMKIT DFENRRSFKC IWLNSQFREE EITLYPDKHG 
CVRDLLEECK KAVELGEKAS GKLRLLEIVS YKIIGVHQED ELLECLSPAT SRTFRIEEIP 
LDQVDIDKEN EMLVTVAHFH KEVFGTFGIP FLLRIHQGEH FREVMKRIQS LLDIQEKEFE 
KFKFAIVMMG RHQYINEDEY EVNLKDFEPQ PGNMSHPRPW LGLDHFNKAP KRSRYTYLEK 
AIKIHN

Genular Protein ID: 2534090564

Symbol: Q6U8A4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6U8A4

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 1 IntAct 1 InterPro 9 KEGG 1 MEROPS 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 Pfam 4 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 1112
  • Mass: 129004
  • Checksum: D7D7A56AD369EB39
  • Sequence:
    • SGCSHSDVGE RTSPIPQQRP LQSHAEMAGN HRLGLEAGDT DDPPRITQNP VINGNVALSD 
GHNTAEEDME DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP 
HQKSVGFFLQ CNAESDSTSW SCHAQAVLKI INYRDDEKSF SRRISHLFFH KENDWGFSNF 
MAWSEVTDPE KGFIDDDKVT FEVFVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ 
TLFFTNQLRK AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS 
FMQHDVQELC RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI 
QLSVKGKKNI FESFVDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLKRFM 
YDPQTDQNIK INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN 
PKGDGKWCKF DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQA 
VTDHDIPQQL VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK 
YTVFKVLKNS SLAELVQSLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE 
LSDNENPWTI FLETVDPELA ASGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS 
CKIRDLLPVM CDRAGFIQDT SLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK 
DDPENDNSEL PTAKEYFRDL YHRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL 
NTDPMLLQFF KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN 
RRSFKCIWLN SQFREEEITL YPDKHGCVRD LLEECKKAVE LGEKASGKLR LLEIVSYKII 
GVHQEDELLE CLSPATSRTF RIEEIPLDQV DIDKENEMLV TVAHFHKEVF GTFGIPFLLR 
IHQGEHFREV MKRIQSLLDI QEKEFEKFKF AIVMMGRHQY INEDEYEVNL KDFEPQPGNM 
SHPRPWLGLD HFNKAPKRSR YTYLEKAIKI HN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.